scholarly journals Multidisciplinary approach in combating childhood obesity

2016 ◽  
Vol 3 (1) ◽  
Author(s):  
Dr.G. G. Kavitha Shree ◽  
Dr.M.R. Premalatha ◽  
Dr.K. Jothilakshmi
Keyword(s):  
Childhood Obesity ◽  
Behavioral Intervention ◽  
Education Program ◽  
Short Term ◽  
Group I ◽  
The Mean ◽  
Group Ii ◽  
Significant Change ◽  
One Year

The study demonstrated the beneficial effect of a multidisciplinary dietary-behavioral-physical intervention on childhood obesity among totally selected 618 school children. Children were classified as Group-I who received both education program and fitness exercise (N=228- Long-term behavioral intervention) and Group-II who were exposed only to education program (N=390 Short-term behavioral intervention). It was found that 28.3 per cent were overweight and 7.9 per cent were obese as per International Obesity Task Force (IOTF) standards at the beginning of study. The initial mean Body Mass Index (BMI) was 21.6+3.9 in Group-I and 21.9+3.4 in Group-II. The BMI reduced to 21.4+3.8 in Group-I and 21.8+3.5 in Group-II after six months at the first phase. After one year, the mean BMI of Group-I reduced significantly to 20.8+ 3.5 (P = 0.0001) due to long-term interventions, whereas the mean BMI of Group-II increased after one year. There was significant reduction in Waist Hip Ratio from initial to final among Group-I alone. There was no significant change in the Pulse Rate among both groups at the end of the study. After one year, among Group-I children, 6.6 per cent with high Blood Pressure and 4.4 per cent who had low BP shifted to normal BP showing a significant change whereas there was no significant change in Group-II. Peak expiratory flow rate improved significantly only in Group-I. There was significant influence of fitness exercise intervention on the fitness level test scores among Group-I after one year but there was no significant changes in Group-II. Thus the study revealed that only long-term combined multidisciplinary interventions can have positive influence in combating childhood obesity than short-term interventions.

scholarly journals High-dose MTX110 (soluble panobinostat) safely administered into the fourth ventricle in a nonhuman primate model

2020 ◽  
Vol 26 (2) ◽  
pp. 127-135 ◽  
Author(s):  
David I. Sandberg ◽  
Natasha Kharas ◽  
Bangning Yu ◽  
Christopher F. Janssen ◽  
Amanda Trimble ◽  
...  
Keyword(s):  
Fourth Ventricle ◽  
Nonhuman Primates ◽  
High Dose ◽  
Normal Brain ◽  
Short Term ◽  
Group I ◽  
Mri Scans ◽  
The Mean ◽  
Group Ii

OBJECTIVEChemotherapy infusions directly into the fourth ventricle may play a role in treating malignant fourth-ventricular tumors. This study tested the safety and pharmacokinetics of short-term and long-term administration of MTX110 (soluble panobinostat; Midatech Pharma) into the fourth ventricle of nonhuman primates.METHODSFour rhesus macaque monkeys underwent posterior fossa craniectomy and catheter insertion into the fourth ventricle. In group I (n = 2), catheters were externalized and lumbar drain catheters were placed simultaneously to assess CSF distribution after short-term infusions. MTX110 (0.5 ml of 300 μM panobinostat solution) was infused into the fourth ventricle daily for 5 consecutive days. Serial CSF and serum panobinostat levels were measured. In group II (n = 2), fourth-ventricle catheters were connected to a subcutaneously placed port for subsequent long-term infusions. Four cycles of MTX110, each consisting of 5 daily infusions (0.5 ml of 300 μM panobinostat solution), were administered over 8 weeks. Animals underwent detailed neurological evaluations, MRI scans, and postmortem histological analyses.RESULTSNo neurological deficits occurred after intraventricular MTX110 infusions. MRI scans showed catheter placement within the fourth ventricle in all 4 animals, with extension to the cerebral aqueduct in 1 animal and into the third ventricle in 1 animal. There were no MRI signal changes in the brainstem, cerebellum, or elsewhere in the brains of any of the animals. Histologically, normal brain cytoarchitecture was preserved with only focal mild postsurgical changes in all animals. Panobinostat was undetectable in serum samples collected 2 and 4 hours after infusions in all samples in both groups. In group I, the mean peak panobinostat level in the fourth-ventricle CSF (6242 ng/ml) was significantly higher than that in the lumbar CSF (9 ng/ml; p < 0.0001). In group II, the mean peak CSF panobinostat level (11,042 ng/ml) was significantly higher than the mean trough CSF panobinostat level (33 ng/ml; p < 0.0001).CONCLUSIONSMTX110 can be safely infused into the fourth ventricle in nonhuman primates at supratherapeutic doses. Postinfusion CSF panobinostat levels peak immediately in the fourth ventricle and then rapidly decrease over 24 hours. Panobinostat is detectable at low levels in CSF measured from the lumbar cistern up to 4 hours after infusions. These results will provide background data for a pilot clinical trial in patients with recurrent medulloblastoma.

