scholarly journals Time to viral load suppression and its associated factors in cohort of patients taking antiretroviral treatment in East Shewa Zone, Oromiya, Ethiopia, 2018

2019 ◽  
Author(s):  
Jemal H Ali
Keyword(s):  
Viral Load ◽  
Marital Status ◽  
Associated Factors ◽  
Plasma Viral Load ◽  
Baseline Viral Load ◽  
Rank Test ◽  
P Value ◽  
People Living With Hiv ◽  
Age Group ◽  
Significant Difference

Abstract Background: Human immuno-deficiency virus is a virus that causes Acquired Immuno- Deficiency Syndrome. The key goal of ART is to achieve and maintain durable viral suppression. Thus, the most important use of the viral load is to monitor the effectiveness of therapy after initiation of ART. The main objective of the study was to determine the time for virological suppression and its associated factors among people living with HIV taking antiretroviral treatments in East shewa zone, Oromiya, Ethiopia. Methods: The study was conducted in East Shewa zone, Oromiya, Ethiopia from August 2017 to January 2018. Patients diagnosed with human immunodeficiency virus presenting to the study health centers between October 3, 2011 and March 1, 2013 were included in the study given the following criteria: age 18 years or greater, eligible to start ART. All patients with baseline viral load measurement were included in the study. Interaction between explanatory variables with the response variable was analyzed by using cross tab features of SPSS, IBM Inc. Significance group comparison was done by Kaplan Meier log rank test. Cox proportional hazard model was used to select significant factors to the variability between groups. Data was collected by using structured questionnaires and interview. A total of ETB 81,120.00 was utilized to carry out the study. Result: plasma viral load was suppressed below detection level in 72% of individuals taking different regimen of ART. The median HIV-1 plasma viral load in the cohort was log 5.3111 copies/ml. Survival curve difference were observed in category of marital status (p-value 0.023) and baseline CD4 values (p-value 0.023) whereas no significant difference were observed in Educational status (p-value 0.404), MUAC (p- value 0.407) BMI(p-value 0.335) and BTB(p-value 0.257). Estimated median time to PVL suppression was 181days (CI: 140.5-221.4) with the age group of 30-39years having minimum time to achieve suppression with 92 days (CI: 60.1-123.8) and the maximum time required to reach the level was age group between 50-59 years. Conclusion: Estimated time to achieve PVL after taking ART was found to be 181 days. Factors affecting time to suppression level was marital status and baseline CD4.

scholarly journals Time to viral load suppression and its associated factors in cohort of patients taking antiretroviral treatment in East Shewa Zone, Oromiya, Ethiopia, 2018

2019 ◽  
Author(s):  
Jemal H Ali
Keyword(s):  
Viral Load ◽  
Marital Status ◽  
Associated Factors ◽  
Plasma Viral Load ◽  
Baseline Viral Load ◽  
P Value ◽  
People Living With Hiv ◽  
Age Group ◽  
Viral Load Measurement ◽  
Load Measurement

Abstract Background A key goal of ART is to achieve and maintain durable viral suppression. Thus, the most important use of the viral load measurement is to monitor the effectiveness of therapy after initiation of ART. The main objective of the study was to determine the time for virological suppression and its associated factors among people living with HIV taking antiretroviral treatments in East Shewa Zone, Oromiya, Ethiopia.Methods: Patients diagnosed with Human Immunodeficiency Virus presenting to the study health centers between October 3, 2011 and March 1, 2013 were included in the study given the following criteria: age 18 years or greater, eligible to start ART. All patients with baseline viral load measurement were included in the study. Interaction between explanatory variables with the response variable was analyzed by using cross tab features of SPSS, IBM Inc. Significance group comparison was done by Kaplan Meier log-rank test. Cox proportional hazard model was used to select significant factors to the variability between groups.Result: Plasma viral load was suppressed below the detection level in 72% of individuals taking different regimen of ART. The median HIV-1 plasma viral load in the cohort was estimated to be log 5.3111 copies/ml. Survival curve difference was observed in the category of marital status (p- value 0.023) and baseline CD4 value (p- value 0.023). The estimated median time to PVL suppression was 181days (CI: 140.5-221.4) with the age group of 30-39years having minimum time to achieve suppression with 92 days (CI: 60.1-123.8) and the maximum time required to reach the level was found among the age group between 50-59 years.Conclusion: The estimated time to achieve PVL after taking ART was found to be 181 days. Factors affecting time to suppression level was marital status and baseline CD4. Keywords: Viral load, ART, Ethiopia, Suppression, HIV

