scholarly journals Spatiotemporal association of low birth weight with Cs-137 deposition after Fukushima at the prefecture level in Japan: an ecological study

2020 ◽  
Author(s):  
Hagen Scherb ◽  
Japan Hayashi Osaka Keiji Hayashi Children's Clinic
Keyword(s):  
Logistic Regression ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Dose Rate ◽  
Pregnancy Outcome ◽  
P Value ◽  
Dependent Manner ◽  
Additional Dose ◽  
Spatiotemporal Trends ◽  
Level Shifts

Abstract Background: Perinatal mortality increased in contaminated prefectures after the Fukushima Daichi Nuclear Power Plant (FDNPP) accidents in Japan in 2011. Elevated numbers of surgeries for cryptorchidism and congenital heart malformations were observed throughout Japan from 2012 onward. The thyroid cancer detection rate (2011 to 2016) was associated with the dose-rate at the municipality level in the Fukushima prefecture. Since the birth weight is a simple and objective indicator for gestational development and pregnancy outcome, the question arises whether the annual birth weight distribution was distorted in a dose-rate-dependent manner across Japan after Fukushima. Data and Methods: The Japanese Ministry of Health, Labour, and Welfare provides prefecture-specific annual counts for 26.158 million live births from 1995 to 2018, of which 2.366 million births (9.04%) with weights < 2500g. Prefecture-specific spatiotemporal trends of the low birth weight proportions were analyzed. Logistic regression allowing for level-shifts from 2012 onward was employed to test whether those level-shifts were proportional to the prefecture-specific dose-rates derived from Cs-137 deposition in the 47 Japanese prefectures. Results: The overall trend of the low birth weight proportion (LBWp) in Japan discloses a jump in 2012 with a jump odds ratio (OR) 1.020, 95%-confidence interval (1.003,1.037), p-value 0.0225. A logistic regression of LBWp on the additional dose-rate after Fukushima adjusted for prefecture-specific spatiotemporal base-line trends yields an OR per µSv/h of 1.098 (1.058, 1.139), p-value < 0.0001. Further adjusting the logistic regression for the annual population size and physician density of the prefectures, as well as for the counts of the dead, the missing, and the evacuees due to earthquake and tsunami (as surrogate measures for medical infrastructure and stress) yields an OR per µSv/h of 1.109 (1.032, 1.191), p-value 0.0046. Conclusion: This study shows increased low birth weight prevalence related to Cs-137 deposition and the corresponding additional dose-rate in Japan from 2012 onward. Previous evidence suggesting compromised gestational development and pregnancy outcome under elevated environmental ionizing radiation exposure is corroborated.

scholarly journals Spatiotemporal association of low birth weight with Cs-137 deposition at the prefecture level in Japan after the Fukushima nuclear power plant accidents: an analytical-ecologic epidemiological study

2020 ◽  
Author(s):  
Hagen Scherb ◽  
Japan Hayashi Osaka Keiji Hayashi Children's Clinic
Keyword(s):  
Logistic Regression ◽  
Birth Weight ◽  
Power Plant ◽  
Nuclear Power Plant ◽  
Low Birth Weight ◽  
Dose Rate ◽  
Nuclear Power ◽  
P Value ◽  
Additional Dose ◽  
Level Shifts

