scholarly journals A functional SNP in miR-625-5p binding site of AKT2 3'UTR is associated with noise-induced hearing loss susceptibility in the Chinese population

2021 ◽  
Author(s):  
Long Miao ◽  
Boshen Wang ◽  
Juan Zhang ◽  
Lihong Yin ◽  
Yuepu Pu
Keyword(s):  
Hearing Loss ◽  
Binding Site ◽  
Binding Affinity ◽  
Chinese Population ◽  
Noise Exposure ◽  
Luciferase Reporter ◽  
Exposure Level ◽  
Noise Induced Hearing Loss ◽  
Potential Biomarker ◽  
Increased Risk

Abstract This study aimed to explore the association of several single nucleotide polymorphisms (SNPs) within the AKT2 gene and noise-induced hearing loss (NIHL) susceptibility and explore the potential mechanism underlying NIHL. Three SNPs (rs2304186, rs41275750 and rs76524493) were genotyped in a Chinese population which consists of 690 NIHL patients and 650 normal hearing controls. Bioinformatic analysis was conducted to predict the potential miRNA-binding site of SNPs. Cell transfection and dual-luciferase reporter assay were performed to investigate the potential molecular mechanism of SNPs involved in NIHL. The results revealed rs2304186 GT genotype (OR = 1.41; 95% CI = 1.09–1.83) and TT genotype (OR = 1.51; 95% CI = 1.08–2.10) imparted increased risk of NIHL, and the increased risk could also be found in a dominant model (OR = 1.44; 95% CI = 1.12–1.84). The stratification analysis showed that rs2304186 GT/TT conferred a higher risk for NIHL, especially in subgroups of male, age (35–45 and > 45 years), noise exposure time (> 16 years), and noise exposure level (≤ 85 and ≥ 92 dB), compared with GG genotype. In addition, the haplotype TCCTACT (rs2304186-rs41275750-rs76524493) was associated with NIHL risk (OR = 1.19; 95% CI = 1.02–1.40). Rs2304186 G allele combined with hsa-miR-625-5p mimics could significantly decrease the luciferase activity compared with T allele, indicating rs2304186 altered the binding affinity of hsa-miR-625-5p to SNP rs2304186 mutation region, thus directly targeting AKT2. In conclusion, our study provides evidence for the first time that SNP rs2304186 of AKT2 3′UTR affects NIHL susceptibility by affecting the binding affinity of has-miR-625-5p in an allele-specific manner and it may act as a potential biomarker of NIHL susceptibility.

scholarly journals Single-Nucleotide Polymorphisms in XPO5 are Associated with Noise-Induced Hearing Loss in a Chinese Population

2020 ◽  
Vol 2020 ◽  
pp. 1-10 ◽  
Author(s):  
Ning Wang ◽  
Boshen Wang ◽  
Jiadi Guo ◽  
Suhao Zhang ◽  
Lei Han ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Chinese Population ◽  
Luciferase Reporter ◽  
Noise Induced Hearing Loss ◽  
Nucleotide Polymorphisms ◽  
Single Nucleotide ◽  
Increased Risk ◽  
Polymerase Chain ◽  
Control Study ◽  
Dual Luciferase Reporter Assay

Objectives.The purpose of this study was to investigate the correlation between single-nucleotide polymorphism (SNP) in 3′UTR of XPO5 gene and the occurrence of noise-induced hearing loss (NIHL), and to further explore the regulatory mechanism of miRNAs in NIHL on XPO5 gene. Methods.We conducted a case-control study involving 1040 cases and 1060 controls. The effects of SNPs on XPO5 expression were studied by genotyping, real-time polymerase chain reaction (qPCR), cell transfection, and the dual-luciferase reporter assay. Results.We genotyped four SNPs (rs2257082, rs11077, rs7755135, and rs1106841) in the XPO5 gene. The rs2257082 AG/GG carriers have special connection to an increased risk of noise-induced hearing loss compared to the AA carriers. The rs11077TG/GG carriers had a significantly increased association with NIHL susceptibility than the TT carriers. There was a higher risk of NIHL in the XPO5 gene rs7755135 CC carriers than in the TT carriers. No statistically significant correlation was obtained with respect to SNPrs1106841. Functional experiments showed that the rs11077 change might inhibit the interaction between miRNAs (miRNA-4763-5p, miRNA-5002-3p, and miRNA-617) and XPO5, with rs11077G allele resulting in overexpression of XPO5. Conclusion. The genetic polymorphism, rs11077, within XPO5 is associated with the risk of noise-induced hearing loss in a Chinese population.

