scholarly journals Promoter Methylation Changes in the Placental DIO3 and CRH Genes Are Involved in the Second Trimester Maternal Depression Induced Preterm Birth and Small for Gestational Age Birth

2021 ◽  
Author(s):  
Jianhui Yang ◽  
Yumin Zhang ◽  
Jiahui Deng ◽  
Xuemei Lin ◽  
Lili Xie ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Birth ◽  
Pregnant Women ◽  
Maternal Depression ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Depression Scale ◽  
Hypertensive Disorder ◽  
Second Trimester ◽  
Promoter Regions

Abstract Background Recent studies suggest that the incidence of preterm birth and SGA birth related to maternal depression, but the mechanism is unclear. The aim of this study was to explore the placental epigenetic changes involved in maternal depression induced preterm birth and small for gestational age birth. Methods Three hundred forty-five pregnant women were enrolled in this cohort study. Maternal depression in the second and third trimesters was assessed using a self-rating depression scale (SDS). We selected placental samples from pregnant women with depression and an equivalent number for samples from pregnant women without depression. Methylation of the promoter regions of the placental DIO3 and CRH genes was determined using next generation sequencing based on bisulfite sequencing PCR (NGS-BSP). Results There were 97 (28.1%) and 95 (27.5%) pregnant women who had depression in the second trimester and third trimester, respectively. The risk factors of preterm birth were older maternal age (RR = 1.43, 95%CI = 1.01–2.03), uterine infection (RR = 129.31, 95%CI = 2.16-7725.55), and maternal depression in the second trimester (RR = 79.97, 95%CI = 3.57-1792.56). The risk factors of SGA birth were low maternal BMI (RR = 0.71, 95%CI = 0.54ཞ0.92), hypertensive disorder complicating pregnancy (HDCP, RR = 4.7, 95%CI = 1.18ཞ18.72), and maternal depression in the second trimester (RR = 3.71, 95%CI = 1.31ཞ12.16). Pregnant women with depression had higher placental methylation of CRH and DIO3 genes, and there was a correlation between placental methylation of CRH and DIO3 genes. Conclusion Our study suggested that the changes in the promoter region of the placental DIO3 and CRH genes were involved in maternal depression in the second trimester induced preterm birth and small for gestational age birth.

Risk Factors for Preterm Birth and Small-for-gestational-age Births among Canadian Women

2012 ◽  
Vol 27 (1) ◽  
pp. 54-61 ◽  
Author(s):  
Maureen Heaman ◽  
Dawn Kingston ◽  
Beverley Chalmers ◽  
Reginald Sauve ◽  
Lily Lee ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Birth ◽  
Gestational Age ◽  
Small For Gestational Age

Early pregnancy serum neopterin concentrations predict spontaneous preterm birth in asymptomatic pregnant women

2016 ◽  
Vol 44 (5) ◽  
Author(s):  
Dan Bogdan Navolan ◽  
Simona Vladareanu ◽  
Imad Lahdou ◽  
Ioana Ciohat ◽  
Christian Kleist ◽  
...  
Keyword(s):  
Preterm Birth ◽  
Pregnant Women ◽  
Early Pregnancy ◽  
Gestational Age ◽  
Odds Ratio ◽  
Considerable Increase ◽  
Second Trimester ◽  
Spontaneous Preterm Birth ◽  
Serum Neopterin

AbstractTo investigate if early pregnancy serum neopterin concentrations (EPSN) could predict spontaneous preterm birth (SPB).EPSN was measured in 92 sera collected from 46 pregnant women with birth at term and 40 sera from 20 pregnant women with preterm birth. Two sera were collected for each case: in the first and early second trimester.EPSN concentrations correlate with gestational age (ρ=0.275, P=0.001), a correlation which was present in both groups: term and preterm birth. EPSN were higher in pregnancies with SPB compared with normal pregnancies (6.27±1.03 vs. 6.04±0.15, P=0.039). Patients with SPB showed a considerable increase of EPSN in the second trimester compared with patients with birth at term (7.30±1.53 vs. 6.16±0.23, P=0.043). A sharper increase was found in the group with SPB before 32 weeks of pregnancy (wp) (9.83±4.36 vs. 6.16±0.23, P=0.016). Pregnant women with an early second trimester serum neopterin value of above 8 nmol/L are associated with a risk of SPB before 32 wp (odds ratio=14.4, P=0.01) and of SPB before 34 wp (odds ratio=3.6, P=0.05), respectively.EPSN increases with the gestational age and predicts SPB in asymptomatic pregnant women.

scholarly journals P0150APREECLAMPSIA ABOUT 252 PATIENTS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Boubchir Akli ◽  
Boubchir Akli ◽  
Brahim Kichou ◽  
MADIOU ALI
Keyword(s):  
Risk Factors ◽  
Adverse Events ◽  
Pregnant Women ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Fetal Death ◽  
Gestational Hypertension ◽  
Adverse Outcomes ◽  
Previous Pregnancy ◽  
Fetal Complications