Abstract Background: Perinatal mortality increased in contaminated prefectures after the Fukushima Daichi Nuclear Power Plant (FDNPP) accidents in Japan in 2011. Elevated counts of surgeries for cryptorchidism and congenital heart malformations were observed throughout Japan from 2012 onward. The thyroid cancer detection rate (2011 to 2016) was associated with the dose-rate at the municipality level in the Fukushima prefecture. Since the birth weight is a simple and objective indicator for gestational development and pregnancy outcome, the question arises whether the annual birth weight distribution was distorted in a dose-rate-dependent manner across Japan after Fukushima. Methods: The Japanese Ministry of Health, Labour, and Welfare provides prefecture-specific annual counts for 26.158 million live births from 1995 to 2018, of which 2.366 million births (9.04%) with weights < 2500 g. Prefecture-specific spatiotemporal trends of the low birth weight proportions were analyzed. Logistic regression allowing for level-shifts from 2012 onward was employed to test whether those level-shifts were proportional to the prefecture-specific dose-rates derived from Cs-137 deposition in the 47 Japanese prefectures. Results: The overall trend of the low birth weight prevalence (LBWp) in Japan discloses a jump in 2012 with a jump odds ratio (OR) 1.020, 95%-confidence interval (1.003,1.037), p-value 0.0246. A logistic regression of LBWp on the additional dose-rate after the FDNPP accidents adjusted for prefecture-specific spatiotemporal base-line trends yields an OR per µSv/h of 1.098 (1.058, 1.139), p-value < 0.0001. Further adjusting the logistic regression for the annual population size and physician density of the prefectures, as well as for the counts of the dead, the missing, and the evacuees due to earthquake and tsunami (as surrogate measures for medical infrastructure and stress) yields an OR per µSv/h of 1.109 (1.032, 1.191), p-value 0.0046.Conclusions: This study shows increased low birth weight prevalence related to Cs-137 deposition and the corresponding additional dose-rate in Japan from 2012 onward. Previous evidence suggesting compromised gestational development and pregnancy outcome under elevated environmental ionizing radiation exposure is corroborated.

scholarly journals Spatiotemporal association of low birth weight with Cs-137 deposition at the prefecture level in Japan after the Fukushima nuclear power plant accidents: an analytical-ecologic epidemiological study

2020 ◽  
Vol 19 (1) ◽  
Author(s):  
Hagen Scherb ◽  
Keiji Hayashi
Keyword(s):  
Logistic Regression ◽  
Birth Weight ◽  
Power Plant ◽  
Nuclear Power Plant ◽  
Low Birth Weight ◽  
Dose Rate ◽  
Pregnancy Outcome ◽  
Nuclear Power ◽  
Additional Dose ◽  
Level Shifts

Abstract Background Perinatal mortality increased in contaminated prefectures after the Fukushima Daichi Nuclear Power Plant (FDNPP) accidents in Japan in 2011. Elevated counts of surgeries for cryptorchidism and congenital heart malformations were observed throughout Japan from 2012 onward. The thyroid cancer detection rate (2011 to 2016) was associated with the dose-rate at the municipality level in the Fukushima prefecture. Since the birth weight is a simple and objective indicator for gestational development and pregnancy outcome, the question arises whether the annual birth weight distribution was distorted in a dose-rate-dependent manner across Japan after Fukushima. Methods The Japanese Ministry of Health, Labour, and Welfare provides prefecture-specific annual counts for 26.158 million live births from 1995 to 2018, of which 2.366 million births (9.04%) with weights < 2500 g. Prefecture-specific spatiotemporal trends of the low birth weight proportions were analyzed. Logistic regression allowing for level-shifts from 2012 onward was employed to test whether those level-shifts were proportional to the prefecture-specific dose-rates derived from Cs-137 deposition in the 47 Japanese prefectures. Results The overall trend of the low birth weight prevalence (LBWp) in Japan discloses a jump in 2012 with a jump odds ratio (OR) 1.020, 95%-confidence interval (1.003,1.037), p-value 0.0246. A logistic regression of LBWp on the additional dose-rate after the FDNPP accidents adjusted for prefecture-specific spatiotemporal base-line trends yields an OR per μSv/h of 1.098 (1.058, 1.139), p-value < 0.0001. Further adjusting the logistic regression for the annual population size and physician density of the prefectures, as well as for the counts of the dead, the missing, and the evacuees due to earthquake and tsunami (as surrogate measures for medical infrastructure and stress) yields an OR per μSv/h of 1.109 (1.032, 1.191), p-value 0.0046. Conclusions This study shows increased low birth weight prevalence related to the Cs-137 deposition and the corresponding additional dose-rate in Japan from 2012 onward. Previous evidence suggesting compromised gestational development and pregnancy outcome under elevated environmental ionizing radiation exposure is corroborated.

