scholarly journals Evaluation of the effects of Vitamin C on Epithelialization of Burn Wounds: A Randomized Clinical Trial

2020 ◽  
Author(s):  
Mohammd Haddadi ◽  
Elaheh Jaghouri ◽  
Davood Robat Sarpooshi ◽  
Fateme Ghobadi ◽  
Hamid Robat Sarpooshi
Keyword(s):  
Clinical Trial ◽  
Vitamin C ◽  
Repeated Measures ◽  
Assessment Tool ◽  
Burn Wound ◽  
Repeated Measures Anova ◽  
Burn Wounds ◽  
Significant Difference ◽  
Treatment Data ◽  
Second Degree

Abstract Objectives The purpose of this study is to determine the effect of topical vitamin C on second-degree burn wounds restoration. This was a clinical trial. The sample size was determined as 30. Participants were selected from patients suffering from second-degree burns who visited the Burn Center of Vaseei Hospital in Sabzevar. Both intervention and control groups targeted one patient.Dressing was changed in a daily manner after cleansing. A topical vitamin C solution was administered on the wounds. The Bates-Jensen Wound Assessment Tool was used to evaluate burn wound parameters in the 1 st , 3 rd , 7 th , and 14 th days of treatment. Data was analyzed using SPSS v.16 and ‘’repeated measures ANOVA. Results The average age of participants was 43.33 ± 11.9 years and 60% of the participants were males and 40% of them were females. The results of repeated measures ANOVA showed a statistically significant difference in mean scores of the wound between the two treatments (P = 0.047), wound healing significantly differed in the two groups and topical vitamin C solution had a significant effect on the acceleration of wound Epithelialization. The administration of topical vitamin C is recommended for epithelialization of second-degree burns.

scholarly journals Evaluation of The Effects of Vitamin C on Epithelialization of Burn Wounds

2020 ◽  
Author(s):  
Mohammd Haddadi ◽  
Elaheh Jaghouri ◽  
Davood Robat Sarpooshi ◽  
Fateme Ghobadi ◽  
Hamid Robat Sarpooshi
Keyword(s):  
Vitamin C ◽  
Repeated Measures ◽  
Assessment Tool ◽  
Burn Wound ◽  
Repeated Measures Anova ◽  
Burn Wounds ◽  
Degree Burn ◽  
Significant Difference ◽  
Treatment Data ◽  
Second Degree

Abstract Objectives: The purpose of the present study is to determine the effect of topical vitamin C on second degree burn wounds restoration. This was a clinical trial. The sample size was determined as 30. The participants were selected from the patients suffering from second degree burns who visited the Burn Center of Vaseei Hospital in Sabzevar. Both intervention and control groups targeted one patient. Dressing was changed in a daily manner after cleansing. Topical vitamin C solution was administered on the wounds. The Bates-Jensen Wound Assessment Tool was used to evaluate burn wound parameters in the 1st, 3rd, 7th and 14th day of treatment. Data analysis was performed using SPSS v.16 and ‘’repeated measures ANOVA.Results: The average age of participants was 43.33 ± 11.9 years and 60% of the participants were males and 40% of them were females. The results of repeated measures ANOVA showed a statistically significant difference in mean scores of wound between the two treatments (P = 0.047), wound healing significantly differed in the two groups and topical vitamin C solution had a significant effect on acceleration of wound Epithelialization. According to the results of this study, administration of topical vitamin C is recommended for epithetlialization of second degree burns.IRCT: IRCT2015101224487N1

scholarly journals The Effects of Topical Vitamin C on Burn Wound Healing

2021 ◽  
Vol 24 (2) ◽  
pp. 204-215
Author(s):  
Mohammad Haddadi ◽  
◽  
Davood Movahedzadeh ◽  
Elaheh Jaghouri ◽  
Hamid Robat Sarpooshi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Vitamin C ◽  
Topical Application ◽  
Repeated Measures ◽  
Assessment Tool ◽  
Intervention Group ◽  
Silver Sulfadiazine ◽  
Control Group ◽  
Burn Wound ◽  
Burn Wounds

