Clinical efficacy and target signaling pathways of natural products in psoriasis treatment: a systematic review

Mapping Intimacies ◽

10.21203/rs.3.rs-1038298/v1 ◽

2021 ◽

Author(s):

Ly Thi Huong Nguyen

Keyword(s):

Natural Products ◽

Signaling Pathways ◽

Clinical Efficacy ◽

Psoriasis Treatment ◽

Novel Drugs ◽

Pharmaceutical Plant ◽

Inflammatory Skin Disorder ◽

Th17 Differentiation ◽

Multiple Signaling

Abstract Background: Psoriasis is a common chronic inflammatory skin disorder, which has adverse effects on patients’ quality of life. Natural products exhibit significant therapeutic capacities with small side effects and might be preferable alternative treatments for patients with psoriasis. Aim of the review: This study summarizes the clinical efficacy of natural products and signaling pathways with the potential targets for psoriasis treatment. Methods: The literature for this article was acquired from PubMed and Web of Science, from Jan 2010 to Dec 2020. The keywords for searching included “psoriasis” and “natural product”, “herbal medicine”, “herbal therapy”, “medicinal plant”, “medicinal herb”, or “pharmaceutical plant”. Results: The anti-psoriatic effect of natural products in clinical studies was summarized. Herbal extracts, natural compounds, and herbal prescriptions could regulate the signaling pathways to alleviate psoriasis symptoms, such as Th17 differentiation, JAK/STAT, NF-κB, MAPK, PI3K/Akt/mTOR, and other signaling pathways, which are involved in the inflammatory response and keratinocyte hyperproliferation. Conclusion: Natural products exerted the anti-psoriatic effect by targeting multiple signaling pathways, providing evidence for the investigation of novel drugs. Further experimental research should be performed to screen and characterize the therapeutic targets of natural products for application in psoriasis treatment.

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Modulation of Multiple Signaling Pathways of the Plant-Derived Natural Products in Cancer

Frontiers in Oncology ◽

10.3389/fonc.2019.01153 ◽

2019 ◽

Vol 9 ◽

Cited By ~ 12

Author(s):

Li-rui Sun ◽

Wei Zhou ◽

Hong-mei Zhang ◽

Qiu-shi Guo ◽

Wei Yang ◽

...

Keyword(s):

Natural Products ◽

Signaling Pathways ◽

Multiple Signaling

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Natural Products Targeting Cancer Stem Cells for Augmenting Cancer Therapeutics

International Journal of Molecular Sciences ◽

10.3390/ijms222313044 ◽

2021 ◽

Vol 22 (23) ◽

pp. 13044

Author(s):

Ari Meerson ◽

Soliman Khatib ◽

Jamal Mahajna

Keyword(s):

Stem Cells ◽

Natural Products ◽

Cancer Stem Cells ◽

Signaling Pathways ◽

Tumor Cells ◽

Cancer Therapeutics ◽

Chemotherapeutic Agents ◽

Biologically Active ◽

Approved Drugs ◽

Multiple Signaling

Cancer stem cells (CSC) have been identified in several types of solid tumors. In some cases, CSC may be the source of all the tumor cells, the cause of the tumor’s resistance to chemotherapeutic agents, and the source of metastatic cells. Thus, a combination therapy targeting non-CSC tumor cells as well as specifically targeting CSCs holds the potential to be highly effective. Natural products (NPs) have been a historically rich source of biologically active compounds and are known for their ability to influence multiple signaling pathways simultaneously with negligible side effects. In this review, we discuss the potential of NPs in targeting multiple signaling pathways in CSC and their potential to augment the efficacy of standard cancer therapy. Specifically, we focus on the anti-CSC activities of flavonoids, FDA-approved drugs originating from natural sources. Additionally, we emphasize the potential of NPs in targeting microRNA-mediated signaling, given the roles of microRNA in the maintenance of the CSC phenotype.

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Dysregulation of Multiple Signaling Neurodevelopmental Pathways during Embryogenesis: A Possible Cause of Autism Spectrum Disorder

Cells ◽

10.3390/cells10040958 ◽

2021 ◽

Vol 10 (4) ◽

pp. 958

Author(s):

Jyoti Upadhyay ◽

Jeevan Patra ◽

Nidhi Tiwari ◽

Nilima Salankar ◽

Mohd Nazam Ansari ◽

...

Keyword(s):

Autism Spectrum Disorder ◽

Signaling Pathways ◽

Developmental Disorders ◽

Autism Spectrum ◽

Spectrum Disorder ◽

Therapeutic Interventions ◽

Social Communications ◽

Novel Drugs ◽

Disease Condition ◽

Multiple Signaling

Understanding the autistic brain and the involvement of genetic, non-genetic, and numerous signaling pathways in the etiology and pathophysiology of autism spectrum disorder (ASD) is complex, as is evident from various studies. Apart from multiple developmental disorders of the brain, autistic subjects show a few characteristics like impairment in social communications related to repetitive, restricted, or stereotypical behavior, which suggests alterations in neuronal circuits caused by defects in various signaling pathways during embryogenesis. Most of the research studies on ASD subjects and genetic models revealed the involvement of mutated genes with alterations of numerous signaling pathways like Wnt, hedgehog, and Retinoic Acid (RA). Despite significant improvement in understanding the pathogenesis and etiology of ASD, there is an increasing awareness related to it as well as a need for more in-depth research because no effective therapy has been developed to address ASD symptoms. Therefore, identifying better therapeutic interventions like “novel drugs for ASD” and biomarkers for early detection and disease condition determination are required. This review article investigated various etiological factors as well as the signaling mechanisms and their alterations to understand ASD pathophysiology. It summarizes the mechanism of signaling pathways, their significance, and implications for ASD.

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