scholarly journals An Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type 8 in Primary School, Southwest China

2019 ◽  
Author(s):  
Duo Li ◽  
Jie-Nan Zhou ◽  
Hong Li ◽  
Cun-Ying He ◽  
Qing-Shan Dai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Primary School ◽  
Primary Schools ◽  
Southwest China ◽  
Close Contact ◽  
Clinical Manifestations ◽  
Epidemic Keratoconjunctivitis ◽  
Blurred Vision ◽  
Epidemiological Characteristics ◽  
Acute Conjunctivitis

Abstract Background: Two outbreaks of epidemic keratoconjunctivitis (EKC) occurred successively with an interval of five days in two primary boarding schools in Weixi Lisu Autonomous County, Diqing, and Tibetan Autonomous Prefecture, Yunnan. The aims of this study were to determine the intensity and characteristics of the outbreaks, as well as the clinical manifestations in the patients, the risk factors for infection and the pathogen responsible for the two outbreaks. Methods: An outbreak investigation was conducted in two primary schools, and a case-control study including patients from the Weixi County Ethnic Primary School was performed. Relevant specimens were collected according to the case definition, and next-generation sequencing was employed to identify the pathogen. An epidemiological investigation method was used to analyse the related epidemiological characteristics, such as risk factors. The phylogenetic tree was constructed by MEGA 7.0. Results: A total of 331 acute conjunctivitis cases, including probable cases of EKC, were reported in the two schools, and the attack rates were 30.59% (171/559, 95%CI: 26.76-34.42) and 20.41% (160/784, 95%CI: 17.58-23.24), respectively. Cases occurred in all grades and classes in both schools, and only one staff member in each school presented illness. The epidemics lasted for 54 days and 45 days, respectively. The patients had typical manifestations of EKC, such as acute onset, follicular hyperplasia, pseudomembrane formation, preauricular lymphadenopathy, corneal involvement and blurred vision, and a relatively long disease course (average 9.40 days, longest 23 days and shortest 7 days). The risk factor for infection was close contact with a patient or personal items contaminated by a patient. The pathogen responsible for the outbreaks was HAdV-8. The virus was highly similar to the 2016 HAdV-8 strain from Tibet, China. Conclusions: This study strongly suggests that HAdV-8 could lead to serious consequences. This is the second report of a HAdV-8-associated EKC outbreak in mainland China. Tibetan HAdV-8 might be circulating in southwest China; therefore, it is necessary to monitor the pathogens causing acute conjunctivitis in this area.

scholarly journals An Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type 8 in Primary School, Southwest China

2019 ◽  
Author(s):  
Duo Li ◽  
Jie-Nan Zhou ◽  
Hong Li ◽  
Cun-Ying He ◽  
Qing-Shan Dai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Primary School ◽  
Primary Schools ◽  
Southwest China ◽  
Close Contact ◽  
Clinical Manifestations ◽  
Epidemic Keratoconjunctivitis ◽  
Blurred Vision ◽  
Epidemiological Characteristics ◽  
Acute Conjunctivitis

Abstract Background: Two outbreaks of epidemic keratoconjunctivitis (EKC) occurred successively with an interval of five days in two primary boarding schools in Weixi Lisu Autonomous County, Diqing, and Tibetan Autonomous Prefecture, Yunnan. The aims of this study were to determine the intensity and characteristics of the outbreaks, as well as the clinical manifestations in the patients, the risk factors for infection and the pathogen responsible for the two outbreaks. Methods: An outbreak investigation was conducted in two primary schools, and a case-control study including patients from the Weixi County Ethnic Primary School was performed. Relevant specimens were collected according to the case definition, and next-generation sequencing was employed to identify the pathogen. An epidemiological investigation method was used to analyse the related epidemiological characteristics, such as risk factors. The phylogenetic tree was constructed by MEGA 7.0. Results: A total of 331 acute conjunctivitis cases, including probable cases of EKC, were reported in the two schools, and the attack rates were 30.59% (171/559, 95%CI: 26.76-34.42) and 20.41% (160/784, 95%CI: 17.58-23.24), respectively. Cases occurred in all grades and classes in both schools, and only one staff member in each school presented illness. The epidemics lasted for 54 days and 45 days, respectively. The patients had typical manifestations of EKC, such as acute onset, follicular hyperplasia, pseudomembrane formation, preauricular lymphadenopathy, corneal involvement and blurred vision, and a relatively long disease course (average 9.40 days, longest 23 days and shortest 7 days). The risk factor for infection was close contact with a patient or personal items contaminated by a patient. The pathogen responsible for the outbreaks was HAdV-8. The virus was highly similar to the 2016 HAdV-8 strain from Tibet, China. Conclusions: This study strongly suggests that HAdV-8 could lead to serious consequences. This is the second report of a HAdV-8-associated EKC outbreak in mainland China. Tibetan HAdV-8 might be circulating in southwest China; therefore, it is necessary to monitor the pathogens causing acute conjunctivitis in this area.