Background and Aim: Topical supplements and vitamins have often been used to accelerate the healing of burn wounds. This study investigated the effects of topical application of vitamin C solution on burn wounds. Methods & Materials: This research was performed on 30 patients with extensive second-degree burns on one or two organs with similar burns. The study subjects were randomly divided into the intervention and control groups. The intervention group received topical application of vitamin C solution in addition to silver sulfadiazine ointment in the burn area; however, only silver sulfadiazine ointment was applied in the burn area in the control group. The wounds were examined and scored on days 1, 3, 7, and 14 using the Bates-Jensen Wound Assessment Tool. The collected data were analyzed in SPSS using repeated-measures Analysis of Variance (ANOVA). Ethical Considerations: This study was approved by the ethics committee of sabzevar university medical sciences. (Code: IR.MEDSAB.REC.1394.60). Results Eighteen of the 30 examined patients were male and 12 were female. Their Mean±SD age and body mass index were 43.03±11.90 years and 27.82±4.08 kg/m2, respectively. Conclusion: The repeated-measures ANOVA data indicated that the study groups were significantly different concerning the final mean scores given to the wounds (P=0.047). In other words, the research groups significantly differed in wound healing; thus, topical application of vitamin C significantly improved wound healing in the study participants.

scholarly journals Comparison of the effectiveness of Aloe Vera Gel with 2% Nitrofurazone ointment on the healing of superficial second-degree burns. Randomised clinical trial

2020 ◽  
Author(s):  
Shokoh Varaei ◽  
Hadi Ranjbar ◽  
Parichehr Sabaghzadeh ◽  
Sanaz Bostani ◽  
Soodabhe Amirsalari
Keyword(s):  
Clinical Trial ◽  
Assessment Tool ◽  
Aloe Vera ◽  
The Body ◽  
Burn Wound ◽  
Aloe Vera Gel ◽  
Degree Burn ◽  
Significant Difference ◽  
The Mean ◽  
Second Degree

Abstract Background Burn injuries are one of the most common sources of trauma globally that comprise a significant drain on long-term personal and healthcare cost Large surface area burn wounds are difficult to manage and may result in significant physiologic and psychological sequelae . The aim of this study was to compare the effectiveness of Aloe Vera gel with Nitrofurazone ointment in the healing of superficial second-degree burn wounds.Methods The present study was a split body controlled, randomized clinical trial. The sample was recruited from patients with superficial second-degree burn wound who were prescribed to treat with 2% Nitrofurazone ointment. Thirty patients with at least two burn, each burn on an alternate side of the body, entered the study — samples allocated to two groups which received Aloe Vera gel or 2% Nitrofurazone ointment on their burns. Bates-Jensen Wound assessment tool (BWAT) was used to evaluate the healing of burns. The burns were evaluated before, one, two and three weeks after the beginning of treatment.Results The mean ± SD of BWAT scores in Aloe Vera zones were 30.32 ± 3.28, 27.33 ± 3.38, 21.33 ± 3.13, 16.12 ± 2.16 respectively (F(2, 65.07) =440.00, p=0.001). The mean ± SD of BWAT scores in Nitrofurazone ointment zones were 30.51 ± 3.79, 28.45 ± 3.49, 23.36 ± 2.89, 19.23 ± 2.11 (F(1, 52.00) =228.00, p=0.001).Conclusions There is a significant difference in (BWAT) scores between intervention and control groups. Aloe Vera gel was as effective as Nitrofurazone ointment in the treatment of superficial second-degree burns.Trial registration IRCT2014113020151N1. Registered 14 December 2014, https://www.irct.ir/trial/17874

scholarly journals Evaluation of the Healing Effects of Hypericum perforatum and Curcumin on Burn Wounds in Rats

