scholarly journals Association of p-phenylenediamine exposure with alterations of pulmonary function, pruritus and health-related quality of life in hair dye manufacturer workers: a cross-sectional study

2020 ◽  
Author(s):  
ming zhang ◽  
Lin Fan ◽  
Meibian Zhang ◽  
Baofeng Liu ◽  
Qiang Zeng

Abstract Background p -Phenylenediamine (PPD) is a common component of hair dye, indicating the clinical characteristics of skin contact allergy and asthma with impaired pulmonary function. Howerver the adverse effects of PPD occupational exposure was rarely mentioned. The purpose of this study was to explore the PPD-induced pulmonary function, pruritus and health-related quality of life (HRQOL) of industrial workers of hair dye. Methods We recruited 124 workers from a hair dye manufacturer exposed to PPD. Individual PPD exposure and pulmonary function of workers were measured. The quality of life and subjective pruritus of workers was also assessed by SF-36 and VAS of pruritus, respectively. Results In the high PPD-exposed group, FVC% (percentage of forced vital capacity) was higher, while FEV1/FVC% (ratio percentage of forced expiratory volume) was lower than that in the low PPD-exposed group ( P <0.05). In terms of the HRQOL, the scores of mental health and vitality of the high PPD-exposed group were the lowest of all groups ( P <0.05), while the score of VAS was significantly higher than that of other two groups ( P <0.001). PPD levels were negatively correlated with vitality and mental health ( P <0.01). Higher PPD exposure level was correlated with a significantly higher VAS level (OR 9.394; 95%CI: 1.710, 51.622; P =0.010). The structural equation model provided a good fit to the data (χ2/df =1.607, GFI =0.901, AGFI =0.934, RMSEA =0.007, IFI =0.977, CFI =0.960, PGFI =0.615). And showed that PPD exposed level have positive effects on VAS level (β = 0.213, P <0.001). Then PPD exposed level partly via lack total score of SF-36 (β = -0.465, P =0.002); on negative effects on VAR level (β = -0.110, P <0.001). Conclusion Occupational PPD exposure might be associated with pulmonary function impairment, poor HRQOL, and subjective pruritus of workers.

2007 ◽  
Vol 13 (8) ◽  
pp. 1038-1045 ◽  
Author(s):  
K.V.L. Turpin ◽  
L.J. Carroll ◽  
J.D. Cassidy ◽  
W.J. Hader

Baseline data from a population-based study examining the health-related quality of life (HRQL) of MS patients about to begin disease modifying therapy was used to determine the factors associated with the HRQL of Saskatchewan adults with relapsing-remitting MS. Participants completed a self-report questionnaire regarding demographic and socioeconomic status, fatigue, comorbid medical conditions, disability level (EDSS), number of attacks in past 6 months, illness intrusiveness (Illness Intrusiveness Ratings Scale), depression (Beck Depression Inventory), and HRQL (SF-36 Health Status Survey). Multiple linear regression models were used to identify the factors associated with the physical and mental health summary scores of the SF-36. We found poorer physical HRQL in those who are female; older; not working; have musculoskeletal or respiratory problems; greater fatigue, higher disability scores, and more MS attacks. High illness intrusiveness; digestive system problems; genitourinary problems; and headaches were associated with poorer mental HRQL. Interestingly, we found an interaction between sex and age in mental HRQL, with worse mental health in older men but better mental health in older women. These findings may assist health care providers in identifying patients who may be at risk for decline in their HRQL, permitting appropriate and timely interventions. Multiple Sclerosis 2007; 13: 1038—1045. http://msj.sagepub.com


2012 ◽  
Vol 20 (2) ◽  
pp. 346-353 ◽  
Author(s):  
Lígia da Silva Leroy ◽  
Maria Helena Baena de Moraes Lopes

This case-control study evaluated whether UI in the puerperium compromises the health-related quality of life (HRQoL) and if so, in which aspects. The study included 344 women (77 case group and 267 control group) up to 90 days postpartum, who were attended the Obstetrics Outpatient Clinic of a public teaching hospital, for the postpartum follow up consultation. A socio-demographic and clinical data questionnaire formulated and validated for the study, the International Consultation on Incontinence Questionnaire - Short-Form (ICIQ-SF), the King's Health Questionnaire (KHQ) and the Medical Outcomes Study 36 - Item Short Form Health Survey (SF-36), were applied. The mean score of the ICIQ-SF was 13.9 (SD: 3.7). The case group presented high mean scores in the domains Impact of the Incontinence, Emotions, Daily Activity Limitations and Physical Limitations, of the KHQ. The groups differed significantly in the domains Physical Aspects, Pain, General Health Status, Vitality, Social Aspects and Mental Health of the SF-36. It is concluded that UI significantly affects the physical and mental health of puerperae.


