scholarly journals A Consensus Definition of Supratotal Resection for Anatomically Distinct Primary Glioblastoma: An AANS/CNS Section on Tumors Survey of Neurosurgical Oncologists

2021 ◽  
Author(s):  
Maureen Rakovec ◽  
Adham M. Khalafallah ◽  
Oren Wei ◽  
David Day ◽  
Jason P. Sheehan ◽  
...  
Keyword(s):  
Contrast Enhancement ◽  
Resonance Imaging ◽  
Consensus Definition ◽  
Primary Glioblastoma ◽  
Temporal Lobes ◽  
Tumor Section ◽  
Treatment Plans ◽  
Definition Of ◽  
The Right ◽  
Supratotal Resection

Abstract Introduction: Supratotal resection (SpTR) of glioblastoma may be associated with improved survival, but published results have varied in part from lack of consensus on the definition and appropriate use of SpTR. A previous small survey of neurosurgical oncologists with expertise performing SpTR found resection 1-2 cm beyond contrast enhancement was an acceptable definition and glioblastoma involving the right frontal and bilateral anterior temporal lobes were considered most amenable to SpTR. The general neurosurgical oncology community has not yet confirmed the practicality of this definition. Methods Seventy-six general neurosurgical oncology members of the AANS/CNS Tumor Section were surveyed using a crowdsourcing approach. Participants were presented with 11 definitions of SpTR and rated each definition’s appropriateness. Participants additionally reviewed magnetic resonance imaging for 10 anatomically distinct glioblastomas and assessed the tumor location's eloquence, perceived equipoise of enrolling patients in a randomized trial comparing gross total to SpTR, and their personal treatment plans. Results Fifty-two neurosurgeons (73.2%) agreed that resection 1-2 cm beyond contrast enhancement was an acceptable definition for SpTR. Cases were divided into three anatomically distinct groups by perceived equipoise between gross total and SpTR. The best clinical trial candidates were right anterior temporal (n=58, 76.3%) and right frontal (n=55, 73.3%) glioblastomas. Conclusion Support exists within the neurosurgical oncology community to adopt the proposed consensus definition of SpTR of glioblastoma and to treat right anterior temporal and right frontal glioblastomas using SpTR. A smaller proportion of general neurosurgical oncologists than SpTR experts consider SpTR feasible in the left anterior temporal lobe.

scholarly journals SURG-21. A CROWDSOURCED CONSENSUS ON SUPRATOTAL RESECTION VERSUS GROSS TOTAL RESECTION FOR ANATOMICALLY DISTINCT PRIMARY GLIOBLASTOMA

2020 ◽  
Vol 22 (Supplement_2) ◽  
pp. ii207-ii208
Author(s):  
Debraj Mukherjee ◽  
Maureen Rakovec ◽  
Chetan Bettegowda ◽  
Christopher Jackson ◽  
Gary Gallia ◽  
...  
Keyword(s):  
Treatment Plan ◽  
Fellowship Training ◽  
Gross Total Resection ◽  
Total Resection ◽  
Consensus Definition ◽  
Post Contrast ◽  
Primary Glioblastoma ◽  
Treatment Plans ◽  
Strongly Agree ◽  
Supratotal Resection

Abstract Gross total resection (GTR) of contrast-enhancing tumor is associated with significantly increased overall survival in primary glioblastoma (GBM). Even when achieved, recurrence is likely, in part due to malignant cells infiltrating outside enhanced regions. Subsequently, there has been increasing interest in performing supratotal resections (SpTRs) for GBM. Published results have varied in part due to a lack of consensus on the definition of SpTR in GBM and its appropriate use. A crowdsourcing approach was used to survey 21 academic neurosurgical oncologists representing 13 health systems nationwide. Participants’ demographics including fellowship training status, years of experience, and operative volume with various techniques was collected. Participants were presented with 11 definitions of SpTR from published, peer-reviewed studies and asked to rate the appropriateness of each definition. Subsequently, participants reviewed T1-weighed post-contrast and FLAIR MR imaging videos in the axial, coronal, and sagittal planes for 22 GBMs. Participants were asked to assess eloquence of the tumor’s location, perceived equipoise of enrolling patients in a randomized clinical trial comparing GTR to SpTR, and their own personal surgical treatment plans. Most neurosurgeons surveyed (n=18, 85.7%) agree or strongly agree that GTR plus resection of some non-contrast enhancement is an appropriate definition for SpTR. Overall, there was only moderate inter-rater agreement, measured using sample variance and the index of qualitative variation, regarding eloquence, equipoise, and personal treatment plans. Neurosurgeons who performed more than 10 SpTRs for GBMs in the past year were more likely than counterparts to recommend it as their personal treatment plan (p< 0.005). Anterior temporal and right frontal GBMs were considered the best randomization candidates. We established a consensus definition for SpTR of GBM and identified anatomically distinct locations deemed most amenable to SpTR. These results will be used to plan prospective trials further investigating the potential clinical utility of SpTR for GBMs.

