scholarly journals The Effect of Seed Location on Functional Connectivity: Evidence from an Image-Based Meta-Analysis

2021 ◽  
Author(s):  
Mengting Li ◽  
Jiawei Sun ◽  
Linlin Zhan ◽  
Yating Lv ◽  
Xize Jia ◽  
...  
Keyword(s):  
Functional Connectivity ◽  
Default Mode Network ◽  
Meta Analysis ◽  
Brain Diseases ◽  
Seed Selection ◽  
Resting State Functional Connectivity ◽  
Future Studies ◽  
Default Mode ◽  
Analytic Maps ◽  
Selection Of

Abstract Default mode network (DMN) is the most involved network in the study of brain development and brain diseases. Resting-state functional connectivity (rs-FC) is the most used method to study DMN, but different studies are inconsistent in the selection of seed. To evaluate the effect of different seed selection on rs-FC, we conducted an image-based meta-analysis (IBMA). We identified 59 coordinates of seed regions of interest (ROIs) within the default mode network (DMN) from 11 studies (retrieved from Web of Science and Pubmed) to calculate the functional connectivity; then, the uncorrected t maps were obtained from the statistical analyses. The IBMA was performed with the t maps. We demonstrate that the overlap of meta-analytic maps across different seeds’ ROIs within DMN is relatively low, which cautions us to be cautious with seeds’ selection. Future studies using the seed-based functional connectivity method should take the reproducibility of different seeds into account. The choice of seed may significantly affect the connectivity results.

Mediating Role of The Default Mode Network On Parental Acceptance/Warmth and Psychopathology in Youth

2021 ◽  
Author(s):  
Kaley Davis ◽  
Emily Hirsch ◽  
Dylan Gee ◽  
Margaret Andover ◽  
Amy Krain Roy
Keyword(s):  
Functional Connectivity ◽  
Default Mode Network ◽  
Resting State ◽  
Parental Attitudes ◽  
Community Sample ◽  
Positive Parenting ◽  
Parental Acceptance ◽  
Resting State Functional Connectivity ◽  
Cross Sectional ◽  
Default Mode

Abstract Humans are reliant on their caregivers for an extended period of time, offering numerous opportunities for environmental factors, such as parental attitudes and behaviors, to impact brain development. The default mode network is a neural system encompassing the medial prefrontal cortex, posterior cingulate cortex, precuneus, and temporo-parietal junction, which is implicated in aspects of cognition and psychopathology. Delayed default mode network maturation in children and adolescents has been associated with greater general dimensional psychopathology, and positive parenting behaviors have been suggested to serve as protective mechanisms against atypical default mode network development. The current study aimed to extend the existing research by examining whether within- default mode network resting-state functional connectivity would mediate the relation between parental acceptance/warmth and youth psychopathology. Data from the Adolescent Brain and Cognitive Development study, which included a community sample of 9,058 children ages 9-10.9 years, were analyzed to test this prediction. Results from the analysis demonstrated a significant mediation, where greater parental acceptance/warmth predicted greater within- default mode network resting-state functional connectivity, which in turn predicted lower psychopathology. Our study provides preliminary support for the notion that positive parenting traits may reduce the risk for psychopathology in youth through their influence on the default mode network. Due to the cross-sectional nature of this study, we can only draw correlational inference; therefore, these relationships should be tested longitudinally in future investigations.

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