HbA1c levels with albuminuria in diabetes mellitus patients

2021 ◽  
Vol 129 (4) ◽  
Author(s):  
Prema Hidayati ◽  
Indah Lestari Daeng Kanang ◽  
Dzulrizka Razak ◽  
Resky Pratiwi Lambang Basri

Introduction: The number of people with diabetes mellitus (DM) worldwide with kidney complications has increased. Glycemic control by assessing HbA1c levels is one factor that influences the occurrence of kidney damage in DM patients. This study aims to determine the relationship between HbA1c levels and the incidence of albuminuria in DM patients. Methods: This study was a cross-sectional analytic observational study with consecutive sampling techniques in DM patients who did not have urinary tract infections and had no history of other kidney diseases, which were then measured for HbA1c levels and protein in the urine. Results: A total of 20 patients (62.5 %) were female, and 12 patients (37.5 %) were male. The average age of the patients was 59.81±4.89 years, and the average length of suffering from DM was 6.21±2.27 years. The average HbA1c level was 8.63±2.15, with an HbA1c level >7 found in 21 patients (65.7 %). In this study, there were 21 patients (65.7 %) with uncontrolled HbA1c levels. In this study, the prevalence of negative albuminuria was 56.2 %, while the prevalence of positive albuminuria was 43.8 %. There was a significant relationship between uncontrolled HbA1c levels and the incidence of albuminuria in DM patients (p=0.03). Conclusion: Uncontrolled HbA1c levels were associated with the incidence of albuminuria in DM patients.

2020 ◽  
Vol 27 (05) ◽  
pp. 963-967
Author(s):  
Amar Nazir ◽  
Fida Muhammad Sheikh ◽  
Sheraz Saleem

Objectives: The study anticipates to appraise HbA1c levels after three months of sitagliptin addition (100mg/day) to patients already using conventional oral antidiabetics in patients of type II diabetes mellitus who have a meager retort to these existing anti diabetics. Study Design: Mainly cross sectional prospective multicenter, open labeled study. Setting: Department of Medicine University medical diagnostic center & District Head Quarter Hospital Sargodha. Period: January 2017 to June 2017. Material & Methods: 100 inadequately controlled diabetics using different types of oral anti diabetics were chosen and an especially designed performa was accomplished. In our study we gave preference to those patients who were on preexisting oral anti diabetics and now dipeptidyl peptidase 4 inhibitors were added for the first time. The patients were instructed (at the baseline visit) to report during the subsequent visit about glycemic control. Patients were not clued-up that glycosylated hemoglobin control was the main seek of the study, so there was no chance for Pygmalion effect. Results: Levels of glycosylated hemoglobin were significantly reduced after three months of treatment compared to baseline, with a mean alteration in HbA1c level from baseline of −0.77% (range, −0.68 to − -0.86%) in the entire study population at three months. The percentage of patients who achieved an HbA1c level of <6.9% significantly increased after three months of treatment, reaching 58.1%. Conclusion: HbA1c significantly lowered in patients with type 2 diabetes mellitus on conventional OADs after adding sitagliptin.


2018 ◽  
pp. 1-4
Author(s):  
Z. Hyde ◽  
K. Smith ◽  
L. Flicker ◽  
D. Atkinson ◽  
S. Fenner ◽  
...  

In this cross-sectional study of 141 Aboriginal Australians aged ≥45 years living in the remote Kimberley region of Western Australia, we explored whether glycated haemoglobin (HbA1c) levels were associated with frailty. Sixty-four participants (45.4%) had a HbA1c level ≥6.5% and 84 participants (59.6%) were frail. A significant trend was observed with regard to HbA1c levels and frailty, with those having HbA1c levels ≥6.5% having the greatest prevalence of frailty (70.3%). In binary logistic regression analyses, having a HbA1c level ≥6.5% was associated with being frail after adjustment for age, sex, and education. This association was attenuated after further adjustment for body mass index (BMI). Poorer glycaemic control is very common and a potential risk factor for frailty in remote-living Aboriginal Australians, and appears to be partly mediated by BMI, a known risk factor for diabetes mellitus. Obesity and diabetes mellitus are potentially important modifiable risk factors for frailty.


e-CliniC ◽  
2014 ◽  
Vol 2 (1) ◽  
Author(s):  
Richie Irvanto Ciandra ◽  
Corry N. Mahama ◽  
Melke J. Tumboimbela