scholarly journals Contributions and limitations of using machine learning to predict noise-induced hearing loss

2021 ◽  
Author(s):  
Feifan Chen ◽  
Zuwei Cao ◽  
Emad M. Grais ◽  
Fei Zhao
Keyword(s):  
Machine Learning ◽  
Hearing Loss ◽  
Roc Curve ◽  
Prediction Error ◽  
Noise Exposure ◽  
Model Construction ◽  
Support Vector ◽  
Exposure Level ◽  
Noise Induced Hearing Loss ◽  
Current Review

Abstract Purpose Noise-induced hearing loss (NIHL) is a global issue that impacts people’s life and health. The current review aims to clarify the contributions and limitations of applying machine learning (ML) to predict NIHL by analyzing the performance of different ML techniques and the procedure of model construction. Methods The authors searched PubMed, EMBASE and Scopus on November 26, 2020. Results Eight studies were recruited in the current review following defined inclusion and exclusion criteria. Sample size in the selected studies ranged between 150 and 10,567. The most popular models were artificial neural networks (n = 4), random forests (n = 3) and support vector machines (n = 3). Features mostly correlated with NIHL and used in the models were: age (n = 6), duration of noise exposure (n = 5) and noise exposure level (n = 4). Five included studies used either split-sample validation (n = 3) or ten-fold cross-validation (n = 2). Assessment of accuracy ranged in value from 75.3% to 99% with a low prediction error/root-mean-square error in 3 studies. Only 2 studies measured discrimination risk using the receiver operating characteristic (ROC) curve and/or the area under ROC curve. Conclusion In spite of high accuracy and low prediction error of machine learning models, some improvement can be expected from larger sample sizes, multiple algorithm use, completed reports of model construction and the sufficient evaluation of calibration and discrimination risk.

scholarly journals Role of CASP7 polymorphisms in noise-induced hearing loss risk in Han Chinese population

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yanmei Ruan ◽  
Jinwei Zhang ◽  
Shiqi Mai ◽  
Wenfeng Zeng ◽  
Lili Huang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Chinese Population ◽  
Conditional Logistic Regression ◽  
Han Chinese ◽  
Control Group ◽  
Environment Interaction ◽  
Noise Induced Hearing Loss ◽  
Han Chinese Population ◽  
Hearing Thresholds ◽  
Increased Risk

AbstractGenetic factors and gene-environment interaction may play an important role in the development of noise induced hearing loss (NIHL). 191 cases and 191 controls were selected by case–control study. Among them, case groups were screened from workers exposed to noise in binaural high-frequency hearing thresholds greater than 25 dB (A). Workers with hearing thresholds ≤ 25 dB (A) in any binaural frequency band were selected to the control group, based on matching factors such as age, exposure time to noise, and operating position. The blood samples from two groups of workers were subjected to DNA extraction and SNP sequencing of CASP3 and CASP7 genes using the polymerase chain reaction ligase detection reaction method. Conditional logistic regression correction was used to analyze the genetic variation associated with susceptibility to NIHL. There was an association between rs2227310 and rs4353229 of the CASP7 gene and the risk of NIHL. Compared with the GG genotype, the CC genotype of rs2227310 reduced the risk of NIHL. Compared with CC genotype, the TT genotype of rs4353229 reduced the risk of NIHL. Workers carrying the rs2227310GG and rs4353229CC genotype had an increased risk of NIHL compared to workers without any high-risk genotype. There were additive interaction and multiplication interaction between CASP7rs2227310 and CNE, and the same interaction between CASP7rs4353229 and CNE. The interaction between the CASP7 gene and CNE significantly increased the risk of NIHL. The genetic polymorphisms of CASP7rs2227310GG and CASP7rs4353229CC were associated with an increased risk of NIHL in Han Chinese population and have the potential to act as biomarkers for noise-exposed workers.

