scholarly journals Association between gene polymorphisms of voltage-dependent Ca2+ channels and hypertension in the Dai people of China: a case-control study

2019 ◽  
Author(s):  
LiFan Huang ◽  
Yan Chu ◽  
Xiaoqin Huang ◽  
Shaohui Ma ◽  
Keqin Lin ◽  
...  
Keyword(s):  
Intracellular Calcium ◽  
Gene Polymorphisms ◽  
Case Control Study ◽  
Statistical Significance ◽  
Case Control ◽  
Chi Square ◽  
Protein Coding ◽  
Protein Coding Genes ◽  
Control Study ◽  
Chi Square Tests

Abstract Background: Abnormal intracellular calcium homeostasis related to the development of hypertension. Because voltage-gated calcium channels (VDCCs) are a key regulator of intracellular calcium concentration, the variations in the VDCC protein-coding genes may have important effects on blood pressure changes and the development of hypertension. To discover the association between the gene polymorphisms of VDCCs and hypertension, we conducted a case-control study in the Dai ethnic group of China.Methods: A total of 1221 samples from Dai individuals were collected, of which 495 were used as cases, and 539 were used as controls. Seventeen single nucleotide polymorphisms (SNPs) in the four protein-coding genes (CACNA1A, CACNA1C, CACNA1S, CACNB2) of VDCCs were identified by multiplex PCR-SNP typing technique. Chi-square tests and regression models were used to analyse the associations of SNPs with hypertension. Results: The results of chi-square tests showed that the allele frequencies of 5 SNPs were significantly different between the case and the control groups (P<0.05), but the statistical significance was lost after Bonferroni’s correction. However, after adjusting for BMI, age, gender and other factors by logistic regression analyses, the results showed that 5 SNPs consistent with chi-square tests (rs2365293, rs17539088, rs16917217, rs61839222 and rs10425859) were still statistically positive.Conclusions: This finding suggested that the significant association of these SNPs with hypertension may be noteworthy in future studies.

scholarly journals Association between gene polymorphisms of voltage-dependent Ca2+ channels and hypertension in the Dai people of China: a case-control study

2020 ◽  
Author(s):  
LiFan Huang ◽  
Yan Chu ◽  
Xiaoqin Huang ◽  
Shaohui Ma ◽  
Keqin Lin ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Nucleotide Polymorphisms ◽  
Chi Square ◽  
Single Nucleotide ◽  
Protein Coding ◽  
Voltage Dependent ◽  
Typing Technique ◽  
Ca2 Channels ◽  
Control Study ◽  
Chi Square Tests

Abstract Background : Abnormal calcium homeostasis related to the development of hypertension. As the key regulator of intracellular calcium concentration, voltage-gated calcium channels (VDCCs), the variations in these genes may have important effects on the development of hypertension. Here we evaluate VDCCs variability with respect to hypertension in the Dai ethnic group of China. Methods : A total of 1034 samples from Dai individuals were collected, of which 495 were used as cases, and 539 were used as controls. Blood pressure was measured using a standard mercury measurement method, three times with a rest for 5 min, and the average was used for analyses. Seventeen single nucleotide polymorphisms (SNPs) in the four protein-coding genes ( CACNA1A, CACNA1C, CACNA1S, CACNB2 ) of VDCCs were identified by multiplex PCR-SNP typing technique. Chi-square tests and regression models were used to analyse the associations of SNPs with hypertension. Results: The results of chi-square tests showed that the allele frequencies of 5 SNPs were significantly different between the case and the control groups (P<0.05), but the statistical significance was lost after Bonferroni’s correction. However, after adjusting for BMI, age, sex and other factors by logistic regression analyses, the results showed that 5 SNPs consistent with chi-square tests (rs2365293, rs17539088, rs16917217, rs61839222 and rs10425859) were still statistically positive. Conclusions: This finding suggested that the significant association of these SNPs with hypertension may be noteworthy in future studies.

scholarly journals Association between gene polymorphisms of voltage-dependent Ca2+ channels andhypertension in the Dai people of China: a case-control study

2020 ◽  
Author(s):  
LiFan Huang ◽  
Yan Chu ◽  
Xiaoqin Huang ◽  
Shaohui Ma ◽  
Keqin Lin ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Nucleotide Polymorphisms ◽  
Chi Square ◽  
Single Nucleotide ◽  
Protein Coding ◽  
Voltage Dependent ◽  
Typing Technique ◽  
Ca2 Channels ◽  
Control Study ◽  
Chi Square Tests

