scholarly journals Peripapillary retinal nerve fibre thickness in patients with primary open-angle glaucoma

2019 ◽  
Author(s):  
Aleksandar Miljkovic ◽  
Nikola Babic ◽  
Davidovic Sofija ◽  
Sava Barisic ◽  
Jelena Ljikar ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Open Angle Glaucoma ◽  
Statistical Processing ◽  
Healthy Population ◽  
Ophthalmological Examination ◽  
Open Angle ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Preperimetric Glaucoma ◽  
The Difference

Abstract Background The purpose of this study was to determine the difference in peripapillary retinal nerve fiber layer (RNFL) thickness in patients with preperimetric glaucoma and open angle glaucoma (POAG) in comparison to healthy population, as well as to determine the difference in thickness of peripapillary RNFL according to progression of the disease.Methods In this study, 120 patients were included . On the basis of clinical finding four groups of patients were formed: group without glaucoma, early POAG group, moderate POAG group and group with preperimetric glaucoma. Complete ophthalmological examination, visual field and optic coherent tomography of peripapillar region of RNFL were performed. The collected data was entered into a specially created database on a personal account, and the statistical processing was done using the SPSS for Windows. Results are displayed through charts and tables.Results The results showed that the thickness of peripapillary RNFL in patients with mild POAG is lesser than in healthy subjects, and thickness in patients with moderate POAG is lesser than in patients with mild POAG, as well as in healthy subjects (59.69±10.63 μm vs 73.44±12.16 μm vs 105.57±11.34 μm). Thickness of peripapillary RNFL in patients with preperimetric glaucoma is significantly lesser than in healthy subjects (83.65±9.24 μm vs 105.57±11. 34 μm). Parameter S together with mean value of peripapillary RNFL thickness (AvgThic) is the best predictors of appearance and progression of preperimetric glaucoma. There is positive correlation between progression of glaucoma (MD value) and AvgThic. The best predictors of appearance and progression of glaucomatous disease are: AvgThic, RNFL thickness in quadrants- S, I, N; and parameters RNFL- Smax, Savg, Iavg. ROC curve has shown that the following parameters are bad markers for progression of the disease: RNFL thickness in quadrant T and Imax.Conclusions We concluded that the determination of thickness of peripapillary RNFL in patients with glaucoma using optical coherent tomography represents the method which distinguishes between patients with POAG, preperimetric glaucoma and healthy population hence it can be used in glaucoma diagnostics and follow-up.

scholarly journals Diagnostic capability of different morphological parameters for primary open‐angle glaucoma in the Chinese population

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Ruoshi Li ◽  
Xia Wang ◽  
Yahui Wei ◽  
Yuan Fang ◽  
Tian Tian ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Chinese Population ◽  
Primary Open Angle Glaucoma ◽  
Early Stage ◽  
Open Angle Glaucoma ◽  
Structural Parameters ◽  
Open Angle ◽  
Fiber Layer ◽  
Diagnostic Capability ◽  
Diagnostic Power

Abstract Background To assess the diagnostic capability of novel Bruch’s membrane opening (BMO)-based disc parameters, the BMO-minimum rim width (BMO-MRW) and the BMO-minimum rim area (BMO-MRA) in the Chinese population and compare them to the retinal nerve fiber layer (RNFL) from optical coherence tomography (OCT) and the rim area (RA) from the Heidelberg retinal tomograph-III (HRT-III). Methods In total, 200 eyes of 77 healthy and 123 primary open-angle glaucoma (POAG) subjects were included in this cross-sectional study. All participants underwent the visual field test and structural measurements by OCT and HRT-III. The areas under the receiver operating characteristic curves (AUCs) of different structural parameters were calculated to assess their diagnostic power and compared using the DeLong test. Results In populations with different characteristics, the BMO-MRW and BMO-MRA had better diagnostic power than the RA. In discriminating between all POAG subjects and healthy controls and between early-stage patients and controls, the global BMO-MRW had comparable AUCs with the RNFL, but the BMO-MRA had lower AUCs than the RNFL. In healthy subjects with macrodiscs, both the global and sectoral BMO-MRW were thinner than those in healthy subjects with normal disc size. The AUCs of BMO-MRA, BMO-MRW and RNFL in subjects with macrodiscs were comparable. Additionally, in the myopic population, the BMO-MRA and BMO-MRW had comparable AUCs with the RNFL. Conclusions The BMO-MRW had comparable diagnostic power with the RNFL, and compared with BMO-MRW, the BMO-MRA might have advantages in certain populations, such as macrodiscs. All OCT-derived parameters exceeded the RA in diagnostic capability.

