Immuno-pathological changes in Indian catfish Clarias magur (Hamilton, 1822) upon experimental challenge with Aeromonas hydropila

2021 ◽  
Vol 68 (3) ◽  
Author(s):  
Chinmayee Muduli ◽  
Gaurav Rathore ◽  
Ranjana Srivastava ◽  
Rajeev K. Singh ◽  
Gayatri Tripathi ◽  
...  
Keyword(s):  
Pathological Changes ◽  
Indian Catfish ◽  
Experimental Challenge

scholarly journals Longitudinal Pathogenesis Study of Young Red Deer (Cervus elaphus) after Experimental Challenge withMycobacterium aviumsubsp.paratuberculosis(MAP)

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Colin Mackintosh ◽  
Gary Clark ◽  
Brendan Tolentino ◽  
Simon Liggett ◽  
Geoff de Lisle ◽  
...  
Keyword(s):  
Lymph Node ◽  
Cervus Elaphus ◽  
Red Deer ◽  
High Antibody ◽  
Pathological Changes ◽  
Post Challenge ◽  
Genetic Studies ◽  
Subclinical Disease ◽  
Antibody Titres ◽  
Experimental Challenge

Paratuberculosis progresses more quickly in young red deer than in sheep or cattle. This study describes the clinical, immunological and pathological changes over a 50-week period in fourteen 4-month-old red deer that received heavy oral challenge withMycobacterium aviumsubsp.paratuberculosis(MAP). At 4 and 12 weeks post challenge they were anaesthetized and a section of jejunal lymph node was surgically removed for culture, histopathology, and genetic studies. All 14 deer became infected, none were clinically affected, and they had varying degrees of subclinical disease when killed at week 50. Week 4 biopsies showed no paratuberculosis lesions, but MAP was cultured from all animals. At weeks 12 and 50 histopathological lesions ranged from mild to severe with corresponding low-to-high antibody titres, which peaked at 12–24 weeks. IFN-γresponses peaked at 8–15 weeks and were higher in mildly affected animals than in those with severe lesions.

Reversal of cardiomyopathy resulting from prenatal exposure to ethanol

1984 ◽  
Vol 42 ◽  
pp. 716-717
Author(s):  
C. Uphoff ◽  
C. Nyquist-Battie
Keyword(s):  
Prenatal Exposure ◽  
Heart Development ◽  
Membrane Integrity ◽  
Ethanol Exposure ◽  
Prenatal Ethanol Exposure ◽  
Pathological Changes ◽  
Prenatally Exposed ◽  
Inner Mitochondrial Membrane ◽  
Fetal Alcohol ◽  
Newborn Mice

Fetal Alcohol Syndrone (FAS) is a syndrome with characteristic abnormalities resulting from prenatal exposure to ethanol. In many children with FAS syndrome gross pathological changes in the heart are seen with septal defects the most prevalent abnormality recorded. Few studies in animal models have been performed on the effects of ethanol on heart development. In our laboratory, it has been observed that prenatal ethanol exposure of Swiss albino mice results in abnormal cardiac muscle ultrastructure when mice were examined at birth and compared to pairfed and normal controls. Fig. 1 is an example of the changes that are seen in the ethanol-exposed animals. These changes include enlarged mitochondria with loss of inner mitochondrial membrane integrity and loss of myofibrils. Morphometric analysis substantiated the presence of these alterations from normal cardiac ultrastructure. The present work was undertaken to determine if the pathological changes seen in the newborn mice prenatally exposed to ethanol could be reversed with age and abstinence.