2020 ◽  
Vol 2020 ◽  
pp. 1-5
Author(s):  
Nevra Seyhan
Keyword(s):  
Wound Healing ◽  
Hypericum Perforatum ◽  
Control Group ◽  
Sprague Dawley ◽  
Burn Wound ◽  
Burn Wounds ◽  
Burn Wound Healing ◽  
Significant Difference ◽  
Group A ◽  
Second Degree

Background. For centuries, medicinal plants have been extensively used in wound healing of burn injuries. The aim of this study is to analyze comparatively the effects of curcumin and Hypericum perforatum (HP) on second-degree burn wounds in rats. Materials and Methods. This experimental study was conducted on 24 male Sprague-Dawley rats with second-degree burns. The animals were randomly divided into three groups. The burns were treated with curcumin (Group B) and Hypericum perforatum (Group C) with daily application. Group A was considered as the control group and received no medication. Histological parameters, reepithelization, granulation tissue formation, inflammation, and angiogenesis were assessed after the scar biopsy at the end of research. Results. All histological parameters of the control group showed statistically significant difference than the other groups (p<0.05). There was no statistically significant difference between Groups B and C in terms of reepithelization and inflammation (p=0.351, p=0.067). In the curcumin group compared with the HP group, a significant difference was observed for two parameters of fibrosis and angiogenesis (p<0.05). Conclusion. Both curcumin and Hypericum perforatum oil are effective in burn wound healing. Our findings showed a better quality of healing in curcumin-treated rats.

scholarly journals Anaesthetic Efficacy of 4% Articaine in Comparison with 2% Lidocaine as Intraligamentary Injections after an Ineffective Inferior Alveolar Nerve Block in Mandibular Molars with Irreversible Pulpitis: A Prospective Randomised Triple-Blind Clinical Trial

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Nazanin Zargar ◽  
Elnaz Shooshtari ◽  
Leila Pourmusavi ◽  
Alireza Akbarzadeh Baghban ◽  
Hengameh Ashraaf ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Nerve Block ◽  
Repeated Measures ◽  
Inferior Alveolar Nerve ◽  
Inferior Alveolar Nerve Block ◽  
Success Rates ◽  
Chi Square ◽  
Repeated Measures Anova ◽  
Significant Difference ◽  
Irreversible Pulpitis

The objective of the current study was to compare the anaesthetic efficacy of supplemental intraligamentary (IL) injection of 4% articaine with that of 2% lidocaine in the mandibular first and second molars with irreversible pulpitis after an ineffective inferior alveolar nerve block injection (IANB) using the same anaesthetic in a randomised triple-blind clinical trial. Seventy-six adult patients, who were diagnosed with irreversible pulpitis in the mandibular first or second molars, were divided into 2 groups and received IANB randomly. In patients with lip numbness, anaesthesia was evaluated with the cold and electrical pulp (EPT) tests, and if the reported number on EPT was below 100, supplemental IL injection was administered using the same anaesthetic. The teeth were retested after 5 minutes. The Heft–Parker visual analogue scale was used to evaluate pain after IANB and IL injections. Statistical analysis was performed using repeated measures ANOVA, chi-square, and independent-sample and paired-sample t-tests. The results showed that there was no significant difference in the success rates of supplemental IL and IANB injections between articaine and lidocaine. Furthermore, there was no significant difference in the success rates of supplemental IL injection with lidocaine between the mandibular first and second molars. However, there was a significant difference in the success rates of supplemental IL injection with articaine between the mandibular first and second molars. Moreover, supplemental IL injections indicated no significant difference in the anaesthetic efficacy between articaine and lidocaine; nevertheless, they were more effective in the mandibular second molars, especially with articaine.

