scholarly journals COVID-19 Evolves in Human Hosts

2020 ◽  
Author(s):  
Yanni Liu ◽  
Bing Liu ◽  
Jiangtao Cui ◽  
Zhi Wang ◽  
Yulong Shen ◽  
...  
Keyword(s):  
Complete Genome ◽  
Time Course ◽  
The Other ◽  
Evolutionary Trees ◽  
Genome Sequences ◽  
Original Host

Today, we are all threatened by an unprecedented pandemic: COVID-19. How different is it from other coronaviruses? Will it be attenuated or become more virulent? Which animals may be its original host? In this study, we analyzed 377 publicly available complete genome sequences for the COVID-19 virus, the previously known flu-causing coronaviruses (HCov-229E, HCov-OC43, HCov-NL63 and HCov-HKU1) and the lethal, pathogenic P3/P4 viruses, SARS, MERS, Victoria, Lassa, Yamagata, Ebola, and Dengue. We found strong similarities between the current circulating COVID-19 and SARS and MERS, as well as COVID-19 in rhinolophines and pangolins. On the contrary, COVID-19 shares little similarity with the flu-causing coronaviruses and the other P3/P4 viruses. Strikingly, we observed divergence of COVID-19 strains isolated from human hosts has steadily increased from December 2019 to March 2020, suggesting COVID-19 is actively evolving in human hosts. From all existing human COVID-19 genome sequences, we calculated the first common model that represents the shared sequences of the human COVID-19 strains, which provides important information for vaccine and antibody development. Geographic and time-course analysis of the evolutionary trees of the human COVID-19 reveals possibly heterogeneous evolutional paths among strains from 21 countries. This finding has important implications to the management of COVID-19 and the development of vaccines.

scholarly journals Complete Genome Sequences of Betanodavirus from Australian Barramundi (Lates calcarifer)

2019 ◽  
Vol 8 (16) ◽  
Author(s):  
Kelly Condon ◽  
Shaun Bochow ◽  
Ellen Ariel ◽  
Terrence L. Miller
Keyword(s):  
Complete Genome ◽  
Phylogenetic Analyses ◽  
The Other ◽  
Nervous Necrosis Virus ◽  
Genome Sequences ◽  
Necrosis Virus ◽  
Lates Calcarifer ◽  
Complete Sequences ◽  
Australian Fish

The complete RNA-1 and RNA-2 genome sequences of Betanodavirus were obtained from Australian barramundi (Lates calcarifer). Phylogenetic analyses revealed that the sequences have closest homology to the red spotted grouper nervous necrosis virus (RGNNV) species and share between 91 and 98% homology with the other two published complete/near-complete sequences of isolates from Australian fish.

scholarly journals Complete Genome Sequences of Four Coxsackievirus A16 Strains Isolated from Four Children with Severe Hand, Foot, and Mouth Disease

2017 ◽  
Vol 5 (31) ◽  
Author(s):  
Shao-Jian Xu ◽  
Hong Yang ◽  
Xiang-Jie Yao ◽  
Hai-Long Zhang ◽  
Yan Ren ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Complete Genome ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
The Other ◽  
Vp1 Gene ◽  
Coxsackievirus A16 ◽  
Genome Sequences ◽  
Foot And Mouth

ABSTRACT Here, we report the complete genome sequences of four coxsackievirus A16 strains isolated from four children with severe hand, foot, and mouth disease. Three of them were assigned to subgenotype B1b based on phylogenetic analysis of the VP1 gene, and the other one belonged to subgenotype B1a.

scholarly journals Complete Genome Sequences of Two Porcine Deltacoronavirus Strains from Henan Province, China

2019 ◽  
Vol 8 (10) ◽  
Author(s):  
Qingqing Liang ◽  
Bingxiao Li ◽  
Honglei Zhang ◽  
Hui Hu
Keyword(s):  
Sequence Analysis ◽  
Complete Genome ◽  
Genomic Sequence ◽  
Henan Province ◽  
Full Length ◽  
The Other ◽  
Genome Sequences ◽  
Fecal Samples ◽  
Genomic Sequence Analysis

In 2016 and 2018, two porcine deltacoronavirus (PDCoV) strains, CH-01 and HNZK-02, were identified from fecal samples of piglets with diarrhea in Henan Province, China. The full-length genomic sequence analysis indicated that these two strains had high nucleotide identities with the other Chinese PDCoV epidemic strains.

scholarly journals Complete genome analysis of African swine fever virus responsible for outbreaks in domestic pigs in 2018 in Burundi and 2019 in Malawi

2021 ◽  
Vol 53 (4) ◽  
Author(s):  
Jean N. Hakizimana ◽  
Jean B. Ntirandekura ◽  
Clara Yona ◽  
Lionel Nyabongo ◽  
Gladson Kamwendo ◽  
...  
Keyword(s):  
Complete Genome ◽  
African Swine Fever Virus ◽  
Gc Content ◽  
Genomic Analysis ◽  
African Swine Fever ◽  
Eastern Africa ◽  
Nucleotide Identity ◽  
Comparative Genomic ◽  
Genome Sequences ◽  
Domestic Pigs

