scholarly journals Compared with the monocyte to high-density lipoprotein ratio (MHR) and the neutrophil to lymphocyte ratio (NLR), the neutrophil to high-density lipoprotein ratio (NHR) is more valuable for assessing the inflammatory process in Parkinson’s disease

2021 ◽  
Vol 20 (1) ◽  
Author(s):  
Zhu Liu ◽  
Qingli Fan ◽  
Shizheng Wu ◽  
Yaqi Wan ◽  
Yancheng Lei
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
High Density Lipoprotein ◽  
Predictive Value ◽  
Disease Duration ◽  
Density Lipoprotein ◽  
High Density ◽  
Neutrophil To Lymphocyte Ratio ◽  
Control Group ◽  
Lymphocyte Ratio

Abstract Background The inflammatory response plays essential roles in the pathological process and prognosis of Parkinson’s disease (PD). This research investigated the predictive value of the neutrophil to high-density lipoprotein ratio (NHR), neutrophil to lymphocyte ratio (NLR), and monocyte to high-density lipoprotein ratio (MHR) for PD. Methods Patients with PD (n = 98) were divided into three groups according to disease duration: < 6 years (n = 55), 6–10 years (n = 29) and > 10 years (n = 14). Based on the classification system of Hoehn and Yahr, grades 1 ~ 2.5 were considered early-stage PD (n = 44), and grades 3 ~ 5 were considered advanced-stage PD (n = 54). In addition, healthy subjects (n = 98) matched to the above PD patients in the same period were selected as the control group. Differences in the NHR, NLR, MHR and other indicators among the groups were evaluated. Results Smoking, drinking, the neutrophil count and the NHR and NLR were remarkably greater and hypertension, index of body mass, the lymphocyte count, and the levels of cholesterol in total, triglycerides, lipoprotein cholesterol with low density and uric acid were sharply lower in the PD group compared with in the control group. Analysis of multifactor logistic regression indicated that the NHR (odds ratio (adjusted OR) = 1.576, 95% CI: 1.053 ~ 2.358, P = 0.027) and NLR (adjusted OR = 1.734, 95% CI: 1.046 ~ 2.876, P = 0.033) were factors of risk for PD, while the MHR was not significantly correlated with PD. The areas under the receiver operating characteristic (ROC) curve (AUCs) for the prediction of PD by the NHR and NLR were 0.654 (95% CI: 0.583 ~ 0.721, P = 0.0001) and 0.69 (95% CI: 0.62 ~ 0.754, P < 0.0001), respectively, and the optimal cutoff values were 1.848 × 109/mmol and 2.62 × 109/mmol. Spearman’s correlation analysis indicated that the NHR was correlated with the disease duration significantly negatively and that the MHR was positively correlated with disease severity. Conclusions In summary, the NHR not only has strong predictive value for PD but is also closely related to disease duration. The NHR may be a better prediction for the long-period clinical results in PD patients than the MHR and NLR. Trial registration Clinical medical reserach center project of Qinghai Province (2017-SF-L1).

scholarly journals Compared with Monocyte to High-Density Lipoprotein Ratio (MHR) and Neutrophil to Lymphocyte Ratio (NLR),Neutrophil to High-Density Lipoprotein Ratio (NHR) is more Valuable in the Inflammatory Process of Parkinson's Disease

2021 ◽  
Author(s):  
Qingli Fan ◽  
Zhu Liu ◽  
Shizheng Wu ◽  
Yancheng Lei
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
High Density Lipoprotein ◽  
Early Stage ◽  
Density Lipoprotein ◽  
High Density ◽  
Neutrophil To Lymphocyte Ratio ◽  
Control Group ◽  
Course Of Disease ◽  
Lymphocyte Ratio