Reduction of cortical volume in schizophrenia on magnetic resonance imaging

1993 ◽  
Vol 23 (3) ◽  
pp. 591-604 ◽  
Author(s):  
I. Harvey ◽  
M. A. Ron ◽  
G. Du Boulay ◽  
D. Wicks ◽  
S. W. Lewis ◽  
...  
Keyword(s):  
Grey Matter ◽  
Resonance Imaging ◽  
Medial Temporal Lobes ◽  
Temporal Lobes ◽  
Cortical Volume ◽  
Parietal Lobes ◽  
Mri Scans ◽  
Schizophrenic Patients ◽  
Schizophrenic Group ◽  
The Right

SynopsisThe MRI scans of 48 schizophrenic patients, fulfilling RDC criteria, were compared to those of 34 healthy controls matched for age, ethnicity and parental social class. The volume of the frontal and anterior parietal lobes was significantly reduced in the schizophrenic group as a result of a selective decrease in cortical volume, with a corresponding increase in the volume of sulcal fluid. Reduction in the volume of the temporal grey matter was more marked on the right, but was not in excess of the loss of volume observed in other areas of the cortex. MRI abnormalities correlated poorly with clinical parameters, although both unemployment and poor pre-morbid adjustment predicted reduced cerebral volume and increased sulcal volume. These results question whether the medial temporal lobes are the only site of structural pathology in schizophrenia.

Inferior Temporal Sulcus as a Site of Corticotomy: Magnetic Resonance Imaging Analysis of Individual Sulcus Patterns

Neurosurgery ◽  
2001 ◽  
Vol 49 (6) ◽  
pp. 1394-1398 ◽  
Author(s):  
Yasushi Miyagi ◽  
Fumio Shima ◽  
Katsuya Ishido ◽  
Takehisa Araki ◽  
Kazufumi Kamikaseda
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Hippocampal Sclerosis ◽  
Resonance Imaging ◽  
Temporal Lobes ◽  
Surface Anatomy ◽  
Selective Amygdalohippocampectomy ◽  
Mri Scans ◽  
Magnetic Resonance Imaging Mri ◽  
The Right

ABSTRACT OBJECTIVE Transcortical approaches to the inferior horn often result in quadrant hemianopsia attributable to the injury to the optic radiation. The inferior temporal sulcus (ITS) has received little attention as an entrance point for the transsulcal approach. We used the method of detecting the ITS with magnetic resonance imaging (MRI) scans and investigated the sulcus pattern of ITS, its incidence rate, and the availability of the ITS to the corticotomy for selective amygdalohippocampectomy. METHODS The sulcus patterns of the ITS of 100 temporal lobes in 50 healthy individuals were classified according to the number of interruptions by gyral bridges, and the localization of the ITS was characterized in relation to the outer surface by means of the surface anatomy scan of MRI. RESULTS Most of the ITS was interrupted by one to three gyral bridges (0 bridges, 8%; one bridge, 27%: two bridges, 37%; three bridges, 20%; more than four bridges or no apparent ITS, 8%). When the ITS was present, it was located 15 mm above the orbitotragus line at a point 20 mm anterior to the tragus. The number of gyral bridges was significantly larger in the left temporal lobes than in the right temporal lobes, regardless of the sex of the subject. CONCLUSION The ITS was clearly identified in 72% of the temporal lobes by the oblique sagittal view of MRI scans; thus, in such cases, the ITS was considered to be a candidate for an entrance point of a small temporal corticotomy. The preoperative observation of the ITS in relation to the orbitotragus line by means of MRI may improve the planning of the transsulcal approaches to deeply seated mesial temporal lesions, such as hippocampal sclerosis.

scholarly journals Glioblastoma Presenting with Steroid-Induced Pseudoregression of Contrast Enhancement on Magnetic Resonance Imaging

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Marcus D. Mazur ◽  
Vinh Nguyen ◽  
Daniel W. Fults
Keyword(s):  
Contrast Enhancement ◽  
Clinical Course ◽  
Histological Diagnosis ◽  
World Health ◽  
Symptom Improvement ◽  
Resonance Imaging ◽  
Diagnostic Dilemma ◽  
Final Histological Diagnosis ◽  
Health Organization ◽  
The Right

