scholarly journals Neuropeptide Y and Asthma Clinical Course

2021 ◽  
Vol 11 (4) ◽  
pp. 410-413
Author(s):  
Yanina Shkatova ◽  
Andrey Budnevsky ◽  
Evgeniy Ovsyannikov ◽  
Galina Prozorova ◽  
Anna Volynkina ◽  
...  
Keyword(s):  
Oxidative Damage ◽  
Neuropeptide Y ◽  
Asthma Control ◽  
Clinical Course ◽  
Asthma Management ◽  
Clinical Manifestations ◽  
Global Strategy ◽  
Asthma Control Test ◽  
Normal Body Weight ◽  
Integral Assessment

Background: The spectrum of clinical manifestations and pathogenetic mechanisms of bronchial asthma (BA) is very wide. Given the complex pathogenesis and syndromic nature of BA, it is not surprising that there is no single universal biomarker. The objective of this study was to evaluate levels of neuropeptide Y (NPY) and its association with levels of leptin, adiponectin, oxidative damage, antioxidant status, spirometry parameters, and asthma control in BA patients. Methods and Results: Overall, 140 patients [35(25%) men and 105(75%) women; mean age of 57.0±9.34 years] with moderate asthma participated in the study. According to body mass index, all patients were divided into three groups. The asthma diagnosis was based on the integral assessment of symptoms, medical history, health status, and spirometry values according to the Global Strategy for Asthma Management and Prevention. (GINA, 2017 REPORT). The Asthma Control Test (АСТ) was used to assess asthma control. NPY was measured in blood serum in EIA. The NPY level was significantly higher in overweight patients and patients with obesity than in patients with normal body weight. The NPY level significantly correlated with leptin (r=0.44; P<0.05), adiponectin (r=-0.24; P<0.05), ImanOx (r=-0.40; P<0.05), PerOx (r=0.58; P<0.05), ACT (r=-0.41; P<0.05), VC (r=-0.31; P<0.05), FEV1 (r=-0.41; P<0.05), FEF25% (r=-0.26; P<0.05), FVC (r=-0.23; P<0.05), Tiffno index (r=-0.36; P<0.05), FEF50% (r=-0.22; P<0.05), and PEF (r=-0.23; P<0.05) Conclusion: The severity of the asthma clinical course is associated with different factors, including oxidative stress, levels of leptin, adiponectin and NPY. NPY seems to be associated with worse asthma control and higher levels of leptin and oxidative damage.

Neuropeptide Y as a potential biomarker in patients with asthma and obesity

2021 ◽  
Vol 31 (6) ◽  
pp. 759-767
Author(s):  
Yanina S. Shkatova ◽  
Sergey N. Avdeev ◽  
Andrey V. Budnevsky ◽  
Ludmila V. Tribuntceva
Keyword(s):  
Body Weight ◽  
Oxidative Damage ◽  
Neuropeptide Y ◽  
Asthma Control ◽  
Clinical Course ◽  
Inverse Correlation ◽  
Positive Correlation ◽  
Normal Body ◽  
Normal Body Weight ◽  
The Relationship

The phenotype of asthma with obesity is particularly difficult to treat, while its prevalence is increasing. In recent years, special attention has been paid to neuropeptide Y (NPY) due to its possible effect on the severity of the clinical course of asthma.Aim. To identify the relationship between the level of NPY and the clinical course of asthma in patients with obesity and overweight.Methods. The study included 113 patients (27, or 23.89% of men and 86, or 76.11% of women) diagnosed with asthma of moderate severity, whose average age was 57.81 ± 13.05 years. Patients were divided into three groups — with normal body weight, overweight, and obesity. The examination included spirometry, body mass index (BMI), and a questionnaire. Also, Asthma Control Test (ACT) was used. The levels of leptin, adiponectin, NPY, and general oxidative damage were measured in all patients.Results. Asthma control was significantly lower in the group of patients with asthma and obesity compared with the normal body weight and overweight patients. Leptin level was significantly higher in the group of patients with asthma and obesity compared with the normal body weight and overweight patients. The level of NPY was significantly higher in the group of patients with obesity than in the patients with normal body weight and overweight. No significant differences in the level of adiponectin were found between the groups. The NPY level had a high inverse correlation with VLC index, a moderate/medium inverse correlation with forced expiratory volume in 1 sec, forced expiratory flow (FEF) at 25%; forced vital capacity, Tiffno index, FEF 50%, peak expiratory flow, ACT score, and a moderate positive correlation with the level of total oxidative damage.Conclusion. A higher level of NPY is observed in patients with asthma and obesity. This level has an inverse correlation with spirometric parameters, asthma control (evaluated via ACT) and a positive correlation with the level of general oxidative damage, which indicates a possible proinflammatory effect of NPY that contributes to an unfavorable course of asthma. Thus, further studies are required to establish the nature of the relationship between NPY and asthma exacerbations, as well as the mechanism of NPY influence on asthma pathogenesis.