673 Effect of Subcutaneous Topical Ozone Therapy on Second Degree Burn Wounds in Rats: An Experimental Study

2021 ◽  
Vol 42 (Supplement_1) ◽  
pp. S193-S193
Author(s):  
Emre Karakaya ◽  
Aydincan Akdur ◽  
H Ebru ◽  
Ayvazoglu Soy ◽  
Alev Ok Atilgan ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Silver Sulfadiazine ◽  
Male Rats ◽  
Control Group ◽  
Ozone Therapy ◽  
Burn Wounds ◽  
Degree Burn ◽  
Significant Difference ◽  
Second Degree

Abstract Introduction Burn is one of the most severe traumas that causes coagulative destruction of the skin. The use of various products that accelerate wound healing in patients with burn may affect the patient’s survival and reduce the complications that may be seen. In the present study we aimed effects of subcutaneous ozone injection on second degree burn wound. Methods A total of 72 Sprague-Dawley male rats included in the study were divided randomly into three groups (control group (CG), silver sulfadiazine group (SG), ozone group (OG)) and each group was divided randomly two subgroups (as sacrificed on d7 and on d14).A deep second degree scald burns were created on the lower back. In CG subcutaneous 0.9% serum saline was injected daily into the burn area. In SG, burns were dressed with silver sulfadiazine daily and in OG subcutaneous ozone was injected daily into the burn area. Tissue hydroxyproline level measurement and histopathological evaluation were done. Results When the groups were compared in terms of weight change, no significant difference was found on the 7th and 14th days. In the evaluation made in terms of tissue hydroxyproline, tissue hydroxyproline level in OG was found to be significantly higher on both the 7th and 14th days (p &lt; 0.001). In histopathological evaluations, it was determined that wound healing in OG was significantly higher than in the other groups. Conclusions According to the results, subcutaneous ozone therapy is more effective than silver sulphadiazine in the healing process of second-degree burn wounds and it can be safely used in the treatment of burn wounds.

scholarly journals Evaluation of an Innovative Digital Assessment Tool in Dental Anatomy

2015 ◽  
Vol 16 (5) ◽  
pp. 366-371 ◽  
Author(s):  
Matt T Lam ◽  
So Ran Kwon ◽  
Fang Qian ◽  
Gerald E Denehy
Keyword(s):  
Gold Standard ◽  
Repeated Measures ◽  
Assessment Tool ◽  
T Test ◽  
Pearson’S Correlation ◽  
Digital Assessment ◽  
Dental Anatomy ◽  
Significant Difference ◽  
Pearson's Correlation ◽  
One Way Anova

ABSTRACT Aim The E4D Compare software is an innovative tool that provides immediate feedback to students’ projects and competencies. It should provide consistent scores even when different scanners are used which may have inherent subtle differences in calibration. This study aimed to evaluate potential discrepancies in evaluation using the E4D Compare software based on four different NEVO scanners in dental anatomy projects. Additionally, correlation between digital and visual scores was evaluated. Materials and methods Thirty-five projects of maxillary left central incisors were evaluated. Among these, thirty wax-ups were performed by four operators and five consisted of standard dentoform teeth. Five scores were obtained for each project: one from an instructor that visually graded the project and from four different NEVO scanners. A faculty involved in teaching the dental anatomy course blindly scored the 35 projects. One operator scanned all projects to four NEVO scanners (D4D Technologies, Richardson, TX, USA). The images were aligned to the gold standard, and tolerance set at 0.3 mm to generate a score. The score reflected percentage match between the project and the gold standard. One-way ANOVA with repeated measures was used to determine whether there was a significant difference in scores among the four NEVO scanners. Paired-sample t-test was used to detect any difference between visual scores and the average scores of the four NEVO scanners. Pearson's correlation test was used to assess the relationship between visual and average scores of NEVO scanners. Results There was no significant difference in mean scores among four different NEVO scanners [F(3, 102) = 2.27, p = 0.0852 one-way ANOVA with repeated measures]. Moreover, the data provided strong evidence that a significant difference existed between visual and digital scores (p = 0.0217; a pairedsample t-test). Mean visual scores were significantly lower than digital scores (72.4 vs 75.1). Pearson's correlation coefficient of 0.85 indicated a strong correlation between visual and digital scores (p < 0.0001). Conclusion The E4D Compare software provides consistent scores even when different scanners are used and correlates well with visual scores. Clinical significance The use of innovative digital assessment tools in dental education is promising with the E4D Compare software correlating well with visual scores and providing consistent scores even when different scanners are used. How to cite this article Lam MT, Kwon SR, Qian F, Denehy GE. Evaluation of an Innovative Digital Assessment Tool in Dental Anatomy. J Contemp Dent Pract 2015;16(5):366-371.

