scholarly journals fMRI findings in cortical brain networks interactions in migraine following repetitive transcranial magnetic stimulation

2021 ◽  
Author(s):  
Kirill Markin ◽  
Artem Trufanov ◽  
Daria Frunza ◽  
Igor Litvinenko ◽  
Dmitriy Tarumov ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Clinical Symptoms ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Migraine Treatment ◽  
Threshold Response ◽  
Affective Symptoms ◽  
Before And After ◽  
Components Analysis ◽  
Visual Network

Abstract Background: Repetitive transcranial magnetic stimulation (rTMS) is one of high-potential non-pharmacological methods for migraine treatment. The purpose of this study is to objectively evaluate the efficacy of rTMS in patients with migraine based on data from functional magnetic resonance imaging (fMRI). Methods: 19 patients with migraine without aura underwent a 5-day course of rTMS of the ventrolateral prefrontal cortex bilaterally, at 10Hz frequency and 60% of motor threshold response of 900 pulses. Resting-state functional MRI (1.5 T) and battery of tests were carried out for each patient to clarify their diagnosis, qualitative and quantitative characteristics of pain, and associated affective symptoms. Changes in functional connectivity (FC) in the brain’s neural networks before and after the treatment were identified through independent components analysis. Results: Over the course of therapy, we observed an increase in FC of the default mode network within it, with pain system components and with structures of the visual network. We also noted a decrease in FC of the salience network with sensorimotor and visual networks, as well as an increase in FC of the visual network. Besides, we identified 5 patients who did not have a positive response to one rTMS course, presumably because of an increased trend to depressive symptoms and neuroimaging criteria for depressive disorder. Conclusions: Our findings provide evidence of a 70% efficacy of rTMS judging by neuroimaging changes and a decrease in clinical symptoms. Moreover, we identified neuroimaging criteria for the therapy efficacy as well as possible predictors of successful/unsuccessful response to the therapy.

Role of d-serine in the beneficial effects of repetitive transcranial magnetic stimulation in post-stroke patients

2020 ◽  
Vol 32 (3) ◽  
pp. 128-134 ◽  
Author(s):  
Masachika Niimi ◽  
Yuko Fujita ◽  
Tamaki Ishima ◽  
Kenji Hashimoto ◽  
Nobuyuki Sasaki ◽  
...  
Keyword(s):  
Amino Acids ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Stroke Patients ◽  
Post Stroke ◽  
Beneficial Effects ◽  
Depressed Patients ◽  
Before And After ◽  
The Impact

AbstractObjective:Abnormalities in neurotransmission via N-methyl-d-aspartic acid receptor (NMDAR) play a role in the pathophysiology of neuropsychiatric disorders. The impact of repetitive transcranial magnetic stimulation (rTMS) on NMDAR-related amino acids remains unknown. We aim to investigate the effects of rTMS on NMDAR-related amino acids in serum of post-stroke patients.Methods:Ninety-five consecutive post-stroke patients with upper limb hemiparesis were recruited. In 27 patients, the Beck Depression Inventory (BDI) score was 10 or higher. Twelve depressed patients underwent rehabilitation in combination with rTMS and 15 non-depressed patients underwent rehabilitation only without rTMS for 14 days. 1 Hz rTMS was applied to the primary motor area in the non-lesional hemisphere. BDI was conducted before and after treatment. Serum glutamine, glutamate, glycine, l-serine, and d-serine levels were measured before and after treatment.Results:There were no differences between depressed patients and non-depressed patients in clinical characteristics, levels of the five amino acids in serum, and the ratio of amino acids. However, in 27 depressed patients, there was a significant correlation between levels of glutamate in serum and BDI (ρ = 0.428, p = 0.026). BDI decreased significantly in depressed patients after treatment with or without rTMS. d-serine decreased in the rehabilitation with rTMS group, but increased in the rehabilitation without rTMS group. l-serine increased in the rehabilitation with rTMS group, but decreased in the rehabilitation without rTMS group.Conclusion:The results suggest that rTMS can modulate NMDAR-related amino acids in blood, producing beneficial effects.

scholarly journals Voluntary movement and repetitive transcranial magnetic stimulation over human motor cortex

2009 ◽  
Vol 106 (5) ◽  
pp. 1593-1603 ◽  
Author(s):  
Gabrielle Todd ◽  
Nigel C. Rogasch ◽  
Stanley C. Flavel ◽  
Michael C. Ridding
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Motor Cortex ◽  
Magnetic Stimulation ◽  
Voluntary Movement ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Voluntary Contraction ◽  
Human Motor Cortex ◽  
Before And After ◽  
Human Motor ◽  
Voluntary Contractions

