scholarly journals Voltammetric Approach for Pharmaceutical Samples Analysis; Simultaneous Quantitative Determination of Resorcinol and Hydroquinone

2021 ◽  
Author(s):  
Ebrahim Nabatian ◽  
Mahdi Mousavi ◽  
Mostafa Pournamdari ◽  
Saeid Ahmadzadeh
Keyword(s):  
Simultaneous Determination ◽  
Electrochemical Impedance ◽  
Limit Of Detection ◽  
Phosphate Buffer Solution ◽  
Regression Equations ◽  
Carbon Paste ◽  
Buffer Solution ◽  
Solution Ph ◽  
Pharmaceutical Samples

Abstract A simple and precise analytical approach developed for single and simultaneous determination of resorcinol (RC) and hydroquinone (HQ) in pharmaceutical samples using carbon paste electrode (CPE) modified with 1-Ethyl-3-methylimidazolium tetrafluoroborate as ionic liquid and ZnFe2O4 nanoparticle. A significant enhancement in the peak current and sensitivity of the proposed sensor observed by using modifiers in the composition of working electrode compared to bare CPE which is in accordance with the results obtained from electrochemical impedance spectroscopy investigations. Electrochemical investigations revealed a well-defined irreversible oxidation peak for RC over a wide concentration range from 3.0 µM to 500 µM in 0.1 M phosphate buffer solution (pH 6.0) with the linear regression equations of Ip (µA) = 0.0276 CRC (µM) + 0.5508 (R2 = 0.997). The limit of detection and quantification for RC analysis were found to be 1.46 µM and 4.88 µM, respectively. However, the obtained SW voltammograms for simultaneous determination of RC and HQ exhibited a desirable peak separation of about 360 mV potential difference and a satisfactory linear response over the range of 50-700 µM and 5-350 µM with the favorable correlation coefficient of 0.991 and 0.995, respectively. The diffusion coefficient (D) of RC and the electron transfer coefficient (α) at the surface of ZnFe2O4/NPs/IL/CPE estimated to be 2.83×10−4 cm s−1 and 0.76. The proposed sensor as a promising and low-cost method successfully applied for determination of RC in commercial pharmaceutical formulations such as the resorcinol cream of 2% O/W emulsion available on the market with the recovery of 98.47±0.04.

scholarly journals Electro-Polymerized Titan Yellow Modified Carbon Paste Electrode for the Analysis of Curcumin

Surfaces ◽  
2021 ◽  
Vol 4 (3) ◽  
pp. 191-204
Author(s):  
Edwin S. D’Souza ◽  
Jamballi G. Manjunatha ◽  
Chenthattil Raril ◽  
Girish Tigari ◽  
Huligerepura J. Arpitha ◽  
...  
Keyword(s):  
Carbon Paste Electrode ◽  
Limit Of Detection ◽  
Phosphate Buffer Solution ◽  
Modified Carbon Paste Electrode ◽  
Carbon Paste ◽  
Buffer Solution ◽  
Solution Ph ◽  
Real Sample Analysis ◽  
Titan Yellow ◽  
Paste Electrode

A modest, efficient, and sensitive chemically modified electrode was fabricated for sensing curcumin (CRC) through an electrochemically polymerized titan yellow (TY) modified carbon paste electrode (PTYMCPE) in phosphate buffer solution (pH 7.0). Cyclic voltammetry (CV) linear sweep voltammetry (LSV) and differential pulse voltammetry (DPV) approaches were used for CRC detection. PTYMCPE interaction with CRC suggests that the electrode exhibits admirable electrochemical response as compared to bare carbon paste electrode (BCPE). Under the optimized circumstances, a linear response of the electrode was observed for CRC in the concentration range 2 × 10−6 M to 10 × 10−6 M with a limit of detection (LOD) of 10.94 × 10−7 M. Moreover, the effort explains that the PTYMCPE electrode has a hopeful approach for the electrochemical resolution of biologically significant compounds. Additionally, the proposed electrode has demonstrated many advantages such as easy preparation, elevated sensitivity, stability, and enhanced catalytic activity, and can be successfully applied in real sample analysis.