scholarly journals An Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type 8 in Primary School, Southwest China

2019 ◽  
Author(s):  
Duo Li ◽  
Jie-Nan Zhou ◽  
Hong Li ◽  
Cun-Ying He ◽  
Qing-Shan Dai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Primary Schools ◽  
Southwest China ◽  
Close Contact ◽  
Case Definition ◽  
Epidemic Keratoconjunctivitis ◽  
Blurred Vision ◽  
Follicular Hyperplasia ◽  
Epidemiological Characteristics ◽  
Acute Conjunctivitis

Abstract Background Two outbreaks of acute conjunctivitis occurred successively with an interval of five days in two boarding primary schools in Weixi Lisu autonomous county, Diqing Tibetan autonomous prefecture, Yunnan. The aims of this study were to determine the intensity of and characteristics of outbreaks, as well as the clinical manifestation of patients and risk factors infected, and the pathogen causing two outbreaks. Methods An outbreak investigation and a case-control study were conducted in two primary schools. The relevant specimens were collected by case definition, Next generation sequencing was adopted to identify the pathogen, and the epidemiological investigation method was used to analyze the related epidemiological characteristics such as risk factors. The phylogenetic tree was constructed by MEGA 7.0. Results A total of 331 acute conjunctivitis cases, as acute hemorrhagic conjunctivitis probable cases, were reported in two schools and the attack rates were 30.59% (171/559, 95%CI: 26.76-34.42) and 20.41% (160/784, 95%CI: 17.58-23.24), respectively. Cases occurred in all grades and classes in both schools, and only one staff was ill in each school. Epidemic situations lasted for 54 days and 45 days, respectively. Epidemic curve of two breaks appearing two peaks indicated the mode of person-to-person transmission for two outbreaks. The patients had typical manifestations of epidemic keratoconjunctivitis (EKC) such as acute onset, follicular hyperplasia, pseudomembrane formation, preauricular lymphadenopathy, corneal involvement and blurred vision, and the longer course of the disease (average 9.40 days, longest 23 days and shortest 7 days). The risk factor in infection was close contact with the patient or personal items contaminated by the patient. The pathogen caused the outbreaks is HAdV-8. The virus was highly homologous to the 2016 HAdV-8 strain in Tibet, China. Conclusions This study strongly suggests that HAdV-8 could lead to serious consequences. This is the second report of a HAdV-8 associated EKC outbreak in mainland of China. Tibetan HAdV-8 might be circulating in southwest China, it is necessary to monitor the pathogen of acute conjunctivitis in this area.

scholarly journals An Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type 8 in Primary School, Southwest China

2019 ◽  
Author(s):  
Duo Li ◽  
Jie-Nan Zhou ◽  
Hong Li ◽  
Cun-Ying He ◽  
Qing-Shan Dai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Primary Schools ◽  
Southwest China ◽  
Close Contact ◽  
Case Definition ◽  
Epidemic Keratoconjunctivitis ◽  
Blurred Vision ◽  
Follicular Hyperplasia ◽  
Epidemiological Characteristics ◽  
Acute Conjunctivitis

Abstract Background Two outbreaks of acute conjunctivitis occurred successively with an interval of five days in two boarding primary schools in Weixi Lisu autonomous county, Diqing Tibetan autonomous prefecture, Yunnan. The aims of this study were to determine the intensity of and characteristics of outbreaks, as well as the clinical manifestation of patients and risk factors infected, and the pathogen causing two outbreaks. Methods An outbreak investigation and a case-control study were conducted in two primary schools. The relevant specimens were collected by case definition, Next generation sequencing was adopted to identify the pathogen, and the epidemiological investigation method was used to analyze the related epidemiological characteristics such as risk factors. The phylogenetic tree was constructed by MEGA 7.0. Results A total of 331 acute conjunctivitis cases, as acute hemorrhagic conjunctivitis probable cases, were reported in two schools and the attack rates were 30.59% (171/559, 95%CI: 26.76-34.42) and 20.41% (160/784, 95%CI: 17.58-23.24), respectively. Cases occurred in all grades and classes in both schools, and only one staff was ill in each school. Epidemic situations lasted for 54 days and 45 days, respectively. Epidemic curve of two breaks appearing two peaks indicated the mode of person-to-person transmission for two outbreaks. The patients had typical manifestations of epidemic keratoconjunctivitis (EKC) such as acute onset, follicular hyperplasia, pseudomembrane formation, preauricular lymphadenopathy, corneal involvement and blurred vision, and the longer course of the disease (average 9.40 days, longest 23 days and shortest 7 days). The risk factor in infection was close contact with the patient or personal items contaminated by the patient. The pathogen caused the outbreaks is HAdV-8. The virus was highly homologous to the 2016 HAdV-8 strain in Tibet, China. Conclusions This study strongly suggests that HAdV-8 could lead to serious consequences. This is the second report of a HAdV-8 associated EKC outbreak in mainland of China. Tibetan HAdV-8 might be circulating in southwest China, it is necessary to monitor the pathogen of acute conjunctivitis in this area.