Abstract Background: Abnormal calcium homeostasis related to the development of hypertension. As the key regulator of intracellular calcium concentration, voltage-gated calcium channels (VDCCs), the variations in these genes may have important effects on the development of hypertension. Here we evaluate VDCCs variability with respect to hypertension in the Dai ethnic group of China.Methods: A total of 1034 samples from Dai individuals were collected, of which 495 were used as cases, and 539 were used as controls. Blood pressure was measured using a standard mercury measurement method, three times with a rest for 5 min, and the average was used for analyses. Seventeen single nucleotide polymorphisms (SNPs) in the four protein-coding genes (CACNA1A, CACNA1C, CACNA1S, CACNB2) of VDCCs were identified by multiplex PCR-SNP typing technique. Chi-square tests and regression models were used to analyse the associations of SNPs with hypertension. Results: The results of chi-square tests showed that the allele frequencies of 5 SNPs were significantly different between the case and the control groups (P<0.05), but the statistical significance was lost after Bonferroni’s correction. However, after adjusting for BMI, age, sex and other factors by logistic regression analyses, the results showed that 5 SNPs consistent with chi-square tests (rs2365293, rs17539088, rs16917217, rs61839222 and rs10425859) were still statistically positive. Conclusions: This finding suggested that the significant association of these SNPs with hypertension may be noteworthy in future studies.

scholarly journals Association between gene polymorphisms of voltage-dependent Ca2+ channels and hypertension in the Dai people of China: a case-control study

2020 ◽  
Author(s):  
LiFan Huang ◽  
Yan Chu ◽  
Xiaoqin Huang ◽  
Shaohui Ma ◽  
Keqin Lin ◽  
...  
Keyword(s):  
Statistical Significance ◽  
Nucleotide Polymorphisms ◽  
Chi Square ◽  
Single Nucleotide ◽  
Protein Coding ◽  
Voltage Dependent ◽  
Typing Technique ◽  
Ca2 Channels ◽  
Control Study ◽  
Chi Square Tests

Abstract Background : Abnormal calcium homeostasis related to the development of hypertension. As the key regulator of intracellular calcium concentration, voltage-gated calcium channels (VDCCs), the variations in these genes may have important effects on the development of hypertension. Here we evaluate VDCCs variability with respect to hypertension in the Dai ethnic group of China. Methods : A total of 1034 samples from Dai individuals were collected, of which 495 were used as cases, and 539 were used as controls. Blood pressure was measured using a standard mercury measurement method, three times with a rest for 5 min, and the average was used for analyses. Seventeen single nucleotide polymorphisms (SNPs) in the four protein-coding genes ( CACNA1A, CACNA1C, CACNA1S, CACNB2 ) of VDCCs were identified by multiplex PCR-SNP typing technique. Chi-square tests and regression models were used to analyse the associations of SNPs with hypertension. Results: The results of chi-square tests showed that the allele frequencies of 5 SNPs were significantly different between the case and the control groups (P<0.05), but the statistical significance was lost after Bonferroni’s correction. However, after adjusting for BMI, age, sex and other factors by logistic regression analyses, the results showed that 5 SNPs consistent with chi-square tests (rs2365293, rs17539088, rs16917217, rs61839222 and rs10425859) were still statistically positive. Conclusions: This finding suggested that the significant association of these SNPs with hypertension may be noteworthy in future studies.

scholarly journals ACCENTUATED PERSONALITIES RELATED TO DAILY CIGARETTES SMOKING IN ROMANIAN COLLEGE STUDENTS – A CASE-CONTROL STUDY

2017 ◽  
Vol 5 ◽  
pp. 377-383
Author(s):  
Cristina Petrescu
Keyword(s):  
College Students ◽  
Cigarette Smoking ◽  
Case Control Study ◽  
Statistical Significance ◽  
Control Sample ◽  
Case Control ◽  
Health Questionnaire ◽  
Chi Square ◽  
Gamma Correlation ◽  
Control Study

Objective: In the study conducted accentuated personalities related to daily cigarette smoking in college students were investigated.Material of study consisted in a case-sample of 349 daily smokers (49.3% females, 50.7% males) and a control-sample of 880 non-smokers (65.3% women, 34.7% men) from an initial group of 1364 (aged 19-30 years) surveyed students.The method was an observational case-control inquiry with two questionnaires applying: Health Questionnaire (60 items-8 items for smoking) and Accentuated Personalities Questionnaire (88 items, alpha-Crohnbach index-0.823). Statistical analysis (chi square and gamma correlation) was performed by SPSS 20 Program.Results: Three accentuated personalities were more prominent in daily smokers in comparison with nonsmokers and were related to daily-smoking with statistical significance: IV-unruly (answers to items: S30–χ2=14.73, γ=0.23; S42-χ2=30.25, γ=0.36; and S52-χ2=32.71, γ=0.35; Sig.0.000), I-demonstrative (S7-χ2=18.89, γ=0.27; S44-χ2=16.24, γ=0.27; and S88-χ2=20.05, γ=0.27; Sig.0.000) and VII-cyclothymic nature (S72-χ2=32.24, γ=0.35; Sig.0.000).CONCLUSION: a relation between accentuated personalities and cigarette smoking is suggested.

