scholarly journals Elevated glycosylated hemoglobin levels and their interactive effects on hypertension risk in nondiabetic Chinese population: a cross-sectional survey

2020 ◽  
Author(s):  
jian song ◽  
nana wei ◽  
yingying zhao ◽  
yuhong jiang ◽  
xuesen wu ◽  
...  
Keyword(s):  
Hba1c Level ◽  
Glycosylated Hemoglobin ◽  
Interactive Effects ◽  
Prevalence Rates ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Hypertension Risk ◽  
History Of ◽  
Family History Of Hypertension ◽  
Hba1c Levels

Abstract Background: Abnormal glucose metabolism has been suggested to be involved in the development of hypertension. This study investigated the effect of the association and potential interaction of glycosylated hemoglobin (HbA1c) and other factors on the risk of hypertension among Chinese nondiabetic adults. Methods : As a cross-sectional survey, the current work deployed a questionnaire survey, anthropometric tests, and biochemical measures for each of the eligible participants. The HbA1c levels were quantified and grouped by quartiles. Correlations between HbA1c and hypertension, isolated systolic hypertension (ISH), and isolated diastolic hypertension (IDH) risk in nondiabetics were investigated by univariate and multivariate logistic analyses. For evaluating the interactive effects, the parameters of relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP), and synergy index (SI) were calculated, respectively. Results : In the current study, 1,462 nondiabetic subjects were enrolled. In total, the prevalence rates of hypertension, ISH and IDH were 22.4%, 9.6% and 4.5%, respectively. When HbA1c levels were grouped by quartile, it was revealed that the prevalence rates of hypertension and ISH were substantially elevated across groups (Pfor trend<0.001). In the multivariable logistic regression analyses, in comparison with the first quartile of HbA1c, the normalized OR for hypertension risk was 1.90 (95% CI: 1.28-2.80) for the highest quartile. Also, the risk of ISH was significantly increased with HbA1c level in the highest quartile relative to in the bottom quartile (OR: 2.23,95% CI:1.47-3.71). However, no significant relationship between the HbA1c level and IDH risk was observed (OR: 1.78, 95% CI: 0.82-3.84). Eventually, it was demonstrated from the interactive effect analysis that HbA1c significantly interacted with abdominal obesity(RERI: 1.48, 95% CI: 0.38-2.58; AP: 0.37, 95% CI: 0.14-0.60 and SI: 1.96, 95% CI: 1.06-3.62) and family history of hypertension(AP: 0.37, 95% CI: 0.05-0.70) in influencing the risk of hypertension in nondiabetic participants.Conclusion: Higher HbA1c levels were associated with an increased risk of hypertension and ISH, but not IDH among Chinese nondiabetic adults. Moreover, the risk of hypertension was also aggravated by the upregulated HbA1c in a synergistic manner alongside abdominal obesity and family history of hypertension.

scholarly journals Elevated glycosylated hemoglobin levels and its interactive effects on hypertension risk in non-diabetic population: a cross-sectional survey in China

2019 ◽  
Author(s):  
jian song ◽  
nana wei ◽  
yingying zhao ◽  
yuhong jiang ◽  
xuesen wu ◽  
...  
Keyword(s):  
Family History ◽  
Abdominal Obesity ◽  
Interactive Effect ◽  
Interactive Effects ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Hypertension Risk ◽  
History Of ◽  
Family History Of Hypertension ◽  
Hba1c Levels