2015 ◽  
Vol 24 (2) ◽  
pp. 199-207
Author(s):  
Md Azharul Islam ◽  
Mst Adiba Akter

This study explored health related quality of life (HRQoL) of substance users (SUs) in Bangladesh in comparison with healthy control groups (CGs). Additionally, role of self esteem and sex on HRQoL was investigated. A trained assistant counselling psychologist measured HRQoL and self‐esteem of 120 SUs and 120 CGs using SF‐36 questionnaire and Rosenberg Self Esteem scale, respectively. SUs were mostly male (79.2%) from middle socioeconomic class (94%). SUs scored poorer in all domains of SF‐36 than the CGs. The magnitude of the effect size was largest for the role physical (effect size = –0.79), general mental health (effect size = –0.76) and social functioning (effect size = –0.73) subscale. Overall mental health was lower than physical health (effect size = –0.897). Males in both groups were better in four sub‐scales while females reported less role limitation due to physical and emotional problems. Self esteem moderated HRQoL of both group with slightly higher magnitude for SUs. HRQoL of SU of Bangladesh was lower than the study population. Dhaka Univ. J. Biol. Sci. 24(2): 199-207, 2015 (July)


2021 ◽  
Author(s):  
Xinping Li ◽  
Yi Chen ◽  
Shuangchun Liu ◽  
Mingsheng Zhang

Abstract Background Understanding the determinants of quality of life for the patients after lung resection would be beneficial to affect the prevention programs and the treatment strategies. This novel study aims to explore the relationship between pulmonary function, physical activity, cardiorespiratory fitness (CRF), dyspnea, and the health-related quality of life (HRQoL) of patients with resected lung cancer. Methods A cross-sectional study design with 38 lung cancer survivors after surgery for one month was conducted. We assessed CRF by measuring maximal oxygen consumption (VO2max) and anaerobic threshold (VT).Forced vital capacity (FVC) was measured using a spirometer. Physical activity, dyspnea, and HRQoLwereinvestigated by 6-minute walking distance (6MWD), Borg dyspnea scales, and the SF-36 Health Survey (SF-36), respectively.Data analyses were conducted using SmartPLS to examine path analyses between the measures. Results There was a significant relationship between CRF andHRQoL in this cohort of cancer survivors.FVC (f2 = 0.265) and 6MWD (f2 = 0.389) have a medium to large effect size on the perceived CRF while CRF (f2 = 0.467) was found to have large effect sizes on perceived QoL. More importantly, our results showed that CRF positively and significantly mediated the paths betweenFVC, 6MWD, andHRQoL[β = 0.22 (0.457*0.474),P < 0.01; β = 0.28 (0.525*0.540), P < 0.01; respectively]. Conclusions Pulmonary function, physical activity, and dyspnea had an indirect effect on the quality of life in patients with resected lung cancer. Furthermore, CRF mediates pulmonary function and physical activity to produces an impact on their quality of life.


2021 ◽  
Author(s):  
Xinping Li ◽  
Yi Chen ◽  
Shuangchun Liu ◽  
Mingsheng Zhang

Abstract Purpose This novel study aims to explore the relationship between pulmonary function, physical activity, cardiorespiratory fitness (CRF), dyspnea, and the health-related quality of life (HRQoL) of patients with resected lung cancer. Methods A cross-sectional study design with 38 lung cancer survivors after surgery for one month was conducted. We assessed CRF by measuring maximal oxygen consumption (VO2max) and anaerobic threshold (VT). Forced vital capacity (FVC) was measured using a spirometer. Physical activity, dyspnea, and HRQoL were investigated by 6-minute walking distance (6MWD), Borg dyspnea scales, and the SF-36 Health Survey (SF-36), respectively. Data analyses were conducted using SmartPLS to examine path analyses between the measures. Results There was a significant relationship between CRF and HRQoL in this cohort of cancer survivors. FVC (f2 = 0.265) and 6MWD (f2 = 0.389) have a medium to large effect size on the perceived CRF while CRF (f2 = 0.467) was found to have large effect sizes on perceived QoL. More importantly, our results showed that CRF positively and significantly mediated the paths between FVC, 6MWD, and HRQoL [β = 0.22 (0.457*0.474),P < 0.01; β = 0.28 (0.525*0.540), P < 0.01; respectively]. Conclusions Pulmonary function, physical activity, and dyspnea had an indirect effect on the quality of life in patients with resected lung cancer. Furthermore, CRF mediates pulmonary function and physical activity to produce an impact on their quality of life.