scholarly journals Research and Discussion on the Relationships between Noise-Induced Hearing Loss and ATP2B2 Gene Polymorphism

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Suhao Zhang ◽  
Enmin Ding ◽  
Haoyang Yin ◽  
Hengdong Zhang ◽  
Baoli Zhu
Keyword(s):  
Hearing Loss ◽  
Gene Polymorphism ◽  
Noise Exposure ◽  
Venous Blood ◽  
Pure Tone Audiometry ◽  
Control Group ◽  
Case Group ◽  
Noise Induced Hearing Loss ◽  
Cochlear Hair Cells ◽  
Potential Biomarker

Long-term and continuous noise exposure can result in noise-induced hearing loss (NIHL), which is a worldwide problem resulting from the interaction of environmental and genetic factors. The ATP2B2 gene polymorphism can destroy cochlear hair cells and increase the risk of NIHL. A case-control study of 760 Chinese textile workers was conducted to investigate the relationship between ATP2B2 polymorphisms and NIHL susceptibility. Venous blood was collected and questionnaires were conducted by professional physicians. A case group and a control group which were typed by individuals’ pure-tone audiometry test results were set. Three polymorphism sites of ATP2B2 were genotyped by using the PCR technique. Analysis results revealed that the C allele of rs3209637 (95%CI=1.08–2.58, odds ratio OR=1.67, P=0.027) was a dangerous factor and could add to risks of NIHL in the Chinese employees. The data of stratified analysis revealed that individuals who are exposed to noise>95 dB with the rs3209637 C genotype have a higher susceptibility to NIHL (OR=1.34, 95%CI=1.07–1.68). Multifactor dimensionality reduction analysis revealed that the interaction between rs14154 and rs3209637 is linked to increased NIHL risk, and for the interaction among rs14154, smoking and drinking had the same function (OR=1.54 and 1.77, 95%CI=1.15–2.07, 1.33–2.37, and P=0.0037 and P<0.0001, respectively). Our results suggest that genetic polymorphism rs3209637 C within ATP2B2 is a risk factor for NIHL among Chinese employees and rs3209637 C could be a potential biomarker for NIHL patients.

scholarly journals Relationship between CDH23 gene and risk of noise-induced hearing loss

2021 ◽  
Author(s):  
Jie Jiao ◽  
Shanfa Yu ◽  
Guizhen Gu ◽  
Guoshun Chen ◽  
Huanling Zhang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Noise Exposure ◽  
Control Group ◽  
Case Group ◽  
Noise Induced Hearing Loss ◽  
Nucleotide Polymorphisms ◽  
Significant Relationships ◽  
Increased Risk ◽  
Main Effects ◽  
The Relationship

Abstract Objective: To investigate the relationship between CDH23 gene and the risk of noise-induced hearing loss (NIHL).Methods: This was a case-control study. Noise-exposed workers worked in a steel factory in North China was recruited and been divided into two groups: the case group (BHFTA ≥40 dB) and the control group (BHFTA<25 dB). We analyzed the association among 18 single nucleotide polymorphisms (SNPs) in CDH23 and NIHL risk using the generalized multifactor dimensionality reduction (GMDR) method. Logistic regression was performed to analyze the main effects of SNPs and the interactions between CNE and SNPs adjusting cumulative noise exposure (CNE), smoking, drinking, physical exercise and hypertension. Results: In this study, 776 subjects of period I and 1117 subjects of period I+II were recruited. The results showed that subjects who carried the AA genotype of rs3802711possessed significantly increased risk of NIHL than those carrying GG (OR: 2.71; 95% CI:1.15, 6.39) and GA+GG (OR: 2.54; 95% CI: 1.09, 6.00) in period I, respectively. For rs11592462, subjects carrying the GG genotype showed a significantly increased risk of NIHL compared with the subjects. Significant relationships were showed between rs10999947, rs3802711, rs10762480, rs3752751, rs3752752, rs3747867, and rs11592462 for NIHL overall and various CNE strata. There was no significant association between the rs1227049 - rs3752752 - rs10999947 - rs3752751 - rs10762480 - rs3802711 - rs11592462 - rs4747195 - rs4747194 - rs10466026 haplotypes and NIHL risk. Conclusions: The genetic variation in the CDH23 gene might play an important role in determining individual susceptibility to NIHL.

