Extrauterine Growth Restriction in Preterm Infants: How to Achieve Optimal Catch-Up Growth During Hospitalization?

2021 ◽  
Author(s):  
Si-Yuan Lan ◽  
Rui Zhang ◽  
Gui-Mei Zhong ◽  
Li-Ya Pan ◽  
Huan-Huan Fu ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Gestational Age ◽  
Medical Center ◽  
Growth Restriction ◽  
Large For Gestational Age ◽  
Contributing Factors ◽  
Appropriate For Gestational Age ◽  
Catch Up ◽  
Extrauterine Growth Restriction ◽  
Preterm Newborns

Abstract Extrauterine growth restriction (EUGR), a serious risk that potentially impairs the growth of preterm infants after birth and during childhood, triggers a thought of how to achieve optimal catch-up growth during hospitalization.We aimed to access the incidence of optimal catch-up growth in small-for-gestational-age (SGA), appropriate-for-gestational age (AGA) and large-for-gestational-age (LGA) infants, and identify the factors for optimal catch-up growth in preterm infants during hospitalization. Premature infants admitted to Shanghai Children’s Medical Center within 24 hours after birth from January 1,2016 to December 31, 2018 were enrolled. Prenatal, neonatal etiological, and nutrition data were collected and analyzed to identify factors associated with optimal catch-up growth during hospitalization. 105 (9.9%) of 1065 preterm newborns achieved predischarge optimal catch-up growth, including 27 (17.2%) of 157 SGA, 74 (8.5%) of 868 AGA, and 4 (10.0%) of 40 LGA infants. Logistic regression analysis indicated SGA, avoiding BPD and less days to regain birth weight as the contributing factors of optimal catch-up growth during hospitalization.Conclusion: SGA infants showed greater potential in predischarge optimal catch-up growth. Early abundant nutrition and avoiding BPD are essential for achieving optimal catch-up growth during hospitalization.

scholarly journals The Post-Discharge Growth of Very Low Birth Weight Preterm Infants

2020 ◽  
pp. 1
Author(s):  
Tuba Ozdemir ◽  
Abdullah Baris Akcan ◽  
Munevver Kaynak Turkmen
Keyword(s):  
Birth Weight ◽  
Low Birth Weight ◽  
Preterm Infants ◽  
Gestational Age ◽  
Very Low Birth Weight ◽  
Ductus Arteriosus ◽  
Somatic Growth ◽  
Growth Time ◽  
Appropriate For Gestational Age ◽  
Catch Up

<p>OBJECTIVE: In the present study, we investigate the growth characteristics of very low birth weight premature infants of up to two years corrected age, considering the factors affecting growth and catch-up growth time.</p><p>STUDY DESIGN: The demographic data, clinical features, and comorbidities of 77 preterm infants with birth weights of less than or equal to 1.500 g were examined, the infants’ growth statuses in the 40th gestational week (gw) and at 6, 12, 18 and 24 months the corrected age, including their weight, height and head circumference, were evaluated.</p><p>RESULTS: The findings revealed that very low birth weight infants should be closely monitored either during their stay in the Neonatal Intensive Care Unit, or for up to 6 months corrected age, paying particular attention to growth data, and the appropriate supportive treatment should be administered. The applied support process is influential on the future somatic growth of preterm infants. It was noted in the study that bronchopulmonary dysplasia, proven sepsis, respiratory distress syndrome, steroid treatment for more than three days, patent ductus arteriosus, and ibuprofen treatment seemed to affect somatic growth negatively.</p><p>CONCLUSION: Small for gestational age newborns were found to catch up with appropriate for gestational age newborns at 2 years corrected age in terms of growth, although the percentage of catch-up growth during follow-up at the 40thgw, and at the 6th, 12th and 18th months was lower than that of appropriate for gestational age newborns.</p>

Hemostatic Parameters in Newborn - I. Effect of Gestation and Rate of Intrauterine Growth

1986 ◽  
Vol 55 (01) ◽  
pp. 047-050 ◽  
Author(s):  
B Dube ◽  
R K Dube ◽  
V Bhargava ◽  
J K Kolindewala ◽  
V L N Kota ◽  
...  
Keyword(s):  
Gestational Age ◽  
The Other ◽  
Plasma Fibrinogen ◽  
Large For Gestational Age ◽  
Term Neonates ◽  
Intrauterine Growth ◽  
Appropriate For Gestational Age ◽  
History Of ◽  
Preterm Babies ◽  
Preterm Newborns