Abstract Background: Inflammatory response plays an important role in the pathologic process and prognosis of Parkinson's disease (PD).We investigated the relationship between the neutrophil to high-density lipoprotein ratio (NHR),neutrophil to lymphocyte ratio (NLR),and monocyte to high-density lipoprotein ratio (MHR) on the prediction of PD and its course and severity.Methods: Patients with Parkinson's disease were selected (n=101) and divided into three groups according to the onset cycle:<6 years (n=64),6-10 years (n=23) and > 10 years(n=14).And according to Hoehn and Yahr classification: 1~2.5 is the early stage (n=55);Grades 3~5 are divided into two groups (n=46).In addition, healthy subjects (n=97) matched with the above pd patients in the same period were selected as the control group.In this way, the influence of NHR, NLR, MHR and other indicators on corresponding groups is evaluated.Results: Neutrophils, NHR and NLR in PD group were significantly higher than those in control group. nevertheless, lymphocyte, total cholesterol, low density lipoprotein and hemoglobin were significantly lower than those in the control group. Multi-factor logistic regression analysis indicated that NHR (odds ratio (OR)=1.456,95%CI:1.007~2.104,P=0.046) and NLR(OR=1.663,95%CI:1.101~2.513,P=0.016) were risk factors for Parkinson's disease, while MHR had no significant correlation with Parkinson's disease. The AUC(area under the ROC curve) of PD predicted by NHR and NLR were 0.648(95%CI:0.572~0.724,P=0.0003) and 0.718 (95%CI:0.646~0.790,P<0.0001),respectively, and the critical values for optimal diagnosis were3.104×109/mmol and 1.939×109/mmol. Spearman analysis showed that NHR was significantly negatively correlated with the course of disease.Conclusions: In summary, NHR not only has strong predictive value for PD disease, but also is closely related to the course of disease. NHR levels may be better predictors of long-term clinical outcomes in PD patients than MHR and NLR.

Prognostic Value of Platelet-Lymphocyte Ratio and High-Density Lipoprotein in Patients with Acute Myocardial Infarct

2021 ◽  
Vol 28 (1) ◽  
pp. 46
Author(s):  
Lestari Lestari ◽  
Sulina Yanti Wibawa ◽  
Amaliyah Tahir Lopa ◽  
Darmawaty Rauf
Keyword(s):  
High Density Lipoprotein ◽  
Predictive Value ◽  
Prognostic Value ◽  
Myocardial Infarct ◽  
Density Lipoprotein ◽  
High Density ◽  
Receiver Operating Characteristics ◽  
Operating Characteristics ◽  
Acute Myocardial Infarct ◽  
Lymphocyte Ratio

Acute Myocardial Infarct (AMI) is the main reason for mortality. Platelet to Lymphocyte Ratio (PLR) describesthrombocyte aggregation and inflammation that is linked to cardiovascular disease. High-Density Lipoprotein (HDL) is antiatherogenic.This study aims to analyze the prognostic value of PLR and HDL in patients with AMI. This study was aretrospective observational study by obtaining laboratory results from complete blood count and lipid profiles frominpatients with AMI (STEMI and NSTEMI) medical records during Mei 2019–August 2020. Receiver Operating Characteristics(ROC) analysis was done to get the PLR and HDL cut-off. Prognostic value evaluation was based on sensitivity, specificity,positive and negative predictive value, and accuracy. Results obtained were from 302 subjects with a mean age of 58.4+9.6years old, with most male patients (74.5%). Receiver operating characteristics curve analysis showed an 0.514 Area UnderCurve (AUC) for PLR with p=0.685. High-density lipoprotein ROC was 0.573 with a p=0.033 (p< 0.05), with HDL cut-off = 50.0;sensitivity 72.7%, specificity 32.3%, positive predictive value 63.3%, negative predictive value 42.0% and 57.3% accuracy.Platelet to lymphocyte ratio mean was lower in the HDL <50 group (187.9) compared to the HDL > 50 (210.8), (p=0.009).High-density lipoprotein can be concluded as a potential prognostic factor of acute myocardial infarct. The lower the HDL,the greater the risk for a poor prognosis. A big-scale prospective study should be held to clarify and confirm these findings.

scholarly journals Effect of fatty Amazon fish consumption on lipid metabolism

2014 ◽  
Vol 27 (1) ◽  
pp. 97-105 ◽  
Author(s):  
Francisca das Chagas do Amaral Souza ◽  
Nadja Pinto Garcia ◽  
Rejane Souza de Aquino Sales ◽  
Jaime Paiva Lopes Aguiar ◽  
Wallice Luiz Paxiúba Duncan ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
High Density Lipoprotein ◽  
High Density Lipoprotein Cholesterol ◽  
Amazon Basin ◽  
Density Lipoprotein ◽  
High Density ◽  
Lipoprotein Cholesterol ◽  
Control Group ◽  
Fatty Fish ◽  
Serum Triglycerides