scholarly journals The Effects of Long-Term Administration of Sodium Nedocromil on Bronchial Hypereactivity

2003 ◽  
Vol 1 (3) ◽  
pp. 119-123 ◽  
Author(s):  
G. Ilonidis ◽  
G. Anogianakis ◽  
CH. Trakatelli ◽  
A. Anogeianaki ◽  
M. Chomatidis ◽  
...  
Keyword(s):  
Allergic Asthma ◽  
Term Treatment ◽  
Bronchial Hyperreactivity ◽  
Methacholine Challenge ◽  
Intrinsic Asthma ◽  
Group I ◽  
Long Term Treatment ◽  
The Mean ◽  
Group Ii

The effect of long-term treatment with sodium nedocromil on airway hypereactivity was investigated in two groups of 20 patients each. Group I patients presented with allergic asthma while Group II patients presented with intrinsic asthma. For each subject of the two groups, the base FEV1 was measured and nebulized methacholine was administrated in consecutively higher concentrations until a decrease in FEV1 of >20 % was observed. Following measurement, all patients included in the study were treated with 12 mg of sodium nedocromil per day for 12 months. At the end of the treatment, bronchial hyperreactivity was evaluated for a second time by administering the same dosage of methacholine that originally produced a decline in FEV1 of >20 %. In Group I patients (allergic asthma) mean FEV1 was 3126 ml, before challenge, while after methacholine challenge FEV1 was 2400ml. Following 1-year of sodium nedocromil administration the FEV1 was 2601ml (P<0.05). Before treatment, the mean fall in FEV1, following methacholine challenge, was 23.67% while following a 1-year-long sodium nedocromil administration this value reduced to 15.70% (P<0.05). Correspondingly, PC20 was 5.59 while after sodium nedocromil administration it increased to 11.66 (P<0.05). In Group II patients (intrinsic asthma) mean FEV1 was 2750 ml, before challenge, while after methacholine challenge FEV1 was 2066ml. Following 1-year of sodium nedocromil administration the FEV1 was 2223ml (P<0.05). Before treatment, the mean fall in FEV1, following methacholine challenge, was 27.65 % while following a 1-year-long sodium nedocromil administration this value reduced to 21.92 % (P<0.05). Correspondingly, PC20 was 5.91 while after sodium nedocromil administration it increased to 6.19 (P<0.05). The results suggest a positive effect of long-term sodium nedocromil administration in bronchial hyperreactivity for both groups of patients.

scholarly journals The Outcome of Diabetic Patients with Cardiomyopathy in Critical Care Unit: Hospital and Short-Term Outcome in a Period of Six Months to One Year

2019 ◽  
Vol 7 (17) ◽  
pp. 2796-2801 ◽  
Author(s):  
Najjat Obaid ◽  
Samir El Hadidy ◽  
Mahmoud El Badry ◽  
Hassan Khaled
Keyword(s):  
Diastolic Function ◽  
Diabetic Cardiomyopathy ◽  
Ischemic Cardiomyopathy ◽  
Diabetic Patients ◽  
Short Term ◽  
Group I ◽  
Significant Difference ◽  
Group Ii ◽  
One Year ◽  
Systolic And Diastolic Function