scholarly journals Noise Exposure and Noise Induced Hearing Loss Among the Traffic Police in Dhaka Metropolitan City

2021 ◽  
Vol 46 (3) ◽  
pp. 219-227
Author(s):  
Abirvab Naha ◽  
Nasima Akhtar ◽  
Pran Gopal Datta ◽  
Mohammad Habibur Rahman ◽  
Riashat Azim Majumder ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Noise Exposure ◽  
Occurrence Rate ◽  
Exposure Level ◽  
Noise Induced Hearing Loss ◽  
Occupational Noise ◽  
Traffic Police ◽  
Metropolitan City ◽  
North And South ◽  
East West

Background: Occupational noise is considered as a global problem with social and physiological impacts, causing noise-induced hearing loss (NIHL). High levels of occupational noise is a problem in all regions of the world. Road traffic produces high noise levels that can cause damage to the traffic police hearing. Hence, occupational hearing loss is a well-known outcome of noise exposure at work. Objectives: The study aimed to measure the noise exposure level at different traffic points and determine the occurrence rate and severity of hearing loss among the traffic police of Dhaka Metropolitan City. Methods: This cross-sectional study was conducted during 2017-2019 in 28 selected traffic points of Dhaka Metropolitan City under four traffic zone (East, West, North, and South) and among 100 traffic police who were working there and met the inclusion and exclusion criteria. Noise exposure level was measured from all selected traffic points with a digital sound level meter. Data were collected by face to face interview with a pretested semi-structured questionnaire followed by an otoscopic examination, tuning fork tests, and a baseline audiogram. To see the association, Chi-square tests or Pearson’s correlation coefficient (r) tests were performed. Results: This study revealed that the average noise exposure level at East, West, North, and South zones are respectively 125.6 dB, 112.9 dB, 121.3 dB, and 119.4 dB. At every point, the noise exposure level was more than the acceptable limit set by the Occupational Safety and Health Administration (OSHA). In the audiometry report of 100 traffic police, 64% had sensorineural hearing loss. Of them 85% had mild, 9% had moderate and 6% with severe hearing loss. Notch in 4 kHz in an audiogram was present in the right ear of 46% of respondents and left ear of 52% respondents. It was observed that hearing loss was significantly associated with increasing age and job duration. Conclusion: Traffic police of Dhaka Metropolitan City is in constant risk of noise induced hearing loss as the ambient noise of this city is very high. Regular assessment and hearing screening is recommended for all the traffic police who are exposed to noise. Bangladesh Med Res Counc Bull 2020; 46(3): 219-227

scholarly journals EFEK BISING MESIN ELEKTRONIKA TERHADAP GANGGUAN FUNGSI PENDENGARAN PADA PEKERJA DI KECAMATAN SARIO KOTA MANADO, SULAWESI UTARA

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Hardini Tjan ◽  
Fransiska Lintong ◽  
Wenny Supit
Keyword(s):  
Hearing Loss ◽  
Work Environment ◽  
Noise Exposure ◽  
Sensorineural Deafness ◽  
Bivariate Analysis ◽  
Fisher Exact Test ◽  
Exposure Level ◽  
Intensity Level ◽  
Noise Induced Hearing Loss ◽  
Cross Sectional

