scholarly journals Antibiogram Profile of Antibacterial Multidrug Resistance in Democratic Republic of Congo: Situation in Bukavu City Hospitals

2021 ◽  
Author(s):  
Justin Ntokamunda Kadima ◽  
Christian Ahadi Irenge ◽  
Patient Birindwa Mulashe ◽  
Félicien Mushagalusa Kasali ◽  
Patient Wimba
Keyword(s):  
Multidrug Resistance ◽  
Democratic Republic ◽  
Democratic Republic Of Congo ◽  
Multidrug Resistant ◽  
Resistant Bacteria ◽  
Klebsiella Pneumonia ◽  
Bacterial Strains ◽  
General Reference ◽  
Coagulase Negative Staphylococci ◽  
Republic Of Congo

Abstract Background Bacterial strains carrying multidrug resistance traits are gaining ground worldwide, especially in countries with limited resources. This study aimed to evaluate the spreading of multidrug-resistant bacteria strains in Bukavu city hospitals in the Democratic Republic of Congo. Methods We analyzed 758 antibiogram data recorded in files of patients consulted between January 2016 and December 2017 at three reference hospitals selected as sentinel sites, namely the Panzi General Reference Hospital (HGP), BIO -PHARM hospital (HBP), and Saint Luc Clinic (CSL). Results Of 758 isolates tested, the laboratories identified 12 bacterial strains in 712 isolates, of which 223(29.42%) presented MDR profile, including Escherichia coli (11.48%), Klebsiella pneumonia (6.07%), Enterobacter (5.8%), Staphylococcus aureus and coagulase-negative staphylococci (1.58%), Proteus mirabilis (1.85%), Salmonella enterica (1.19%), Pseudomonas aeruginosa (0.53%), Streptococcus pneumonia (0.4%)), Citrobacter (0.13%), Neisseria gonorrhea (0.13%), Enterococcus faecalis (0.13%) and Morganella morganii (0.13%). Infected patients were significantly adults (73.1% vs. 21.5%) compared to children and mainly women (63.7% vs. 30.9%; p = 0.001). Conclusion The observed expansion requires that hospital therapeutic committees set up an effective clinical management system and define the right combinations of antibiotics.

scholarly journals Implementing a Short Regimen for Multidrug-Resistant Tuberculosis in Kinshasa, Democratic Republic of Congo: A Cohort Study 2014-2017

2020 ◽  
Vol 08 (03) ◽  
pp. 111-126
Author(s):  
Innocent Murhula Kashongwe ◽  
Leopoldine Mbulula ◽  
Fina Mawete ◽  
Nicole Anshambi ◽  
Nadine Maingowa ◽  
...  
Keyword(s):  
Cohort Study ◽  
Democratic Republic ◽  
Democratic Republic Of Congo ◽  
Multidrug Resistant ◽  
Republic Of Congo ◽  
Resistant Tuberculosis ◽  
Multidrug Resistant Tuberculosis

scholarly journals The determinants of premature birth during the year 2018 at the General Reference Hospital of Malemba in the Democratic Republic of Congo

2020 ◽  
Vol 37 ◽  
Author(s):  
Fiston Ilunga Mbayo ◽  
Yannick Bienge Nsenga ◽  
Gloire Kasongo Lupitshi ◽  
Kennedy Twite Nyemba ◽  
Cédrick Mwamba Mpingisha ◽  
...  
Keyword(s):  
Premature Birth ◽  
Democratic Republic ◽  
Democratic Republic Of Congo ◽  
General Reference ◽  
Republic Of Congo ◽  
Reference Hospital

scholarly journals Analysis of Implementation of Drugs Management Policy in Public & Private Hospitals in the Democratic Republic of Congo

2021 ◽  
pp. 29-47
Author(s):  
Assani Ramazani Raymond ◽  
Lutula Ndjadi Raphael
Keyword(s):  
Democratic Republic ◽  
Democratic Republic Of Congo ◽  
Generic Drugs ◽  
Management Policy ◽  
Drug Management ◽  
General Reference ◽  
Private Hospitals ◽  
Republic Of Congo ◽  
Management Standards ◽  
Reference Hospital