scholarly journals Spatiotemporal association of low birth weight with Cs-137 deposition at the prefecture level in Japan after the Fukushima nuclear power plant accidents: an analytical-ecologic epidemiological study

2020 ◽  
Author(s):  
Hagen Scherb ◽  
Japan Hayashi Osaka Keiji Hayashi Children's Clinic
Keyword(s):  
Logistic Regression ◽  
Birth Weight ◽  
Power Plant ◽  
Nuclear Power Plant ◽  
Low Birth Weight ◽  
Dose Rate ◽  
Nuclear Power ◽  
P Value ◽  
Additional Dose ◽  
Level Shifts

Abstract Background: Perinatal mortality increased in contaminated prefectures after the Fukushima Daichi Nuclear Power Plant (FDNPP) accidents in Japan in 2011. Elevated counts of surgeries for cryptorchidism and congenital heart malformations were observed throughout Japan from 2012 onward. The thyroid cancer detection rate (2011 to 2016) was associated with the dose-rate at the municipality level in the Fukushima prefecture. Since the birth weight is a simple and objective indicator for gestational development and pregnancy outcome, the question arises whether the annual birth weight distribution was distorted in a dose-rate-dependent manner across Japan after Fukushima. Methods: The Japanese Ministry of Health, Labour, and Welfare provides prefecture-specific annual counts for 26.158 million live births from 1995 to 2018, of which 2.366 million births (9.04%) with weights < 2500 g. Prefecture-specific spatiotemporal trends of the low birth weight proportions were analyzed. Logistic regression allowing for level-shifts from 2012 onward was employed to test whether those level-shifts were proportional to the prefecture-specific dose-rates derived from Cs-137 deposition in the 47 Japanese prefectures. Results: The overall trend of the low birth weight prevalence (LBWp) in Japan discloses a jump in 2012 with a jump odds ratio (OR) 1.020, 95%-confidence interval (1.003,1.037), p-value 0.0246. A logistic regression of LBWp on the additional dose-rate after the FDNPP accidents adjusted for prefecture-specific spatiotemporal base-line trends yields an OR per µSv/h of 1.098 (1.058, 1.139), p-value < 0.0001. Further adjusting the logistic regression for the annual population size and physician density of the prefectures, as well as for the counts of the dead, the missing, and the evacuees due to earthquake and tsunami (as surrogate measures for medical infrastructure and stress) yields an OR per µSv/h of 1.109 (1.032, 1.191), p-value 0.0046. Conclusions: This study shows increased low birth weight prevalence related to the Cs-137 deposition and the corresponding additional dose-rate in Japan from 2012 onward. Previous evidence suggesting compromised gestational development and pregnancy outcome under elevated environmental ionizing radiation exposure is corroborated.

scholarly journals Clinical profile and factors determining outcome of intramural very low birth weight babies in a tertiary care centre: a retrospective study

2017 ◽  
Vol 5 (2) ◽  
pp. 520
Author(s):  
Devi Meenakshi K. ◽  
Arasar Seeralar A. T. ◽  
Srinivasan Padmanaban
Keyword(s):  
Risk Factors ◽  
Logistic Regression ◽  
Regression Analysis ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Logistic Regression Analysis ◽  
Very Low Birth Weight ◽  
Tertiary Care ◽  
P Value ◽  
Increased Risk

Background: Very low birth weight (VLBW) babies are at increased risk of a number of complications both immediate and late. Worldwide it has been observed that these babies contribute to a significant extent to neonatal mortality and morbidity. Aim of the study was to study the risk factors contributing to mortality in VLBW babies and to evaluate the morbidity pattern in these infants.Methods: A retrospective analysis of data retrieved from the case records of VLBW babies admitted in the NICU of Kilpauk Medical College between January 2015 to December 2015. Out of the 2360 intramural babies admitted during the study period, 99 babies were less than 1500 gms. The risk factors for these babies were analyzed for their association with the outcome. Data were statistically analyzed.Results: In present study, we found that sex of the baby, gestational age, obstetric score, birth asphyxia, pulmonary haemorrhage, ROP and presence of shock were found to be associated with increased mortality. By logistic regression analysis it was observed that birth weight of the baby (p value 0.002), duration of stay (p value 0.0006), presence of shock (p<0.0001), were the risk factors significantly associated with poor outcome.Conclusions: Among the maternal and neonatal factors analyzed in the study using logistic regression analysis, birth weight, duration of hospital stay and presence of shock were significantly related to poor outcome. Of these presence of shock was the single most important factor that predicted increased mortality.