AbstractSeveral African swine fever (ASF) outbreaks in domestic pigs have been reported in Burundi and Malawi and whole-genome sequences of circulating outbreak viruses in these countries are limited. In the present study, complete genome sequences of ASF viruses (ASFV) that caused the 2018 outbreak in Burundi (BUR/18/Rutana) and the 2019 outbreak in Malawi (MAL/19/Karonga) were produced using Illumina next-generation sequencing (NGS) platform and compared with other previously described ASFV complete genomes. The complete nucleotide sequences of BUR/18/Rutana and MAL/19/Karonga were 176,564 and 183,325 base pairs long with GC content of 38.62 and 38.48%, respectively. The MAL/19/Karonga virus had a total of 186 open reading frames (ORFs) while the BUR/18/Rutana strain had 151 ORFs. After comparative genomic analysis, the MAL/19/Karonga virus showed greater than 99% nucleotide identity with other complete nucleotides sequences of p72 genotype II viruses previously described in Tanzania, Europe and Asia including the Georgia 2007/1 isolate. The Burundian ASFV BUR/18/Rutana exhibited 98.95 to 99.34% nucleotide identity with genotype X ASFV previously described in Kenya and in Democratic Republic of the Congo (DRC). The serotyping results classified the BUR/18/Rutana and MAL/19/Karonga ASFV strains in serogroups 7 and 8, respectively. The results of this study provide insight into the genetic structure and antigenic diversity of ASFV strains circulating in Burundi and Malawi. This is important in order to understand the transmission dynamics and genetic evolution of ASFV in eastern Africa, with an ultimate goal of designing an efficient risk management strategy against ASF transboundary spread.

scholarly journals Complete Genome Sequences of Four Extensively Drug-Resistant Acinetobacter baumannii Isolates from Thailand

2020 ◽  
Vol 9 (40) ◽  
Author(s):  
Peechanika Chopjitt ◽  
Thidathip Wongsurawat ◽  
Piroon Jenjaroenpun ◽  
Parichart Boueroy ◽  
Rujirat Hatrongjit ◽  
...  
Keyword(s):  
Acinetobacter Baumannii ◽  
Complete Genome ◽  
Sequence Type ◽  
Clinical Isolates ◽  
Drug Resistant ◽  
Genome Sequences ◽  
Content Type ◽  
Type Isolate ◽  
Resistant Genes ◽  
Extensively Drug Resistant

ABSTRACT Here, we report the complete genome sequences of four clinical isolates of extensively drug-resistant Acinetobacter baumannii (XDRAB), isolated in Thailand. These results revealed multiple antimicrobial-resistant genes, each involving two sequence type 16 (ST16) isolates, ST2, and a novel sequence type isolate, ST1479.

scholarly journals Complete Genome Sequences of Six Novel Macaca mulatta Papillomavirus Types Isolated from Genital Sites of Rhesus Monkeys in Hong Kong SAR, China

2018 ◽  
Vol 7 (22) ◽  
Author(s):  
Teng Long ◽  
Po Yee Wong ◽  
Wendy C. S. Ho ◽  
Robert D. Burk ◽  
Paul K. S. Chan ◽  
...  
Keyword(s):  
Hong Kong ◽  
Macaca Mulatta ◽  
Complete Genome ◽  
Rhesus Monkeys ◽  
Genome Sequences ◽  
Content Type ◽  
Complete Genomes ◽  
Hong Kong Sar

The complete genomes of six Macaca mulatta papillomavirus types isolated from genital sites of rhesus monkeys were characterized, and less than 72% identity with the complete L1 genes of known papillomaviruses was found. Macaca mulatta papillomavirus type 2 (MmPV2), MmPV3, and MmPV6 cluster into the genus Alphapapillomavirus, and MmPV4, MmPV5, and MmPV7 cluster into the genus Gammapapillomavirus.

scholarly journals Complete Genome Sequences of Six Measles Virus Strains

2018 ◽  
Vol 6 (13) ◽  
Author(s):  
My V. T. Phan ◽  
Claudia M. E. Schapendonk ◽  
Bas B. Oude Munnink ◽  
Marion P. G. Koopmans ◽  
Rik L. de Swart ◽  
...  
Keyword(s):  
Next Generation Sequencing ◽  
Complete Genome ◽  
Measles Virus ◽  
Genetic Characterization ◽  
Critical Component ◽  
Wild Type ◽  
Genome Sequences ◽  
Virus Strains ◽  
Generation Sequencing

ABSTRACT Genetic characterization of wild-type measles virus (MV) strains is a critical component of measles surveillance and molecular epidemiology. We have obtained complete genome sequences of six MV strains belonging to different genotypes, using random-primed next generation sequencing.

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