scholarly journals Association of the SNP rs112369934 near TRIM66 Gene with POAG Endophenotypes in African Americans

Genes ◽  
2021 ◽  
Vol 12 (9) ◽  
pp. 1420
Author(s):  
Claire D. Kim ◽  
Harini V. Gudiseva ◽  
Brendan McGeehan ◽  
Ebenezer Daniel ◽  
Gui Shuang Ying ◽  
...  
Keyword(s):  
African Americans ◽  
Open Angle Glaucoma ◽  
Open Angle ◽  
Nucleotide Polymorphism ◽  
Fiber Layer ◽  
Single Nucleotide ◽  
Qualitative And Quantitative ◽  
Suggestive Association ◽  
Rnfl Thickness ◽  
Cup To Disc Ratio

We investigated the association of the single nucleotide polymorphism (SNP) rs112369934 near the TRIM66 gene with qualitative and quantitative phenotypes of primary open-angle glaucoma (POAG) in African Americans (AA). AA subjects over 35 years old were recruited for the Primary Open-Angle African American Glaucoma Genetics (POAAGG) study in Philadelphia, PA. Glaucoma cases were evaluated for phenotypes associated with POAG pathogenesis, and the associations between rs112369934 and phenotypes were investigated by logistic regression analysis and in gender-stratified case cohorts: The SNP rs112369934 was found to have a suggestive association with retinal nerve fiber layer (RNFL) thickness and cup-to-disc ratio (CDR) in 1087 male AA POAG cases, individuals with the TC genotype having thinner RNFL (95% CI 0.85 to 6.61, p = 0.01) and larger CDR (95% CI −0.07 to −0.01, p = 0.02) than those with wildtype TT. No other significant associations were found. In conclusion SNP rs112369934 may play a role in POAG pathogenesis in male AA individuals. However, this SNP has been implicated in higher POAG risk in both male and female AA POAG cases.

scholarly journals Vessel Density in the Macular and Peripapillary Areas in Preperimetric Glaucoma to Various Stages of Primary Open-Angle Glaucoma in Taiwan

2021 ◽  
Vol 10 (23) ◽  
pp. 5490
Author(s):  
Chung-Kuang Ko ◽  
Kuan-I Huang ◽  
Fang-Ying Su ◽  
Mei-Lan Ko
Keyword(s):  
Late Stage ◽  
Primary Open Angle Glaucoma ◽  
Dynamic Range ◽  
Open Angle Glaucoma ◽  
Vessel Density ◽  
Ganglion Cell Complex ◽  
Open Angle ◽  
Fiber Layer ◽  
Cross Sectional ◽  
Preperimetric Glaucoma

Peripapillary and macular vessel density (VD) are reduced in myopic non-glaucomatous eyes, the dynamic range of VD may be decreased by myopia, and whether VD measurement has the potential in differentiating stages of glaucoma severity in patients with myopic glaucoma remains questionable. This observational, cross-sectional study aimed to clarify the changes in peripapillary and macular VDs in preperimetric glaucoma (PPG) and primary open-angle glaucoma in the early, moderate, and late stages. A total of 1228 eyes from 661 participants (540 normal, 67 PPG, and 521 glaucomatous) were included. Participants underwent free blood tests at the internal medicine clinic to retrieve systemic data. Patients with glaucoma were grouped by disease severity, defined by glaucomatous visual field mean defect, including early-(224 eyes), moderate-(103 eyes), and late-stage glaucoma (194 eyes), and further divided into advanced (158 eyes) and terminal glaucoma (36 eyes). Macular VD, peripapillary VD, circumpapillary retinal nerve fiber layer (cpRNFL) thickness, and ganglion cell complex (GCC) thickness were evaluated and divided into superior and inferior parts. One-way analysis of variance was performed, followed by Tukey’s post-hoc test. The peripapillary VD was significantly different between the healthy and PPG groups and the early-, moderate-, and late-stage glaucoma subgroups (all p < 0.001). Peripapillary VD measurements are helpful in differentiating the various stages of glaucoma even in patients with myopic glaucoma.

scholarly journals Corneal Endothelial Cell Density and Retinal Nerve Fiber Layer in Primary Open Angle Glaucoma, Normal Tension Glaucoma and Ocular Hypertension