scholarly journals Electrochemical Investigation of Catechol at Poly(niacinamide) Modified Carbon Paste Electrode: A Voltammetric Study

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
A. B. Teradale ◽  
S. D. Lamani ◽  
B. E. Kumara Swamy ◽  
P. S. Ganesh ◽  
S. N. Das
Keyword(s):  
Carbon Paste Electrode ◽  
Limit Of Detection ◽  
Phosphate Buffer Solution ◽  
Modified Carbon Paste Electrode ◽  
Rate Variation ◽  
Carbon Paste ◽  
Buffer Solution ◽  
Limit Of Quantification ◽  
Paste Electrode

A polymeric thin film modified electrode, that is, poly(niacinamide) modified carbon paste electrode (MCPE), was developed for the electrochemical determination of catechol (CC) by using cyclic voltammetric technique. Compared to bare carbon paste electrode (BCPE), the poly(niacinamide) MCPE shows good electrocatalytic activity towards the oxidation of catechol in phosphate buffer solution (PBS) of physiological pH 7.4. All experimental parameters were optimized. Poly(niacinamide) modified carbon paste electrode gave a linear response between concentration of CC and its anodic peak current in the range within 20.6–229.0 μM. The limit of detection (3S/M) and limit of quantification (10S/M) were 1.497 μM and 4.99 μM, respectively. From the study of scan rate variation, the electrode process was found to be adsorption-controlled. The involvement of protons and electrons in the oxidation of CC was found to be equal. The probable electropolymerisation mechanism of niacinamide was proposed. Finally, this method can be used in development of a sensor for sensitive determination of CC.

scholarly journals Electrochemical Polymerised Graphene Paste Electrode and Application to Catechol Sensing

2019 ◽  
Vol 13 (1) ◽  
pp. 81-87 ◽  
Author(s):  
Jamballi G. Manjunatha
Keyword(s):  
Modified Electrode ◽  
Limit Of Detection ◽  
Phosphate Buffer Solution ◽  
Sample Pretreatment ◽  
Differential Pulse ◽  
Buffer Solution ◽  
Solution Ph ◽  
Graphene Paste Electrode ◽  
Paste Electrode

Objective: To build up an advantageous strategy for sensitive determination of catechol (CC), a poly (proline) modified graphene paste electrode (PPMGPE) was fabricated and used as a voltammetric sensor for the determination of CC. Methods: The performance of the modified electrode was studied using cyclic voltammetric (CV) and differential pulse voltammetric method (DPV). The modified electrode was characterized by CV and DPV. The surface of the modified electrode was examined by FESEM. The electrochemical behavior of CC in phosphate buffer solution (pH 7.5) was inspected using bare graphene paste electrode (BGPE) and PPMGPE. Results & Conclusion: The PPMGPE shows a lower limit of detection, calculated to be 8.7×10–7mol L−1 (S/N=3). This modified electrode was applied successfully for the determination of CC in water samples without applying any sample pretreatment.

Non-enzymatic determination of purine nucleotides using a carbon dot modified glassy carbon electrode

2019 ◽  
Vol 11 (30) ◽  
pp. 3866-3873 ◽  
Author(s):  
R. Karthikeyan ◽  
D. James Nelson ◽  
S. Abraham John
Keyword(s):  
Glassy Carbon ◽  
Low Cost ◽  
Phosphate Buffer Solution ◽  
Purine Nucleotides ◽  
Buffer Solution ◽  
Solution Ph ◽  
Carbon Dot ◽  
Enzymatic Determination ◽  
Sensitive Determination

Selective and sensitive determination of one of the purine nucleotides, inosine (INO) using a low cost carbon dot (CD) modified glassy carbon (GC) electrode in 0.2 M phosphate buffer solution (pH 7.2) was demonstrated in this paper.

scholarly journals Carvacrol electrochemical reaction characteristics on screen printed electrode modified with La2O3/Co3O4 nanocomposite