scholarly journals Magnitude of Low Birth Weight and Associated Factors among Newborns Delivered in Dangla Primary Hospital, Amhara Regional State, Northwest Ethiopia, 2017

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Asmare Talie ◽  
Mekuanint Taddele ◽  
Mulunesh Alemayehu
Keyword(s):  
Logistic Regression ◽  
Birth Weight ◽  
Food Intake ◽  
Low Birth Weight ◽  
Associated Factors ◽  
Previous History ◽  
P Value ◽  
Future Health ◽  
Additional Food ◽  
Primary Hospital

Background. Low birth weight is defined as a live born infant weighs less than 2 500 g regardless of gestational age. Globally, the prevalence of low birth weight ranges from 3% to 15%. Birth weight plays an important role in infant mortality, morbidity, development, and future health. The prevalence of low birth weight in Ethiopia was estimated to be 14% which is one of the highest percentages in the world. So, the aim of this study is to assess magnitude and associated factors of low birth weight among newborns delivered at Dangla Primary Hospital, Amhara Region, Ethiopia. Methods. An institution-based cross-sectional study was conducted at Dangla Primary Hospital from September 27 to June 10, 2017. Systematic random sampling technique was used to select the 232 study participants. A structured and pretested questionnaire was used to collect data. Data quality was assured by pretesting, training, and frequent supervision. Descriptive statistics were performed for the descriptive part of the study. Binary and multiple logistic regression analyses were conducted to identify independent predictors of low birth weight. Those variables and p-value < 0.25 were included in the multivariable logistic regression for controlling the possible effect of confounders. Finally, variables which had significant association were identified on the basis of AOR, with 95%CI and with P-value <0.05. Results. Magnitude of low birth weight was 10.3 %. Previous history of low birth weight [AOR = 3.2, 95% CI: (1.13-9.9)], additional food intake during the last pregnancy [AOR = 5.0, 95% CI: (1.2-16.2)], and preterm delivery [AOR = 2.1, 95% CI: (3.1-19.2)] were independent predictors of low birth weight. Conclusion. Magnitude of low birth weight in Dangla Primary Hospital was high. So, strengthening counseling systems for women through quality antenatal care on advantage of additional food intake and previous bad obstetric outcome is necessary to alleviate the delivery of low birth weight neonates in the study area.

scholarly journals Pregnancy outcome in isolated oligohydramnios diagnosed in third trimester

2021 ◽  
Vol 10 (5) ◽  
pp. 1914
Author(s):  
Pratibha Singh ◽  
Vibha Rani Pipal ◽  
Dharmendra Kumar Pipal ◽  
Navdeep Kaur Ghuman ◽  
Garima Yadav ◽  
...  
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Amniotic Fluid ◽  
Pregnancy Outcome ◽  
Preterm Delivery ◽  
Neonatal Outcome ◽  
Low Risk ◽  
Control Group ◽  
P Value ◽  
Third Trimester