scholarly journals Time to viral load suppression and its associated factors in cohort of patients taking antiretroviral treatment in East Shewa Zone, Oromiya, Ethiopia, 2018

2019 ◽  
Author(s):  
Jemal H Ali
Keyword(s):  
Viral Load ◽  
Marital Status ◽  
Associated Factors ◽  
Plasma Viral Load ◽  
Baseline Viral Load ◽  
P Value ◽  
People Living With Hiv ◽  
Age Group ◽  
Viral Load Measurement ◽  
Load Measurement

Abstract Background A key goal of ART is to achieve and maintain durable viral suppression. Thus, the most important use of the viral load measurement is to monitor the effectiveness of therapy after initiation of ART. The main objective of the study was to determine the time for virological suppression and its associated factors among people living with HIV taking antiretroviral treatments in East Shewa Zone, Oromiya, Ethiopia. Methods: Patients diagnosed with Human Immunodeficiency Virus presenting to the study health centers between October 3, 2011 and March 1, 2013 were included in the study given the following criteria: age 18 years or greater, eligible to start ART. All patients with baseline viral load measurement were included in the study. Interaction between explanatory variables with the response variable was analyzed by using cross tab features of SPSS, IBM Inc. Significance group comparison was done by Kaplan Meier log-rank test. Cox proportional hazard model was used to select significant factors to the variability between groups. Result : Plasma viral load was suppressed below the detection level in 72% of individuals taking different regimen of ART. The median HIV-1 plasma viral load in the cohort was estimated to be log 5.3111 copies/ml. Survival curve difference was observed in the category of marital status (p- value 0.023) and baseline CD4 value (p- value 0.023). The estimated median time to PVL suppression was 181days (CI: 140.5-221.4) with the age group of 30-39years having minimum time to achieve suppression with 92 days (CI: 60.1-123.8) and the maximum time required to reach the level was found among the age group between 50-59 years. Conclusion : The estimated time to achieve PVL after taking ART was found to be 181 days. Factors affecting time to suppression level was marital status and baseline CD4. Keywords: Viral load, ART, Ethiopia, Suppression, HIV

scholarly journals Time to viral load suppression and its associated factors in cohort of patients taking antiretroviral treatment in East Shewa zone, Oromiya, Ethiopia, 2018

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Jemal Hassen Ali ◽  
Tewodros Getinet Yirtaw
Keyword(s):  
Human Immunodeficiency Virus ◽  
Viral Load ◽  
Marital Status ◽  
Associated Factors ◽  
Plasma Viral Load ◽  
Antiretroviral Treatment ◽  
Baseline Viral Load ◽  
People Living With Hiv ◽  
Age Group ◽  
Immunodeficiency Virus