2020 ◽  
Vol 37 (1) ◽  
Author(s):  
Bakht Samar Khan ◽  
Abid Nawaz ◽  
Lyla Shami ◽  
Zubaida Irshad ◽  
Mansoor Ahmad
Keyword(s):  
Endothelial Cell ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Open Angle Glaucoma ◽  
Corneal Endothelial Cell ◽  
Open Angle ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
Retinal Nerve Fiber

Purpose:  To compare the corneal endothelial cell density (CED) and retinal nerve fiber layer thickness (RNFL) in primary open angle glaucoma (POAG), normal tension glaucoma (NTG) and ocular hypertension (OHT). Study Design:  Cross sectional Observational study. Place and Duration of Study:  Khyber Teaching Hospital, Peshawar, from April 2016 to March 2018. Methods:   Patients having a single IOP reading of 21 mm Hg or more with glaucomatous cupping, visual field defect and open angle were labeled as POAG. Patients with IOP less than 21 mm Hg with same findings were labeled as NTG. Those eyes with raised IOP (more than 21 mm Hg), normal visual field and optic disc were labeled as OHT. Corneal endothelial cell count, central corneal thickness and retinal nerve fiber layer (RNFL) thickness were measured in patients of POAG, NTG and OHT. These were compared with normal age matched values. Results:  Thirty eyes with POAG, 10 with OHT and 10 with NTG were included in the study. In patients with POAG there was 13.33% CED and 27.7% mean RNFL thickness loss. In patients with NTG there was 3.06% CED and 34.04% mean RNFL thickness loss. In patients with OHT there was 7.17% CED and 5.5% mean RNFL thickness loss. Conclusion:  The loss of both RNFL thickness and CED occurs in POAG, OHT and NTG. Severe loss of RNFL thickness occurs in POAG and NTG while severe loss of CED occurs in POAG and OHT. Mild loss of RNFL thickness occurs in OHT while mild loss of CED occurs in NTG. Key Words:  Specular Microscopy, Optical Coherence Tomography, Nerve Fiber Layer, Open Angle Glaucoma, Ocular Hypertension.

scholarly journals Diagnostic capability of different morphological parameters for primary open-angle glaucoma in the Chinese population.

2020 ◽  
Author(s):  
Ruoshi Li ◽  
Xia Wang ◽  
Yahui Wei ◽  
Yuan Fang ◽  
Tian Tian ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Chinese Population ◽  
Primary Open Angle Glaucoma ◽  
Early Stage ◽  
Open Angle Glaucoma ◽  
Structural Parameters ◽  
Open Angle ◽  
Fiber Layer ◽  
Diagnostic Capability ◽  
Diagnostic Power

Abstract Background: To assess the diagnostic capability of novel Bruch’s membrane opening (BMO)-based disc parameters, the BMO-minimum rim width (BMO-MRW) and the BMO-minimum rim area (BMO-MRA) in the Chinese population and compare them to the retinal nerve fiber layer (RNFL) from optical coherence tomography (OCT) and the rim area (RA) from the Heidelberg retinal tomograph-III (HRT-III).Methods: In total, 200 eyes of 77 healthy and 123 primary open-angle glaucoma (POAG) subjects were included in this cross-sectional study. All participants underwent the visual field test and structural measurements by OCT and HRT-III. The areas under the receiver operating characteristic curves (AUCs) of different structural parameters were calculated to assess their diagnostic power and compared using the DeLong test.Results: In populations with different characteristics, the BMO-MRW and BMO-MRA had better diagnostic power than the RA. In discriminating between all POAG subjects and healthy controls and between early-stage patients and controls, the global BMO-MRW had comparable AUCs with the RNFL, but the BMO-MRA had lower AUCs than the RNFL. In healthy subjects with macrodiscs, both the global and sectoral BMO-MRW were thinner than those in healthy subjects with normal disc size. The AUCs of BMO-MRA, BMO-MRW and RNFL in subjects with macrodiscs were comparable. Additionally, in the myopic population, the BMO-MRA and BMO-MRW had comparable AUCs with the RNFL.Conclusions: The BMO-MRW had comparable diagnostic power with the RNFL, and compared with BMO-MRW, the BMO-MRA might have advantages in certain populations, such as macrodiscs. All OCT-derived parameters exceeded the RA in diagnostic capability.

scholarly journals Diagnostic capability of different morphological parameters for primary open-angle glaucoma in the Chinese population.