Abstract Background Abnormal glucose metabolism have been suggested to be involved in the development of hypertension. The present study aimed to investigate the associations and potential interactions of hemoglobin A1c (HbA1c) with other factors on the risk of hypertension among Chinese non-diabetic adults. Methods As a cross-sectional survey, the current work provided questionnaire survey, anthropometric tests and biochemical measure for each of the eligible participants. The HbA1c levels were quantified and grouped by quartiles. The correlation between HbA1c and hypertension risk in non-diabetic were investigated by univariate and multivariate analyses. For evaluating the interactive effects, the parameters of Relative Excess Risk due to Interaction (RERI), Attributable Proportion due to Interaction (AP) and Synergy Index (SI) were calculated, respectively. Results In the current study, 1462 non-diabetic subjects were enrolled. Totally, the prevalence of hypertension was 22.4% (n=327) in the individuals without diabetes. When the HbA1c levels were grouped by quartiles, it was revealed that the prevalence of hypertension substantially elevated across groups ( P for trend <0.001). In the multivariable logistic regression analyses, in comparison with the first quartile of HbA1c, the normalized OR for hypertension risk were 1.90 (95% CI:1.28-2.80) for the highest quartile. Besides, the ROC curve analysis indicated that the best threshold of HbA1c as the predictor for hypertension risk was 4.95 in non-diabetic subjects, with the AUC of 0.60 (0.58-0.63). Eventually, it was demonstrated from the interactive effect analysis that the HbA1c significantly interacted with abdominal obesity (RERI: 1.48, 95% CI: 0.38- 2.58; AP: 0.37, 95% CI: 0.14-0.60 and SI: 1.96, 95% CI: 1.06-3.62) and family history of hypertension (AP: 0.37, 95% CI: 0.05-0.70) on the risk of hypertension in non-diabetic participants. Conclusion The risk of hypertension was aggravated by the up-regulated HbA1c in an independent and synergistic manner with abdominal obesity and family history of hypertension in Chinese subjects without diabetes.

scholarly journals Elevated glycosylated hemoglobin levels and its interactive effects on hypertension risk in non-diabetic population: a cross-sectional survey in China

2020 ◽  
Author(s):  
jian song ◽  
nana wei ◽  
yingying zhao ◽  
yuhong jiang ◽  
xuesen wu ◽  
...  
Keyword(s):  
Family History ◽  
Abdominal Obesity ◽  
Interactive Effect ◽  
Interactive Effects ◽  
Cross Sectional Survey ◽  
Cross Sectional ◽  
Hypertension Risk ◽  
History Of ◽  
Family History Of Hypertension ◽  
Hba1c Levels

Abstract Background Abnormal glucose metabolism have been suggested to be involved in the development of hypertension. The present study aimed to investigate the associations and potential interactions of hemoglobin A1c (HbA1c) with other factors on the risk of hypertension among Chinese non-diabetic adults. Methods As a cross-sectional survey, the current work provided questionnaire survey, anthropometric tests and biochemical measure for each of the eligible participants. The HbA1c levels were quantified and grouped by quartiles. The correlation between HbA1c and hypertension risk in non-diabetic was investigated by univariate and multivariate analyses. For evaluating the interactive effects, the parameters of Relative Excess Risk due to Interaction (RERI), Attributable Proportion due to Interaction (AP) and Synergy Index (SI) were calculated, respectively. Results In the current study, 1462 non-diabetic subjects were enrolled. Totally, the prevalence of hypertension was 22.4% (n=327) in the individuals without diabetes. When the HbA1c levels were grouped by quartiles, it was revealed that the prevalence of hypertension substantially elevated across groups ( P for trend <0.001). In the multivariable logistic regression analyses, in comparison with the first quartile of HbA1c, the normalized OR for hypertension risk were 1.90 (95% CI:1.28-2.80) for the highest quartile. Also, the risk of ISH also significantly increased with HbA1c levels in the highest quartile as compared with the bottom quartile(OR: 2.23,95% CI:1.47-3.71). Besides, the ROC curve analysis indicated that the best threshold of HbA1c as the predictor for hypertension risk was 4.95 in non-diabetic subjects, with the AUC of 0.60 (0.58-0.63). Eventually, it was demonstrated from the interactive effect analysis that the HbA1c significantly interacted with abdominal obesity (RERI: 1.48, 95% CI: 0.38-2.58; AP: 0.37, 95% CI: 0.14-0.60 and SI: 1.96, 95% CI: 1.06-3.62) and family history of hypertension (AP: 0.37, 95% CI: 0.05-0.70) on the risk of hypertension in non-diabetic participants. Conclusion The risk of hypertension was aggravated by the up-regulated HbA1c in an independent and synergistic manner with abdominal obesity and family history of hypertension in Chinese subjects without diabetes.

scholarly journals Association and interaction of hemoglobin glycation index with hypertension risk: a community-based cross-sectional survey