Background: The aim of this study was to compare the outcomes of pregnancies complicated by isolated oligohydramnios with the low risk pregnancies with normal amniotic fluid volume.Methods: The present study is a retrospective cohort study of singleton pregnancies diagnosed with Isolated oligohydramnios (AFI≤5) in their third trimester (N=35). Pregnancy outcome was compared with a matched control group of low risk pregnancies with amniotic fluid volume >5 (N=30).Results: The overall incidence of Isolated oligohydramnios was 0.7-0.8%. In oligohydramnios group, significant association were found in null-parity (60% vs 23.33%, p-value<0.005), Fetal growth retardation (25.71% vs 0% p-value<0.02), preterm delivery (22.85% vs 3.33%, p-value 0.025), rate of Induction of labor (40% vs 10%) and cesarean rate for non-reassuring fetal heart rate (20% vs 3.33%, p-value<0.001). Likewise, the incidence of low birth weight was (54.28% vs 13.33%, p-value<0.001) and NICU admissions was (20% vs 0%, p-value<0.01), but there was no difference in Apgar score finding. NICU stay was of short duration and all babies discharged in stable condition, there were no stillbirth or early neonatal death in both groups.Conclusions: Isolated oligohydramnios has an adverse influence on pregnancy and neonatal outcome in the form of FGR, preterm delivery, increased rate of Induction and cesarean section. Despite the high incidence of low birth weight and NICU admissions, the overall early neonatal outcome was similar to the other low risk pregnancies.

MYOMA PLACENTA RELATIONSHIP & PREGNANCY OUTCOME

2021 ◽  
pp. 3-4
Author(s):  
Savita Chandra
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Pregnancy Outcome ◽  
P Value ◽  
Obstetric Outcome ◽  
Premature Rupture Of Membranes ◽  
Premature Rupture ◽  
Antepartum Haemorrhage

During the two years study period, 8557 deliveries took place, of which 114 were pregnancies with myoma giving the incidence as 1.33%. 12 of the 114 pregnancies ended in abortion, i.e.10.5%. The myoma placenta relationship and the obstetric outcome was analyzed in the remaining 102 pregnancies which continued beyond 22 weeks. Of these, 41.2% had complications. Premature rupture of membranes was the commonest complication seen in 22.5%. No case of preeclampsia or antepartum haemorrhage occurred in the 'no contact' category. Amongst the cases where the placenta was either in contact or superimposed on the broid, 85.5% -87.5% developed one or more complication. The myoma placenta relationship was found to be statistically signicant, p value <0.001. 39.3% were caesarean deliveries. Overall 37.25% were low birth weight neonates. There were two stillbirths, both in the superimposed category.

scholarly journals CORRELATION BETWEEN BMI AND PREGNANCY OUTCOME AMONG POSTNATAL MOTHERS WITH PREGNANCY INDUCED HYPERTENSION IN SELECTED HOSPITALS BANGALORE

2015 ◽  
Vol 05 (01) ◽  
pp. 062-067
Author(s):  
Prathima P. ◽  
S Anuchitra
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Pregnancy Outcome ◽  
Normal Weight ◽  
Reproductive Age ◽  
P Value ◽  
Pregnancy Induced Hypertension ◽  
Low Birth Weight Babies ◽  
Induced Hypertension ◽  
Postnatal Mothers

Abstract Title : Correlation between BMI and pregnancy Outcome among postnatal mothers with pregnancy Induced hypertension in selected hospital Bangalore. Objectives: To identify and correlate BMI and pregnancy Outcome among postnatal mothers with pregnancy Induced hypertension. Method: A non experimental correlation design was utilized among 80 postnatal mothers who were diagnosed as Pregnancy induced hypertension during their antenatal period selected as samples by using purposive sampling technique. Demographic data were collected by interview method, their BMI was calculated, pregnancy outcomes were identified from records by using an outcome checklist. Results : Underweight mothers had low birth weight babies and received NICU care. Among normal weight mothers 17.5 % delivered by LSCS, 15% babies were low birth weight babies 12.5 were preterm babies among them 10% received NICU care. In the overweight group 18.75% undergone LSCS, 18.75% were LBW and 1.25% VLBW, 8.75% babies were preterm, 12.5% newborn received NICU care. Among Obese mothers 8.75% delivered by LSCS, 6.25% of LBW babies, 5% were preterm and all of them received NICU care. There is a positive correlation between BMI and diagnosis and type of delivery. Significant at .01 and .05 Level (p value .008 and .019 respectively). Negative correlation between birth weight and diagnosis and gestational age. r = -.499 significant at .01 level (p value .000) Conclusion: Obesity and under weight is a leading, preventable cause of mortality worldwide. Preeclampsia increases maternal and perinatal morbidity and mortality rates. All women who are in reproductive age group and under risk to develop pregnancy induced hypertension need to be educated about to maintenance of normal weight before pregnancy. Nurses have more responsibility on creating awareness among women how to maintain normal weight to avoid development of complications to the mother and newborn.

