scholarly journals Incidence and Characteristics of Retinoblastoma in Poland: The First Nationwide Study 2010-2017

2021 ◽  
Author(s):  
Michał Szymon Nowak ◽  
Bożena Romanowska-Dixon ◽  
Iwona Grabska-Liberek ◽  
Michał Żurek
Keyword(s):  
North America ◽  
Mortality Rate ◽  
United States Of America ◽  
Disease Burden ◽  
External Beam Radiotherapy ◽  
Eastern European ◽  
Live Births ◽  
Prompt Treatment ◽  
Plaque Radiotherapy ◽  
Eastern European Countries

Retinoblastoma is the most common intraocular paediatric eye cancer. It accounts for approximately 11% of primary cancers occurring in the first age of life, with 95% of diagnoses before 5 years of age [1-3]. Since retinoblastoma is very aggressive, early diagnosis and prompt treatment are vital for children to preserve their sight and life. In western countries in Europe and North America, retinoblastoma is diagnosed early so the chances of saving the patient’s life and preserving vision are good. However, in large regions of Africa and Asia, where the diagnosis of retinoblastoma is delayed, the deadly effect is observed [2-5]. In these regions, socioeconomic factors and poor recognition of the seriousness of the disease result in a high mortality rate of up to 70%. At the same time, the mortality rate in Europe and North America is 3-5 % [2]. Besides, the incidence of retinoblastoma also varies by race and region, from 40 to 60 per million live births, which corresponds to 1 per 16,000 - 24,000 live births, with the greatest disease burden recorded in the countries of Asia and Africa where the highest birth rates are recorded [2,3 However, the nationwide studies of the retinoblastoma epidemiology have been conducted in many countries, such as Sweden, Finland, Netherlands, Singapore, Great Britain, United States of America, Korea and Taiwan, there is a lack of data from Eastern European countries like Poland [1,3-11]. The management of retinoblastoma may also differ between developed and developing countries. The current strategy of retinoblastoma treatment aims to save the life, eye, vision and cosmetics of the child, in order of priority. Medical management of retinoblastoma includes surgical treatment (enucleation), external beam radiotherapy, systemic chemotherapy with or without focal therapies such as cryotherapy, laser photocoagulation and plaque radiotherapy. Recently, intra-arterial and intravitreal chemotherapies have been used to treat retinoblastoma with the ability to save globes that otherwise would have been enucleated [2,3]. The present study aimed to investigate the incidence and characteristics of retinoblastoma in the overall population of Poland in the years 2010-2017 and to report the changes that occurred during that period.

scholarly journals The lower COVID-19 related mortality and incidence rates in Eastern European countries are associated with delayed start of community circulation

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0243411
Author(s):  
Alban Ylli ◽  
Yan Yan Wu ◽  
Genc Burazeri ◽  
Catherine Pirkle ◽  
Tetine Sentell
Keyword(s):  
Mortality Rate ◽  
Life Expectancy ◽  
Incidence Rates ◽  
European Countries ◽  
Time Interval ◽  
Eastern European ◽  
Average Life ◽  
Average Life Expectancy ◽  
Eastern European Countries ◽  
Related Mortality

Background The purpose of this analysis was to assess the variations in COVID-19 related mortality in relation to the time differences in the commencement of virus circulation and containment measures in the European Region. Methods The data for the current analysis (N = 50 countries) were retrieved from the John Hopkins University dataset on the 7th of May 2020, with countries as study units. A piecewise regression analysis was conducted with mortality and cumulative incidence rates introduced as dependent variables and time interval (days from the 22nd of January to the date when 100 first cases were reported) as the main predictor. The country average life expectancy at birth and outpatient contacts per person per year were statistically adjusted for in the regression model. Results Mortality and incidence were strongly and inversely intercorrelated with days from January 22, respectively -0.83 (p<0.001) and -0.73 (p<0.001). Adjusting for average life expectancy and outpatients contacts per person per year, between days 33 to 50 from the 22nd of the January, the average mortality rate decreased by 30.1/million per day (95% CI: 22.7, 37.6, p<0.001). During interval 51 to 73 days, the change in mortality was no longer statistically significant but still showed a decreasing trend. A similar relationship with time interval was found for incidence. Life expectancy and outpatients contacts per person per year were not associated with mortality rate. Conclusion Countries in Europe that had the earliest COVID-19 circulation suffered the worst consequences in terms of health outcomes, specifically mortality. The drastic social isolation measures, quickly undertaken in response to those initial outbreaks appear effective, especially in Eastern European countries, where community circulation started after March 11th. The study demonstrates that efforts to delay the early spread of the virus may have saved an average 30 deaths daily per one million inhabitants.

scholarly journals The lower COVID-19 related mortality and incidence rates in Eastern European countries are associated with delayed start of community circulation