2020 ◽  
Author(s):  
Jing Mi ◽  
Jian Song ◽  
Yingying Zhao ◽  
xue-sen wu
Keyword(s):  
Family History ◽  
Interactive Effect ◽  
Cross Sectional Survey ◽  
Community Based ◽  
Cross Sectional ◽  
Hypertension Risk ◽  
Increased Risk ◽  
History Of ◽  
Family History Of Hypertension ◽  
Hemoglobin Glycation

Abstract BackgroundHemoglobin glycation index (HGI) is considered to be a convenient measurable indicator to assess the inter-individual variation of HbA1c. In the present study, we tested the relationship between HGI and risk of hypertension, and further explored the possible interacting influences of HGI with other such factors on hypertension risk among Chinese individuals.Methods The eligible subjects were chosen from a community-based cross-sectional survey in China. We collected relevant data and clinical indicators for each participant. HGI was calculated as “measured HbA1c-predicted HbA1c” and divided into four categories according to quartile. The following indicators were used to assess interactive effects：(1) relative excess risk due to interaction (RERI); (2) attributable proportion due to interaction (AP); and (3) synergy index (SI). Statistical analysis was performed using R software.ResultsSpecifically, 1777 eligible participants were selected in this cross-sectional survey. There were 433 subjects who were identified to have hypertension (24.4%). A significant increase in the prevalence of hypertension from Q1 to Q4 of HGI was observed (P<0.001). Multivariable logistic model demonstrated that subjects at the highest HGI group had a substantially increased risk of being hypertensive than subjects in the first quartile of HGI, as indicated by the OR value of 1.87(95%CI: 1.26-2.78). Moreover, a significant interaction between family history of hypertension and HGI on hypertension risk was detected (RERI:1.36,95%CI:0.11-2.63; AP: 0.43, 95%CI:0.17-0.69; and SI:2.68, 95% CI:1.10-6.48). The interactive effect between HGI and abdominal obesity was also found to be significant, as estimated by the value of RERI (1.04, 95%CI:0.24-1.85), AP (0.33, 95% CI: 0.11-0.56) and SI (1.96, 95%CI:1.01-3.79). However, in the analysis of the interaction between HGI and general obesity, only the AP value (0.28, 95%CI: 0.01-0.54) was observed to be significant.ConclusionHigh HGI was independently associated with the risk of hypertension. Moreover, HGI significantly shared interactions with obesity and family history of hypertension that influenced the risk of hypertension.

scholarly journals Association of hemoglobin glycation index and its interaction with obesity/family history of hypertension on hypertension risk: a community-based cross-sectional survey

2020 ◽  
Author(s):  
Jing Mi ◽  
Jian Song ◽  
Yingying Zhao ◽  
xue-sen wu
Keyword(s):  
Family History ◽  
Interactive Effect ◽  
Cross Sectional Survey ◽  
Community Based ◽  
Cross Sectional ◽  
Hypertension Risk ◽  
Increased Risk ◽  
History Of ◽  
Family History Of Hypertension ◽  
Hemoglobin Glycation

Abstract BackgroundHemoglobin glycation index (HGI) is considered to be a convenient measurable indicator to assess the inter-individual variation of HbA1c. In the present study, we tested the relationship between HGI and risk of hypertension, and further explored the possible interacting influences of HGI with other such factors on hypertension risk among Chinese individuals.Methods The eligible subjects were chosen from a community-based cross-sectional survey in China.We collected relevant data and clinical indicators for each participant. HGI was calculated as “measured HbA1c-predicted HbA1c” and divided into four categories according to quartile. The following indicators were used to assess interactive effects：(1) relative excess risk due to interaction (RERI); (2) attributable proportion due to interaction (AP); and (3) synergy index (SI). Statistical analysis was performed using R software.ResultsSpecifically, 1777 eligible participants were selected in this cross-sectional survey. There were 433 subjects who were identified to have hypertension (24.4%). A significant increase in the prevalence of hypertension from Q1 to Q4 of HGI was observed (P<0.001). Multivariable logistic model demonstrated that subjects at the highest HGI group had a substantially increased risk of being hypertensive than subjects in the first quartile of HGI, as indicated by the OR value of 1.87(95%CI: 1.26-2.78). Moreover, a significant interaction between family history of hypertension and HGI on hypertension risk was detected (RERI:1.36,95%CI:0.11-2.63; AP: 0.43, 95%CI:0.17-0.69; and SI:2.68, 95% CI:1.10-6.48). The interactive effect between HGI and abdominal obesity was also found to be significant, as estimated by the value of RERI (1.04, 95%CI:0.24-1.85), AP (0.33, 95% CI: 0.11-0.56) and SI (1.96, 95%CI:1.01-3.79). However, in the analysis of the interaction between HGI and general obesity, only the AP value (0.28, 95%CI: 0.01-0.54) was observed to be significant.ConclusionHigh HGI was independently associated with the risk of hypertension. Moreover, HGI significantly shared interactions with obesity and family history of hypertension that influenced the risk of hypertension.