scholarly journals Asthma control and management among schoolchildren in urban Uganda: results from a cross-sectional study

2019 ◽  
Vol 4 ◽  
pp. 168 ◽  
Author(s):  
Harriet Mpairwe ◽  
Pius Tumwesige ◽  
Milly Namutebi ◽  
Marble Nnaluwooza ◽  
Tonny Katongole ◽  
...  
Keyword(s):  
Asthma Control ◽  
Asthma Management ◽  
Cross Sectional Study ◽  
P Value ◽  
Asthma Diagnosis ◽  
Sectional Study ◽  
Asthma Control Test ◽  
Cross Sectional ◽  
Children With Asthma ◽  
Control And Management

Background: Children from low- and middle-income countries have poor asthma control, mainly because of poor management. The extent of this problem in Uganda is not well known, but such information would be useful to guide policy and practice. We therefore conducted a cross-sectional study among schoolchildren with asthma in urban Uganda, to assess the level of asthma control and management. Methods: Schoolchildren aged 5-17 years were enrolled, asthma was diagnosed by the study medical team. Asthma control was assessed using the Asthma Control Test and the childhood Asthma Control Test. Data on previous asthma management was obtained using interviewer-led questionnaires. Data were analysed using multiple linear and multiple logistic regression. Results: We enrolled 561 children with asthma, of whom only 56% had ever had an asthma diagnosis. We categorised asthma as well-controlled (55.5%), partly-controlled (29.5%) and poorly-controlled (15.0%). Poor asthma control was associated with increasing age (adjusted regression coefficient [95% confidence interval], p-value: -1.07 [-1.20, -0.94], p<0.0001), concurrent allergic rhinitis (-1.33 [-2.28, -0.38], p=0.006), and city residence in early life (-1.99 [-3.69, -0.29], p=0.06). Regular use of inhaled asthma medication in the last 12 months was very low; 18.1% for salbutamol and 6.7% for inhaled corticosteroids. The main barriers to inhaled asthma medication use were lack of prescription (47.6%) and inaccurate diagnosis (38.8%). Increased inhaler use was associated with tertiary education of the fathers (adjusted odds ratio [95% confidence interval], p-value: 5.19 [2.39-11.28], p<0.0001), city residence in early life (4.66 [1.79-12.43], 0.002) and an asthma diagnosis prior to enrolment (11.39 [6.35-20.43], p<0.0001). Conclusions: This study confirms that children with asthma in Uganda generally have inadequate asthma control, which is attributable to poor asthma management. This could be improved through re-training of medical workers and patient education, and by increasing availability and affordability of essential asthma medications.

scholarly journals Assessment of disease control in patients with asthma

Medicina ◽  
2009 ◽  
Vol 45 (12) ◽  
pp. 943 ◽  
Author(s):  
Guoda Pilkauskaitė ◽  
Kęstutis Malakauskas ◽  
Raimundas Sakalauskas
Keyword(s):  
Lung Function ◽  
Asthma Control ◽  
Control Level ◽  
Asthma Management ◽  
Control Test ◽  
Uncontrolled Asthma ◽  
Asthma Control Test ◽  
Inhaled Steroids ◽  
Asthma Patients ◽  
Β2 Agonists