BACKGROUND: Diabetes mellitus (DM) is a major risk factor for heart failure (HF) and coronary artery disease (CAD). DM may cause structural changes involving the left ventricle (LV) systolic and diastolic function. AIM: To compare patients who have diabetes and ischemic cardiomyopathy (ICM) to those with diabetic cardiomyopathy (DMCMP) regarding LV systolic function, diastolic function, in hospital long term and short-term mortality. METHODS: Ninety diabetic patients with heart failure and left ventricular ejection fraction (LVEF) ≤ 35%, admitted to Critical Care Medicine department Cairo University were divided into two groups based on coronary angiography results; group I (ICM) n = 48 patients and group II (DMCMP) n = 42 patients. RESULTS: Group I patients had higher mean age (63 ± 7 years), (p = 0.004), Hypertension (p ˂ 0.001) and dyslipidemia (p = 0.008) were significantly more present in group I compared to group II. No significant differences were found regarding LVEF, global longitudinal strain (GLS), E/A and E/É ratio in both groups. A significant difference in the wall motion score index (WMSI) in group I; (1.4 ± 0.4) versus group II; (1.1 ± 0.2), (p = 0.005) was found. In the study, 6 patients had a cardiogenic shock with no documented in-hospital mortality. At 6 months, statistically, significantly higher mortality rates were found in group I, (p = 0.006), while at one year there was no significant difference in the mortality between the two groups, (p = 0.077). In comparison of the survived and non-survived patients at 6 months and one year in group I (ICM) there was a significant difference in LVEF (40 ± 6% vs 23 ± 6%, p ˂ 0.001), GLS (- 8.1 ± 2.4 vs - 4.6 ± 2.6, p = 0.007), E/A (1.25 ± 0.91 vs 1.8 ± 0.5, p = 0.038), E/É (11.68 ± 7.5 vs 21.3 ± 3.6, p = 0.001) respectively. In group ll (DMCMP) there was no documented mortality at 6 months follow up, however, at one year there was statistically significant difference in the mortality between survived and non-survived patients; the LVEF (35 ± 8% vs 25 ± 2%, p = 0.014), GLS (-7.9 ± 2.9% vs -5 ± 0.1%, p = 0.032), E/A (1.45 ± 0.8 vs 3.3 ± 0, p = 0.006) respectively. The E/É ratio in group ll was not significantly different between the groups (15.73 ± 5.3 vs 15 ± 1, p = 0.873). CONCLUSION: The combination of cardiomyopathy and diabetes affects LV systolic and diastolic function; however; ischemic cardiomyopathy and diabetic cardiomyopathy had a similar systolic and diastolic function. Ischemic cardiomyopathy is associated with worse prognosis compared to diabetic cardiomyopathy.

scholarly journals Short and Long-Term Follow up Results of Daily 5 Mg Tadalafil as a Treatment for Erectile Dysfunction and Premature Ejaculation

2021 ◽  
Author(s):  
Tarek Gharib ◽  
Ibrahim Abdelal ◽  
Adel Elatreisy ◽  
Elsayed Salih ◽  
Ahmed Sebaey
Keyword(s):  
Erectile Dysfunction ◽  
Premature Ejaculation ◽  
P Value ◽  
Group I ◽  
Significant Difference ◽  
Long Term Follow Up ◽  
The Mean ◽  
Group Ii

Abstract Objective: To evaluate effectiveness and safety of a 5mg tadalafil daily treatment for men with erectile dysfunction (ED) and premature ejaculation (PE) and assessment of long-term follow up by persistence of improvement 2 years after stoppage of tadalafil.Materials and Methods: The study included 160 patients diagnosed with erectile dysfunction from April 2018 to June 2020. All were evaluated using the international index of erectile function questionnaire-5 (IIEF-5) to evaluate ED and intravaginal ejaculatory latency time (IELT) for PE. Patients subdivided into two equal groups. I included 80 patients treated with tadalafil 5 mg daily for 3 months, and group II included 80 patients treated with a placebo for same period. After 3 months treatment and 2 years later after stoppage of tadalafil, all patients were assessed for ED and PE using the same questionnaires. Results: The mean IELT and IIEF pretreatment were 37±11.24 s and 13.2±4.2 respectively for group I, while in group II was 35.98±10.8 s and 13.12±4.11, respectively. After 3 months of treatment, the mean value of IELT in group I showed a highly significant improvement from 37±11.24 sec to 120.5±47.37 sec (p-value < 0.001), but for group II, the mean values of IELT showed no significant improvement from baseline 35.98±10.8 to endpoint 39.43±13.6 ( p-value > 0.05). As regarding the IIEF, there was a highly significant improvement from baseline 13.2±4.2 to endpoint 20.45±4.5 in group I (p-value < 0.001) while there was no significant difference in group II from baseline 13.12±4.11 to endpoint 15±4.84 (p-value > 0.05) . 2 years later after stoppage of tadalafil , 75 patients from group I complete follow up and there was significant improvement in IELT and IIEF form base line (37±11.24) (13.2±4.2) to endpoint (98±18.3) (19.1±2.3) respectively but less than the results after 3 months treatment.ConclusionDaily Tadalafil 5 mg was effective, tolerable, and safe treatment for patients suffering from ED and PE. Long-term follow up after 2 years declared persistence of significant improvement.