Abstract: Noise induced hearing loss is caused by noise loud in the long period and a noisy work environment. Noisy work environment is a major problem in occupational health in various countries. The relationship between excessive noise exposure and hearing loss has been recognised since ancient times. Early epidemiological studies of noise induced hearing loss explored the damage risk relationship between occupational noise exposure level and the degree of hearing loss. The purpose of this study is to determine effect of engine noise electronics to auditory disfunction. The research methodeology used is an analytical method with a cross sectional approach. Samples were of 20 person taken from workers at the playground timezone and amazone. Data were obtained through questionnaires and examination of hearing function with the audiometri. Data were analyzed by using the Statistical Product and Service Solutions program (SPSS) and using the Fisher Exact test. Conclusion: The results showed that : There is a 75% hearing loss in all worker. The results of bivariate analysis showed there is no significant association between the hearing loss with the intensity level of noise (p = 0,032). The most common hearing loss is sensorineural deafness which generally occours in both ear. From the result of this study it can be concluded that the workers who work in a place that has the high intensity noise have greater risk of suffening from hearing loss. Keywords: Timezone and Amazone Workers, Noisy, Hearing.     Abstrak: Gangguan pendengaran akibat bising ialah gangguan pendengaran yang disebabkan akibat terpajan oleh bising yang cukup keras dalam jangka waktu yang cukup lama dan biasanya disebabkan oleh bising di lingkungan kerja. Bising lingkungan kerja merupakan masalah utama pada kesehatan kerja di berbagai negara. Hubungan antara paparan bising yang berlebihan dan kehilangan pendengaran telah dikenal sejak zaman kuno. Awal studi epidemiologi, gangguan pendengaran yang disebabkan oleh bising mengeksplorasi adanya hubungan atau faktor resiko antara pekerjaan, paparan tingkat kebisingan dan derajat gangguan pendengaran. Tujuan penelitian ini untuk mengetahui efek bising mesin elektronika terhadap gangguan fungsi pendengaran. Metode penelitian yang digunakan yaitu metode analitik dengan menggunakan rancangan cross sectional study. Sampel berjumlah 20 orang yang diambil dari pekerja di tempat bermain timezone dan amazone. Data diperoleh melalui kuisioner dan pemeriksaan fungsi pendengaran dengan menggunakan Audiometri. Data dianalisis dengan menggunakan Statistical Program Product and Service Solution (SPSS) dan menggunakan uji Fisher Exact. Simpulan: Hasil penelitian menunjukkan bahwa : Terdapat gangguan pendengaran sebesar 75 % pada seluruh pekerja. Hasil analisis bivariat menunjukan ada hubungan yang bermakna antara gangguan pendengaran dengan tingkat intensitas bising (p =  0,032).  Gangguan pendengaran yang paling banyak diderita oleh pekerja adalah tuli sensorineural (persepsi) yang umumnya terjadi pada kedua telinga. Dari hasil penelitian ini dapat disimpulkan bahwa pekerja yang bekerja pada intensitas bising yang tinggi memiliki resiko lebih besar menderita gangguan pendengaran. Kata Kunci: Pekerja Timezone & Amazone, Bising, Pendengaran

scholarly journals Screening for Noise-Induced Hearing Loss among Palm Oil Mill Workers in Peninsular Malaysia: A Comparison across Noise Exposure Levels

Standards ◽  
2022 ◽  
Vol 2 (1) ◽  
pp. 32-42
Author(s):  
Sirri Ammar ◽  
Aziah Daud ◽  
Ahmad Filza Ismail ◽  
Ailin Razali
Keyword(s):  
Hearing Loss ◽  
Palm Oil ◽  
Noise Exposure ◽  
High Risk Group ◽  
Vulnerable Groups ◽  
Exposure Level ◽  
Noise Induced Hearing Loss ◽  
Cross Sectional ◽  
Exposure Levels ◽  
Palm Oil Mill

Background: Palm oil mill workers in Malaysia are exposed to hazardous levels of noise in the workplace, and thus are at risk of developing noise-induced hearing loss (NIHL). In 2019, Malaysia introduced a new noise regulation, which reduced the level of permissible noise exposure. Objectives: This study aims to determine the prevalence of NIHL among palm oil mill workers based on screening data and assess the effects of different noise exposure levels on NIHL. Methods: A cross-sectional study was conducted by analyzing data from noise risk assessment reports of selected mills and screening audiometric data from workers. NIHL was defined as bilateral high-frequency hearing loss. Results: The overall NIHL prevalence was 50.8%. Noise exposure level and age were significant predictors of NIHL among the workers. The risk of developing NIHL was high even for workers who were not categorized in the high-risk group. Conclusions: In view of the findings, a precautionary approach is needed when evaluating the risk of NIHL in the study population. Vulnerable groups of workers must be protected from occupational noise hazards through the implementation of effective hearing conservation programs in the workplace.

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