Corticosteroid-induced reduction in contrast enhancement on radiographic imaging is most commonly associated with lymphoma but has been reported in other entities, including glioma. This finding may represent a diagnostic dilemma. Concern that steroid-induced cytotoxicity obscures histological diagnosis of suspected lymphoma may lead to postponement of a biopsy. If glioma is not considered in the differential diagnosis, reduction in tumor contrast enhancement may be misinterpreted as disease regression rather than a transient radiographic change. We report a case of a patient with an enhancing right temporoparietal mass adjacent to the atrium of the lateral ventricle. After treatment with dexamethasone was started, the mass exhibited marked reduction in contrast enhancement, with symptom improvement. The clinical course suggested lymphoma, and surgery was not performed. Subsequent screening for extra-axial lymphoma was negative. Two weeks later, the patient developed worsening symptoms, and repeat T1-weighted imaging showed interval increase in size and enhancement. The findings suggested a possible diagnosis of malignant glioma. The patient underwent a stereotactic-guided craniotomy for excision of the right temporoparietal mass lesion. Final histological diagnosis was glioblastoma multiforme, World Health Organization grade IV.

scholarly journals Unilateral Isolated Proximal Femoral Focal Deficiency

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Emek Doğer ◽  
Şule Y. Köpük ◽  
Yiğit Çakıroğlu ◽  
Özgür Çakır ◽  
Gülseren Yücesoy
Keyword(s):  
Antenatal Diagnosis ◽  
Early Recognition ◽  
Resonance Imaging ◽  
Left Femur ◽  
Femur Length ◽  
Skeletal Dysplasias ◽  
The Family ◽  
Treatment Plans ◽  
Proximal Femoral Focal Deficiency ◽  
The Right

Objective. To discuss a patient with a prenatal diagnosis of unilateral isolated femoral focal deficiency.Case. Antenatal diagnosis of unilateral isolated femoral focal deficiency was made at 20 weeks of gestation. The length of left femur was shorter than the right, and fetal femur length was below the fifth percentile. Proximal femoral focal deficiency was diagnosed. After delivery, the diagnosis was confirmed with skeletal radiographs and magnetic resonance imaging. In prenatal ultrasonographic examination, the early recognition and exclusion of skeletal dysplasias is important; moreover, treatment plans should be initiated, and valuable information should be provided to the family.

scholarly journals Axial Psoriatic Disease: Clinical and Imaging Assessment of an Underdiagnosed Condition

2021 ◽  
Vol 10 (13) ◽  
pp. 2845
Author(s):  
Ivan Giovannini ◽  
Alen Zabotti ◽  
Carmelo Cicciò ◽  
Matteo Salgarello ◽  
Lorenzo Cereser ◽  
...  
Keyword(s):  
Unmet Needs ◽  
X Rays ◽  
Resonance Imaging ◽  
Consensus Definition ◽  
Pet Ct ◽  
Axial Disease ◽  
Axial Symptoms ◽  
Definition Of ◽  
Axial Involvement

The frequent involvement of the spine and sacroiliac joint has justified the classification of psoriatic arthritis (PsA) in the Spondyloarthritis group. Even if different classification criteria have been developed for PsA and Spondyloarthritis over the years, a well-defined distinction is still difficult. Although the majority of PsA patients present peripheral involvement, the axial involvement needs to be taken into account when considering disease management. Depending on the definition used, the prevalence of axial disease may vary from 25 to 70% in patients affected by PsA. To date, no consensus definition has been reached in the literature and the definition of axial involvement in PsA has varied from isolated sacroiliitis to criteria used in ankylosing spondylitis. This article reviews the unmet needs in the clinical and radiological assessment of axial PsA, reporting the various interpretations of axial involvement, which have changed over the years. Focusing on both imaging and clinical standpoints, we reported the prevalence of clinical and radiologic features, describing the characteristics of axial disease detectable by X-rays, magnetic resonance imaging, and PET-CT, and also describing the axial symptoms and outcome measures in patients affected by axial disease.

scholarly journals Somatotypological features of topographic kidney anatomy of patients without any kidney and urinary tract diseases

2018 ◽  
pp. 56-61
Author(s):  
V.M. Monastyrskyi ◽  
V.I. Pivtorak
Keyword(s):  
Magnetic Resonance Imaging ◽  
Statistical Analysis ◽  
Urinary Tract ◽  
Magnetic Resonance ◽  
Horizontal Plane ◽  
Spatial Position ◽  
Resonance Imaging ◽  
Kidney Anatomy ◽  
Definition Of ◽  
The Right