ABSTRACT: Stroke is a big health problem in all industrial nations. In Indonesia, the prevalence of stroke keeps on increasing with each passing year. In addition to physical complaints suffered, sexual function may affect the patient’s. Erectile dysfunction is a problem that often arises in stroke patients. Purpose: This research is aimed in understanding describe of erectile dysfunction and the relationship between the risk factor namely diabetes mellitus and hypertension among stroke patients. Methods: The research method used is analytic descriptive with cross sectional approach. The study subjects were 40 men stroke patients, recruited by consecutive sampling in Polyclinic Neurology RSUP Prof. Dr. R. D. Kandou Manado during the period of November to December 2013. The measurement of erectile dysfunction used International Index of Erectile function/IIEF-5. Conclusion: Stroke patients who experience erectile dysfunction by 85%, with the highest amount on mild erectile dysfunction and mild to moderate erectile dysfunction at  35% dan 32,5%. Age most experienced erectile dysfunction are in the age group 35-44 years and >75 years. Low levels of education may suffer from erectile dysfunction is higher than the high education level. And the insiden of erectile dysfunction among stroke patients having risk factor of diabetes mellitus were higher than haven’t (OR=2,391). While hypertension risk factors correlated with a reduced risk of disease (OR=0,771). Keywords: Stroke, erectile dysfunction, diabetes mellitus, hypertension   ABSTRAK: Stroke merupakan masalah kesehatan yang besar di negara-negara industri, prevalensi stroke di Indonesia terus meningkat dari tahun ke tahun. Selain keluhan fisik yang diderita, keadaan fungsi seksual dapat mempengaruhi penderita. Disfungsi ereksi merupakan masalah yang sering timbul pada pasien stroke. Tujuan: Penelitian ini bertujuan untuk mengetahui gambaran disfungsi ereksi dan hubungan diabetes melitus dan hipertensi terhadap kejadian disfungsi ereksi pada pasien stroke. Metode: Jenis penelitian yang digunakan adalah deskriptif analitik dengan pendekatan cross sectional. Jumlah sampel sebanyak 40 pasien stroke laki-laki yang diambil secara consecutive sampling di Poliklinik Neurologi RSUP Prof. Dr. R. D. Kandou Manado selama bulan November - Desember 2013. Pengukuran disfungsi ereksi menggunakan International Index of Erectile Function/IIEF-5. Simpulan: Pasien stroke yang mengalami disfungsi ereksi sebesar 85% dengan jumlah terbanyak pada disfungsi ereksi ringan dan disfungsi ereksi ringan sampai sedang sebesar 35% dan 32,5%. Umur terbanyak mengalami disfungsi ereksi terletak pada kelompok umur 35-44 tahun dan >75 tahun. Tingkat pendidikan rendah dapat mengalami disfungsi ereksi lebih tinggi daripada yang tingkat pendidikannya tinggi. Dan insiden disfungsi ereksi diantara pasien stroke yang mempunyai faktor resiko diabetes melitus adalah lebih tinggi daripada yang tidak mempunyai faktor resiko tersebut (OR=2,391). Sedangkan faktor resiko hipertensi berkorelasi dengan berkurangnya resiko penyakit (OR=0,771). Kata Kunci: Stroke, disfungsi ereksi, diabetes melitus, hipertensi


2020 ◽  
Author(s):  
jian song ◽  
nana wei ◽  
yingying zhao ◽  
yuhong jiang ◽  
xuesen wu ◽  
...  