Repetitive transcranial magnetic stimulation (rTMS) can induce short-term reorganization of human motor cortex. Here, we investigated the effect of rTMS during relaxation and weak voluntary muscle contraction on motor cortex excitability and hand function. Subjects ( n = 60) participated in one of four studies. Single transcranial magnetic stimuli were delivered over the motor area of the first dorsal interosseus for measurement of motor evoked potential (MEP) size before and after real or sham rTMS delivered at an intensity of 80% of active motor threshold. rTMS involved trains of stimuli applied at 6 Hz for 5 s and repeated every 30 s for 10 min. Resting MEP size was suppressed for 15 min after rTMS during relaxation. However, MEP suppression was abolished when additional brief voluntary contractions were performed before and after rTMS ( study 1). Resting MEP size was suppressed for 30 min after rTMS during weak voluntary contraction. MEP suppression was present even though voluntary contractions were performed before and after rTMS ( study 2). The MEP suppression most likely reflects a decrease in motor cortical excitability. Surprisingly, rTMS during voluntary contraction did not alter maximal finger tapping speed or performance on a grooved pegboard test, object grip and lift task ( study 3), and visuomotor tracking task ( study 4). These studies document the complex relationship between voluntary movement and rTMS-induced plasticity in motor cortex. This work has implications for the optimization of rTMS parameters for improved efficacy and potential therapeutic applications.

Impact of Low-Frequency Transcranial Magnetic Stimulation on Brain Automatic Information Processing

2006 ◽  
Vol 20 (4) ◽  
pp. 267-275 ◽  
Author(s):  
O. Laloyaux ◽  
M. Ansseau ◽  
M. Hansenne
Keyword(s):  
Information Processing ◽  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Low Frequency ◽  
Automatic Information Processing ◽  
Automatic Information ◽  
Before And After ◽  
Left And Right ◽  
The Impact

Repetitive transcranial magnetic stimulation (rTMS) is considered a powerful method for the study of the relationships between cortical activity and cognitive processes. Previous ERPs studies that focused on P300 response have shown that inhibitory/excitatory effects on prefrontal cortex (PFC), induced by low- and high-frequency rTMS, were able to modulate controlled but not automatic information processing. The present study assessed the impact of inhibition over left and right PFC induced by rTMS on mismatch negativity (MMN), which is known to represent automatic cerebral processes for detecting change. Auditory MMN was recorded in 20 subjects before and after application of left and right PFC 1-Hz rTMS for 15 min. MMN was also recorded before and after a sham-occipital 1-Hz rTMS as control condition. Results showed that 1-Hz rTMS induced no modification to either MMN latency or amplitude. In addition, N100 and P200 components to the frequent tones were not affected by rTMS. These results are consistent with previous findings showing that rTMS over both PFC is unable to disrupt automatic information processing. However, since two sites were stimulated in the present study, no definite conclusions about the inability of rTMS to disrupt automatic processing can be made.

scholarly journals Low-Frequency Repetitive Transcranial Magnetic Stimulation to Right Parietal Cortex Disrupts Perception of Briefly Presented Stimuli

Perception ◽  
2019 ◽  
Vol 48 (4) ◽  
pp. 346-355 ◽  
Author(s):  
Christina J. Howard ◽  
Hayley Boulton ◽  
Stacey A. Bedwell ◽  
Charlotte A. Boatman ◽  
Katherine L. Roberts ◽  
...  
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Parietal Cortex ◽  
Visual Discrimination ◽  
Magnetic Stimulation ◽  
Discrimination Task ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Low Frequency ◽  
Visual Evidence ◽  
Rapid Accumulation ◽  
Before And After

Right parietal cortex has recently been linked to the temporal resolution of attention. We therefore sought to investigate whether disruption to right parietal cortex would affect attention to visual stimuli presented for brief durations. Participants performed a visual discrimination task before and after 10 minutes repetitive transcranial magnetic stimulation (1 Hz) to right or central parietal cortex as well as 20 minutes after the second block of trials. Participants reported the spatial frequency of a masked Gabor patch presented for a brief duration of 60, 120, or 240 ms. We calculated error magnitudes by comparing accuracy to a guessing model. We then compared error magnitudes to blocks with no stimulation, producing a measure of baselined performance. Baselined performance was poorer at longer stimulus durations after right parietal than central parietal stimulation, suggesting that right parietal cortex is involved in attention to briefly presented stimuli, particularly in situations where rapid accumulation of visual evidence is needed.

scholarly journals Role of Repetitive Transcranial Magnetic Stimulation on Drug Resistant Focal Epilepsy: A Controlled Clinical Study

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
S Ashour ◽  
A Gaber ◽  
T Hussein ◽  
A Kamal
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Magnetic Stimulation ◽  
Focal Epilepsy ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Low Frequency ◽  
Baseline Period ◽  
Epileptogenic Zone ◽  
Drug Resistant ◽  
Resting Motor Threshold ◽  
Before And After