scholarly journals Association of hemoglobin glycation index and its interaction with obesity /family history of hypertension on hypertension risk: a community-based cross-sectional survey

2020 ◽  
Author(s):  
Jing Mi ◽  
Jian Song ◽  
Yingying Zhao ◽  
xue-sen wu
Keyword(s):  
Family History ◽  
Interactive Effect ◽  
Cross Sectional Survey ◽  
Community Based ◽  
Cross Sectional ◽  
Hypertension Risk ◽  
Increased Risk ◽  
History Of ◽  
Family History Of Hypertension ◽  
Hemoglobin Glycation

Abstract Background: Hemoglobin glycation index (HGI) is considered to be a convenient measurable indicator to assess the inter-individual variation of HbA1c. In the present study, we tested the relationship between HGI and risk of hypertension, and further explored the possible interacting influences of HGI with other such factors on hypertension risk among Chinese individuals.Methods : The eligible subjects were chosen from a community-based cross-sectional survey in China. We collected relevant data and clinical indicators for each participant. HGI was calculated as “measured HbA1c-predicted HbA1c” and divided into four categories according to quartile. The following indicators were used to assess interactive effects：(1) relative excess risk due to interaction (RERI); (2) attributable proportion due to interaction (AP); and (3) synergy index (SI). Statistical analysis was performed using R software.Results: Specifically, 1777 eligible participants were selected in this cross-sectional survey. There were 433 subjects who were identified to have hypertension (24.4%). A significant increase in the prevalence of hypertension from Q1 to Q4 of HGI was observed (P<0.001). Multivariable logistic model demonstrated that subjects at the highest HGI group had a substantially increased risk of being hypertensive than subjects in the first quartile of HGI, as indicated by the OR value of 1.87(95%CI: 1.26-2.78). Moreover, a significant interaction between family history of hypertension and HGI on hypertension risk was detected (RERI:1.36,95%CI:0.11-2.63; AP: 0.43, 95%CI:0.17-0.69; and SI:2.68, 95% CI:1.10-6.48). The interactive effect between HGI and abdominal obesity was also found to be significant, as estimated by the value of RERI (1.04, 95%CI:0.24-1.85), AP (0.33, 95% CI: 0.11-0.56) and SI (1.96, 95%CI:1.01-3.79). However, in the analysis of the interaction between HGI and general obesity, only the AP value (0.28, 95%CI: 0.01-0.54) was observed to be significant.Conclusion: High HGI was independently associated with the risk of hypertension. Moreover, HGI significantly shared interactions with obesity and family history of hypertension that influenced the risk of hypertension.

scholarly journals Association of hemoglobin glycation index and its interaction with obesity/family history of hypertension on hypertension risk: a community-based cross-sectional survey

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Jing Mi ◽  
Jian Song ◽  
Yingying Zhao ◽  
Xuesen Wu
Keyword(s):  
Family History ◽  
Interactive Effect ◽  
Cross Sectional Survey ◽  
Community Based ◽  
Cross Sectional ◽  
Hypertension Risk ◽  
Increased Risk ◽  
History Of ◽  
Family History Of Hypertension ◽  
Hemoglobin Glycation