Abstract Background: Abnormal glucose metabolism has been suggested to be involved in the development of hypertension. This study investigated the effect of the association and potential interaction of glycosylated hemoglobin (HbA1c) and other factors on the risk of hypertension among Chinese nondiabetic adults. Methods : As a cross-sectional survey, the current work deployed a questionnaire survey, anthropometric tests, and biochemical measures for each of the eligible participants. The HbA1c levels were quantified and grouped by quartiles. Correlations between HbA1c and hypertension, isolated systolic hypertension (ISH), and isolated diastolic hypertension (IDH) risk in nondiabetics were investigated by univariate and multivariate logistic analyses. For evaluating the interactive effects, the parameters of relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP), and synergy index (SI) were calculated, respectively. Results : In the current study, 1,462 nondiabetic subjects were enrolled. In total, the prevalence rates of hypertension, ISH and IDH were 22.4%, 9.6% and 4.5%, respectively. When HbA1c levels were grouped by quartile, it was revealed that the prevalence rates of hypertension and ISH were substantially elevated across groups (Pfor trend<0.001). In the multivariable logistic regression analyses, in comparison with the first quartile of HbA1c, the normalized OR for hypertension risk was 1.90 (95% CI: 1.28-2.80) for the highest quartile. Also, the risk of ISH was significantly increased with HbA1c level in the highest quartile relative to in the bottom quartile (OR: 2.23,95% CI:1.47-3.71). However, no significant relationship between the HbA1c level and IDH risk was observed (OR: 1.78, 95% CI: 0.82-3.84). Eventually, it was demonstrated from the interactive effect analysis that HbA1c significantly interacted with abdominal obesity(RERI: 1.48, 95% CI: 0.38-2.58; AP: 0.37, 95% CI: 0.14-0.60 and SI: 1.96, 95% CI: 1.06-3.62) and family history of hypertension(AP: 0.37, 95% CI: 0.05-0.70) in influencing the risk of hypertension in nondiabetic participants.Conclusion: Higher HbA1c levels were associated with an increased risk of hypertension and ISH, but not IDH among Chinese nondiabetic adults. Moreover, the risk of hypertension was also aggravated by the upregulated HbA1c in a synergistic manner alongside abdominal obesity and family history of hypertension.


PUINOVAKESMAS ◽  
2020 ◽  
Vol 1 (2) ◽  
pp. 84-93
Author(s):  
Putri Nur Cahyani ◽  
Atik Martsiningsih ◽  
Budi Setiawan

Background: People with Type 2 Diabetes Mellitus in Indonesia continue to increase in prevalence. Understanding of complications due to this disease, one of which is diabetic nephropathy or damage to kidney nephrons. Objective: To determine the relationship between HbA1c levels and creatinine levels in patients with Type 2 Diabetes Mellitus. Method: This study was an observational experiment using a cross sectional approach based on secondary data. The research was carried out in February to April 2020. The population of this research study is a member of Prolanis (Chronic Disease Management Advanced Program) in Gamping 1 Puskesmas Sleman Yogyakarta. Sample with 24 patients. Analysis of data using the Spearman’s test. Results: From the results of the normality test using the Shapiro Wilk test data obtained were not normally distributed so that continued with the Spearman rank test obtained r of -0.006 and p values with sig. (2-tailed) of 0.961 or> 0.05 (H0 received). This means that there is no relationship between HbA1c levels and blood creatinine levels in patients with type 2 DM. Conclusion: There is no relationship between HbA1c levels and creatinine levels in patients with Type 2 Diabetes Mellitus.


2021 ◽  
Vol 6 (1) ◽  
pp. 1-6
Author(s):  
Nian Afrian Nuari

  Diabetes mellitus is a metabolic disease that has characteristics of high blood sugar levels (hyperglycemia), this can occur due to abnormalities in insulin secretion. The aim of this study was to determine the relationship of hemoglobin levels with long suffering  Diabetes Mellitus patients.  This study used was correlational design with a cross sectional approach.  The population in this study were 225 people with a sample of 67 respondents with purposive sampling technique.  Data was collected by checking hemoglobin levels and Quesioner. The results showed that almost all respondents had normal hemoglobin levels and most of the respondents had  long history of suffering from Diabetes Mellitus for 5-10 years..  Data analysis used was the Rho Spearman test and can not found the relationship between hemoglobin levels and long suffering Diabetes Mellitus (p value = 0.565). History of suffering from Diabetes Mellitus,did not necessarily have low hemoglobin levels, because it can be noticed from other factors such as routine taking medication, diet, exercise, and lifestyle that can affect the condition of diabetes patients themselves.  Diabetes Mellitus patients need to maintain the blood sugar levels and hemoglobin levels with a healthy lifestyle, take the recommended diet, routinely consume drugs, and check blood sugar levels regularly.