Abstract Background A key goal of Antiretroviral Treatment (ART) is to achieve and maintain durable viral suppression. Thus, the most important use of viral load measurement is to monitor the effectiveness of therapy after initiation of ART. The main objective of the study was to determine the time for virological suppression and its associated factors among people living with HIV taking antiretroviral treatments in East Shewa Zone, Oromiya, Ethiopia. Methods Patients diagnosed with Human Immunodeficiency Virus presenting to the study health centers between October 3, 2011 and March 1, 2013 were included in the study given the following criteria: age 18 years or greater, eligible to start ART. All patients with baseline viral load measurements were included in the study. Interaction between explanatory variables with the response variable was analyzed by using cross tab features of (Statistical Package for the Social Sciences) SPSS, International Business Machines (IBM) Inc. Significance group comparison was done by Kaplan Meier log-rank test. Cox proportional hazard model was used to select significant factors to the variability between groups. Result Plasma viral load was suppressed below the detection level in 72% of individuals taking a different regimen of ART. The median Human Immunodeficiency virus (HIV)-1 plasma viral load in the cohort was estimated to be log 5.3111 copies/ml. The study observed Survival curve difference in the category of marital status (p-value 0.023) and baseline cluster of differentiation 4 (CD4) value (p-value 0.023). The estimated median time to Plasma Viral Load (PVL) suppression was 181 days (CI: 140.5–221.4) with the age group of 30–39 years having minimum time to achieve suppression with 92 days (CI: 60.1–123.8) and the maximum time required to reach the level was found among the age group between 50 and 59 years. Conclusion The study found that the estimated time to achieve PVL after taking ART to be 181 days. Factors affecting time to suppression level were marital status and baseline CD4.

scholarly journals Depression and associated factors among HIV-positive youths attending antiretroviral therapy clinics in Jimma town, southwest Ethiopia

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0244879
Author(s):  
Derara Girma ◽  
Sahilu Assegid ◽  
Yenealem Gezahegn
Keyword(s):  
Viral Load ◽  
Associated Factors ◽  
Opportunistic Infections ◽  
Multivariable Analysis ◽  
Baseline Viral Load ◽  
Hiv Positive ◽  
P Value ◽  
Prevalence Of Depression ◽  
High Baseline Viral Load ◽  
Jimma Town

Background Depression is recognized as a prominent health problem and a growing public health concern in HIV-positive youths. Despite this fact, in Ethiopia, there is a dearth of evidence on the prevalence of depression and its associated factors among HIV-positive youths. Methods A facility-based cross-sectional study was conducted from March 16 to June 01, 2020, among 331 HIV-positive youths attending antiretroviral therapy clinics in Jimma town. A systematic random sampling technique was used to enroll study participants. Bivariable and multivariable logistic regression was done to identify factors associated with depression. Variables with a p-value ≤0.25 on the bivariable analysis were candidates for multivariable analysis. Adjusted odds ratios with the respective 95% CI were calculated and p-value <0.05 were used to set statistically significant variables in the multivariable analysis. Results Out of a total of 331 sampled HIV positive youth, 325 have participated in this study with a response rate of 98.2%. The prevalence of depression was 30.2% (95%CI:25.2%-35.1%). Female sex (AOR = 4.12, 95%CI:2.28–7.47), history of hospital admission (AOR = 2.45, 95%CI:1.28–4.70), discontinued education due to HIV/AIDS illness (AOR = 2.09, 95%CI:1.12–3.90), poor treatment adherence (AOR = 2.23, 95%CI:1.04–4.78), opportunistic infections (AOR = 2.16, 95%CI:1.17–3.97), high baseline viral load (AOR = 3.35, 95%CI:1.82–6.16) and ≤6 months duration of HIV diagnosis (AOR = 3.14, 95%CI: 1.47–5.72) were factors significantly associated with depression. Conclusion This study demonstrated a high prevalence of depression among HIV-positive youths. Factors such as female sex, treatment non-adherence, opportunistic infections, <six months since diagnosed with HIV, hospitalization history, high baseline viral load, and school discontinuation due to HIV/AIDS were significantly associated with depression. Therefore, we recommend regular screening for depression co-morbidity among HIV-positive youths and linkage with mental health service providers.