scholarly journals DDEL-09. HIGH DOSE MTX110 (SOLUBLE PANOBINOSTAT) SAFELY ADMINISTERED INTO THE FOURTH VENTRICLE IN A NON-HUMAN PRIMATE MODEL

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii285-iii285
Author(s):  
Rachael W Sirianni ◽  
Natasha Kharas ◽  
Bangning Yu ◽  
Christopher F Janssen ◽  
Amanda Trimble ◽  
...  
Keyword(s):  
Fourth Ventricle ◽  
High Dose ◽  
Short Term ◽  
Primate Model ◽  
Lumbar Drain ◽  
Group I ◽  
Term Administration ◽  
Mri Scans ◽  
Group Ii

Abstract OBJECTIVE This study tested the safety and pharmacokinetics of short-term and long-term administration of MTX110 (soluble panobinostat; Midatech Pharma, UK) into the fourth ventricle of non-human primates. METHODS Four rhesus macaque monkeys underwent posterior fossa craniectomy and catheter insertion into the fourth ventricle. In Group I (n=2), catheters were externalized and lumbar drain catheters were placed simultaneously to assess cerebrospinal fluid (CSF) distribution after short-term infusions. MTX110 (0.5 ml of 300 μM panobinostat solution) was infused into the fourth ventricle daily for five consecutive days. Serial CSF and serum panobinostat levels were measured. In Group II (n=2), fourth ventricle catheters were connected to a subcutaneously-placed port for subsequent long-term infusions. Four cycles of MTX110, each consisting of 5 daily infusions (0.5 ml of 300 μM panobinostat solution), were administered over 8 weeks. Animals underwent detailed neurological evaluations, MRI scans, and post-mortem histological analysis. RESULTS Neurological assessments, MRI, and histology confirmed catheter placement and an absence of neurotoxicity. Panobinostat was undetectable in serum collected two and four hours after infusions in all samples in both groups. In Group I, mean peak panobinostat level in fourth ventricle CSF (6242 ng/ml) was significantly higher than in lumbar CSF (9 ng/ml; p &lt; 0.0001). In Group II, mean peak CSF panobinostat level (11,042 ng/ml) was significantly higher than mean trough CSF level (33 ng/ml; p&lt;0.0001). CONCLUSION MTX110 can be safely delivered via 4th ventricle at supra-therapeutic doses. These results provide data for a pilot clinical trial in patients with recurrent medulloblastoma.

Hemodynamic and Cardiac Effects of Erythropoietin in Patients on Regular Dialysis

1992 ◽  
Vol 15 (6) ◽  
pp. 349-353 ◽  
Author(s):  
J. Pascual ◽  
J.L. Teruel ◽  
R. Marcén ◽  
F. LiañO ◽  
J.L. Moya ◽  
...  
Keyword(s):  
Posterior Wall ◽  
Left Ventricular ◽  
Cardiac Work ◽  
Group I ◽  
Group Ii ◽  
One Year ◽  
Long Term Impact ◽  
And Function

The long-term impact of erythropoietin (EPO) treatment on cardiac structures and function was prospectively studied in eight hypertensive (Group I) and seven normotensive (Group II) patients on hemodialysis (HD). Doppler-echocardiograms were done before EPO and at two and twelve months of treatment. Mean hemoglobin (± SD) before EPO was 6.4 ± 0.9; it rose significantly up to two months and then remained constant. At two months, cardiac index (CI) had significantly decreased, while peripheral vascular resistances increased. Five patients required increased antihypertensive drug treatment. No changes were seen in myocardial parameters at this short follow-up. After one year, left ventricular mass index (LVMi) decreased (p < 0.05) in both groups concomitantly with a decrease in diastolic diameter and septum and posterior wall thicknesses. Basal LVMi was higher in Group I than in Group II, and after one year the regression was more marked in Group II. Left cardiac work showed prompt and steady improvement in both groups. Maintained partial correction of anemia with EPO during one year was associated with a return to normal of high CI, decreased left cardiac work and impressive regression of left ventricular hypertrophy.