2020 ◽  
Author(s):  
Ruoshi Li ◽  
Xia Wang ◽  
Yahui Wei ◽  
Yuan Fang ◽  
Tian Tian ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Chinese Population ◽  
Primary Open Angle Glaucoma ◽  
Early Stage ◽  
Open Angle Glaucoma ◽  
Structural Parameters ◽  
Open Angle ◽  
Fiber Layer ◽  
Diagnostic Capability ◽  
Diagnostic Power

Abstract Background To assess the diagnostic capability of novel Bruch’s membrane opening (BMO)-based disc parameters, the BMO-minimum rim width (BMO-MRW) and the BMO-minimum rim area (BMO-MRA) in the Chinese population and compare them to the retinal nerve fiber layer (RNFL) from optical coherence tomography (OCT) and the rim area (RA) from the Heidelberg retinal tomograph-III (HRT-III). Methods In total, 200 eyes of 77 healthy and 123 primary open-angle glaucoma (POAG) subjects were included in this cross-sectional study. All participants underwent the visual field test and structural measurements by OCT and HRT-III. The areas under the receiver operating characteristic curves (AUCs) of different structural parameters were calculated to assess their diagnostic power and compared using the DeLong test. Results In populations with different characteristics, the BMO-MRW and BMO-MRA had better diagnostic power than the RA. In discriminating between all POAG subjects and healthy controls and between early-stage patients and controls, the global BMO-MRW had comparable AUCs with the RNFL, but the BMO-MRA had lower AUCs than the RNFL. In healthy subjects with macrodiscs, both the global and sectoral BMO-MRW were thinner than those in healthy subjects with normal disc size. The AUCs of BMO-MRA, BMO-MRW and RNFL in subjects with macrodiscs were comparable. Additionally, in the myopic population, the BMO-MRA and BMO-MRW had comparable AUCs with the RNFL. Conclusions The BMO-MRW had comparable diagnostic power with the RNFL, and compared with BMO-MRW, the BMO-MRA might have advantages in certain populations, such as macrodiscs. All OCT-derived parameters exceeded the RA in diagnostic capability.

scholarly journals Structure and Function Relationship of Activated Retinal Glia in Primary Open-Angle Glaucoma Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Christoph Nützi ◽  
Andreas Schötzau ◽  
Matthias C. Grieshaber
Keyword(s):  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Light Sensitivity ◽  
Fundus Photography ◽  
Retinal Sensitivity ◽  
Open Angle ◽  
Central Visual Field ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Custom Made

Purpose. To evaluate clinically activated retinal astrocytes and Müller cells (ARAM) regarding retinal sensitivity and retinal nerve fiber layer (RNFL) thickness in primary open-angle glaucoma (POAG). Methods. Central visual field (VF; i.e., retinal sensitivity) was measured with a custom-made macular pattern by microperimetry and correlated with the presence (ARAM+) or absence (ARAM−) of ARAM on red-free fundus photography and with the corresponding RNFL by optical coherence tomography (OCT). Results. In the eyes of POAG patients, ARAM+ had overall a significantly lower retinal sensitivity (ARAM+: 7.34 dB, ARAM−: 11.9 dB; p<0.001) and lower RNFL thickness in the inferior peripapillary quadrants compared to ARAM− (RNFL superior: ARAM+ 74.2 μm, ARAM− 77.5 μm; RNFL temporal: ARAM+ 46.8 μm, ARAM− 53.0 μm, p<0.001; and RNFL inferior: ARAM+ 63.2 μm, ARAM− 73.1 μm, p<0.001). Within the same eye, ARAM+ showed a lower retinal sensitivity compared to ARAM− ([ARAM− (11.13 dB)] − [ARAM+ (9.56 dB) = 1.57 dB; p=0.25). The proportion of ARAM+ per eye correlated strongly with reduced retinal light sensitivity (p=0.02), corresponding lower peripapillary RNFL thickness (p=0.02), and lower RNFL temporal quadrant thickness (p<0.01), but not with greater age (p=0.45). Conclusion. ARAM was more frequently identified in the eyes with a lower retinal sensitivity and peripapillary RNFL thickness and may be a clinical sign in the macula for an advanced stage of POAG.