Abstract Copyright 2019 Department of Neuropsychiatry, Ain Shams University. Unauthorized reproduction of this article is prohibited Purpose This study was designed to evaluate the therapeutic effect of low-frequency repetitive transcranial magnetic stimulation (rTMS) on patients with drug resistant focal epilepsy. Methods Fifty-five patients with drug resistant neocortical focal epilepsy were screened and 30 patients were divided into two groups (active and sham ) were given (0.5 hz , 1000 pulses , 90%of resting motor threshold (rMT)) on stimulation site detected by correlation between clinical semiology, EEG and or MRI finding. Seizures frequency, severity and seizure free days were compared for one month before and after rTMS with no change in antiepileptic drugs. We assumed 50% seizure reductionrate after rTMS. Results Seizures significantly decreased following rTMS treatment 50% seizure reduction was achieved 87.5%inthe active rTMS groupand50% in the sham rTMS group(p > 0.03).in the follow-up period compared to baseline period. Seizure free days %increase in active group 20.7% compared to sham group 7.5% (p = 0.0501). Significance Low-frequency rTMS delivered into the epileptogenic zone had a significant antiepileptic effect on patients with drug resistant neocortical focal epilepsy. © 2018 Department of Neuropsychiatry, Ain Shams University

A single session of repetitive transcranial magnetic stimulation of the prefrontal cortex reduces cue-induced craving in patients with gambling disorder

2017 ◽  
Vol 41 (1) ◽  
pp. 68-74 ◽  
Author(s):  
A. Gay ◽  
C. Boutet ◽  
T. Sigaud ◽  
A. Kamgoue ◽  
J. Sevos ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Transcranial Magnetic Stimulation ◽  
High Frequency ◽  
Magnetic Stimulation ◽  
Gambling Disorder ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Gambling Behavior ◽  
Single Session ◽  
Left Dlpfc ◽  
Before And After

AbstractBackgroundGambling disorder (GD) is common and disabling addictive disorder. In patients with substance use disorders, the application of repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex (DLPFC) offers promise to alleviate craving. We hypothesized that applying real compared to sham rTMS over the left DLPFC would reduce gambling craving in patients with GD.MethodsIn a randomized sham-controlled crossover design, 22 treatment-seeking patients with GD received real or sham treatment with high frequency rTMS over the left DLPFC followed a week later by the other type of treatment. Before and after each rTMS session, participants rated their gambling craving (from 0 to 100) before and after viewing a gambling video used as a cue. We used the Yale-Brown Obsessive Compulsive Scale adapted for Pathological Gambling to assess gambling behavior before and 7 days after each rTMS session.ResultsAs compared to sham (mean +0.74; standard deviation ± 3.03), real rTMS significantly decreased cue-induced craving (−2.12 ± 3.39; F(1,19) = 4.87; P = 0.04; partial η2 = 0.05; 95% CI: 0.00–0.21). No significant effect of rTMS was observed on gambling behavior.ConclusionsPatients with GD reported decreased cue-induced craving following a single session of high frequency rTMS applied over the left DLPFC. Further large randomized controlled studies are needed to determine the usefulness of rTMS in GD.

Effects of Repetitive Transcranial Magnetic Stimulation on Hypothalamic-Pituitary-Adrenal axis of Patients With Depression

2011 ◽  
Vol 26 (S2) ◽  
pp. 1143-1143
Author(s):  
M. He ◽  
Z. Gu ◽  
X. Wang ◽  
X. Tian
Keyword(s):  
Transcranial Magnetic Stimulation ◽  
Hpa Axis ◽  
Magnetic Stimulation ◽  
Rating Scale ◽  
Repetitive Transcranial Magnetic Stimulation ◽  
Plasma Concentrations ◽  
Control Group ◽  
Plasma Acth ◽  
Hypothalamic Pituitary Adrenal ◽  
Before And After

ObjectiveTo investigate the effects of sleep electroencephalogram-modulated repetitive transcranial magnetic stimulation (SEM-rTMS) and conventional rTMS (C-rTMS) on the activity of hypothalamic-pituitary-adrenal (HPA) axis in patients with depression.MethodsIn a double-blind, randomized controlled trial, 164 patients diagnosed with depression were randomized to treatment with SEM-rTMS (n = 57), C-rTMS (n = 55) or sham rTMS (n = 52) for 30 min every day for 10 d. Before and after treatment plasma concentrations of adrenocorticotropic hormone (ACTH) and cortisol (CORT) were measured, and the 24-item Hamilton Depression Rating Scale (HAMD-24) was used for assessment.ResultsThe HAMD-24 scores and plasma ACTH and CORT concentrations of these depressive patients before treatment were significantly different from those of the normal control group (P < 0.05). The HAMD-24 scores and plasma ACTH and CORT concentrations in the SEM-r TMS group and conventional rTMS group were decreased significantly (P < 0.05). There was a significant positive correlation between the HAMD-24 scores and plasma ACTH (n = 240, r = 0.105, P = 0.048) and CORT concentrations (n = 240, r = 0.126, P = 0.023) in the patients with depression before and after treatment.ConclusionThe antidepressant effect of rTMS, including SEM-rTMS, may be related to its decreasing HPA axis activity. (This trail was registered. No: ChiCTR-TRC-00000465).

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