PERAN WARGA PEDULI AIDS CAHAYA CARE TUREN DALAM MENINGKATKAN KUALITAS HIDUP ODHA

2017 ◽  
Vol 3 (1) ◽  
Author(s):  
Tri Nurhudi Sasono
Keyword(s):  
Quality Of Life ◽  
Antiretroviral Drugs ◽  
P Value ◽  
People Living With Hiv ◽  
Purposive Sampling ◽  
Significant Difference ◽  
Development Goals ◽  
Living With Hiv ◽  
Hiv Aids

Abstract : Indicator of the health welfare through Sustanable Development Goals (SDGs) is to reduce the incidence of HIV-AIDS, decrease the rate of the epidemic and maintain the quality of life of people living with HIV-AIDS (PLWHA). Trend cases of HIV-AIDS is the most recent spread among people, especially housewives. In Malang until 2015 found 278 Housewife of 409 cases of AIDS. The prevalence of HIV-AIDS in Malang Regency is ranked second after Surabaya city in East Java. For the importance of public participation and citizen care AIDS Cahaya Care Turen take responsibility for the condition. Determination Rule Goverment number 2 2015 year on the Participation of the community response to HIV-AIDS in Malang as a legal rule. Concerned Citizens activities AIDS (WPA). WPA Cahaya Care Turen is increases HIV risk and quality of life PLWHA. The purpose of this study was to determine the role of Citizens AIDS Cahaya Care Quality of Care Turen against people living with HIV in Puskesmas Turen Malang. The study design using a quasi-experimental, with purposive sampling using a sampling technique. Total number of research subjects 23. Based on test results obtained with the Wilcoxon p value <0.005, which means that there is a significant difference before and after PLWHA joining participated in the WPA Cahaya Care Turen. The conclusion of this study is WPA activities involving people living with HIV and at risk groups can optimize compliance with antiretroviral drugs that have an impact on improving the quality of life of PLHIV. Suggestions in this research is done WPA Program activities are structured and ongoing cross-sector in order to improve the quality of life and empower PLWHA.Keywords : WPA Cahaya Care Turen, Quality of life, PLWHA Abstrak : Salah satu indikator kesejahteraan kesehatan melalui Sustanable Development Goals (SDGs) adalah menekan angka kejadian HIV-AIDS, menurunkan laju epidemik dan mempertahankan kualitas hidup Orang dengan HIV-AIDS (ODHA). Trend kasus HIV-AIDS terkini terbanyak adalah menjangkit dikalangan masyarakat khususnya pada ibu rumah tangga. Kabupaten Malang sampai dengan tahun 2015 ditemukan 278 Ibu Rumah Tangga dari 409 kasus AIDS. Prevalensi HIV-AIDS di Kabupaten Malang ini merupakan peringkat kedua di Jawa Timur setelah Kota Surabaya. Untuk itu pentingnya peran serta masyarakat dan warga peduli AIDS Cahaya Care Turen ikut bertanggung jawab terhadap kondisi tersebut. Penetapan Peraturan Bupati Malang no.2 th.2015 tentang Peran serta masyarakat penanggulangan HIV-AIDS di Kabupaten Malang diharapkan dapat mengurangi risiko penularan HIV dan meningkatkan kualitas hidup ODHA. Tujuan dari penelitian ini adalah untuk mengetahui Peran Warga Peduli AIDS Cahaya Care Turen terhadap Kualitas ODHA Di Wilayah Kerja Puskesmas Turen Kabupaten Malang. Desain penelitian menggunakan quasi eksperimen, dengan teknik sampling menggunakan purposive sampling. Jumlah subyek penelitian sejumlah 23. Berdasarkan hasil uji dengan Wilcoxon didapatkan nilai p value < 0.005 yang berarti bahwa terdapat perbedaan bermakna sebelum dan sesudah ODHA bergabung mengikuti kegiatan WPA Cahaya Care Turen. Kesimpulan dalam penelitian ini adalah kegiatan WPA dengan melibatkan ODHA dan kelompok beresiko dapat mengoptimalkan kepatuhan obat ART sehingga berdampak terhadap peningkatan kualitas hidup ODHA. Saran dalam penelitian ini adalah dilakukannya Program kegiatan WPA yang terstruktur dan berkesinambungan lintas sektor guna meningkatkan kualitas hidup dan memberdayakan ODHA.     Kata kunci : WPA Cahaya Care Turen, kualitas hidup, ODHA