2019 ◽  
Vol 7 (1) ◽  
Author(s):  
Monica Welliangan ◽  
Mayer F. Wowor ◽  
Arthur E. Mongan

Abstract: Glycosuria is a condition characterized by an excess of sugar in the urine. Diabetes mellitus (DM) is one of the causes of glycosuria. Mortality risks of pregnant women and their babies increase in diabetes during pregnancy. Gestational diabetes mellitus (GDM) is DM diagnosed in 2nd and 3rd trimesters of pregmancy in women without DM before pregnancy. The probability of GDM among women with family history of DM is 3.46 times higher than those without family history. This study was aimed to evaluate the urine glucose level among primigravids who had diabetic parents in Manado. This was a descriptive observational study with a cross sectional design. Urine samples were obtained by using non-probability sampling with consecutive sampling adjusted to the criteria and time. The results showed that glycosuria (urin sugar level ≥50mg/dL) was found in three subjects (10%), most in age group of 20-35 years old and in 1st trimester. Conclusion: Some of the primigravids in this study had glycosuria.Keywords: DM, glycosuria, DM family history Abstrak: Glukosuria adalah kondisi dimana glukosa ditemukan dalam urin. Salah satu penyebab glukosuria ialah diabetes melitus (DM). Risiko kematian ibu dan bayi meningkat pada DM dalam kehamilan. Diabetes melitus gestasional (DMG) adalah DM yang terdiagnosis pada trimester dua atau tiga kehamilan yang bukan DM sebelum kehamilan. Peluang DMG pada wanita dengan riwayat DM dalam keluarga sebesar 3,46 lebih besar daripada wanita tanpa riwayat keluaarga. Penelitian ini bertujuan untuk mengetahui kadar glukosa urin pada primigravida dengan orang tua penyandang DM di Kota Manado. Jenis penelitian ialah deskriptif observasional dengan desain potong lintang. Penelitian ini menggunakan non-probability sampling jenis consecutive sampling untuk mendapatkan urin dari semua subyek penelitian sesuai dengan kriteria dan waktu yang ditentukan. Hasil penelitian mendapatkan glukosuria (kadar glukosa urin ≥50mg/dL) pada 3 subyek (10%) dengan karakteristik cenderung pada kelompok usia 20-35 tahun dan pada trimester satu. Simpulan: Sebagian primigravida dengan orang tua penyandang DM memiliki glukosuria.Kata kunci: DM, glukosuria, riwayat DM pada orang tua


2021 ◽  
Vol 9 (T3) ◽  
pp. 316-320
Author(s):  
Susilowati Susilowati ◽  
Karina Sugih Arto ◽  
Aridamuriany D. Lubis

BACKGROUND: Diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia that occurs due to impaired both in insulin secretion and insulin action. Children with type 1 diabetes mellitus should be targeted to achieve a glycated hemoglobin (HbA1C) level ≤7.0% to reduce the risk of complications and improve quality of life. The majority of children with type 1 diabetes mellitus exhibit poor self-care and Health-related Quality of life behavior. AIM: The objective of the study was to determine the relationship between HbA1C level and the quality of life among type 1 diabetes mellitus in children. METHODS: A cross-sectional study was conducted among 30 children with type 1 diabetes mellitus who attended at pediatric endocrine clinic Haji Adam Malik general hospital and Universitas Sumatera Utara hospital Medan. Sampling was carried out in April 2020–July 2020. HbA1C level and self-administered questionnaire were used to assess the quality of life. Spearman correlation test was conducted to assess the correlation between HbA1C levels and the quality of life. RESULTS: The mean of HbA1C level was 10.35 ± 2.68. No significant correlation between HbA1C level and the quality of life of children with type 1 diabetes mellitus (r = 0.264, p > 0.05) CONCLUSIONS: There was no significant correlation between HbA1C levels and the quality of life of children with type 1 diabetes mellitus.


2019 ◽  
Vol 11 (02) ◽  
pp. 135
Author(s):  
Eva Putriningrum ◽  
Eniyati . ◽  
Fatimah Dewi Anggraeni