scholarly journals An Outbreak of Epidemic Keratoconjunctivitis Caused by Human Adenovirus Type 8 in Primary School, Southwest China

2019 ◽  
Author(s):  
Duo Li ◽  
Jie-Nan Zhou ◽  
Hong Li ◽  
Cun-Ying He ◽  
Qing-Shan Dai ◽  
...  
Keyword(s):  
Risk Factors ◽  
Primary Schools ◽  
Southwest China ◽  
Close Contact ◽  
Case Definition ◽  
Epidemic Keratoconjunctivitis ◽  
Blurred Vision ◽  
Follicular Hyperplasia ◽  
Epidemiological Characteristics ◽  
Acute Conjunctivitis

Abstract Background Two outbreaks of acute conjunctivitis occurred successively with an interval of five days in two boarding primary schools in Weixi Lisu autonomous county, Diqing Tibetan autonomous prefecture, Yunnan. The aims of this study were to determine the intensity of and characteristics of outbreaks, as well as the clinical manifestation of patients and risk factors infected, and the pathogen causing two outbreaks. Methods An outbreak investigation and a case-control study were conducted in two primary schools. The relevant specimens were collected by case definition, Next generation sequencing was adopted to identify the pathogen, and the epidemiological investigation method was used to analyze the related epidemiological characteristics such as risk factors. The phylogenetic tree was constructed by MEGA 7.0. Results A total of 331 acute conjunctivitis cases, as acute hemorrhagic conjunctivitis probable cases, were reported in two schools and the attack rates were 30.59% (171/559, 95%CI: 26.76-34.42) and 20.41% (160/784, 95%CI: 17.58-23.24), respectively. Cases occurred in all grades and classes in both schools, and only one staff was ill in each school. Epidemic situations lasted for 54 days and 45 days, respectively. Epidemic curve of two breaks appearing two peaks indicated the mode of person-to-person transmission for two outbreaks. The patients had typical manifestations of epidemic keratoconjunctivitis (EKC) such as acute onset, follicular hyperplasia, pseudomembrane formation, preauricular lymphadenopathy, corneal involvement and blurred vision, and the longer course of the disease (average 9.40 days, longest 23 days and shortest 7 days). The risk factor in infection was close contact with the patient or personal items contaminated by the patient. The pathogen caused the outbreaks is HAdV-8. The virus was highly homologous to the 2016 HAdV-8 strain in Tibet, China. Conclusions This study strongly suggests that HAdV-8 could lead to serious consequences. This is the second report of a HAdV-8 associated EKC outbreak in mainland of China. Tibetan HAdV-8 might be circulating in southwest China, it is necessary to monitor the pathogen of acute conjunctivitis in this area.

scholarly journals Perception of Environmental Risk Factors Scale for the primary school students

2016 ◽  
Vol 13 (2) ◽  
pp. 3150
Author(s):  
Nilüfer Özabacı ◽  
Eda Yeşilkaya
Keyword(s):  
Risk Factors ◽  
Primary School ◽  
Environmental Risk ◽  
Primary Schools ◽  
Environmental Risk Factors ◽  
Family Interactions ◽  
Primary School Students ◽  
School Students ◽  
Family Attitudes ◽  
Family Perceptions

The purpose of this study was to develop a scale to determine the effect of perception of environmental risk factors on primary school students. The participants of this study were 409 students of both low and high socio-economic level from 2 primary schools in Gaziantep. Confirmatory factor analysis and path analysis were used for scale development study. As a result of the analysis, it has been determined that the scale has a structure composed of six subscales and 55 items. Subscales of the scale are; perceptions of in school experience, perceptions of oneself, perceptions of family attitudes, perceptions of family interactions, perceptions of problems within the family, perceptions of the nearest living area. Cronbach Alpha for the scale was found to be .85.