2018 ◽  
Vol 73 (1) ◽  
pp. 65-72 ◽  
Author(s):  
Anne-Caroline Clause-Verdreau ◽  
Étienne Audureau ◽  
Alain Leplège ◽  
Joël Coste

BackgroundInterest in monitoring health-related quality of life (HRQoL) in general populations has increased in the past 20 years, reinforced by population ageing and repeated economic crises. This study aims to identify temporal trends in HRQoL in France between 1995 and 2016 and to assess disparities according to demographic and socioeconomic characteristics.MethodsData from repeated population-based cross-sectional surveys conducted in 1995, 2003 and 2016 were used. HRQoL was measured using the Medical Outcomes Study 36-item Short Form (SF-36) questionnaire.ResultsA substantial decrease in score was observed between 1995 and 2016 for both genders in almost all subscales of the SF-36, with the largest decrease being in the mental health dimension for men. However, the age group 18–54 years were the most affected with persistent negative or even worsening trends in HRQoL. The largest decreases were among men aged 45–54 years and women aged 35–44 years in most dimensions, and among the age group 18–24 years in vitality. Conversely, an overall improvement was noted among the age group 65–84 years. People in employment were more affected than the unemployed by the decline in several HRQoL dimensions.ConclusionA general decline in HRQoL was found between 1995 and 2016 in the French population, but with wide disparities in trends between age groups. Young and especially middle-aged, employed people exhibited persistent negative and worsening trends. Consistent with evidence from traditional mental health morbidity and mortality indicators, our findings raise questions about the potential influence of macro-socioeconomic factors, especially the 2008 crisis; these observations deserve special attention from health policy-makers.


Author(s):  
Rama Krishna Prudhivi ◽  
Shaik Ayesha ◽  
Promod Giri ◽  
Anuradha .

End stage renal disease is the final stage of chronic kidney disease in which the kidneys longer function well enough to meet needs of life. The treatments for ESRD are dialysis or kidney transplant. Hemodialysis (HD) is the most common type of dialysis which can cause significant impairment in health related quality of life (HRQOL) and outcomes. The aim of the present study was to learn about the quality of life in patients receiving dialysis treatment and to evaluate the influence of various factors associated with poor HRQOL. In addition, this study compares SF-36 scores of various domains between survival and deceased patients. The study was a prospective observational, analytical study, conducted for 7 months in IPD/OPD of Dialysis Department at Sagar Hospitals, Bengaluru. The validated and authorized health related quality of life questionnaire (RAND SF-36) consists of 36 questions measuring physical and mental health status was used. Statistical significance of differences in physical component summary and mental component summary was calculated by using Kruskal-Wallis test and the Mann-Whitney U test. A total of 126 patients meeting the study criteria participated and completed the study. Overall, 85(67%) were male and the mean ± standard deviation age was 58.10± 11.38 years. Both PCS and MCS scores have significant negative association with age, total number of chronic medications and the total number of chronic co-morbid diseases. Among eight scales of SF-36, Bodily Pain (BP), Physical Function (PF), Role limitation due to Physical health (RP) and Vitality scores were significantly higher in surviving patients when compared to that of deceased patients respectively. Our study showed that important variables like PF, BP, RP and VT scores can be taken into consideration when dealing with hemodialysis patients. Healthcare providers should be aware of poor physical health as well as mental health among female gender, elderly patients, unemployed patients, patients with no formal education, multiple co-morbid diseases, and multiple chronic medications to improve their quality of life. 


2020 ◽  
Vol 103 (11) ◽  
pp. 1185-1193

Background: The systemic lupus erythematosus (SLE) patients oftentimes suffer from both physical and psychosocial challenges that may lead to low health-related quality of life (HRQoL). However, limited research has been done in this area. Objective: To examined mental health status and HRQoL among SLE patients in Thailand. Materials and Methods: The present study was a cross-sectional study conducted at the rheumatology clinic of four major hospitals in Thailand. The paper-based questionnaire consisted of demographic, health history such as depression, anxiety, stress Scale (DASS-21), and the Rosenberg self-esteem scale (RSE), and the disease-specific Lupus Quality of Life scale (LupusQoL). Depending on the variable’s level of measurement such as categorical or continuous, Spearman’s Rho or Pearson’s product moment correlation coefficients were used to explore the relationships among the variables. Hierarchical multiple regression was used to identify the predictors of LupusQoL. Results: Among the 387 participants, many might have experienced depression, anxiety, and stress (30%, 51%, and 29%, respectively). Self-esteem among the participants was good (31.8 out of 40). All eight domains of LupusQoL were affected with intimate relationship domain being impacted the most. The overall LupusQoL was significantly associated with the number of prescribed medications (r=–0.23), depression (r=–0.70), anxiety (r=–0.58), stress (r=–0.67), and self-esteem (r=0.59), p<0.001. Significant predictors of the overall LupusQoL were mental health status (depression, anxiety, and stress) and self-esteem, F (3, 81)=43.10, p<0.001, adjusted R²=0.60. Conclusion: SLE patients should be holistically assessed in both physical and psychological aspects. In addition to proper medical treatments, healthcare providers should use a multidisciplinary team approach to resolve the patients’ psychosocial issues, which in turn, may increase the patients’ quality of life. Self-care education may be necessary to help the patients manage the condition and decrease the number of medications. Keywords: Mental health, Quality of life, SLE, Thailand


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