Study the Prevalence of Depression in Patients Attending Comprehensive Care Centre, Islamabad, Pakistan

2021 ◽  
Vol 4 (9) ◽  
pp. 1-6
Author(s):  
Mehak Nimra ◽  
Sobia Yousaf ◽  
Huma Naz ◽  
Hira Nain ◽  
Tahreem Shahid ◽  
...  
Keyword(s):  
Alcohol Use ◽  
Clinical Care ◽  
Comprehensive Care ◽  
P Value ◽  
People Living With Hiv ◽  
Care Centre ◽  
Neuropsychiatric Complications ◽  
Significant Difference ◽  
Prevalence Of Depression ◽  
Age Category

Abstract: Depression is one of the most common neuropsychiatric complications of HIV disease, and this leads to worse HIV-related health outcomes. With 350 million people affected worldwide, rates of depression are roughly two times greater in people living with HIV than in the general population. Objective: Determine prevalence of depression in patients attending Comprehensive Care Centre Shifa international Hospital, Islamabad Design: Descriptive cross-sectional quantitative study.  Settings: Shifa international Hospital, Islamabad Comprehensive Care Centre, Methods: This data is from a bigger study ‘prevalence of alcohol use disorders and depression in patients attending Comprehensive Care Centre (CCC). The study population consisted of PLWHA attending the CCC. Two hundred and seventy-two (N=272) participants from CCC attendants were recruited. All consenting male and female aged 18-65 years were interviewed using the researcher’s designed questioner to collect their socio-demographic characteristics. Fully completed questionnaires were entered into excel sheets and analyzed using the Statistical Package for Social Sciences (SPSS) Version 20.  Results: The overall prevalence of depression was 23.8%, with mild depression at 9.7%, moderate depression at 10.4% and severe depression accounting for 3.7%, respectively. Depression was associated with alcohol use (p=0.024). A significant difference between depression and age where depression levels worsens as age advances; respondents in age category of 18-21 years had less or no depression compared to those in the age category of 33 years and above. We found an association between depression and employment. Those laid-off work (1/3), and the retired (15%) had more depression compared to the employed (11%) or self-employed 6%, with a P value of 0.55 (borderline). On multivariate analysis severity of depression (OR=5.5, 95% CI of OR [2.1 –14.3], p<0.0001) was associated with male gender (OR=10, 95% CI of OR [3.6 –28.3], p<0.0001). Conclusion: The study findings indicate a high prevalence of depressive symptoms in patients attending the CCC. There is need to set-up appropriate interventions and strategies to reduce the prevalence of mental health disorders into routine HIV clinical care and support.

scholarly journals Condom use and associated factors among HIV-positive patients accessing care at a private tertiary health institution in the southwest, Nigeria

2020 ◽  
Vol 3 (1) ◽  
pp. 49-58
Author(s):  
Ngozi Adefala ◽  
Kolawole Sodeinde ◽  
Abiodun Osinaike ◽  
Fikayo Bamidele ◽  
Adebola Omotosho
Keyword(s):  
Condom Use ◽  
Associated Factors ◽  
Study Data ◽  
Sexual Pleasure ◽  
University Teaching ◽  
Good Knowledge ◽  
Categorical Variables ◽  
P Value ◽  
People Living With Hiv ◽  
Cross Sectional

