Compared with Monocyte to High-Density Lipoprotein Ratio (MHR) and Neutrophil to Lymphocyte Ratio (NLR),Neutrophil to High-Density Lipoprotein Ratio (NHR) is more Valuable in the Inflammatory Process of Parkinson's Disease
Abstract Background: Inflammatory response plays an important role in the pathologic process and prognosis of Parkinson's disease (PD).We investigated the relationship between the neutrophil to high-density lipoprotein ratio (NHR),neutrophil to lymphocyte ratio (NLR),and monocyte to high-density lipoprotein ratio (MHR) on the prediction of PD and its course and severity.Methods: Patients with Parkinson's disease were selected (n=101) and divided into three groups according to the onset cycle:<6 years (n=64),6-10 years (n=23) and > 10 years(n=14).And according to Hoehn and Yahr classification: 1~2.5 is the early stage (n=55);Grades 3~5 are divided into two groups (n=46).In addition, healthy subjects (n=97) matched with the above pd patients in the same period were selected as the control group.In this way, the influence of NHR, NLR, MHR and other indicators on corresponding groups is evaluated.Results: Neutrophils, NHR and NLR in PD group were significantly higher than those in control group. nevertheless, lymphocyte, total cholesterol, low density lipoprotein and hemoglobin were significantly lower than those in the control group. Multi-factor logistic regression analysis indicated that NHR (odds ratio (OR)=1.456,95%CI:1.007~2.104,P=0.046) and NLR(OR=1.663,95%CI:1.101~2.513,P=0.016) were risk factors for Parkinson's disease, while MHR had no significant correlation with Parkinson's disease. The AUC(area under the ROC curve) of PD predicted by NHR and NLR were 0.648(95%CI:0.572~0.724,P=0.0003) and 0.718 (95%CI:0.646~0.790,P<0.0001),respectively, and the critical values for optimal diagnosis were3.104×109/mmol and 1.939×109/mmol. Spearman analysis showed that NHR was significantly negatively correlated with the course of disease.Conclusions: In summary, NHR not only has strong predictive value for PD disease, but also is closely related to the course of disease. NHR levels may be better predictors of long-term clinical outcomes in PD patients than MHR and NLR.