SummaryThe present study comprises of 208 term, 159 preterm and 18 post-term neonates born to mothers with no history of drug intake or any disease likely to effect coagulation of the newborn. PT, TT and KCCT were relatively prolonged and plasma fibrinogen reduced to varying degree in newborns (as compared to adults). There was further prolongation of TT and reduction in plasma fibrinogen levels amongst preterm newborns as compared to term babies; TT was more prolonged amongst post-term babies also. PT was significantly more prolonged till 30 weeks of gestation, after which a near plateau was formed. KCCT showed significant improvement after 33 weeks and a further trend to normalisation after 38 weeks of gestation. Serum FDP values showed too much of variation for any meaningful statistical analysis but generally FDPs were higher in preterm babies. Intrauterine growth rate had no significant effect on these parameters amongst preterms -similar values for SGA (small for gestational age), AGA (appropriate for gestational age) and LGA (large for gestational age). On the other hand, amongst term babies SGA neonates had significantly prolonged PT and low plasma fibrinogen as compared to AGA; LGA babies also showed more prolongation of TT as compared to AGA.

scholarly journals Incidence and associated factors of extrauterine growth restriction (EUGR) in preterm infants, a cross-sectional study in selected NICUs in Ethiopia

2020 ◽  
Vol 4 (1) ◽  
pp. e000765
Author(s):  
Netsanet Workneh Gidi ◽  
Robert L Goldenberg ◽  
Assaye K Nigussie ◽  
Elizabeth McClure ◽  
Amha Mekasha ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Gestational Age ◽  
Low Income ◽  
Associated Factors ◽  
Cross Sectional Study ◽  
Growth Restriction ◽  
Sectional Study ◽  
Cross Sectional ◽  
Increased Risk ◽  
Extrauterine Growth Restriction

BackgroundPreterm infants have high risk of developing growth restriction and long-term complications. Enteral feeding is often delayed in neonatal intensive care units (NICUs) for the fear of feeding intolerance and the associated necrotising enterocolitis, and recent advances in nutritional support are unavailable in low-income countries.ObjectiveThe aim of this study was to assess the incidence and associated factors of extrauterine growth restriction (EUGR) among preterm infants in selected NICUs in Ethiopia.MethodThis was a cross-sectional study involving a subgroup analysis of preterm infants admitted to hospitals, from a multicentre descriptive study of cause of illness and death in preterm infants in Ethiopia, conducted from 2016 to 2018. EUGR was defined as weight at discharge Z-scores <−1.29 for corrected age. Clinical profiles of the infants were analysed for associated factors. SPSS V.23 software was used for analysis with a significance level of 5% and 95% CI.ResultFrom 436 preterm infants included in the analysis, 223 (51%) were male, 224 (51.4%) very low birth weight (VLBW) and 185 (42.4%) small for gestational age (SGA). The mean (SD) of weight for corrected age Z-score at the time of discharge was −2.5 (1.1). The incidence of EUGR was 86.2%. Infants who were SGA, VLBW and longer hospital stay over 21 days had increased risk of growth restriction (p-value<0.01). SGA infants had a 15-fold higher risk of developing EUGR at the time of discharge from hospital than those who were appropriate or large for gestational age (OR (95% CI)=15.2 (4.6 to 50.1).ConclusionThe majority of the infants had EUGR at the time of discharge from the hospital, which indicates suboptimal nutrition. Revision of national guidelines for preterm infants feeding and improvement in clinical practice is highly required.

Extrauterine growth restriction in preterm infants of gestational age ≤32 weeks

2008 ◽  
Vol 50 (1) ◽  
pp. 70-75 ◽  
Author(s):  
Motoichiro Sakurai ◽  
Kazuo Itabashi ◽  
Yuko Sato ◽  
Satoshi Hibino ◽  
Katsumi Mizuno
Keyword(s):  
Preterm Infants ◽  
Gestational Age ◽  
Growth Restriction ◽  
Extrauterine Growth Restriction

Neonatal Hyperviscosity: I. Incidence

PEDIATRICS ◽  
1979 ◽  
Vol 63 (6) ◽  
pp. 833-836
Author(s):  
Frederick H. Wirth ◽  
Karen E. Goldberg ◽  
Lula O. Lubchenco
Keyword(s):  
Birth Weight ◽  
Sea Level ◽  
Gestational Age ◽  
Medical Center ◽  
Newborn Infants ◽  
Large For Gestational Age ◽  
University Of Colorado ◽  
Appropriate For Gestational Age ◽  
The Mean ◽  
The University