ABSTRAKLatar Belakang: Stunting adalah masalah kurang gizi kronis yang disebabkan oleh asupan gizi yang kurang dalam waktu cukup lama akibat pemberian makanan yang tidak sesuai kebutuhan gizi. DIY merupakan daerah prioritas untuk intervensi stunting, prevalensi stunting tertinggi terdapat di Kabupaten Gunung Kidul yaitu 19,82%. Di BPM Yuliati, pada bulan Januari – Juni 2018, terdapat 20,45% bayi mengalami lahir stunting.  Tujuan: Diketahuinya hubungan bayi lahir stunting dengan pertumbuhan dan perkembangan pada bayi. Metode: Jenis penelitian ini merupakan penelitian deskripsi korelasi dengan menggunakan pendekatan cross sectional. Populasi dalam penelitian ini adalah bayi yang berusia maksimal 12 bulan pada saat dilakukan penelitian. Teknik pengambilan sampel menggunakan consecutive sampling sebanyak 61 bayi. Analisis data menggunakan analisis korelasi Chi Square.  Hasil : Sebagian besar responden dengan riwayat lahir stunting mengalami pertumbuhan dengan kategori normal yaitu sebanyak 27 responden (44,26%), dan 3 responden (4,92%) masuk dalam kategori tidak normal, dan pada perkembangan bayi dengan riwayat lahir stunting, sebagian besar responden mempunyai perkembangan yang normal yaitu sebanyak 25 responden (40,98%), dan terdapat 5 responden (8,20%) yang masuk ke dalam kategori meragukan. Kesimpulan : Tidak terdapat hubungan antara riwayat bayi lahir stunting dengan pertumbuhan pada bayi, dan terdapat hubungan antara bayi dengan riwayat lahir stunting dengan perkembangan pada bayi.Kata Kunci : Lahir Stunting, Pertumbuhan, Perkembangan RELATIONSHIP BETWEEN NEWBORN WITH STUNTING AND BABY’S GROWTH AND DEVELOPMENT IN BPM YULIATI SEMANU GUNUNG KIDUL YOGYAKARTAABSTRACTBackground: Stunting is a chronic malnutrition problem caused by a lack of nutritional intake for a long time due to the provision of food that does not meet nutritional needs. Yogyakarya is the priority area for stunting intervention. The highest prevalence of stunting in Yogyakarta is in Gunung Kidul Regency as much as 19.82%. In January - June 2018, 20.45% of babies in BPM Yuliati suffer from stunting. Objective: The aim of this research is to acknowledge the relationship between newborn with stunting and baby’s growth and development. Method: This type of research was a correlation description study used a cross sectional approach. The population in this study were infants aged a maximum of 12 months at the time of the study. The sampling technique used consecutive sampling of 61 infants. Data analysis using Chi Square correlation analysis. Results: Most respondents with a birth history of stunting experienced growth in the normal category of 27 respondents (44.26%), and 3 respondents (4.92%) were in the abnormal category, and in the development of infants with a history of stunting, partly The large number of respondents has a normal development of 25 respondents (40.98%), and there are 5 respondents (8.20%) who fall into the dubious category. Conclusion: There is no relationship between the history of stunting born babies and babies’ growth and development, and there is a relationship between stunting birth history with development in infants.Keywords: Birth Stunting, Growth, Development


2018 ◽  
Vol 5 (suppl_1) ◽  
pp. S274-S275
Author(s):  
Daniel Rojas-Bolivar ◽  
Zheng Zhu ◽  
Yamilee Hurtado ◽  
Milagros Zavaleta ◽  
Jorge Sanchez ◽  
...  

Abstract Background Diabetes mellitus (DM) increases the risk of tuberculosis disease (TB) and is associated with poor TB treatment outcomes in the general population. We examined the relationship between TB and DM in prison inmates in Peru. Methods We analyzed data from a cross-sectional, national survey of adult prison inmates in Peru conducted in 2016. The survey collected sociodemographic and medical information via standardized interview. Medical conditions were defined by self-report. We used multivariate logistic models for adjusted analyses of the relationship between TB and DM. Results Of 75,971 inmates, 3,104 (4.3%) reported a history of TB diagnosis. Table 1 shows the characteristics of the TB and non-TB groups. The prevalence of DM was higher in the TB group compared with the non-TB group (4.2% vs. 2.4%; P &lt; 0.001). In multivariate analysis, DM was associated with twice the odds of having had a diagnosis of TB (adjusted OR = 2.2; 95% CI: 1.8–2.7). Male sex, Spanish language, no college/university education, reimprisonment, hypertension, and HIV infection were also associated with increased odds of prevalent TB (Figure 1). Conclusion There was a high prevalence of TB among prison inmates in Peru. DM was associated with an increased likelihood of prevalent TB. Our results are consistent with findings in noninstitutionalized populations and underscore the need to implement aggressive screening and treatment interventions for both TB and DM in prison settings. Disclosures All authors: No reported disclosures.


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