Short-term vestibular responses to repeated rotations

2000 ◽  
Vol 10 (1) ◽  
pp. 17-23
Author(s):  
Seung Cheol Ahn ◽  
Chae Yong Lee ◽  
Dong Wook Kim ◽  
Moo Hoo Lee
Keyword(s):  
Time Constant ◽  
Phase Changes ◽  
Short Term ◽  
Mean Values ◽  
Ocular Reflex ◽  
Group I ◽  
Vestibulo Ocular Reflex ◽  
The Mean ◽  
Group Ii ◽  
Sinusoidal Rotations

To investigate the short-term vestibular habituation, we performed the 4 successive velocity step tests on 28 volunteers, the peak velocity of which was 100 deg/sec with acceleration and deceleration of 100 deg / sec 2 . As the repeated rotations might alter the vestibulo-ocular reflex (VOR), sinusoidal rotations at a frequency of 0.16 Hz were also given before and after the 4 successive velocity step tests to investigate the changes of gain and phase of VOR. The 28 volunteers were divided into two groups, group I and II, according to their responses to repeated rotations. In group I (25 subjects, mean age 23.7 year), the mean values of the slow cumulative eye position (SCEP), the time integral of eye velocity during nystagmus, was reduced after each trial of the 4-successive velocity step tests as follows; 403.4 ± 29 degree (1st trial), 346.2 ± 37 degree (2nd trial), 278.3 ± 33 degree (3rd trial) and 256.6 ± 36 degree (4th trial). The time constant of the nystagmus was also reduced as follows; 12.9 ± 0.78 second (1st trial), 12 ± 0.63 second (2nd trial), 9.7 ± 0.78 second (3rd trial) and 9.9 ± 0.54 second (4th trial). In group II (3 subjects, mean age 28.3 year), the mean values of SCEP gradually increased; 774.3 ± 135 degree (1st trial), 1127 ± 178 degree (2nd trial), 1096.3 ± 123.4 degree (3rd trial) and 1225.7 ± 199.7 degree (4th trial). The time constant of the nystagmus increased; 15.7 ± 2.7 second (1st trial), 22 ± 4.5 second (2nd trial), 22.3 ± 3.3 second (3rd trial) and 23.3 ± 5.7 second (4th trial). The gain of vestibulo-ocular reflex (VOR) induced by sinusoidal rotations at a frequency 0.16 Hz increased in both groups: 0.59 ± 0.03 to 0.78 ± 0.06 (group I) and 0.65 ± 0.07 to 1.15 ± 0.06 (group II). Phase changes were also observed. In group I, the phase was shifted from 0.6 ± 0.6 degree to − 0.40 ± 0.6 degree. In group II, the phase was shifted from 3.67 ± 1.86 degree to − 0.33 ± 0.33 degree. The repeated rotation did not induce a common nystagmic response in all subjects. Thus, person to person variations should be considered in short term vestibular habituation.

scholarly journals Efficacy of LA Axxess burs, Gates Glidden drills and Protaper Sx in obtaining straight line access in mesiobuccal roots of mandibular first molars: A cone-beam computed tomography assessment

2016 ◽  
Vol 10 (04) ◽  
pp. 486-490
Author(s):  
Promila Verma ◽  
Rhythm Bains ◽  
A. P. Tikku ◽  
Anil Chandra ◽  
Shibha Mehta
Keyword(s):  
Computed Tomography ◽  
Cone Beam Computed Tomography ◽  
Cone Beam ◽  
Group Iii ◽  
Group I ◽  
Straight Line ◽  
The Mean ◽  
Group Ii ◽  
Significant Change ◽  
Mandibular Teeth

ABSTRACT Objective: This study aims at cone-beam computed tomography (CBCT) evaluation of the ability of Gates Glidden (GG) drills, Protaper Sx, and LA Axxess burs to produce a straight line access (SLA) in mesiobuccal canals of mandibular first molars. Methodology: Forty-five freshly extracted mandibular teeth with a canal curvature of 10-20&deg; were taken for the study and divided into three groups according to the instruments used for cervical preflaring: Group I (LA Axxess burs), Group II (GG drills), and Group III (Protaper Sx). Pre- and post-instrumentation CBCT images were evaluated for comparing the ability of GG drills, Protaper Sx and LA Axxess burs to produce an SLA in mesiobuccal canals of mandibular first molars. Results: There was no significant change (P = 0.06) in the angle in the preSLA images of LA Axxess Group I (12.37 &plusmn; 1.01), GG Group II (13.39 &plusmn; 1.74), and Protaper Sx Group III (13.90 &plusmn; 1.74). The mean decrease in the angle from preSLA to postSLA was significant for all the three groups (P = 0.0001). However, the mean change was highest in Group I (4.25 &plusmn; 1.14), followed by Group II (3.28 &plusmn; 1.22) and Group III (2.89 &plusmn; 1.53). Conclusion: LA Axxess burs were the most effective in reducing the coronal curvature and produced a straighter access to apical third compared to GG Drills and Protaper Sx.