Capillary hematocrits were performed on 790 infants during the first four hours after birth. These infants were delivered between August 8 and December 7, 1974, at the University of Colorado Medical Center, which is at an altitude of 1,061 m above sea level. When the capillary hematocrit was 7% or greater, venous hematocrit and blood viscosity were determined. Capillary hematocrits obtained from warmed heels in the first hour after birth were spuriously high and not consistently related to venous hematocrit. Venous polycythemia, defined as a hematocrit of 65% or greater, occurred in 4% of the newborn population. Hyperviscosity (2 SD above the mean for newborns) occurred in 5% of the newborn infants. At a venous hematocrit of 65% or greater, hyperviscosity was predictable, but some infants with venous hematocrits between 60% and 64% also had hyperviscosity of the blood. The incidence of polycythemia and hyperviscosity was further related to birth weight and gestational age. The infants who were small for gestational age were at highest risk of polycythemia and hyperviscosity, followed by infants who were large for gestational age. However, the greatest number of infants with hvperviscosity were term appropriate for gestational age. Preterm infants with gestational ages of less than 34 weeks were not affected.

scholarly journals Perinatal Asphyxia Among Neonates Admitted Jimma Medical Center, Jimma, Ethiopia

2020 ◽  
Vol 7 ◽  
pp. 2333794X2098130
Author(s):  
Ebissa Bayana Kebede ◽  
Adugna Olani Akuma ◽  
Yonas Biratu Tarfa
Keyword(s):  
Gestational Age ◽  
Medical Center ◽  
Perinatal Asphyxia ◽  
Mode Of Delivery ◽  
Large For Gestational Age ◽  
Systematic Sampling ◽  
P Value ◽  
Health Extension Workers ◽  
Severe Problem ◽  
Prolonged Labor

Background: Perinatal asphyxia is a severe problem which causes serious problem in neonates in developing countries. This study is aimed to determine magnitude of perinatal asphyxia and its associated factors. Methods: A cross-sectional study design was conducted among neonates admitted over a period of 4 years on 740 samples. Systematic sampling method was employed to get required samples from log book. Epi-data 3.1 is used for data entry and the entered data was exported to SPSS Version 23 for analysis. Bivariable and multiple variable logistic regressions analysis were applied to see the association between dependent and independent variables. Finally, P-value <.05 at 95% CI was declared statistically significant. Results: The main significant factor associated to perinatal asphyxia were prolonged labor ( P = .04, AOR = 1.68 95%CI: [1.00, 2.80]), being primipara ( P = .003, AOR = 2.06, 95%CI: [1.28, 3.30]), Small for Gestational Age (SGA) ( P = .001, AOR = 4.35, 95%CI: [1.85, 10.19]), Large for Gestational Age ( P = .001, AOR = 16.75, 95%CI: [3.82, 73.33]) and mode of delivery. Conclusion: The magnitude of perinatal asphyxia was 18%. Prolonged labor, parity, birth size, mode of delivery, and APGAR score at 1st minute were significantly associated with perinatal asphyxia. So, Nurses, Midwives, Medical Doctors, and health extension workers have to engage and contribute to on how to decrease the magnitude of perinatal asphyxia.

Influence of Ear Protectors on the Sleep of Preterm Newborns: A Randomized Controlled Clinical Study

2018 ◽  
Vol 29 (4) ◽  
pp. 260-267
Author(s):  
Mônica Hiromi Sato ◽  
Mavilde da Luz Gonçalves Pedreira ◽  
Ariane Ferreira Machado Avelar ◽  
Miriam Harumi Tsunemi ◽  
Kelly Cristina Sbampato Calado Orsi ◽  
...  
Keyword(s):  
Preterm Infants ◽  
Gestational Age ◽  
Total Sleep Time ◽  
Sleep Time ◽  
Exclusion Criteria ◽  
Randomized Controlled ◽  
Significant Difference ◽  
Controlled Clinical Study ◽  
Preterm Newborns ◽  
Current Weight

The purpose of this study was to compare the effect of ear protectors on the sleep of preterm newborns during the “quiet” times in intermediate care nursery. This was a clinical, randomized, controlled crossover study conducted in two neonatal units in São Paulo, Brazil. The sample consisted of preterm infants who met the inclusion and exclusion criteria for the study. Polysomnography and unstructured observation were used for data collection. Twenty-four preterm infants with a mean gestational age of 33.2 weeks and current weight of 1.747 g were analyzed. There was no significant difference in the total sleep time of preterm infants with and without the use of ear protectors. Newborns with lower gestational age showed a significant reduction in total sleep time with the use of ear protectors ( p < .05). The use of ear protection did not increase the total sleep time for preterm infants.

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