Objective: This study aimed to assess the knowledge, attitude and practice towards condom utilization and other associated factors among people living with HIV/AIDS enrolled in the Virology clinic in Babcock University Teaching Hospital (BUTH) Ilishan, Ogun state, Nigeria. Methods: This cross-sectional study was conducted among 285 ART users selected using a systematic random sampling method. The minimum sample size was estimated using the formula z2pq/d2 and a 24% prevalence extracted from a previous similar study. Data were elicited using a structured interviewer-administered questionnaire, analyzed using SPSS version 20, and presented as tables. The Chi-square test was used to assess associations between categorical variables. The level of significance was set at the 95% confidence interval with a p-value of 0.05. Results: From the total respondents, 180(63.2%) were females, 93.7% had good knowledge, 141(49.5%) believed ARV prevents transmission of HIV and 144 (50.5%) strongly agreed that condom reduces sexual pleasure. Majority 254 (89.1%) were currently using condoms, 131 (46.0%) used a condom consistently, while 108 (37.9%) frequently use a condom during sexual intercourse. The Use of condoms had statistically significant associations with occupation (p<0.001), married at pre-diagnosis of HIV (p<0.001), married at post-diagnosis of HIV (p<0.001) and education (p= 0.015). Conclusion: The majority of the respondents had good knowledge and were using condoms. Discussions on safe sex and improved positive attitudes towards condom-use should, however, be encouraged further.

scholarly journals The THE SPECTRUM OF OPPORTUNISTIC INFECTIONS AND ASSOCIATED FACTORS AMONG PEOPLE LIVING WITH HIV/AIDS ON HIGHLY ACTIVE ANTI-RETROVIRAL THERAPY AT MERPATI CLINIC, BALI, INDONESIA: A RETROSPECTIVE STUDY

2020 ◽  
pp. 68-71
Author(s):  
NOVIANA JOENPUTRI ◽  
KETUT SURYANA
Keyword(s):  
Retrospective Study ◽  
Marital Status ◽  
Cell Count ◽  
Associated Factors ◽  
Opportunistic Infections ◽  
People Living With Hiv ◽  
Cd4 Cell Count ◽  
Highly Active ◽  
Living With Hiv ◽  
Cd4 Cell

Objective: Infections contributed to higher morbidity and mortality in people living with HIV/AIDS (PLWHA) in both developed and developing countries. This study aimed to describe the spectrum of opportunistic infections (OIs) and associated factors among PLWHA on highly active antiretroviral therapy (HAART) at Merpati Clinic, Wangaya Regional General Hospital in Denpasar, Bali. Methods: This was a retrospective study. All of PLWHA, who still receiving HAART at Merpati Clinic from January 2018 to January 2020, who met inclusion and exclusion criteria, were included as subjects in this study. All data were collected through a review of the complete medical record of patients. Results: The prevalence of OIs in this study was 43.4%. Most PLWHA who experienced OIs were male (68.8%), age ≤40 y old with a median of age 36 y old, educational status senior high school (57.7%), married (62.1%), employed (89.7%), CD4 cell count ≥ 200 cells/µl (67.6%) and transmission route of HIV non-Intravenous (IV) drug user (99.2%). Sex, age, marital status, and CD4 cell count were significantly associated with OIs, p=0.000, p=0.005, p=0.005, and p=0.000, respectively. Conclusion: The commonest OI in this study was pulmonary tuberculosis. The presence of OIs was associated with sex, age of HIV diagnosis, marital status, and CD4 cell count. With the knowledge of OIs spectrum, clinicians are expected to be able to prevent, diagnose and treat OIs promptly to decrease the morbidity and mortality caused by OIs efficiently.

scholarly journals KNOWLEDGE OF HEPATITIS PREVENTION AMONG REPRODUCTIVE AGE GROUP WOMEN FROM PAKISTAN DEMOGRAPHIC HEALTH SURVEY DATA 2012-13