scholarly journals Prevalence, infection intensity and associated risk factors of Intestinal Schistosomiasis among primary school Children in Lira District, Northern Uganda

2019 ◽  
Author(s):  
John Paul Byagamy ◽  
Geoffrey Maxwell Malinga ◽  
Harriet Angwech ◽  
Robert Opiro ◽  
Richard Echodu ◽  
...  
Keyword(s):  
Risk Factors ◽  
Primary School ◽  
School Children ◽  
Primary Schools ◽  
Infection Intensity ◽  
Public Health Education ◽  
Primary School Children ◽  
Cross Sectional ◽  
Intestinal Schistosomiasis ◽  
Associated Risk Factors

Abstract Objective: The aim of this cross-sectional study was to determine the prevalence, infection intensity and associated risk factors of intestinal schistosomiasis among primary school children in Lira district, Uganda. The study was conducted among 532 primary school pupils aged 6-16 years from eight randomly selected primary schools (March-May 2017). Stool samples were collected and examined for schistosomiasis using Odongo-Aginya method. Data on socio-demographic characteristics and risk factors were obtained using questionnaires. Results: The overall prevalence of Schistosoma mansoni was 35.7% indicating a moderate infection. Both males and females were equally affected with S. mansoni . Ogur sub county had highest prevalence (42.1%) than others. Akangi and Akano primary schools both had highest (21.1%) prevalence compared to the others. Individuals aged 14-16 and 10-14 years had heavy infections (mean epg) of 600 and 565 eggs, respectively than those aged 6-9 years. With regard to risk factors, source of drinking water, sub-county location and primary school were associated with infection. Participants who fetch water from spring (85,44.7%) had higher infection than those who fetch from other sources. The study recommends provision of safe water, periodic treatment of school-aged children with praziquantel and public health education to reduce prevalence of S. mansoni .

scholarly journals CT Imaging Changes of Corona Virus Disease 2019 (COVID-19): A multi-center study in Southwest China

2020 ◽  
Author(s):  
Xiaoming Li ◽  
Wenbing Zeng ◽  
Xiang Li ◽  
Haonan Chen ◽  
Linping Shi ◽  
...  
Keyword(s):  
Southwest China ◽  
Virus Disease ◽  
Close Contact ◽  
Clinical Manifestations ◽  
Ct Images ◽  
Chest Ct ◽  
Ground Glass ◽  
Pleural Thickening ◽  
First Case ◽  
Short Period

Abstract Background: Since the first case of a coronavirus disease 2019 (COVID-19) infection pneumonia was detected in Wuhan, China, a series of confirmed cases of the COVID-19 were found in Southwest China. The aim of this study was to describe the imaging manifestations of hospitalized patients with confirmed COVID-19 infection in southwest China. Methods: In this retrospective study, data were collected from 131 patients with confirmed coronavirus disease 2019 (COVID-19) from 3 Chinese hospitals. Their common clinical manifestations, as well as characteristics and evolvement features of chest CT images, were analyzed. Results: A total of 100 (76%) patients had a history of close contact with people living in Wuhan , Hubei. The clinical manifestations of COVID-19 included cough, fever. Most of the lesions identified in chest CT images were multiple lesions of bilateral lungs, lesions were more localized in the peripheral lung, 109 (83%) patients had more than two lobes involved, 20 (15%) patients presented with patchy ground glass opacities, patchy ground glass opacities and consolidation of lesions co-existing in 61 (47%) cases. Complications such as pleural thickening, hydrothorax, pericardial effusion, and enlarged mediastinal lymph nodes were detected but only in rare cases. For the follow-up chest CT examinations (91 cases), We found 66 (73%) cases changed very quickly, with an average of 3.5 days, 25 cases (27%) presented absorbed lesions, progression was observed in 41 cases (46%), 25 (27%) cases showed no significant changes. Conclusion: Chest CT plays an important role in diagnosing COVID-19. The imaging pattern of multifocal peripheral ground glass or mixed consolidation is highly suspicious of COVID-19, that can quickly change over a short period of time.

scholarly journals Clinical and Epidemiological Characteristics and Outcome of Patients With Covid-19 in Sri Lanka; An Observational Study

2020 ◽  
Author(s):  
Meththananda Herath ◽  
Jayasekera Madduma Mudiyanselage Priyamali thusharika ◽  
Pathirage Loku pathirage Manoji Muditha Kumari ◽  
Thushan Amila Wijesinghe Wedikkula Acharige ◽  
karthick Gunananthan ◽  
...  
Keyword(s):  
Sri Lanka ◽  
Sore Throat ◽  
Close Contact ◽  
Clinical Manifestations ◽  
Nasal Discharge ◽  
Common Symptom ◽  
Course Of Illness ◽  
High Dependency ◽  
Hospital Stays ◽  
Epidemiological Characteristics