SERUM PROLACTINE LEVEL IN PATIENTS OF PSORIASIS VULGARIS AND ITS CORRELATION WITH DISEASE SEVERITY: A CASE-CONTROL STUDY

2019 ◽  
Vol 3 (6) ◽  
Author(s):  
Pawan Kumar Saini ◽  
Devendra Yadav ◽  
Rozy Badyal ◽  
Suresh Jain ◽  
Arti Singh ◽  
...  
Keyword(s):  
Disease Severity ◽  
Prolactin Level ◽  
Case Control Study ◽  
Statistical Significance ◽  
Case Control ◽  
Serum Prolactin ◽  
P Value ◽  
Serum Prolactin Level ◽  
R Value ◽  
Control Study

Background: Psoriasis is an autoimmune chronic inflammatory disorder affecting the skin mediated by T-lymphocytes resulting in production of cytokines which cause hyperproliferation of keratinocytes.  Several factors and hormones like Prolactin have an action similar to these cytokines in promoting the multiplication of keratinocytes and other cells like lymphocytes and epithelial cells may have a role on the etiopathogenesis of psoriasis. Aim:-The aim of study is to compare the serum Prolactin levels in patients of psoriasis with a control group. Setting and study design: This is a case-control study conducted in the department of Dermatology, Venereology and Leprosy GMC, Kota over a period of 1year from July 2017 to June 2018 Material and method: The study included 100 cases of psoriasis (60 males and 40 females) and 100 controls similar for age and sex. Serum Prolactin levels were measured by ECLIA and results were obtained. Statistical analysis: Mean and standard deviation were calculated for each variable. Statistical significance of the results was analyzed using correlation analysis (Pearson correlation coefficient) and independent samples t-test. Statistical significance was assumed at p value<0.05. Result: Serum Prolactin level was significantly higher in cases of psoriasis compared to controls (p-value <0.001). PASI score and serum Prolactin levels were found to have a positive correlation (r value = 0.337; p-value: 0.001). No significant  correlation was found between serum levels of Prolactin and duration of disease r value= -0.034, P value =0.733). Serum Prolactin level was higher in male patients compared to females patients. Conclusion:- High serum Prolactin may be a biological marker of disease severity in psoriasis and may have a role in the pathogenesis of psoriasis. Further studies with large sample size are required to confirm this hypothesis.

HUBUNGAN ANTARA USIA, PARITAS, PEKERJAAN DAN INDEK MASSA TUBUH DENGAN KEJADIAN PROLAP ORGAN PANGGUL BERDASARKAN SKOR PELVIC ORGAN PROLAPSE QUANTIFICATION

2019 ◽  
Vol 2 (1) ◽  
pp. 39-44
Author(s):  
Ermawati Ermawati ◽  
Hafni Bachtiar
Keyword(s):  
Pelvic Organ Prolapse ◽  
Case Control Study ◽  
Pelvic Organ ◽  
Case Control ◽  
T Test ◽  
Pelvic Organ Prolapse Quantification ◽  
Chi Square ◽  
Chi Square Test ◽  
Control Study

Prolap organ panggul merupakan kondisi yang mempengaruhi kualitas hidup wanita. Prolaps organ panggul ini dapat disebabkan oleh perlukaan sewaktu proses persalinan, proses penuaan, komposisi jaringan pada seorang wanita, batuk- batuk kronis, atau sering melakukan pekerjaan berat. Pengenalan dini prolaps terkait dengan prognosis pemulihan anatomik dan fungsional organ panggul. Hingga kini, penerapannya dalam dunia klinis belum banyak sehingga pelatihan dan pembelajaran lebih lanjut tentang pelvic organ prolapse quantification (POPQ) jelas diperlukan. Penelitian ini dilakukan dengan metode case control study di polikilinik Obgin RSUP. Dr. M. Djamil Padang mulai bulan September 2013 sampai jumlah sampel terpenuhi sebanyak 98 orang. Dengan 49 orang kelompok kontrol dan 49 orang kelompok kasus .Analisis dilakukan untuk menilai hubungan usia, paritas, pekerjaan dan indek massa tubuh dengan kejadian prolap organ panggul berdasarkan skor POPQ. Data disajikan dalam bentuk tabel. Data diuji dengan t test dan chi square test. Jika p<0,05 menunjukan hasil yang bermakna. Terdapat hubungan yang bermakna antara usia dengan kejadian prolap organ panggul dengan (p<0,05) dan OR 27,871.terdapat hubungan yang bermakna antara paritas dengan kejadian prolap organ panggul dengan (p<0,05) dan OR 52,970.Dari analisa statistik pekerjaan tidak bisa di uji secara statistik.indek massa tubuh tidak terdapat hubungan yang bermakna terhadap kejadian prolap organ panggul.(p>0,05)

