scholarly journals Zak Gene֝s Expression in Patients With Helicobacter Pylori Infection

2021 ◽  
Author(s):  
Delniya Khani ◽  
Manouchehr Ahmadi Hedayati ◽  
Farshad Sheikhesmaeili ◽  
Roghaie Ghadiany ◽  
Sherko Nasseri
Keyword(s):  
Gene Expression ◽  
Gastric Cancer ◽  
Cell Cycle ◽  
Helicobacter Pylori ◽  
Gastric Adenocarcinoma ◽  
Case Control Study ◽  
Case Control ◽  
Rt Pcr ◽  
H Pylori ◽  
Control Study

Abstract Background: ZAK protein is a member of the MLK family proteins defined as mediators in the cell cycle. A survey of zak gene expression in gastric antral epithelial cells (GAECs) of gastritis and gastric adenocarcinoma patients with Helicobacter pylori genotypes infection can elucidate carcinogenesis of H. pylori genotypes.Methods: In a case-control study, zak gene expression was evaluated in GAECs biopsy samples of gastritis patients with (n 23) and without H. pylori infection (n 27) and gastric adenocarcinoma patients with (n 21) and without (n 32) H. pylori infection. The zak gene expression was measured using the relative Real-Time RT PCR.Results: zak gene expression was higher in GAECs of gastritis cancer than in gastric adenocarcinoma, indicating the protective effect of ZAK against gastric cancer (p< 0.005). Conclusion: Reducing zak gene expression has the negative corelations with H. pylori infection and gastric adenocarcinoma.

Ethnicity and H. Pylori as Risk Factors for Gastric Cancer in Malaysia: A Prospective Case Control Study

2007 ◽  
Vol 102 (1) ◽  
pp. 40-45 ◽  
Author(s):  
Khean-Lee Goh ◽  
Phaik-Leng Cheah ◽  
Noorfaridah Md ◽  
Kia-Fatt Quek ◽  
Navaratnam Parasakthi
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Case Control Study ◽  
Case Control ◽  
H Pylori ◽  
Control Study ◽  
Prospective Case Control Study

Su1854 Association of TP53 Arg72pro Variants With Gastric Cancer Risk in Helicobacter pylori Infected Subjects: A Nation-Wide Case-Control Study in Spain

2012 ◽  
Vol 142 (5) ◽  
pp. S-519 ◽  
Author(s):  
Maria Asuncion Garcia-Gonzalez ◽  
Enrique Quintero ◽  
Luis Bujanda ◽  
David Nicolás-Pérez ◽  
Rafael Benito ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Gastric Cancer Risk ◽  
Tp53 Arg72pro ◽  
Control Study

scholarly journals The Association between dietary total antioxidant capacity with the risk of helicobacter pylori infection among adult: a case–control study

2020 ◽  
Author(s):  
Mohammadhassan Sohouli ◽  
Niloufar Haghshenas ◽  
Somaye Fatahi
Keyword(s):  
Helicobacter Pylori ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Case Control Study ◽  
Case Control ◽  
Antioxidant Power ◽  
Total Antioxidant ◽  
H Pylori ◽  
Control Study ◽  
Dietary Total Antioxidant Capacity

Abstract Background Dietary total antioxidant capacity (DTAC) has been assumed as a useful tool to assess the relationship between the cumulative antioxidant food capacity and several chronic disorders. The aim of this study was to evaluate the association between DTAC and risk of Helicobacter pylori in a case-control study.Methods This case-control study was carried out among 150 patients with Helicobacter pylori and 302 healthy subjects aged 18–55 years. Dietary data were collected using a validated 168- items quantitative food frequency questionnaire. DTAC was calculated based on the ferric reducing-antioxidant power (FRAP) values that reported by US Department of Agriculture. Results The mean age and BMI of the study participants were 38.70 years and 25.86, respectively. Compared with control subjects, participants with H pylori significantly were older and had higher BMI and smoking use. Patients with H pylori compared with control individuals had also lower intake of total fiber, vitamin E, vitamin C, vitamin D, total dairy, whole grain and vegetables. Compared with participants in the lowest tertile of DTAC, those in the highest terrtile had a significantly lower OR for H pylori after further adjustment for potential confounders (Model 2: OR, 0.20; 95% CI, 0.10 – 0.40; P for trend, < 0.001).Conclusions Our findings showed that a high DTAC was associated with a reduced risk of Helicobacter pylori in adult, which reflects the increased intake of natural dietary antioxidants to prevent the progression of Helicobacter pylori. However, further studies are needed to investigate the t relation between DTAC and risk of Helicobacter pylori.