Abstract Background Clinical manifestations of coronavirus disease 2019 (COVID19) can vary from asymptomatic to profusely symptomatic due to many factors. Having data on the clinical characteristics of the affected patients is important for the screening and diagnosis of COVID-19. Main objective of this study is to evaluate the clinical and epidemiological characteristics and outcomes of patients with COVID-19 admitted to six treatment centres in Sri Lanka. Methods For the specific epidemic situation of COVID-19, we chose to conduct a descriptive retrospective study from six treatment centres in the country between March 10, 2020 and May 30, 2020. Results The study included 431 laboratory confirmed patients with COVID-19. Of them, 335 (78.2%) were males and their mean age was 37 years. Most patients (373: 86.5%) had had close contact with COVID-19 positive patients. The majority were asymptomatic (243: 56.3%) and of the symptomatic patients, the most common symptom was sore throat (81, 19%), followed by cough (72, 17%), headache (72, 17%), fever (50, 12%), and nasal discharge (36, 8%). Eight patients required either high dependency care or intensive unit care two of them succumbed to the illness (0.5%). Hydroxychloroquine (HCQ) was used as a treatment in 248 patients and they had a significantly longer (17.6 days) duration of hospital stays compared those who were not treated (13.6 days) with HCQ. When the HCQ was not used as a treatment, asymptomatic individuals had significantly shorter durations of hospital (11.1 days) stays compared to symptomatic individuals (14.3 days). Conclusions The majority of patients remained asymptomatic during the course of illness. The most common symptom was sore throat, seen in one fifth of patients, followed by cough, and headache. Our study also indicated the possibility of reduced viral clearance and hence longer duration of hospital stays with HCQ.

scholarly journals Soil-Transmitted Helminths Infection and Associated Risk Factors among Primary School Pupils in Omogho and Awa Communities, Anambra State, Nigeria

2021 ◽  
pp. 56-64
Author(s):  
Amarachukwu Nwankwo ◽  
Anthony Chibuike Onyebueke ◽  
Kindness Chidi Irikannu ◽  
Chibumma Immaculata Nzeukwu ◽  
Ifediba Vivian Onwuzulike ◽  
...  
Keyword(s):  
Risk Factors ◽  
Primary School ◽  
Primary Schools ◽  
Public Health Problem ◽  
Cross Sectional Survey ◽  
Anambra State ◽  
Soil Transmitted Helminths ◽  
Faecal Samples ◽  
Significant Difference ◽  
Primary School Pupils

Background: Soil-Transmitted Helminths (STHs) remain a public health problem. Infections are widely distributed in tropical and subtropical areas of the world. Aim: This study was to investigate the prevalence and intensity of STH infections, the prevalence of STH mixed infections in relation to age and sex, and to identify the risk factors associated with STH infections among pupils in Omogho and Awa rural communities in Orumba North Local Government Area, Anambra State, Nigeria. Study design: The study was a cross-sectional survey of faecal samples collected from 453 randomly selected pupils from four primary schools. Duration of study: The study was conducted between June and September 2017. Materials and methods: The faecal samples were examined by direct smear and formol ether concentration techniques. Questionnaires based survey was done to determine the risk factors of STH among the pupils. Results: The overall prevalence of STH infections was 44.2%. Among the schools, Primary School, Awa had the highest prevalence (17.0%) while Daughters of Mary Mother of Mercy Primary School, Omogho, had the least prevalence (5.3%). Others were Community Primary School, Omogho (12.8%) and Community Primary School, Awa (9.1%). There was no significant difference in the prevalence of STH infections among the primary school pupils (p = 0.36, p > .05). Ascaris lumbricoides (17.2%) was highest while Strongyloides stercoralis (2.0%) was the least prevalent. Other STHs observed were hookworms (15.9%) and Trichuris trichiura (9.1%). Pupils who do not practice proper hygiene had highest infections. A total of 149(32.9%) who do not wash hands after the use of toilet had more infections than 51(11.3%) who wash their hands. There was significant difference on prevalence of STH with responses on hygiene practices (p = 0.00, p < .05). Conclusion: Absence of good toilet facility and adequate water supply in the schools made it difficult for the pupils to practice good hygiene. An integrated control of STH which should include provision of adequate toilet facilities for pupils, piped drinking water, chemotherapy and health education is recommended.

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