Detection of serum uric acid in primary open angle glaucoma: A pilot study

2020 ◽  
pp. 112067212094401
Author(s):  
Rita Serra ◽  
Florence Coscas ◽  
Antonio Pinna ◽  
Marcella Peri ◽  
Ignazio Zucca ◽  
...  
Keyword(s):  
Uric Acid ◽  
Pilot Study ◽  
Visual Field ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Serum Levels ◽  
Mean Deviation ◽  
Ophthalmological Examination ◽  
Open Angle ◽  
Rnfl Thickness

Purpose: To assess the association between the serum levels of uric acid (UA) and primary open-angle glaucoma (POAG). Methods: In this pilot study, 46 eyes of 23 patients with a clinical history of POAG and 30 eyes of 15 healthy subjects were included. All patients underwent a complete ophthalmological examination, including best corrected visual acuity (BCVA), intraocular pressure (IOP), and gonioscopy. Visual field parameters, such as mean deviation (MD) and pattern standard deviation (PSD), and optical coherence tomography (OCT) values of the optic nerve head, including retinal nerve fiber layer (RNFL) thickness and vertical cup/disc ratio (VCDR), were noted. A blood sample was collected from each subject for serum UA measurement. Results: IOP, MD, PSD, RNFL thickness, and VCDR resulted significantly different in POAG patients, when compared with controls ( p < 0.05). POAG patients showed significantly lower levels of mean serum UA than healthy controls (4.00 ± 0.66 mg/dL vs 4.95 ± 0.86 mg/dL, respectively, p < 0.0001). Furthermore, severe POAG patients showed mean serum levels of UA lower than mild POAG patients (3.36 ± 0.70 mg/dL vs 4.22 ± 0.51 mg/dL, respectively, p = 0.01). Visual field and OCT parameters were statistically correlated with the mean serum levels of UA in POAG eyes ( p < 0.05). Conclusion: Results suggest that in POAG patients, serum UA levels may be decreased and correlated with visual field and OCT parameters worsening. Further larger multi-center prospective studies are necessary to confirm our findings and establish the role of UA in glaucoma.

scholarly journals Relationship between optic nerve head topography and nerve fiber layer thickness with central corneal thickness in patients with primary open-angle glaucoma

2020 ◽  
pp. 66-66
Author(s):  
Natasa Civcic-Kalinic ◽  
Miroslav Stamenkovic ◽  
Nada Civcic ◽  
Stefan Brunet
Keyword(s):  
Central Corneal Thickness ◽  
Primary Open Angle Glaucoma ◽  
Open Angle Glaucoma ◽  
Corneal Thickness ◽  
Area Ratio ◽  
Open Angle ◽  
Fiber Layer ◽  
Rnfl Thickness ◽  
Disc Area ◽  
Thin Cornea

Introduction/Objective. In patients with primary open-angle glaucoma (POAG) we explored the relationship between optic nerve head (ONH) topography parameters and retinal nerve fiber layer (RNFL) thickness with central corneal thickness (CCT). Methods. This retrospective study included 97 patients (97 eyes) with primary open-angle glaucoma. Patients were divided into a thin CCT<540?m (45 eyes) and a thick CCT?540?m (52 eyes) group, using ultrasonic pachymeter. Topographic measurements of the ONH parameters and RNFL thickness was performed using optical coherence tomography (OCT). The outcomes were compared with the thin and thick CCT and correlated with the thin CCT of the subjects. Results. There were significantly lower mean intraocular pressure (IOP) (p<0.0001) and CCT (p<0.0001) in patients with thin CCT compared to patients with thick CCT. Statistically significant differences of ONH parameters were found in thin cornea group compared to thick cornea group in: cup/disc area ratio (p<0.03), vertical cup/disc ratio (p<0.01) and rim volume (p<0.01). Statistically significant differences of RNFL thickness were found in thin cornea group compared to thick cornea group in: average (p<0.001), superior (p<0.03), inferior (p<0.03) and nasal (p<0.01). Significant positive correlation was found between thin CCT and OCT parameters in: optic disc area (r=0.429, p=0.003), cup/disc area ratio (r=0.287, p=0.05), horizontal cup/disc ratio (r=0.472, p<0.001), vertical cup/disc ratio (r=0.578, p<0.001), average RNFL (r=0.796, p<0.001), superior RNFL (r=0.665, p<0.001), inferior RNFL (r=0.650, p<0.001), nasal RNFL (r=0.611, p<0.001) and temporal RNFL thickness (r=0.601, p<0.001). Conclusion. POAG patients with thin cornea will probably develop larger glaucoma changes than those with a thicker cornea. Ultrasonic pachymetry measurements of CCT and OCT analysis of ONH topography parameters and RNFL thickness provide significant information in early diagnosis and monitoring progression of POAG.

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