Abstract Background Hemoglobin glycation index (HGI) is considered to be a convenient measurable indicator to assess the inter-individual variation of HbA1c. In the present study, we tested the relationship between HGI and risk of hypertension, and further explored the possible interacting influences of HGI with other such factors on hypertension risk among Chinese individuals. Methods The eligible subjects were chosen from a community-based cross-sectional survey in China. We collected relevant data and clinical indicators for each participant. HGI was calculated as “measured HbA1c-predicted HbA1c” and divided into four categories according to quartile. The following indicators were used to assess interactive effects: (1) relative excess risk due to interaction (RERI); (2) attributable proportion due to interaction (AP); and (3) synergy index (SI). Statistical analysis was performed using R software. Results Specifically, 1777 eligible participants were selected in this cross-sectional survey. There were 433 subjects who were identified to have hypertension (24.4%). A significant increase in the prevalence of hypertension from Q1 to Q4 of HGI was observed (p < 0.001). Multivariable logistic model demonstrated that subjects at the highest HGI group had a substantially increased risk of being hypertensive than subjects in the first quartile of HGI, as indicated by the OR value of 1.87 (95% CI 1.26–2.78). Moreover, a significant interaction between family history of hypertension and HGI on hypertension risk was detected (RERI: 1.36, 95% CI 0.11–2.63; AP: 0.43, 95% CI 0.17–0.69; and SI:2.68, 95% CI 1.10–6.48). The interactive effect between HGI and abdominal obesity was also found to be significant, as estimated by the value of RERI (1.04, 95% CI 0.24–1.85), AP (0.33, 95% CI 0.11–0.56) and SI (1.96, 95% CI 1.01–3.79). However, in the analysis of the interaction between HGI and general obesity, only the AP value (0.28, 95% CI 0.01–0.54) was observed to be significant. Conclusion High HGI was independently associated with the risk of hypertension. Moreover, HGI significantly shared interactions with obesity and family history of hypertension that influenced the risk of hypertension.

scholarly journals Effects of Sitagliptin on HbA1c levels in uncontrolled hyperglycemia in diabetics using conventional OAD’s.

2020 ◽  
Vol 27 (05) ◽  
pp. 963-967
Author(s):  
Amar Nazir ◽  
Fida Muhammad Sheikh ◽  
Sheraz Saleem
Keyword(s):  
Diabetes Mellitus ◽  
Hba1c Level ◽  
Glycosylated Hemoglobin ◽  
Type Ii Diabetes Mellitus ◽  
Cross Sectional ◽  
Entire Study ◽  
Dipeptidyl Peptidase 4 ◽  
Diagnostic Center ◽  
Dipeptidyl Peptidase 4 Inhibitors ◽  
Hba1c Levels

Objectives: The study anticipates to appraise HbA1c levels after three months of sitagliptin addition (100mg/day) to patients already using conventional oral antidiabetics in patients of type II diabetes mellitus who have a meager retort to these existing anti diabetics. Study Design: Mainly cross sectional prospective multicenter, open labeled study. Setting: Department of Medicine University medical diagnostic center & District Head Quarter Hospital Sargodha. Period: January 2017 to June 2017. Material & Methods: 100 inadequately controlled diabetics using different types of oral anti diabetics were chosen and an especially designed performa was accomplished. In our study we gave preference to those patients who were on preexisting oral anti diabetics and now dipeptidyl peptidase 4 inhibitors were added for the first time. The patients were instructed (at the baseline visit) to report during the subsequent visit about glycemic control. Patients were not clued-up that glycosylated hemoglobin control was the main seek of the study, so there was no chance for Pygmalion effect. Results: Levels of glycosylated hemoglobin were significantly reduced after three months of treatment compared to baseline, with a mean alteration in HbA1c level from baseline of −0.77% (range, −0.68 to − -0.86%) in the entire study population at three months. The percentage of patients who achieved an HbA1c level of <6.9% significantly increased after three months of treatment, reaching 58.1%. Conclusion: HbA1c significantly lowered in patients with type 2 diabetes mellitus on conventional OADs after adding sitagliptin.

scholarly journals Interaction of lipid accumulation product and family history of hypertension on hypertension risk: a cross-sectional study in the Southern Chinese population