The conducted analysis of modern literature shows that most of the establishednormative parameters of the placement of kidneys in healthy people have not beensufficiently studied, with researchers practically do not take into account the constitutionalfeatures of the organism. The purpose of the study was to determine the topographicanatomical position of the kidneys in the frontal, sagittal and horizontal planes on thebasis of MRI in patients of different somatotypes without any kidney and urinary tractdiseases. Complex examination of 65 patients of the first and second mature age ofdifferent somatotypes, which did not have kidney and urinary tract diseases, wasperformed. To determine the somatotype, we used the mathematical scheme forB.Heath and J.Carter (1990), with the definition of the endomorphic, mesomorphic andectomorphic components of the somatotype. The renal topography was conducted ona Philips Intera-1.5T magnetic resonance imaging (standard magnetic resonance protocolincluded scanning in sagittal, frontal, and axial projections to obtain T1 weighted imaging).The angles of inclination were measured in the frontal, sagital and horizontal planes tomeasure spatial position of the kidneys. The statistical analysis of the obtained resultswas carried out using the "STATISTICA 5.5" program, using parametric and non-parametricmethods for evaluating the obtained results. It was established that the angle ofinclination of the kidney on the right side in the frontal and sagittal planes was greater in1.23-1.41 times than in men and in women of representatives of all somatotypes. Theangle between the axis and the line drawn through the middle of the vertebral bodiesdid not statistically significantly change, depending on the somatotype, sex and on theside of the study in a horizontal plane. The angles of inclination of the kidney axis aredefined in three planes: the frontal, horizontal, and sagittal in the patients, with thekidney axis directed downwards outward and forward. Representatives of allsomatotypes differed statistically significantly the angles of inclination of the left axisfrom the right kidneys in the frontal and sagittal planes

THE CONCEPT OF CONSTITUTIONAL AND LEGAL GUARANTEES OF ELECTORAL RIGHTS

2020 ◽  
Vol 10 (4) ◽  
pp. 85-90
Author(s):  
VLADIMIR TROYAN ◽  
Keyword(s):  
Scientific Research ◽  
Formal Aspect ◽  
Universal Approach ◽  
Right To Vote ◽  
Definition Of ◽  
The Right

The relevance of the interpretation of constitutional and legal guarantees of the right to vote is mediated by isolated scientific research in this area, as well as the lack of a universal approach to legal guarantees. In this regard, the purpose of the article is to argue and disclose the author’s definitive aspect of the claimed guarantees. In the work, the author named and characterized the normative (based exclusively on legal means) with the perspective of a branch of legal and technical; regulatory and institutional (combines the formal aspect with the activities of authorized entities) and associated legal (including a set of legal and other aspects) approaches to the definition of legal guarantees. Based on the second approach, as well as combining the guarantees of the right to vote directly guarantees of the subjective right itself and guarantees of its implementation, the author offers a definition of constitutional and legal guarantees of the right to vote.

administrasi ketatausahaan sekolah

2020 ◽  
Author(s):  
Isra Revenia
Keyword(s):  
Information Needs ◽  
Control Functions ◽  
Definition Of ◽  
The Right ◽  
And Control

This article is made to know the destinantion and the administrasi functions of the school in order to assist the leader of an organazation in making decisions and doing the right thing, recording of such statements in addition to the information needs also pertains to the function of accountabilitty and control functions. Administrative administration is the activity of recording for everything that happens in the organization to be used as information for leaders. While the definition of administration is all processing activities that start from collecting (receiving), recording, processing, duplicating, minimizing and storing all the information of correspondence needed by the organization. Administration is as an activity to determine everything that happens in the organization, to be used as material for information by the leadership, which includes all activities ranging from manufacturing, managing, structuring to all the preparation of information needed by the organization.

SELF ASSESSMENT TO KNOW UNDERSTANDING MATHEMATIC CONCEPT

2018 ◽  
Vol 3 (1) ◽  
pp. 14-21
Author(s):  
Deni Iriyadi
Keyword(s):  
Qualitative Study ◽  
Qualitative Analysis ◽  
Resolution Limit ◽  
Self Assessment ◽  
Limit Concept ◽  
Research Instrument ◽  
Definition Of ◽  
The Right

This research is a qualitative study aimed to determine the students' understanding of the concept of matter limit. The subjects were students of class XI IPA 1 SMA Negeri 1 Watampone. The concept includes the definition of the limit. Data obtained using a research instrument in the form of self-assessment and then proceed with the interview subjects were selected based on the results of self-assessment has been done before. Analysis using qualitative analysis of students' understanding of the concept of the limit concept. The results of this study indicate that students' understanding of concepts some of which are not / do not understand especially regarding definitions limit. In addition students are also wrong about the resolution limit. Students who understand the concept of limit dinyakatakan them restate concepts, including examples and classify the sample to non-completion of function and limit the right results.

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