scholarly journals Helicobacter pylori infection among type 2 diabetics: a case control study

2020 ◽  
Vol 8 (3) ◽  
pp. 1047
Author(s):  
Hafiz Qazi Muhammad Amir ◽  
Omaila Ikram ◽  
Muhammad Tayyab Zia ◽  
Fareha Kashan Theba ◽  
Naila Ikram ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Case Control Study ◽  
Case Control ◽  
Helicobacter Pylori Infection ◽  
P Value ◽  
Type 2 Diabetics ◽  
Dyspeptic Symptoms ◽  
H Pylori ◽  
Control Study

Background: Helicobacter pylori infection has been associated with hyperglycemia among type 2 diabetics. The objective of this study was to compare the H. pylori infection frequency in diabetic and non-diabetic patients.Methods: This case-control study was done at Al-Tibri Medical College and Hospital from May 2019 to August 2019. After written and informed consent, patients between 18-75 years with epigastric burning, dyspepsia, regurgitation were included and with history of eradication therapy, antibiotic or NSAID use in the last 6 months or surgery of upper GI tract months were excluded. Type 2 diabetics were placed in one group and non-diabetic individuals in another. Both groups were compared for presence of H. pylori infection. Data was analysed using SPSS. Demographic variables included age, gender and status of H. pylori infection. Quantitative data was expressed as frequency and percentages. Chi-square test was applied to test for significance keeping p-value of <0.05 statistically significant.Results: From 480 patients, 355 patients showed positive H. pylori, among them 282 were diabetic and 73 non-diabetic (p-value <0.001). Amongst the 355 diabetics, 55% were male Among 73 non-diabetics, 64% were male. All the patients in the study had dyspeptic symptoms and complained of dyspepsia, epigastric burning and regurgitation.Conclusions: A substantial relationship between H. pylori infection among type 2 diabetes mellitus patients was observed compared to non-diabetics. As a result, diabetic patients having active dyspeptic symptoms should undergo further confirmatory tests for diagnosing H. pylori infection.

scholarly journals The Association between dietary total antioxidant capacity with the risk of helicobacter pylori infection among adult: a case–control study

2020 ◽  
Author(s):  
Mohammadhassan Sohouli ◽  
Niloufar Haghshenas ◽  
Somaye Fatahi
Keyword(s):  
Helicobacter Pylori ◽  
Antioxidant Capacity ◽  
Total Antioxidant Capacity ◽  
Case Control Study ◽  
Case Control ◽  
Antioxidant Power ◽  
Total Antioxidant ◽  
H Pylori ◽  
Control Study ◽  
Dietary Total Antioxidant Capacity

Abstract Objective Dietary total antioxidant capacity (TAC) has been assumed as a useful tool to assess the relationship between the cumulative antioxidant food capacity and several chronic disorders. The aim of this study was to evaluate the association between DTAC and risk of Helicobacter pylori in a case-control study. Methods This case-control study was carried out among 150 patients with Helicobacter pylori and 302 healthy subjects aged 18–55 years. Dietary data were collected using a validated 168- items quantitative food frequency questionnaire. DTAC was calculated based on the ferric reducing-antioxidant power (FRAP) values that reported by US Department of Agriculture. Results The mean age and BMI of the study participants were 38.70 years and 25.86, respectively. Compared with control subjects, participants with H pylori significantly were older and had higher BMI and smoking use. Patients with H pylori compared with control individuals had also lower intake of total fiber, vitamin E, vitamin C, vitamin D, total dairy, whole grain and vegetables. Compared with participants in the lowest tertile of DTAC, those in the highest terrtile had a significantly lower OR for H pylori after further adjustment for potential confounders (Model 2: OR, 0.20; 95% CI, 0.10–0.40; P for trend, < 0.001). Conclusions Our findings showed that a high DTAC was associated with a reduced risk of Helicobacter pylori in adult, which reflects the increased intake of natural dietary antioxidants to prevent the progression of Helicobacter pylori. However, further studies are needed to investigate the t relation between DTAC and risk of Helicobacter pylori.

scholarly journals Helicobacter pylori serological biomarkers of gastric cancer risk in the MCC-Spain case-control Study

2017 ◽  
Vol 50 ◽  
pp. 76-84 ◽  
Author(s):  
Nerea Fernández de Larrea-Baz ◽  
Beatriz Pérez-Gómez ◽  
Angelika Michel ◽  
Beatriz Romero ◽  
Virginia Lope ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Helicobacter Pylori ◽  
Cancer Risk ◽  
Case Control Study ◽  
Case Control ◽  
Gastric Cancer Risk ◽  
Serological Biomarkers ◽  
Control Study
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