2020 ◽  
Author(s):  
Alban Ylli ◽  
Yan Yan Wu ◽  
Genc Burazeri ◽  
Catherine Pirkle ◽  
Tetine Sentell
Keyword(s):  
Mortality Rate ◽  
Life Expectancy ◽  
Incidence Rates ◽  
European Countries ◽  
Time Interval ◽  
Eastern European ◽  
Average Life ◽  
Average Life Expectancy ◽  
Eastern European Countries ◽  
Related Mortality

AbstractBackgroundThe purpose of this analysis was to assess the variations in COVID-19 related mortality and incidence rates in relation to the time differences in the commencement of virus circulation and containment measures in different countries of the European Region.MethodsThe data for the current analysis (N=50 countries) were retrieved from the John Hopkins University dataset on the 7th of May 2020, with countries as study units. A piecewise regression analysis was conducted with mortality and cumulative incidence rates introduced as dependent variables and time interval (days from the 22nd of January to the date when 100 first cases were reported) as the main predictor. The country average life expectancy at birth was statistically adjusted for in the regression model.ResultsMortality and incidence were strongly and inversely intercorrelated with days from January 22, respectively −0.83 (p<.0001) and −0.73 (p<.0001). Adjusting for average life expectancy, between days 33 to 50 from the 22th of the January, the average mortality rate decreased by 30.4/million per day (95% CI: 23.2, 37.1, p<0.0001). During interval 51 to 73 days, the change in mortality was no longer statistically significant but still showed a decreasing trend. A similar relationship with time interval was found in incidence. Life expectancy was not associated with mortality rate.ConclusionCountries in Europe which observed the earliest COVID-19 circulation, suffered the worst consequences in terms of health outcomes, specifically mortality. The drastic social isolation measures, undertaken especially in Eastern European countries, where community circulation started after March 11th, may have been timely. This may explain their significantly lower COVID-related mortality compared with the Western European countries.

scholarly journals Trends in ischaemic heart disease and cerebrovascular disease mortality in Europe: an observational study from 1990–2017

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
M Hammond-Haley ◽  
A Hartley ◽  
M Essa ◽  
A Delago ◽  
D.C Marshall ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Heart Disease ◽  
Mortality Rate ◽  
The Netherlands ◽  
European Countries ◽  
Eastern European ◽  
Males And Females ◽  
Eastern European Countries ◽  
Mortality Improvements ◽  
Cvd Mortality

Abstract Background Cardiovascular disease remains the leading cause of death worldwide. Previously, we identified a growing disparity between Western and Eastern European countries for mortality from ischaemic heart disease (IHD) and cerebrovascular disease (CVD). Purpose To describe current trends in mortality from IHD and CVD. Methods IHD and CVD age-standardized death rates (ASDR) for European countries between 1990–2017 were extracted from the World Health Organization mortality database using the International Classification of Diseases 9th and 10th Edition codes. Jointpoint regression analysis was used to describe trends over this period. Results Between 1990–2017, IHD mortality declined in all included countries except Croatia (+3% in males and +23% in females). Largest mortality improvements were generally seen in Western European countries, including the Netherlands, UK and Sweden, which saw greater than 65% improvements for both sexes. Estonia was a notable exception, which, after the Netherlands, demonstrated the second highest improvement in mortality (−69% in males, −74% in females). Hungary and Greece saw the smallest improvements in IHD mortality (approximately −12% to −27%). Results of jointpoint regression analysis for selected European countries are shown in Figure 1. In 2017 Lithuania had the highest mortality rate in both males and females (279.4/100,000 and 261.3/100,000, respectively) whilst the Netherlands had the lowest mortality in males and females (32.6/100,00 and 15.3/100,000, respectively). This represents an approximately 8.5-fold difference in IHD mortality in males and a 10.5-fold difference in females between these two countries. CVD mortality declined in all included countries between 1990–2017. Estonia saw the greatest improvements in both males and females (−80.8% and −84.9%, respectively), followed by Austria, Portugal and the Czech Republic (over 70% reductions in both sexes). Bulgaria, Romania and Lithuania saw the smallest reductions (approximately −17% to −33%). In 2017, Bulgaria had the highest CVD mortality rate in both males and females (149.9/100,000 and 113.1/100,000, respectively), whilst the lowest mortality rate was observed in Austria (21.8/100,000 and 19.5/100,000 for males and females, respectively). This represents an approximately 7-fold difference in CVD mortality in males and a 6-fold difference in females between these two countries. Conclusions IHD and CVD mortality rates continue to decrease for men and women across Europe. While certain Eastern European countries have demonstrated considerable mortality improvements over this observation period, in general the disparity between Eastern and Western Europe persists, with further work required to understand and address these inequalities. Squares: male. Circles: female Funding Acknowledgement Type of funding source: None

