The Effect of Conventional Versus Electronic Cigarette Use on Treatment Outcomes of Peri-Implant Disease
Abstract Background: Treatment outcomes associated with the peri-implant diseases are significantly influenced by individual habits. Several studies identified smoking as one of the important risk factors associated with ineffective treatment outcomes. The present study aims to compare changes in periodontal clinical parameters between conventional and electronic cigarette smokers with non-smokers. It further evaluates changes of salivary inflammatory biomarkers (IL-1 β, IL-6, MMP-8 and TIMP1) after treating peri-implantitis. Participants were divided into three groups: conventional cigarette smokers, E-smokers and non-smokers; each consisting of 20 participants. Results: Findings of the study indicated that the change in gingival color from red to pink is significantly higher in cigarette smokers and non-smokers when compared with electronic smokers (p=0.043). The gingival consistent changed to be firm in cigarettes smokers and non-smokers. The prevalence of PI, BOP and PD it has reduced across the groups of cigarette and smokers over the four intervals of observation. Besides, no statistically significant difference with the means values of KTW. The level of MMP-8 at baseline of three groups had reduced but increased marginally at sixth month and at the completion of one year among cigarette and e-smokers. The mean IL-6 values had significantly reduced, except for electronic smoking. The IL-1 β values had significantly increased in all groups. The increase of TIMP-1 values in non-smokers is higher at all the three-time points. Conclusion: All clinical parameters show enhancement post treatment. However, salivary biological biomarkers (MMP-8, IL-1 β and IL-6) have shown a decline in all groups treated.