2019 ◽  
Vol 9 (2) ◽  
pp. 113-123 ◽  
Author(s):  
Sayed Zia Mohammadi ◽  
Hadi Beitollahi ◽  
Tahereh Rohani ◽  
Hossein Allahabadi
Keyword(s):  
Limit Of Detection ◽  
Phosphate Buffer Solution ◽  
Differential Pulse ◽  
Co3o4 Nanoparticles ◽  
Electrochemical Characteristics ◽  
Screen Printed Electrode ◽  
Buffer Solution ◽  
Voltammetric Techniques ◽  
Screen Printed

Electrochemical characteristics of carvacrol were investigated on a screen-printed electrode (SPE) modified with La2O3/Co3O4 nanocomposite by using voltammetric techniques, which displayed a well-defined peak for sensitive carvacrol determination in phosphate buffer solution (PBS) at pH 7.0. La2O3/Co3O4 nanoparticles demonstrated suitable catalytic activity for carvacrol determination by differential pulse voltammetry (DPV) technique. Besides, determination of carvacrol in a real samples was recognized in the light of electrochemical findings and a validated voltammetric technique for quantitative analysis of carvacrol in a real formulation was proposed. The DPV peak currents were found to be linear in the concentration range of 10.0 to 800.0 μM. The limit of detection (LOD) was found to be 1.0 μM.

Microwave-assisted synthesis of NaA nanozeolite from slag and performance of Ag-doped nanozeolite as an efficient material for determination of hydrogen peroxide

RSC Advances ◽  
2016 ◽  
Vol 6 (57) ◽  
pp. 52058-52066 ◽  
Author(s):  
Seyed Naser Azizi ◽  
Shahram Ghasemi ◽  
Mehrnaz Mikhchian
Keyword(s):  
Hydrogen Peroxide ◽  
Phosphate Buffer Solution ◽  
Modified Carbon Paste Electrode ◽  
Microwave Assisted Synthesis ◽  
Carbon Paste ◽  
Buffer Solution ◽  
Microwave Assisted ◽  
And Performance ◽  
Paste Electrode

A new amperometric sensor is prepared based on a Ag doped NaA nanozeolite modified carbon paste electrode (Ag/ACPE) in order to detect hydrogen peroxide (H2O2) in phosphate buffer solution (PBS, pH 7.0).

Electrocatalytic performance of a zinc sulphide nanoparticles-modified carbon paste electrode for the simultaneous determination of acetaminophen, guanine and adenine

2018 ◽  
Vol 10 (11) ◽  
pp. 1362-1371 ◽  
Author(s):  
Mallappa Mahanthappa ◽  
Nagaraju Kottam ◽  
Shivaraj Yellappa
Keyword(s):  
Carbon Paste Electrode ◽  
Phosphate Buffer ◽  
Phosphate Buffer Solution ◽  
Zinc Sulphide ◽  
Modified Carbon Paste Electrode ◽  
Carbon Paste ◽  
Buffer Solution ◽  
Guanine And Adenine ◽  
Paste Electrode

The simultaneous electroanalysis of acetaminophen (AC), guanine (G) and adenine (A) was successfully achieved on the zinc sulphide nanoparticles-modified carbon paste electrode (ZnS NPs/CPE) in phosphate buffer solution (PBS).

A Facile In-Situ Development of L-Valine Film onto the Surface of Carbon Paste Electrode Towards the Detection of Environmentally Hazardous 4-Amino Phenol

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
T. Venu Gopal ◽  
Tukiakula Madhusudana Reddy ◽  
P. Shaikshavali ◽  
G. Venkataprasad ◽  
P. Gopal
Keyword(s):  
Cyclic Voltammetry ◽  
Carbon Paste Electrode ◽  
Electrochemical Impedance ◽  
Limit Of Detection ◽  
Small Scale ◽  
Carbon Paste ◽  
Relative Standard ◽  
Paste Electrode