International guidelines indicate that the main criterion of asthma management is asthma control level. The aim of this study was to assess asthma control and its relation with age, gender, and lung function. Material and methods. A total of 106 family physicians and 13 pulmonologists and allergists took part in this study. Each doctor had selected 10–15 asthma patients and had sent invitations to them by post. On the visit day, the patients themselves filled in the Asthma Control Test. The doctors interviewed the patients and filled in a special questionnaire. Pulmonologists and allergists also assessed lung function by performing spirometry. According to the results of the Asthma Control Test, the disease control level was indicated as “totally controlled” (25 points), “well controlled” (24–20 points), and “uncontrolled” (19 points or less). Results. A total of 876 asthma patients were examined. Uncontrolled asthma was diagnosed to 56.2% of the patients, 36.5% of patients had well controlled and 7.3% totally controlled asthma. There was no significant difference in asthma control level comparing men and women. A correlation between asthma control level and age was found revealing poorer asthma control in older patients. Ninety-five percent of patients were treated with inhaled steroids; most of them had used inhaled steroids in combination with long-acting β2 agonists. It was found that lung function correlated with clinical symptoms of asthma, the demand of shortacting β2 agonists, and asthma control level. Conclusion. The study showed that uncontrolled asthma was diagnosed to more than half of the patients, despite most of them used inhaled steroids. Asthma control was worsening with the age of patients with asthma and it correlated with lung function. We suggest that periodical assessment of asthma control should help to optimize asthma management.

scholarly journals Life Quality and Cytokines Profile in Patients with Asthma and Osteoarthritis

2021 ◽  
Vol 11 (2) ◽  
pp. 137-140
Author(s):  
Yuliya Ivanchuk ◽  
Ludmila Tribuntceva ◽  
Andrey Budnevsky ◽  
Yanina Shkatova ◽  
Evgeniy Ovsyannikov ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Oxidative Damage ◽  
Asthma Control ◽  
Antioxidant Status ◽  
Life Questionnaire ◽  
Asthma Control Test ◽  
Tnf Α ◽  
Group 2 ◽  
Group 1

The objective of this study was to evaluate levels of leptin, adiponectin, IL-4, IL-6, TNF-α, oxidative damage, and antioxidant status in patients with bronchial asthma (BA), compared to patients who suffer from both BA and osteoarthritis (OA), and analyze the quality of life in such patients. Methods and Results: The study included 103 patients (34 men and 69 women) diagnosed with moderate asthma aged from 30 to 70 years (mean age of 58.52±7.14 years). The levels of IL-4, IL-6, TNF-α, adiponectin, leptin, total antioxidant status (TAS), and total oxidative damage (TOD) were measured. Two questionnaires were used in this study: Asthma Quality of Life Questionnaire (AQLQ) and Asthma Control Test (АСТ). The levels of leptin, TNF-α, and Il-6 were significantly higher in Group 2 than in Group 1. On the contrary, the IL-4 level was higher in Group 1 than in Group 2. The TAS value was significantly higher in Group 1 than in Group 2 (P=0.0001). The TOD value was significantly higher in Group 2 than in Group 1 (P=0.0000). The domains of AQLQ(S) activity, symptoms, and emotions were decreased in patients of Group 2. The values of the ACT test were 18.0±2.61 points and 16.78±1.92 points in Group 1 and Group 2, respectively (P=0.0077). Conclusion: In patients with both asthma and osteoarthritis, levels of inflammatory cytokines, such as leptin, IL-6, and TNF-α, are significantly elevated as well as values of total oxidative status, which correlate with poorer asthma control and quality of life.

Asthma Management Responsibility, Control, and Quality of Life Among Emerging Adolescents

2019 ◽  
Vol 45 (1) ◽  
pp. 40-49
Author(s):  
Mallory Netz ◽  
David A Fedele ◽  
Rachel Sweenie ◽  
Dawn Baker ◽  
Michael Light ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Asthma Control ◽  
Healthcare Providers ◽  
Asthma Management ◽  
Life Questionnaire ◽  
Act Scores ◽  
Asthma Control Test ◽  
Significant Difference ◽  
Related Quality