Abstract Background and Aims The main objective was to estimate the prevalence of pre-eclampsia (PE) in pregnant women in Tizi-ouzou (Algeria). Secondary objectives were to estimate the frequency of PE risk factors, and the incidence of maternal and fetal complications. Methods Our study was observational, prospective and descriptive, including all pregnant women at the prenatal appointment in the 2 maternity units of Tizi-ouzou, between January 2012 and June 2013. PE was diagnosed if gestational hypertension was associated with proteinuria > 300mg/24h, after 20 weeks of gestation. Results We had 252 cases of PE on 3225 pregnant women. The prevalence of PE was 7.8% (CI 95%: 6.9%–8.7%). The most frequent PE risk factors were nulliparity (56%), age >40 years (27%), obesity (26%) and PE in any previous pregnancy (21%). The incidence of maternal adverse events was 28.7% (CI 95%: 23.1%–34.3%), including 5 deaths. The rates of prematurity, small for gestational age infant and fetal death were 58.2%, 49.7% and 6.7%, respectively. Conclusion The prevalence of PE in pregnant women in Tizi-ouzou is around 8%. The incidence of maternal and fetal adverse outcomes remains high. Only earlier diagnosis and closer monitoring could improve the prognosis of our patients, since the treatment of PE remains currently childbirth.

scholarly journals Examining the predictive accuracy of metabolomics for small-for-gestational-age babies: a systematic review

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e031238 ◽  
Author(s):  
Debora Farias Batista Leite ◽  
Aude-Claire Morillon ◽  
Elias F Melo Júnior ◽  
Renato T Souza ◽  
Fergus P McCarthy ◽  
...  
Keyword(s):  
Pregnant Women ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Predictive Accuracy ◽  
Grey Literature ◽  
Synthesis Methods ◽  
Significant Heterogeneity ◽  
Second Trimester ◽  
Case Control Studies ◽  
Eligibility Criteria

IntroductionTo date, there is no robust enough test to predict small-for-gestational-age (SGA) infants, who are at increased lifelong risk of morbidity and mortality.ObjectiveTo determine the accuracy of metabolomics in predicting SGA babies and elucidate which metabolites are predictive of this condition.Data sourcesTwo independent researchers explored 11 electronic databases and grey literature in February 2018 and November 2018, covering publications from 1998 to 2018. Both researchers performed data extraction and quality assessment independently. A third researcher resolved discrepancies.Study eligibility criteriaCohort or nested case–control studies were included which investigated pregnant women and performed metabolomics analysis to evaluate SGA infants. The primary outcome was birth weight <10th centile—as a surrogate for fetal growth restriction—by population-based or customised charts.Study appraisal and synthesis methodsTwo independent researchers extracted data on study design, obstetric variables and sampling, metabolomics technique, chemical class of metabolites, and prediction accuracy measures. Authors were contacted to provide additional data when necessary.ResultsA total of 9181 references were retrieved. Of these, 273 were duplicate, 8760 were removed by title or abstract, and 133 were excluded by full-text content. Thus, 15 studies were included. Only two studies used the fifth centile as a cut-off, and most reports sampled second-trimester pregnant women. Liquid chromatography coupled to mass spectrometry was the most common metabolomics approach. Untargeted studies in the second trimester provided the largest number of predictive metabolites, using maternal blood or hair. Fatty acids, phosphosphingolipids and amino acids were the most prevalent predictive chemical subclasses.Conclusions and implicationsSignificant heterogeneity of participant characteristics and methods employed among studies precluded a meta-analysis. Compounds related to lipid metabolism should be validated up to the second trimester in different settings.PROSPERO registration numberCRD42018089985.

scholarly journals Antenatal depressive symptoms and adverse perinatal outcomes

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Despina Pampaka ◽  
Stefania I. Papatheodorou ◽  
Mohammad AlSeaidan ◽  
Rihab Al Wotayan ◽  
Rosalind J. Wright ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Preterm Birth ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Statistical Significance ◽  
Depression Scale ◽  
Large For Gestational Age ◽  
Antenatal Depressive Symptoms ◽  
Adverse Pregnancy ◽  
In Pregnancy

Abstract Background The association of antenatal depression with adverse pregnancy, birth, and postnatal outcomes has been an item of scientific interest over the last decades. However, the evidence that exists is controversial or limited. We previously found that one in five women in Kuwait experience antenatal depressive symptoms. Therefore, the aim of this study was to examine whether antenatal depressive symptoms are associated with preterm birth (PTB), small for gestational age (SGA), or large for gestational age (LGA) babies in this population. Methods This was a secondary analysis based on data collected in the Transgenerational Assessment of Children’s Environmental Risk (TRACER) Study that was conducted in Kuwait. Logistic regression analysis was used to examine whether antenatal depressive symptoms assessed using the Edinburgh Depression Scale (EDS) were associated with preterm birth, small for gestational age, and large for gestational age babies. Results A total of 1694 women had complete information about the outcomes of interest. Women with depressive symptoms in pregnancy had increased, albeit non-significant, odds of having PTB (OR = 1.41; 95%CI: 0.81, 2.45), SGA babies (OR = 1.26; 0.80, 1.98), or LGA babies (OR = 1.27; 0.90, 1.79). Antenatal depressive symptoms had similar increased odds for the three outcomes even after adjusting for several covariates though none of these reached statistical significance. Conclusions In the present study, the depressive symptoms in pregnancy did not predict adverse birth outcomes, such as PTB, SGA, and LGA, which adds to the currently non-conclusive literature. However, further research is needed to examine these associations, as the available evidence is quite limited.