Effect of the short-term progestagen treatments plus PMSG prior ram introduction on the estrus synchronization and the fertility of Ile de France ewes

2011 ◽  
Vol 27 (3) ◽  
pp. 1157-1166 ◽  
Author(s):  
N. Metodiev ◽  
E. Raicheva
Keyword(s):  
Control Group ◽  
Estrus Synchronization ◽  
Mating Season ◽  
Short Term ◽  
Group I ◽  
Group Control ◽  
The Mean ◽  
Group Ii ◽  
In The Beginning

The aim of the present study was to evaluate the effect of the short-term progestagen treatments plus PMSG prior ram introduction on the estrus synchronization and the fertility of Ile de France ewes in the beginning of mating season. The study was carried out with 36 pure-bred ewes (aged 4-6 years) during April 2009. The ewes were divided in 3 groups (n=12 for each group): group I - vaginal sponge impregnated with 30mg FGA for six days, as at the time of placement of sponge 125 ?g cloprostenolum was put i.m At the time of removal of the sponge 250 UI PMSG was put i.m.; group II- the same as the I group, but without cloprostenolum treatment: III group - control. The teasers were introduced to ewes 24h after the sponge removal and ewes in estrus was inseminated artificially. The following parameters were studied: effect of estrus synchronization (EES) ewes in estrus was recorded twice daily for the first 6 days after sponge removal; onset, end and duration of estrus for group I and II, fertility (at first estrus) and fecundity (calculated after lambing). The data for fertility and fecundity for the control group was obtained as ewes were fertilized during 30 days from the begging of the breeding. A significant effect of both schemes to estrus synchronization was determined F=33,33, P<0,001). The EES, fertility and fecundity for group I, II and III were - 91,66%, 63,64% and 142,0%; 91,66%, 45,45% and 140,0 %; 8,33%, 91,66% and 140,0% respectively. The mean onset, end and duration of estrus was 51,27 h, 77,45 h and 27,27h for the I group and 57,82h, 87,27h and 29,45 h respectively for the II group. We conclude that the scheme applied for the first group is better to use for estrus synchronization in the beginning of mating season.

scholarly journals Precision resection of pulmonary tuberculoma using Nd:YAG-laser

2022 ◽  
Vol 99 (12) ◽  
pp. 27-32
Author(s):  
I. A. Dyachkov ◽  
I. Ya. Motus ◽  
A. V. Bazhenov ◽  
S. N. Skornyakov ◽  
R. B. Berdnikov
Keyword(s):  
Nd:Yag Laser ◽  
Pathological Process ◽  
Long Term Results ◽  
Laser Resection ◽  
Group I ◽  
Surgical Methods ◽  
Duration Of Surgery ◽  
The Mean ◽  
Group Ii

The objective of the study: a comparative study of immediate and long-term results of pulmonary tuberculoma precision resection with Nd:YAG-laser with a wavelength of 1,318 nm and atypical resection with suturing devices.Subjects and Methods. Two groups of 58 patients each were compared. The groups were comparable in terms of gender, age, the nature of the concomitant pathology and the main pathological process. In Group I, patients were operated on using precision 1,318-nm Nd:YAG-laser resection, and in Group II, the sublobar resection with suturing devices were used.Results. The mean duration of hospital stay in Groups I and II was 19.10 ± 6.02 and 19.20 ± 6.02 days respectively (p > 0.05), the duration of surgery made 65 [55; 75] and 55 [45; 60] minutes (p > 0.05), the mean volume of surgical blood loss was 50 [33; 70] and 70 [50; 165] ml (p > 0.05), and the mean duration of pleural cavity drainage after surgery was 4 [3; 5] and 4 [3; 6] days (p > 0.05). Statistically significant differences were noted in the mean volume of the resected part of the lung: 14.0 ± 7.4 mm3 in Group I versus 95.0 ± 9.7 mm3 in Group II (p ≤ 0.05). The complete clinical and radiological cure was achieved in 70% of patients in Group I and 82% in Group II. According to MSCT data, in 91.6% of cases, a thin linear scar is formed in the area of precision intervention.Conclusion: The surgical methods are comparable in terms of immediate and long-term results but precision laser resection minimizes the removal of intact tissue during the removal of tuberculomas.

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