2020 ◽  
Vol 9 (3) ◽  
pp. 135-138
Author(s):  
Faiz Rasul Awan ◽  
Muhammad Safdar Baig ◽  
Atiq ur Rehman Khan
Keyword(s):  
International Development ◽  
Survey Data ◽  
Health Survey ◽  
Demographic And Health Survey ◽  
Reproductive Age ◽  
P Value ◽  
Cluster Sampling ◽  
Age Group ◽  
Significant Difference ◽  
Reproductive Age Group

Background: Pakistan and Egypt bear more than 80% of the burden of disease as more than 12 million people are suffering from hepatitis B or C infection and there is addition of about 150000 new cases each year.Methods: We have used secondary data PDHS - Pakistan Demographic and Health Survey, DHS has become the gold standard of survey data in developing countries, a project by ORC Macro with financial support from the USAID for the International Development carried out as multistage, cluster sampling for its data collection on multiple questions, most pertinent from our study point view the maternal and child health related to knowledge attitude and practices of hepatitis and its prevention. Results:The final multivariate model six variables came out to be statistically significant with their adjusted odd's ration p-value and 95% confidence interval i.e., use of new disposable syringe every time for therapeutic injection purpose, the respondent being rich as wealth index, reading newspapers and magazines, watching television as source of information, area of residence being urban and with higher educational level came out to be most important variable which are making statistically significant difference for prevention of hepatitis among females of reproductive age group as our study population from Pakistan Demographic and Health Survey 2012-13. Conclusion: It is quite evident from the results of our study that use of new disposal syringes, being rich , being educated, having access to information resources like watching television, listening radio, reading newspaper & magazine and being as an urban dwellers are significant factor among women of reproductive age groups for prevention of hepatitis.

scholarly journals Effect of Application Time of Two Different Disinfectants on the Surface Roughness of an Elastomeric Impression Material

2020 ◽  
Author(s):  
Tahir Karaman ◽  
Faruk Oztekin ◽  
Samet Tekin
Keyword(s):  
Surface Roughness ◽  
Sodium Hypochlorite ◽  
Quaternary Ammonium ◽  
Rank Test ◽  
Control Group ◽  
P Value ◽  
Sodium Hypochlorite Solution ◽  
Application Time ◽  
Impression Material ◽  
Significant Difference

Introduction: Pathogens, such as cytomegalovirus, hepatitis B virus, hepatitis C virus, herpes simplex virus types 1 and 2, and human immunodeficiency virus are transmitted, threatening the health of dental laboratory workers, especially as a result of saliva and blood contact of patients. To prevent cross-infection, impression materials should be disinfected at the end of the impression process in the mouth. Aim: To study the effect of application time of sodium hypochlorite and quaternary ammonium-based disinfectant solution on the surface roughness of an elastomeric impression material. Materials and Methods: In this in-vitro study done during March 2020, 10 disc-shaped samples were used in each group, with a total of 110 samples obtained from a light body elastomeric impression material with dimensions of 15×3 mm. The samples were kept in a sodium hypochlorite solution (Wizard; Rehber Kimya, Istanbul, Turkey) at concentrations of 1% and 5% for 1, 5, 10, and 30 minutes and in a quaternary ammonium-based disinfectant (Zeta 7 Solution, Zhermack SpA, Italy) for 10 and 30 minutes. Surface roughness measurements were taken with a profilometer device. The data obtained were statistically analysed by Kolmogorov-Smirnov test and Wilcoxon signed rank test for dependent/paired groups for the continuous data. The significance level was set to α=0.05. Results: A statistically significant difference was found between the control group and the 1% sodium hypochlorite (30 min p-value 0.037), and 5% sodium hypochlorite (30 min p-value 0.017). The statistical evaluation of the surface roughness of the samples with different concentrations of sodium hypochlorite and the same times was done and found statistically significant at 30 mins, p-value 0.021. Conclusion: The prolonged application of the sodium hypochlorite disinfectant at 1% and 5% concentrations caused a significant increase in the light body elastomeric impression material’s surface roughness

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