Pragmatic Language Performance of Children Adopted Internationally

2019 ◽  
Vol 28 (2) ◽  
pp. 501-514
Author(s):  
Deborah A. Hwa-Froelich ◽  
Hisako Matsuo
Keyword(s):  
Social Communication ◽  
False Belief ◽  
Pragmatic Language ◽  
Eastern European ◽  
Language Performance ◽  
Emotion Identification ◽  
False Belief Understanding ◽  
Quasi Experimental ◽  
Pragmatic Communication ◽  
Eastern European Countries

Purpose Pragmatic language is important for social communication across all settings. Children adopted internationally (CAI) may be at risk of poorer pragmatic language because of adverse early care, delayed adopted language development, and less ability to inhibit. The purpose of this study was to compare pragmatic language performance of CAI from Asian and Eastern European countries with a nonadopted group of children who were of the same age and from similar socioeconomic backgrounds as well as explore the relationship among emotion identification, false belief understanding, and inhibition variables with pragmatic language performance. Method Using a quasi-experimental design, 35 four-year-old CAI (20 Asian, 15 Eastern European) and 33 children who were not adopted were included in this study. The children's pragmatic language, general language, and social communication (emotion identification of facial expressions, false belief understanding, inhibition) were measured. Comparisons by region of origin and adoption experience were completed. We conducted split-half correlation analyses and entered significant correlation variables into simple and backward regression models. Results Pragmatic language performance differed by adoption experience. The adopted and nonadopted groups demonstrated different correlation patterns. Language performance explained most of the pragmatic language variance. Discussion Because CAI perform less well than their nonadopted peers on pragmatic communication measures and different variables are related to their pragmatic performance, speech-language pathologists may need to adapt assessment and intervention practices for this population.

European Integration

2020 ◽  
Author(s):  
Johann P. Arnason
Keyword(s):  
European Integration ◽  
Eastern European ◽  
The European Union ◽  
Historical Processes ◽  
History Of ◽  
External Conditions ◽  
Eastern European Countries ◽  
Totalitarian Regimes ◽  
The Eu

Different understandings of European integration, its background and present problems are represented in this book, but they share an emphasis on historical processes, geopolitical dynamics and regional diversity. The introduction surveys approaches to the question of European continuities and discontinuities, before going on to an overview of chapters. The following three contributions deal with long-term perspectives, including the question of Europe as a civilisational entity, the civilisational crisis of the twentieth century, marked by wars and totalitarian regimes, and a comparison of the European Union with the Habsburg Empire, with particular emphasis on similar crisis symptoms. The next three chapters discuss various aspects and contexts of the present crisis. Reflections on the Brexit controversy throw light on a longer history of intra-Union rivalry, enduring disputes and changing external conditions. An analysis of efforts to strengthen the EU’s legal and constitutional framework, and of resistances to them, highlights the unfinished agenda of integration. A closer look at the much-disputed Islamic presence in Europe suggests that an interdependent radicalization of Islamism and the European extreme right is a major factor in current political developments. Three concluding chapters adopt specific regional perspectives. Central and Eastern European countries, especially Poland, are following a path that leads to conflicts with dominant orientations of the EU, but this also raises questions about Europe’s future. The record of Scandinavian policies in relation to Europe exemplifies more general problems faced by peripheral regions. Finally, growing dissonances and divergences within the EU may strengthen the case for Eurasian perspectives.

Knowledge about basic life support in European students

2014 ◽  
Vol 155 (21) ◽  
pp. 833-837 ◽  
Author(s):  
József Marton ◽  
Attila Pandúr ◽  
Emese Pék ◽  
Krisztina Deutsch ◽  
Bálint Bánfai ◽  
...  
Keyword(s):  
Basic Life Support ◽  
Life Support ◽  
European Countries ◽  
Eastern European ◽  
Knowledge And Skills ◽  
European Students ◽  
Western European ◽  
Eastern European Countries ◽  
European Youth

Introduction: Better knowledge and skills of basic life support can save millions of lives each year in Europe. Aim: The aim of this study was to measure the knowledge about basic life support in European students. Method: From 13 European countries 1527 volunteer participated in the survey. The questionnaire consisted of socio-demographic questions and knowledge regarding basic life support. The maximum possible score was 18. Results: Those participants who had basic life support training earned 11.91 points, while those who had not participated in lifesaving education had 9.6 points (p<0.001). Participants from former socialist Eastern European countries reached 10.13 points, while Western Europeans had average 10.85 points (p<0.001). The best results were detected among the Swedish students, and the worst among the Belgians. Conclusions: Based on the results, there are significant differences in the knowledge about basic life support between students from different European countries. Western European youth, and those who were trained had better performance. Orv. Hetil., 2014, 155(21), 833–837.

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