Sindrom Penyakit Tropis sebagai Prediktor Terjadinya Malnutrisi Balita di Daerah Pesisir

2020 ◽  
Vol 4 (2) ◽  
pp. 107-119
Author(s):  
Swaidatul Masluhiya AF ◽  
Irma Irma
Keyword(s):  
Confidence Interval ◽  
Case Control Study ◽  
Case Control ◽  
Chi Square ◽  
Control Study

Masalah kesehatan masyarakat yang cukup seriuspada kelompok usia balita sampai saat ini adalah kejadian malnutrisi, hal iniberdampak pada gangguan pertumbuhan dan perkembangan fisik balita. Malnutrisi juga dapat menyebabkan balita menjadi rentan terhadap penyakit infeksi. Beberapa faktor penyebab malnutrisi diantaranya faktor makanan dan penyakit infeksi yang mungkin diderita anak, faktor ketahanan pangan dikeluarga, pola pengasuhan anak, pelayanan kesehatan dan kesehatan lingkungan. Tujuan penelitian ini adalah untuk mengetahui apakah sindrom penyakit tropis merupakan prediktor terjadinya gizi kurang pada balita. Penelitian ini termasuk penelitian observasional analitik dengan rancangan Case Control Study. Populasi dalam penelitian ini adalah seluruh pasangan ibu dan balita yang ada di daerah pesisir kecamatan Nambo Kota Kendari denganteknik simple randam sampling di dapatkan jumlah sampel  sebanyak 164 orang yang terdiri dari dua kelompok yaitu kelompok kasus dan kelompok kontrol dengan perbandingan 1:1. Data dianalisis secara statistik dengan uji Chi square pada tingkat kepercayaan 95% (α=0,05) dengan mempertimbangkan nilai Odd Ratio dan nilai Confidence Interval. Hasil penelitian ini menunjukan bahwa sindrom penyakit tropis (diare dengan р-value = 0,001 dan OR = 4,162, batuk – batuk dengan р-value = 0,001 dan OR = 3,552,ISPAnon pneumoni dengan р-value = 0,004 dan OR = 3,003) merupakan faktor prediktor terjadinya malnutrisi pada balita sedangkan infeksi cacing dengan р-value = 0,056 dan OR= 1,773 bukan merupakan faktor prediktor terjadinya malnutrisi pada balita di daerah pesisir Kecamatan Nambo Kota Kendari

scholarly journals COVID-19 and Its Symptoms’ Panoply: A Case-Control Study of 919 Suspected Cases in Locked-Down Ovar, Portugal

2021 ◽  
pp. 1-8
Author(s):  
Regina Sá ◽  
Tiago Pinho-Bandeira ◽  
Guilherme Queiroz ◽  
Joana Matos ◽  
João Duarte Ferreira ◽  
...  
Keyword(s):  
Large Scale ◽  
Case Control Study ◽  
Statistical Significance ◽  
Case Control ◽  
Case Definition ◽  
Suspected Case ◽  
Risk Characteristics ◽  
Increased Risk ◽  
Wide Range ◽  
Control Study

<b><i>Background:</i></b> Ovar was the first Portuguese municipality to declare active community transmission of SARS-CoV-2, with total lockdown decreed on March 17, 2020. This context provided conditions for a large-scale testing strategy, allowing a referral system considering other symptoms besides the ones that were part of the case definition (fever, cough, and dyspnea). This study aims to identify other symptoms associated with COVID-19 since it may clarify the pre-test probability of the occurrence of the disease. <b><i>Methods:</i></b> This case-control study uses primary care registers between March 29 and May 10, 2020 in Ovar municipality. Pre-test clinical and exposure-risk characteristics, reported by physicians, were collected through a form, and linked with their laboratory result. <b><i>Results:</i></b> The study population included a total of 919 patients, of whom 226 (24.6%) were COVID-19 cases and 693 were negative for SARS-CoV-2. Only 27.1% of the patients reporting contact with a confirmed or suspected case tested positive. In the multivariate analysis, statistical significance was obtained for headaches (OR 0.558), odynophagia (OR 0.273), anosmia (OR 2.360), and other symptoms (OR 2.157). The interaction of anosmia and odynophagia appeared as possibly relevant with a borderline statistically significant OR of 3.375. <b><i>Conclusion:</i></b> COVID-19 has a wide range of symptoms. Of the myriad described, the present study highlights anosmia itself and calls for additional studies on the interaction between anosmia and odynophagia. Headaches and odynophagia by themselves are not associated with an increased risk for the disease. These findings may help clinicians in deciding when to test, especially when other diseases with similar symptoms are more prevalent, namely in winter.

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