Introduction: This study, which was conducted from January 1, 2015 to December 31, 2018,           aims to assess the level of compliance with formal drug management standards at the Mangobo General Reference Hospital and the Kisangani Millennium Polyclinic and to verify which of                   the two medical structures successfully applies formal drug management standards more than the other. Methods: The study involved 30 randomly selected subjects, 15 at the Mangobo General Reference Hospital and 15 at the Kisangani Millennium Polyclinic, as well as all the agents involved in drug management in these two hospitals in the Democratic Republic of Congo. For data collection, we used the questionnaire and comparative analysis. Results: After analysis, we found that the formal standards of drug management would be impeccably respected at the Kisangani Millennium Polyclinic compared to the Mangobo General Reference Hospital. Furthermore, 87% of respondents confirmed the existence of the national list of essential and generic drugs at the Mangobo General Reference Hospital and 67% at the Kisangani Millennium Polyclinic. 73% of respondents confirmed the logistic cycle of control of drug supply at the Mangobo General Reference Hospital; 40% of the respondents confirmed that the managers of the Kisangani Millennium Polyclinic make greater use of the service criteria used to select medicines; finally, 73% of the managers use the monthly average calculation of the consumption of medicines to calculate the consumption of their medicines at the pharmacy of the Kisangani Millennium Polyclinic.

scholarly journals Biofilm Formation and Antibiotic resistance of Enterobacteriaceae isolates from Surgical Site infections in Hôpital de Référence Saint Joseph, Kinshasa, Democratic Republic of Congo

2020 ◽  
Author(s):  
Jean-Marie Liesse Iyamba ◽  
Rodriguez Musomoni Mabankama ◽  
Cyprien Mbundu Lukukula ◽  
Joseph Welo Unya ◽  
Daniel Tassa Okombe ◽  
...  
Keyword(s):  
Antibiotic Resistance ◽  
Biofilm Formation ◽  
Democratic Republic ◽  
Democratic Republic Of Congo ◽  
Surgical Site Infections ◽  
Multidrug Resistant ◽  
Diffusion Method ◽  
Republic Of Congo ◽  
E Coli ◽  
Multidrug Resistant Organisms

Abstract Background: Enterobacteriaceae are one of the most predominant pathogen in surgical site infections. In recent years we oberved increase in resistance among bacteria from surgical site infections. The aim of this study was to evaluate antimicrobial suceptibility pattern of Enterobacteriaceae isolates from surgical site infections, the biofilm formation and the production of OXA-48 carbapenemase.Methods: A total of 41 Enterobacteriaceae (19 Escherchia coli, 8 Enterobacter sp., 9 Citrobacter sp., and 5 Serratia sp. ) clinical isolates were collected from patients with SSI in Hôpital Saint Joseph (Kinshasa) for diagnostic purposes. The pus samples were cultured and the antibiotic susceptibility profile of the isolates were determined by disk-diffusion method following Clinical and Laboratory Standards Institute 2012 recommendations. OXA-48-producing Enterobacteriaceae were detected using ChromaticTM OXA-48 chromogenic medium. Crystal Violet Staining Method was used to assess the ability of bacteria strains to form a biofilm. Results: All Enterobacteriacea isolates studied were biofilm producers and highly resistant to the majority of antibiotics tested. E. coli, Enterobacter sp., Citrobacter sp., and Serratia sp. were 100 % resistant cefotaxime, imipenem, and amoxicillin-clavulanic acid, and ampicillin. Serratia sp. isolates were 100% and 80% sensitive to norfloxacine and amikacine respectively. There was relationship between antibiotic resistance and biofilm production. E. coli, Enterobacter sp., and Citrobacter sp. strains were all OXA-48 producers.Conclusion: The results of the present study demonstrate the emergence of multidrug resistant organisms, the correlation between antibiotic resistance- biofilm formation and OXA-48 production. These results suggest the implementation of antimicrobial resistance survey programm in order to prevent and combat the spread of multidrug resistant organisms in hospital and community in Democratic Republic of Congo.

scholarly journals Low Detection Rate of Multidrug-Resistant and Rifampicin-Resistant Tuberculosis in the Democratic Republic of Congo: Trend Analysis 2013-2017

2019 ◽  
Vol 07 (04) ◽  
pp. 212-219
Author(s):  
Innocent Kashongwe Murhula ◽  
Fina Mawete ◽  
Lay Ofali ◽  
Michel Kaswa ◽  
Francois Lepira Bompeka ◽  
...  
Keyword(s):  
Trend Analysis ◽  
Detection Rate ◽  
Democratic Republic ◽  
Democratic Republic Of Congo ◽  
Multidrug Resistant ◽  
Republic Of Congo ◽  
Resistant Tuberculosis
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