Abstract Objective To examine how asthma control is related to the association between the division of responsibility for asthma management and asthma-related quality of life among early adolescents. Methods Forty-nine youth aged 10–15 years (Mage = 12.25, 57.1% female) with a physician-verified asthma diagnosis completed the Standardized Pediatric Asthma Quality of Life Questionnaire (PAQLQ) and Asthma Control Test (ACT). Youth and their caregivers also completed the Asthma Responsibility Questionnaire (ARQ). Higher ACT scores indicate better asthma control. Results There was a significant difference in ARQ scores between youth and caregivers (p &lt; .001, d = .94). Youth reported sharing equal responsibility for asthma management with caregivers, while caregivers reported having more responsibility relative to youth. Greater youth-reported ARQ (p = .004) and greater ACT scores (p &lt; .001) were associated with higher PAQLQ scores. ACT scores moderated the effect of youth-reported ARQ on PAQLQ scores (p = .043). For youth with lower ACT scores, higher youth-reported responsibility was associated with higher PAQLQ scores; while for youth with higher ACT scores, PAQLQ scores were high regardless of perceived responsibility. The interaction between caregiver ARQ scores and ACT scores was not significant. Conclusion This study suggests youth and caregivers report discrepant ARQ for asthma management tasks. Responsibility and level of asthma control are important factors for PAQLQ, with results indicating that fostering responsibility is an important factor, even among youth with poorly controlled asthma. Findings suggest that healthcare providers should assess family responsibility and help caregivers support adolescents in developing asthma management skills.

scholarly journals The Role of Pharmacists in General Practice in Asthma Management: A Pilot Study

Pharmacy ◽  
2018 ◽  
Vol 6 (4) ◽  
pp. 114 ◽  
Author(s):  
Louise Deeks ◽  
Sam Kosari ◽  
Katja Boom ◽  
Gregory Peterson ◽  
Aaron Maina ◽  
...  
Keyword(s):  
General Practice ◽  
Pilot Study ◽  
Asthma Control ◽  
Action Plan ◽  
Asthma Management ◽  
Asthma Control Test ◽  
Appropriate Prescribing ◽  
Device Use ◽  
Practice Methods

Background: Asthma is principally managed in general practice. Appropriate prescribing and medication use are essential, so general practice pharmacists appear suitable to conduct asthma management consultations. This pilot study aimed to evaluate the asthma management role of a pharmacist in general practice. Methods: Analysis of an activity diary and stakeholder interviews were conducted to identify interventions in asthma management; determine whether asthma control changed following pharmacist input; and determine acceptability of asthma management review by a pharmacist in one general practice in Canberra, Australia. Results: Over 13 months, the pharmacist saw 136 individual patients. The most common activities were asthma control assessment; recommendations to adjust medication or device; counselling on correct device use; asthma action plan development and trigger avoidance. For patients with multiple consultations, the mean Asthma Control Test score improved from the initial to last visit (14.4 ± 5.2 vs. 19.3 ± 4.7, n = 23, p < 0.0001). Eight of the 19 (42%) patients moved from having poor to well-controlled asthma. Case studies and qualitative data indicated probable hospital admission avoidance and stakeholder acceptability of asthma management by a practice pharmacist. Conclusions: This pilot study demonstrated it is feasible, acceptable and potentially beneficial to have a general practice pharmacist involved in asthma management. Fuller evaluation is warranted.

scholarly journals Disease control in patients with asthma and respiratory symptoms (wheezing, cough) during sleep

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Jonathan Doenges ◽  
Elisabeth Kuckuck ◽  
Werner Cassel ◽  
Olaf Hildebrandt ◽  
Andreas Weissflog ◽  
...  
Keyword(s):  
Asthma Control ◽  
Respiratory Symptoms ◽  
Asthma Management ◽  
Objective Evaluation ◽  
Uncontrolled Asthma ◽  
Asthma Control Test ◽  
Asthmatic Patients ◽  
Significant Difference ◽  
Asthma Patients ◽  
Act Score