OBJECTIVE: The present study aimed to evaluate the effect of feeding diets enriched with fatty fish from the Amazon basin on lipid metabolism. METHODS: Male Wistar rats were divided into four groups: control group treated with commercial chow; Mapará group was fed diet enriched with Hypophthalmus edentatus; Matrinxã group was fed diet enriched with Brycon spp.; and, Tambaqui group was fed diet enriched with Colossoma macropomum. Rats with approximately 240g±0.60 of body weight were fed ad libitum for 30 days, and then were sacrificed for collection of whole blood and tissues. RESULTS: The groups treated with enriched diets showed a significant reduction in body mass and lipogenesis in the epididymal and retroperitoneal adipose tissues and carcass when compared with the control group. However, lipogenesis in the liver showed an increase in Matrinxã group compared with the others groups. The levels of serum triglycerides in the treated groups with Amazonian fish were significantly lower than those of the control group. Moreover, total cholesterol concentration only decreased in the group Matrinxã. High Density Lipoprotein cholesterol levels increased significantly in the Mapará and Tambaqui compared with control group and Matrinxã group. The insulin and leptin levels increased significantly in all treatment groups. CONCLUSION: This study demonstrated that diets enriched with fatty fish from the Amazon basin changed the lipid metabolism by reducing serum triglycerides and increasing high density lipoprotein-cholesterol in rats fed with diets enriched with Mapará, Matrinxã, and Tambaqui.

scholarly journals Effect of Some Strains of Lactic Acid Bacteria and Their Mixture on the Level of Fats and Cholesterol in Albino Rats (Rattus norvegicus) Male with Hypothyroidism Induced Using Carbimazole

2021 ◽  
Vol 34 (1) ◽  
pp. 139-146
Author(s):  
Elham K. Nasser ◽  
Kithar R. Majeed ◽  
Hayder I. Ali
Keyword(s):  
High Density Lipoprotein ◽  
Low Density Lipoprotein ◽  
Control Sample ◽  
Density Lipoprotein ◽  
High Density ◽  
Control Group ◽  
Albino Rats ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Fortified Milk

Fortified milk containing Lactobacillus plantarum, L. casei, and L. acidophilus isolates and their mixture were used in dosing the male albino rats at an age of 9-12 weeks at an average of 23 g with induced hypothyroidism at a concentration of 0.6 g.kg-1 of carbimazole. Total cholesterol, triglycerides, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL) were estimated. The results showed a significant increase in the level of triglycerides (TG), cholesterol and triglycerides. Low-density lipoprotein (LDL) and very-low-density lipoprotein (VLDL), with a significant decrease in the level of high-density lipoprotein (HDL) in infected male mice, compared to the control sample, and upon dosing with liquid milk fortified, it returned to its normal level without significant differences from the control group.

l-Carnitine-induced amelioration of HFD-induced hepatic dysfunction is accompanied by a reduction in hepatic TNF-α and TGF-β1

2018 ◽  
Vol 96 (6) ◽  
pp. 713-725 ◽  
Author(s):  
Mabrouk Attia Abd Eldaim ◽  
Fatma Mohamed Ibrahim ◽  
Saher Hassan Orabi ◽  
Azza Hassan ◽  
Hesham Saad El Sabagh
Keyword(s):  
Protein Expression ◽  
High Density Lipoprotein ◽  
Body Mass ◽  
Density Lipoprotein ◽  
Basal Diet ◽  
Serum Levels ◽  
High Density ◽  
Control Group ◽  
Tnf Α ◽  
Tgf Β1

In this study, we evaluated the possible mechanisms through which l-carnitine ameliorates the adverse effects from obesity in rats, induced with a high-fat diet (HFD). For this, 56 albino Wister rats were randomly assigned to 7 groups. The control group was fed a basal diet and injected with saline. The second group was fed the basal diet and injected with l-carnitine (200 mg/kg body mass, by intraperitoneal injection; i.p.). The third group were fed the HFD. The fourth group was fed the HFD and injected with l-carnitine (200 mg/kg body mass, i.p.) for 8 weeks. The fifth group was fed the HFD for 10 weeks. The sixth group were fed the HFD for 10 weeks and were also injected with l-carnitine (200 mg/kg body mass, i.p.) during the final 2 weeks. The seventh group was fed the HFD diet for 8 weeks then the basal diet for 2 weeks. The HFD induced significantly increased levels of hyperglycemia, lipid peroxidation, pathological changes, TNF-α and TGF-β1 protein expression in hepatic tissue, food intake, body weight gain, serum levels of total and non-high-density lipoprotein cholesterol, ketone bodies, triacylglycerol, urea, creatinine, AST, and ALT. However, the HFD diet significantly decreased serum levels of high-density lipoprotein (HDL) and hepatic levels of reduced glutathione. l-Carnitine ameliorated the effects of the HFD on the above-mentioned parameters. This study indicated that l-carnitine had protective and curative effects against HFD-induced hepatosteatosis by reducing hepatic oxidative stress and protein expression of TNF-α and TGF-β1.

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