scholarly journals Intestinal failure after necrotising enterocolitis: incidence and risk factors in a Swedish population-based longitudinal study

2018 ◽  
Vol 2 (1) ◽  
pp. e000316 ◽  
Author(s):  
Tomas Sjoberg Bexelius ◽  
Margareta Ahle ◽  
Anders Elfvin ◽  
Oscar Björling ◽  
Jonas F Ludvigsson ◽  
...  
Keyword(s):  
Risk Factors ◽  
Preterm Birth ◽  
Abdominal Surgery ◽  
Preterm Infants ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Intestinal Failure ◽  
Population Based ◽  
Necrotising Enterocolitis ◽  
Surgical Removal

Background and objectivePaediatric intestinal failure (IF) is a disease entity characterised by gut insufficiency often related to short bowel syndrome. It is commonly caused by surgical removal of a large section of the small intestine in association with necrotising enterocolitis (NEC), which usually affects premature infants. This study investigated the incidence and risk of IF in preterm infants with or without NEC.DesignA matched cohort study to investigate the incidence and risk factors for IF in a population-based setting in Sweden from 1987 to 2009 using the Swedish Patient Register.ParticipantsInfants with a diagnosis of NEC (n=720) were matched for gestational age and year of birth with reference individuals without NEC (n=3656). The study cohort was censored at death, IF or at end of follow-up (2 years of age). We calculated HRs with 95%CIs for IF using Cox regression, adjusting for pertinent perinatal factors.ResultsIF was 15 times more common in the infants with NEC compared with the reference infants (HR=7.2, with 95% CI 3.7 to 14.0). Other risk factors for IF were small for gestational age, extreme preterm birth and abdominal surgery. Neonatal mortality in infants with NEC decreased from 20.6% in 1987–1993 to 10.4% in 2007–2009.ConclusionIF was more common in the infants with NEC but was also linked to extreme preterm birth, a history of abdominal surgery and small for gestational age. IF was more common at the end of the study period, indicating that it increases when more preterm infants with NEC survive the neonatal period.

scholarly journals Maternal and Perinatal Outcomes of White Coat Hypertension During Pregnancy

Hypertension ◽  
2020 ◽  
Vol 76 (1) ◽  
pp. 157-166 ◽  
Author(s):  
Sonia Johnson ◽  
Becky Liu ◽  
Erkan Kalafat ◽  
Basky Thilaganathan ◽  
Asma Khalil
Keyword(s):  
Preterm Birth ◽  
Pregnant Women ◽  
Risk Ratio ◽  
Gestational Age ◽  
Small For Gestational Age ◽  
Gestational Hypertension ◽  
White Coat Hypertension ◽  
Chronic Hypertension ◽  
Increased Risk ◽  
Risk Of Preeclampsia

The aim of this meta-analysis is to investigate whether white-coat hypertension (WCH) has an adverse effect on maternal, fetal, and neonatal outcomes. Medline, EMBASE, www.Clinicaltrials.gov , and Cochrane Library databases were searched electronically in December 2019. The outcomes were compared between pregnant women with WCH and normotensive controls, women with chronic hypertension, gestational hypertension or any hypertensive disorder of pregnancy. Twelve studies were eligible for inclusion in the systematic review. Women with WCH enrolled below 20 weeks had a significantly increased risk of preeclampsia (pooled risk ratio [RR], 5.43 [95% CI, 2.00–14.71]). Furthermore, women with WCH had increased risk of delivering a small-for-gestational-age newborn (RR, 2.47 [95% CI, 1.21–5.05], P =0.013) and preterm birth (RR, 2.86 [95% CI, 1.44–5.68], P =0.002). The risk of preeclampsia (risk ratio, 0.43 [95% CI, 0.23–0.78], P =0.005), small-for-gestational-age (RR, 0.46 [95% CI, 0.26–0.82], P =0.008), preterm birth (RR, 0.47 [95% CI, 0.31–0.71], P <0.001) were significantly lower with WCH compared with women with gestational hypertension. Women with WCH delivered ≈1 week later compared with women with chronic hypertension (mean difference, 1.06 weeks [95% CI, 0.44–1.67 weeks]; P <0.001). WCH is associated with a worse perinatal and maternal outcome than normotension, but better outcomes than gestational hypertension and chronic hypertension. Therefore, diagnosis of WCH should be ascertained in pregnant women presenting with hypertension. When the diagnosis is confirmed, these women require monitoring for developing preeclampsia, small-for-gestational-age and preterm birth.

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