Abstract Introduction The Global Initiative for Asthma (GINA)-defined criteria for asthma control include questions about daytime symptoms, limitation of activity, nocturnal symptoms, need for reliever treatment and patients’ satisfaction. Patients with nocturnal symptoms like wheezing and cough often suffer from lower sleep quality and impaired daytime performance. The lack of an appropriate method for standardized and objective monitoring of respiratory symptoms leads to difficulties in asthma management. The aim of this study is to present a new method for automated wheeze and cough detection during sleep and to assess the actual level of asthma control by the Asthma Control Test (ACT). Methods Respiratory symptoms like wheezing and cough were recorded with the LEOSound-Monitor for one night in 55 asthmatic patients in their individual domestic setting. Patients were asked to assess their level of asthma subjectively with the ACT. The study consisted of 37 women and 18 men, with a mean age of 41 years, and a mean BMI of 27 kg/m2. Most of the patients had been taking an ICS/LABA combination and would resort to a SABA as their rescue medication. Results 60% of the participants were classed as having controlled, and 40% were classed as having partially- or uncontrolled asthma. During sleep wheezing was found in 8 of the 55 asthma patients (14.5%) and coughing was found in 30 patients (54.5%). The median ACT score in wheezing-patients was 14, while in non-wheezing patients it was 21. Uncontrolled asthma was found in 6 of the 8 wheezing-patients. Coughing versus non-coughing patients did not show a significant difference in the ACT-score (20, 22 respectively). Conclusion Wheezing is a sign of uncontrolled asthma. The ACT-score in wheezing patients is worse compared to patients without wheezing. LEOSound proofed to be a useful tool in providing an objective evaluation of respiratory symptoms, like coughing and wheezing. In clinical practice, this may allow an improvement in asthma therapy.

scholarly journals Smartphone app for asthma self-management – a literature review of contents and functions

2019 ◽  
Vol 10 (4) ◽  
pp. 3269-3276
Author(s):  
Ghozali MT ◽  
Satibi ◽  
Zullies Ikawati ◽  
Lutfan Lazuardi
Keyword(s):  
Asthma Control ◽  
Action Plan ◽  
Asthma Management ◽  
Self Management ◽  
Smartphone App ◽  
Asthma Control Test ◽  
Quality Health ◽  
The Many ◽  
Air Quality Health Index

A self-management is an important thing in achieving optimum health outcomes. One of the many effective ways that help improve the outcomes of self-management in asthma is through the use of smartphone applications or popularly known as apps. The apps have been designed to help patients in controlling asthma complaints. This study aimed to examine contents and functions featured in the reviewed studies as well as to suggest what functions and contents should be featured in an asthma self-management smartphone app. This study used a systematic approach to examine and review the contents and functions of asthma management apps from selected studies. Inclusion criteria of the study included studies related to the use of asthma control or asthma self-management apps, providing information about contents and features of asthma apps, apps in the reviewed studies designed for laypersons or patients, studies published in peer-reviewed scientific journals in English, and original articles. All the studies had been taken from 2013 to 2018 from three databases, namely Pubmed, Science Direct, and ProQuest. Exclusion criteria included full text unable to be accessed and unable to obtain complete full statistical data. Results of this study showed that the most popular functions and contents featured in the asthma apps involved asthma education, medication use monitor, medication reminder, asthma control test, peak flow meter, asthma symptom monitor, and asthma action plan. Less popular functions and contents included a chat with others, Air Quality Health Index, and Quality of Life Questionnaires. 

scholarly journals Controlo da asma infantil: principais fatores asociados

2019 ◽  
Vol 19 (1) ◽  
pp. 1-41
Author(s):  
Andreia Filipa Sousa Félix ◽  
Bruno Acácio Branco Rocha Lopes ◽  
Maria Adriana Pereira Henriques ◽  
Maria de la Salete Rodrigues Soares
Keyword(s):  
Asthma Control ◽  
Childhood Asthma ◽  
Symptom Management ◽  
Rescue Therapy ◽  
Asthma Management ◽  
Public Health Problem ◽  
Bronchial Obstruction ◽  
Asthma Control Test ◽  
International Guidelines ◽  
Management Intervention