scholarly journals Determinant Analysis of Low Birth Weight among Young Pregnant Women in Blitar District

2020 ◽  
Vol 4 (1) ◽  
pp. 86-91
Author(s):  
Etti Suryani ◽  
Yuly Peristiowati ◽  
Yenny Puspitasari
Keyword(s):  
Logistic Regression ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Antenatal Care ◽  
Pregnant Women ◽  
Binary Logistic Regression ◽  
P Value ◽  
Routine Antenatal Care ◽  
Determinant Analysis ◽  
Cluster Random Sampling

Background : Low birth weight, commonly called LBW, is a major cause of infant mortality in Indonesia whereas its prevalence tends to increase from year to year. Purpose: This study aimed to analyze the determinants of gravida status, routine antenatal care, and comorbidities in LBW among young pregnant women in Blitar. Method : The research design was case-control using proportional cluster random sampling with a sample of 223 respondents. The data were analyzed with the binary logistic regression. Results : The results showed 214 respondents (96%) were primigravida, 23 respondents (10.3%) were not attended antenatal care routinely, 66 respondents (30%) had comorbidity, and 20 respondents (9%) delivered LBW baby. The statistical analysis of logistic regression showed there was no influence from gravida status and comorbidities, and routine antenatal care indicateda p-value of 0.000 which meant it was determined LBW among <20 years old pregnant women in Blitar. The interpretation of odd value was the group of < 20 years old pregnant women who were not attended routine ANC had a risk of 10 times to deliver LBW baby compared to the group of < 20 years old pregnant women who attended routine ANC. Conclusion : This study concluded that routine antennal care might prevent LBW for young pregnant women

scholarly journals Effect of gestational weight gain on pregnancy outcome of Indian mothers

2020 ◽  
Vol 9 (4) ◽  
pp. 1681
Author(s):  
Keyur Patel ◽  
Megha Chaudhary ◽  
Maitri Shah
Keyword(s):  
Weight Gain ◽  
Birth Weight ◽  
Low Birth Weight ◽  
Pregnant Women ◽  
Pregnancy Outcome ◽  
Gestational Weight Gain ◽  
P Value ◽  
Gestational Weight ◽  
Group 2 ◽  
Group 1

Background: Gestational weight gain (GWG) and pre-pregnancy body mass index (BMI) play important roles in determining the pregnancy outcome. The weight gain recommendations by the IOM are based on Western WHO BMI cut-offs, making it difficult to generalize their findings to Asian Indians. We aimed to compare GWG among healthy pregnant women across different BMI with the IOM guidelines-2009. We also aimed to evaluate associated feto-maternal outcomes with GWG among the pregnant women enrolled in the study.Methods: A retrospective cohort study conducted at department of obstetrics and gynecology, from April 2019 to November 2019. Postnatal mothers whose weight was registered at first trimester of pregnancy and at term and delivered in SSG hospital were included. According to IOM Women were divided into: Group 1 less than recommended weight gain and Group 2 recommended weight gain.Results: Significant difference was seen in the baby weight between the two groups (p value <0.05). 92.75% of babies had low birth weight in Group 1 as compared to 42.21% in Group 2. On performing univariate logistic regression, significant association was seen between GWG and low birth weight (p <0.05), no association was seen between GWG and caesarean (p value >0.05), and no association was seen between GWG and preterm deliveries (p >0.05).Conclusions: Majority of patients in the both groups had term delivery. Women gaining less than recommended weight gain during pregnancy had new born with significantly lower birth weight. There was no association of mode of deliveries and GWG.

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