Abstract A small scale of environmentally hazardous 4-aminophenol can show significant impact on human health. Hence, in the present work, we have designed L-Valine film (Vf) modified carbon paste electrode (Vf/CPE) for the determination of 4-aminophenol. Herein, a facile in-situ L-Valine film was developed by electrochemical polymerization method onto the surface of bare carbon paste electrode (BCPE) with the help of cyclic voltammetry (CV) technique. A two-folds of electrochemical peak current enhancement was achieved at Vf/CPE in comparison with BCPE towards the determination of 4-aminophenol in optimum pH 7.0 of phosphate buffer solution (PBS). This was achieved due to the large surface area and conductive nature of Vf/CPE, which was concluded through the techniques of cyclic voltammetry and electrochemical impedance spectroscopy (EIS). The effect of pH of buffer and scan rate studies were successfully studied. Morphological changes of BCPE and Vf/CPE was studied with the help of scanning electron microscopy (SEM). The formation of Vf on CPE was also analyzed by Fourier transform infrared (FTIR) spectra. Under the optimized conditions, the limit of detection (LOD) and limit of quantification (LOQ) values of 4-aminophenol were estimated with the aid of chronoamperometry (CA) technique and was found to be 9.8 μM and 32 μM, respectively. Finally the proposed method was found to have satisfactory repeatability, reproducibility and stability results with low relative standard deviation (RSD) values.

scholarly journals Online Coupling of Lab-on-Valve Format to Amperometry Based on Polyvinylpyrrolidone-Doped Carbon Paste Electrode and Its Application to the Analysis of Morin

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Yang Wang ◽  
Guojun Yao ◽  
Jie Tang ◽  
Chun Yang ◽  
Qin Xu ◽  
...  
Keyword(s):  
Carbon Paste Electrode ◽  
Supporting Electrolyte ◽  
Phosphate Buffer Solution ◽  
Current Response ◽  
Oxidation Peak ◽  
Carbon Paste ◽  
Buffer Solution ◽  
Electrochemical Behaviors ◽  
Paste Electrode

The potential capabilities and analytical performance of lab-on-valve (LOV) manifold as a front end to amperometry have been explored for the on-line determination of morin. Meanwhile, the electrochemical behaviors of morin were investigated based on polyvinylpyrrolidone- (PVP-) doped carbon paste electrode (CPE), which found that PVP can significantly improve its oxidation peak current. The excellent amperometric current response was achieved when the potential difference (ΔE) of 0.6 V was implemented in pH 6.5 phosphate buffer solution (PBS) that served as the supporting electrolyte. A well-defined oxidation peak has been obtained in studies using PVP as a modifier of CPE based on the oxidation of morin. The present work introduces the LOV technique as a useful tool for amperometric measurement, documents advantages of using programmable flow, and outlines means for miniaturization of assays on the basis of PVP modified CPE. The proposed method was applied successfully to the determination of morin in real samples, and the spiked recoveries were satisfactory.

Enhanced Electrochemical Determination Of Riboflavin In Biological And Pharmaceutical Samples At Poly (Arginine) Modified Carbon Paste Electrode

2019 ◽  
Vol 14 (4) ◽  
pp. 216-223 ◽  
Author(s):  
Girish Tigari ◽  
J.G. Manjunatha ◽  
D.K. Ravishankar ◽  
G. Siddaraju
Keyword(s):  
Carbon Paste Electrode ◽  
Limit Of Detection ◽  
Phosphate Buffer Solution ◽  
Differential Pulse ◽  
Modified Carbon Paste Electrode ◽  
Current Response ◽  
Carbon Paste ◽  
Serum Samples ◽  
Buffer Solution ◽  
Paste Electrode

An electrogenerated Polyarginine modified carbon paste electrode (PAMCPE) was fabricated through a simple electropolymerization procedure. The devised electrode was characterized by cyclic voltammetry (CV) and Field Emission Scanning Electron Microscopy (FESEM). This electrode was utilized for electrocatalytic estimation of Riboflavin (RF) and its instantaneous resolution with ascorbic acid (AA) and folic acid (FA) in phosphate buffer solution (PBS) of pH 6.0 by differential pulse voltammetry (DPV). It was observed to be a very responsive electrode for the electrochemical detection and quantification of RF. It was revealed that PAMCPE generates higher current response towards RF contrast to the bare carbon paste electrode (BCPE). Under optimized condition, the RF oxidation current values were linearly reliant on the RF concentration increment with a limit of detection (LOD) of 9.3·10-8 M using DPV. The stable PAMCPE was effectively applied for estimation of RF in B-complex pill and complex human blood serum samples.

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