Introducción: El asma aparece como una enfermedad inflamatoria crónica de las vías respiratorias y se caracteriza por episodios de obstrucción bronquial reversible pudiendo ser desencadenada por varios factores. Se constituye como la enfermedad infantil más común, una importante causa de internamiento hospitalario y un problema de salud pública. Las directrices internacionales sobre la gestión del asma reconocen que el tratamiento reside en el control actual y en el riesgo de exacerbaciones, basándose en la gestión de los síntomas. En cuanto a la percepción del control del asma infantil, existen discrepancias entre la percepción de los cuidadores y las indicaciones internacionales.Objetivos: Describir y analizar los datos clínicos, sociodemográficos y factores asociados al control del asma infantil.Metodología: Estudio metodológico, cuantitativo y transversal, en una muestra de niños, entre los 6 y los 11 años, con asma y cuidadores. El control del asma ha sido evaluado por el instrumento Childhood Asthma Control Test.Resultados: La muestra fue compuesta por 60 niños y cuidadores. 12% (n = 7) de los niños presentan asma no controlada y 53% (n = 32) asma parcialmente controlada. En el 38% (n = 23) de los cuidadores existieron discrepancias entre el grado clasificado mediante las pautas internacionales y su percepción. El análisis de Regresión Logística confirma que los niños con necesidades de terapia inhalatoria de rescate presentan 7 veces mayor probabilidad de que el asma no esté controlada.Conclusión: Resulta perentoria la necesidad de aprehender la complejidad de los factores que interfieren en el control del asma, existiendo necesidad de programas de intervención de gestión de síntomas centrados en los cuidadores, en el niño y en las necesidades identificadas. Introduction: Asthma is an airways chronic and inflammatory disease characterized by episodes of reversible bronchial obstruction and can be triggered by several factors. It is the most common childhood disease, an important hospitalization cause and a public health problem. International guidelines of asthma management recognize that treatment based on current management and exacerbations risk, which are based on symptom management. Regarding the control perception of childhood asthma, there are discrepancies between the caregiver’s perception and the international indications.Objectives: To describe and analyze the clinical, sociodemographic and factors associated with childhood asthma control.Methodology: Methodological, quantitative and transversal study, in a sample of 60 children, between 6 and 11 years, and caregivers. Asthma control was evaluated by the instrument childhood Asthma Control Test.Results: The sample consisted of 60 children and caregivers. 12% (n = 7) of the children had uncontrolled asthma, 53% (n = 32) partly controlled asthma. In 38% (n = 23) of the caregivers there were discrepancies between the grade classified through the international guidelines and their perception. Logistic Regression analysis confirms that children with inhalational rescue therapy needs 7 times more likely asthma to be uncontrolled.Conclusion: The complexity of the factors that interfere in the control of asthma is urgent and there is a need for symptom management intervention programs focused on the caregivers, the child and the identified needs. Introdução: A asma apresenta-se como uma doença crónica e inflamatória das vias aéreas caracterizada por episódios de obstrução brônquica reversível podendo ser desencadeada por diversos fatores. Constitui-se como a doença infantil mais comum, uma importante causa de internamento hospitalar e um problema de saúde pública. As diretrizes internacionais sobre a gestão da asma reconhecem que o tratamento reside no controlo atual e no risco de exacerbações, sendo baseados na gestão de sintomas. Relativamente à perceção do controlo da asma infantil, existem discrepâncias entre a perceção dos cuidadores e as indicações internacionais.Objetivos: Descrever e analisar os dados clínicos, sociodemográficos e fatores associados ao controlo da asma infantil. Metodologia: Estudo metodológico, quantitativo e transversal, numa amostra de crianças, entre os 6 e os 11 anos, com asma e cuidadores. O controlo da asma foi avaliado pelo instrumento Childhood Asthma Control Test. Resultados: A amostra foi composta por 60 crianças e cuidadores. 12% (n=7) das crianças apresentam asma não controlada e 53% (n=32) asma parcialmente controlada. Em 38% (n=23) dos cuidadores existiram discrepâncias entre o grau classificado mediante as guidelines internacionais e a sua perceção. A análise de Regressão Logística confirma que as crianças com necessidades de terapêutica inalatória de resgate apresentam 7 vezes maior probabilidade da asma estar não controlada. Conclusão: Torna-se perentório a necessidade de apreensão da complexidade dos fatores que interferem no controlo da asma, existindo necessidade de programas de intervenção de gestão de sintomas centrados nos cuidadores, na criança e nas necessidades identificadas.

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