REPRODUCTIVE PERFORMANCE OF HAMSTERS WITH POLYACRYLAMIDE IMPLANTS CONTAINING ETHINYLOESTRADIOL

1972 ◽  
Vol 70 (2) ◽  
pp. 385-395 ◽  
Author(s):  
B. K. Davis ◽  
I. Noske ◽  
M. C. Chang
Keyword(s):  
Reproductive Performance ◽  
Mature Female ◽  
Pregnancy Rates ◽  
List Type ◽  
Pathological Changes ◽  
Apparent Effect ◽  
Tissue Sections ◽  
Main Target

ABSTRACT Mature female hamsters bearing subcutaneous polyacrylamide (PAA) implants, with ethinyloestradiol (EO), for at least 10 days prior to mating revealed: 0.5 and 2.5 mg EO in 7% PAA significantly disturb the timing of oestrus and mating, but have no apparent effect on rate of pregnancy, ovulation and implantation. 2.5 mg EO in 20 and 40% PAA conspicuously reduces the likelihood of pregnancy, although the occurrence of oestrus and mating are affected only slightly. Fertility in these hamsters was virtually restored, judging from pregnancy rates, when they were remated 11 days, or more, following removal of their implants (37 days after implantation), but significantly more foetuses were resorbed in these litters. From tissue sections of skin and muscle at the implant site, ovary, uterus, pituitary, adrenals and liver, PAA implants, without EO, cause no overt pathological changes in the bearer. Effects characteristic of oestrogen are present when these implants contain EO, and these include a conspicuous thickening of the epidermis and dermis; haemorrhagic lesions were also noted in the maternal placenta of animals with EO implants. There is an association between reproductive performance and the rate of EO release by an implant. A 7% PAA implant with 2.5 mg EO can release most of it within 2 days, and principally influences events (oestrus and mating) that precede the main target (pregnancy) of a 20% PAA implant, which releases the steroid over the longer interval of 7 days.

Cognitive dysfunctions associated with white matter damage due to cardiovascular burden – determinants and interpretations

2014 ◽  
Vol 45 (3) ◽  
pp. 334-345 ◽  
Author(s):  
Paweł Krukow
Keyword(s):  
Cerebral Cortex ◽  
White Matter ◽  
Cardiovascular Diseases ◽  
Cognitive Disorder ◽  
Theoretical Background ◽  
Dynamic Aspect ◽  
Pathological Changes ◽  
White Matter Damage ◽  
Neuropsychological Disorders ◽  
Considerable Research

AbstractAlthough considerable research has been devoted to cognitive functions deteriorating due to diseases of cardiovascular system, rather less attention has been paid to their theoretical background. Progressive vascular disorders as hypertension, atherosclerosis and carotid artery stenosis generate most of all pathological changes in the white matter, that cause specific cognitive disorder: disconnection syndromes, and disturbances in the dynamic aspect of information processing. These features made neuropsychological disorders secondary to cardiovascular diseases different than the effects of cerebral cortex damage, which may be interpreted modularly.

EFFECT OF KAGOCEL PREPARATION ON THE GENERATIVE FUNCTION OF EXPERIMENTAL ANIMALS AT ITS ADMINISTRATION IN THE INFANTILE PERIOD OF THEIR DEVELOPMENT

2017 ◽  
pp. 42-49
Author(s):  
T. A. Borovskaya ◽  
M. E. Poluektova ◽  
A. V. Vychuzhanina ◽  
V. A. Mashanova ◽  
Yu. A. Shchemerova
Keyword(s):  
Toxic Effect ◽  
Reproductive System ◽  
Safety Profile ◽  
Therapeutic Dose ◽  
Antiviral Drug ◽  
Experimental Studies ◽  
Reproductive Age ◽  
Pathological Changes ◽  
Pediatric Practice ◽  
Experimental Animals

In experimental studies on rats (males, females) at their infantile stage starting from 10 days, a potential delayed toxic effect of the antiviral drug Kagocel on the reproductive system was studied. The drug was administered for 12 days in a therapeutic dose and at a dose 10-fold higher than the therapeutic one. Reproductive safety was estimated after animals reached the reproductive age (2.5 months). It was found out that the drug, when administered in both doses, does not decrease the fertility of animals, does not induce morphological and pathological changes in the sex glands, and does not have toxic effect on the offspring. Obtained data characterize Kagocel as a preparation with a wide reproductive safety profile and show that it can be used in pediatric practice for infants.

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