BMJ Open ◽  
2019 ◽  
Vol 9 (11) ◽  
pp. e029253
Author(s):  
JunXuan Huang ◽  
XinYu Bao ◽  
YiXian Xie ◽  
XiaoXia Zhang ◽  
Xin Peng ◽  
...  
Keyword(s):  
Family History ◽  
Chinese Population ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Lipid Accumulation Product ◽  
Cross Sectional ◽  
Hypertension Risk ◽  
Southern Chinese ◽  
History Of ◽  
Family History Of Hypertension

ObjectivesThis study aimed at investigating the applicability of a novel index based on waist circumference (WC) and triglyceride (TG) which was named lipid accumulation product (LAP) in the Southern Chinese population, and compared the predictive effects of LAP and other obesity indicators on hypertension risk. Moreover, this study investigated the interactive effects of LAP and family history of hypertension.MethodsA total number of 2079 of community-dwelling adults in Southern China were enrolled in this cross-sectional study. The participants underwent questionnaire surveys, anthropometric tests and laboratory examinations. Themultinomial logistic regression model and receiver operating characteristic curves, including LAP, body mass index (BMI), waist-to-hip ratio (WHR), WC and TG, were used to assess the association between hypertension risk and obesity indexes. The interaction effects were evaluated by relative excess risk of interaction (RERI), attributable proportion due to interaction (AP) and synergy index (SI).ResultsHigher LAP levels have a relatively higher risk of having hypertension in both sexes (males: adjusted OR=2.79 per SD increase, 95% CI 1.43 to 5.44, p<0.001; females: adjusted OR=3.15, 95% CI 1.56 to 6.39, p<0.001). LAP (area under the curve=0.721; 95% CI 0.680 to 0.761) is a better indicator in identifying hypertension risk than BMI, WHR and TG in females, but WC performed better in males. A significant interaction between LAP and family history of hypertension was observed in males (RERI=1.652, 95% CI 0.267 to 3.037; AP=0.516, 95% CI 0.238 to 0.794; SI=3.998, 95% CI 0.897 to 17.820), but there is no statistically significant difference in females.ConclusionsLAP significantly associates with hypertension risk in the Southern Chinese population. It has better performance than BMI, WHR and TG on predicting hypertension risk of the Southern Chinese female population. Moreover, LAP and family history of hypertension might synergistically increase the risk of hypertension.

HbA1c levels with albuminuria in diabetes mellitus patients

2021 ◽  
Vol 129 (4) ◽  
Author(s):  
Prema Hidayati ◽  
Indah Lestari Daeng Kanang ◽  
Dzulrizka Razak ◽  
Resky Pratiwi Lambang Basri
Keyword(s):  
Diabetes Mellitus ◽  
Hba1c Level ◽  
Kidney Diseases ◽  
Average Length ◽  
Cross Sectional ◽  
Consecutive Sampling ◽  
History Of ◽  
Tract Infections ◽  
The Relationship ◽  
Hba1c Levels

Introduction: The number of people with diabetes mellitus (DM) worldwide with kidney complications has increased. Glycemic control by assessing HbA1c levels is one factor that influences the occurrence of kidney damage in DM patients. This study aims to determine the relationship between HbA1c levels and the incidence of albuminuria in DM patients. Methods: This study was a cross-sectional analytic observational study with consecutive sampling techniques in DM patients who did not have urinary tract infections and had no history of other kidney diseases, which were then measured for HbA1c levels and protein in the urine. Results: A total of 20 patients (62.5 %) were female, and 12 patients (37.5 %) were male. The average age of the patients was 59.81±4.89 years, and the average length of suffering from DM was 6.21±2.27 years. The average HbA1c level was 8.63±2.15, with an HbA1c level >7 found in 21 patients (65.7 %). In this study, there were 21 patients (65.7 %) with uncontrolled HbA1c levels. In this study, the prevalence of negative albuminuria was 56.2 %, while the prevalence of positive albuminuria was 43.8 %. There was a significant relationship between uncontrolled HbA1c levels and the incidence of albuminuria in DM patients (p=0.03). Conclusion: Uncontrolled HbA1c levels were associated with the incidence of albuminuria in DM patients.

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