scholarly journals Sufficient therapeutic effect of cryopreserved frozen adipose-derived regenerative cells on burn wounds

2018 ◽  
Author(s):  
Yasuhiko Kaita ◽  
Takehiko Tarui ◽  
Hideaki Yoshino ◽  
Takeaki Matsuda ◽  
Yoshihiro Yamaguchi ◽  
...  
Keyword(s):  
Wound Healing ◽  
Therapeutic Effect ◽  
Healing Process ◽  
Control Group ◽  
Type I ◽  
Burn Wound ◽  
Burn Wounds ◽  
Burn Wound Healing ◽  
Significant Difference ◽  
Regenerative Cells

AbstractThe purpose of this study was to evaluate whether cryopreserved (frozen) adipose-derived regenerative cells (ADRCs) have a therapeutic effect on burn wound healing as well as freshly isolated (fresh) ADRCs.Full thickness burns were created on dorsum of nude mice and burn wound was excised. The wound was covered by artificial dermis with; (i) fresh ADRCs, (ii) frozen ADRCs, and (iii) PBS (control). The assessment for wound healing was performed by morphological, histopathological and immunohistochemical analyses.In vivo analyses exhibited the significant therapeutic effect of frozen ADRCs on burn wound healing up to the similar or higher level of fresh ADRCs. There were significant differences of wound closure, epithelized tissue thickness, and neovascularization between the treatment groups and control group. Although there was no significant difference of therapeutic efficacy between fresh ADRC group and frozen ADRC group, frozen ADRCs improved burn wound healing process in dermal regeneration with increased great type I collagen synthesis compared with fresh ADRCs.These findings indicate that frozen ADRCs allow us to apply not only quickly but also for multiple times, and the cryopreserved ADRCs could therefore be useful for the treatment of burn wounds in clinical settings.

The effects of Arnebia euchroma ointment on second-degree burn wounds: a randomized clinical trial

2016 ◽  
Vol 189 ◽  
pp. 107-116 ◽  
Author(s):  
Ebrahim Nasiri ◽  
Seyed Jalal Hosseinimehr ◽  
Ahmad Zaghi Hosseinzadeh ◽  
Mohammad Azadbakht ◽  
Jafar Akbari ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Randomized Clinical Trial ◽  
Burn Wounds ◽  
Arnebia Euchroma ◽  
Degree Burn ◽  
Second Degree

Sight-Singing Scores of High School Choristers with Extensive Training in Movable Solfège Syllables and Curwen Hand Signs

2008 ◽  
Vol 56 (3) ◽  
pp. 255-266 ◽  
Author(s):  
Alan C. McClung
Keyword(s):  
High School ◽  
Knowledge Base ◽  
Repeated Measures ◽  
The Other ◽  
Sight Singing ◽  
Repeated Measures Anova ◽  
Pedagogical Strategy ◽  
Extensive Training ◽  
Significant Difference ◽  
The Mean

Randomly chosen high school choristers with extensive training in solfège syllables and Curwen hand signs ( N = 38) are asked to sight-sing two melodies, one while using Curwen hand signs and the other without. Out of a perfect score of 16, the mean score with hand signs was 10.37 ( SD = 4.23), and without hand signs, 10.84 ( SD = 3.96). A repeated-measures ANOVA revealed no statistically significant difference, F(1, 37) = .573, p = .454. These findings support the results of five earlier studies; however, because earlier studies were limited to students who were minimally trained in movable solfège syllables and Curwen hand signs, this study expands the knowledge base. Relationships between performance scores and instrumental experience, class grade, sight-singing experience, and hand sign experience were also examined. A pedagogical strategy for linking Curwen hand signs with students' preferred modes of learning (especially the kinesthetic mode) is recommended.

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