Clinical features of 35 COVID-19 patients with hospitalization for more than 20 days

Abstract Background: As we know, some patients with Coronavirus disease 2019 (COVID-19) may stay longer in the hospital, but whether the different hospitalization days are associated with different clinical features is not clear yet. Methods: This study is a single-centered, observational and retrospective case series.97 patients with COVID-19 were divided into two groups:patients with hospitalization for more than 20 days (Group1,n=35)and those with hospitalization for less than 20 days (Group2,n=62).Data were collected Results Acute Respiratory Distress Syndrome(ARDS) and Hospital acquired pneumonia (HAP)were more common in Group1 than in Group2 . There were more patients administered quadruple antiviral therapy in Group1 than in Group2 . In group1, 14.3% patients’ specimens showed positive again after they were discharged from the hospital.Compared with Group2,Group1 had higher percentages of oxygenation index<300mmHg leucopenia and lymphopenia. In Group1, 19 patients were treated with chloroquine phosphate,whose nucleic acid tests were negative soon,but 5 patents who hadn’t used the medicine had positive testing again . Conclusions: COVID-19 patients with longer hospitalization are more severe and need more quadruple antiviral therapy ;For patients who don't use chloroquine phosphate, the nucleic acid tests are more likely to return to positive again even if they have no symptoms at that time .

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Clinical features of cats with aqueous tear deficiency: a retrospective case series of 10 patients (17 eyes)

Journal of Feline Medicine and Surgery ◽

10.1177/1098612x18810867 ◽

2018 ◽

Vol 21 (10) ◽

pp. 944-950 ◽

Cited By ~ 3

Author(s):

Lisa K Uhl ◽

Akihiko Saito ◽

Hiroko Iwashita ◽

David J Maggs ◽

Jonathan P Mochel ◽

...

Keyword(s):

Clinical Features ◽

Ocular Surface ◽

Clinical Signs ◽

Case Series ◽

Reference Interval ◽

Clinical Findings ◽

Response To Therapy ◽

Ocular Surface Disease ◽

Retrospective Case ◽

Schirmer Tear Test

Objectives The aim of this study was to describe the clinical findings, diagnostic test results and response to therapy of cats with Schirmer tear test 1 (STT-1) values below the reference interval. Methods The medical records of three institutions were searched for cats with ocular surface disease and STT-1 values <9 mm/min, confirmed at two or more separate visits. Results Ten cats (17 eyes) were included. The mean ± SD (range) age and STT-1 values in affected eye(s) were 6.1 ± 5.7 (0.2–16) years and 2.4 ± 3.1 (0–8) mm/min, respectively. Concurrent ocular surface disease was bilateral in 5/10 cats. Clinical signs included conjunctivitis (14/17 eyes), corneal ulceration (6/17 eyes), non-ulcerative keratitis (4/17 eyes), symblepharon (4/17 eyes), eosinophilic keratitis (3/17 eyes), corneal sequestrum (3/17 eyes), corneal fibrosis (2/17 eyes) and meibomitis (2/17 eyes). Management included: topically applied lacrimomimetics, antiviral drugs, corticosteroids or immunomodulatory drugs; orally administered famciclovir; or surgical procedures, in various combinations. Response to therapy (defined as an increase in STT-1 value of ⩾5 mm/min) was transient (seen at a single reassessment) in 65% of eyes and sustained (seen at ⩾2 consecutive reassessments) in 18% of eyes. Conclusions and relevance Clinical features seen in cats with low STT-1 values are described, although the association between aqueous deficiency and the reported ocular changes is unknown at this time. We encourage clinicians to assess the tear film in cats with ocular surface disease, and initiate therapy with lacrimomimetics if STT-1 values are repeatedly below normal. Such information will further define aqueous tear deficiency in cats, providing a better understanding of disease prevalence, pathogenesis and treatment.

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NEAR FATAL AMITRAZ: A NOT SO UNCOMMON POISONING

10.36106/gjra/5601517 ◽

2021 ◽

pp. 42-43

Author(s):

Rohan J Desai ◽

Prasad Ugargol

Keyword(s):

Mechanical Ventilation ◽

Respiratory Failure ◽

Clinical Features ◽

Case Series ◽

Agricultural Product ◽

Common Symptom ◽

Retrospective Case ◽

Case Series Study ◽

Cns Depression ◽

Series Study

Background: Amitraz is a pharmaceutical, veterinary, and agricultural product which is used worldwide to control ectoparasites in animals. Its widespread use has led to increased cases of poisoning in rural parts of India. Aim: To study the clinical features, complications, laboratory abnormalities and outcome of the patients with acute amitraz intoxication. Methodology: The study is a retrospective case series study conducted in HSK hospital between the period of Feb 2019 and May 2020. Results: A total of 11 patients were analysed and results revealed CNS depression and vomiting in 8 of those patients with 1 patient with respiratory failure requiring mechanical ventilation. Conclusion: Amitraz poisoning appears to be severe with CNS depression being the most common symptom. But most patients stabilise and recover quickly. Patients should be monitored for respiratory failure as it is a dreadful complication. Treatment is symptomatic as no antidote is available.

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The Use of a Kinetic Therapy Rotational Bed in Pediatric Acute Respiratory Distress Syndrome: A Case Series

Children ◽

10.3390/children7120303 ◽

2020 ◽

Vol 7 (12) ◽

pp. 303

Author(s):

Daniel T. Cater ◽

Aimee R. Ealy ◽

Erin Kramer ◽

Samer Abu-Sultaneh ◽

Courtney M. Rowan

Keyword(s):

Acute Respiratory Distress Syndrome ◽

Respiratory Distress Syndrome ◽

Respiratory Distress ◽

Distress Syndrome ◽

Case Series ◽

Published Data ◽

Arterial Line ◽

Prone Positioning ◽

Retrospective Case ◽

Oxygenation Indices

Patients with acute respiratory distress syndrome (ARDS) commonly have dependent atelectasis and heterogeneous lung disease. Due to the heterogenous lung volumes seen, the application of positive end expiratory pressure (PEEP) can have both beneficial and deleterious effects. Alternating supine and prone positioning may be beneficial in ARDS by providing more homogenous distribution of PEEP and decreasing intrapulmonary shunt. In pediatrics, the pediatric acute lung injury and consensus conference (PALICC) recommended to consider it in severe pediatric ARDS (PARDS). Manually prone positioning patients can be burdensome in larger patients. In adults, the use of rotational beds has eased care of these patients. There is little published data about rotational bed therapy in children. Therefore, we sought to describe the use of a rotational bed in children with PARDS. We performed a retrospective case series of children who utilized a rotational bed as an adjunctive therapy for their PARDS. Patient data were collected and analyzed. Descriptive statistical analyses were performed and reported. Oxygenation indices (OI) pre- and post-prone positioning were analyzed. Twelve patients with PARDS were treated with a rotational bed with minimal adverse events. There were no complications noted. Three patients had malfunctioning of their arterial line while on the rotational bed. Oxygenation indices improved over time in 11 of the 12 patients included in the study while on the rotational bed. Rotational beds can be safely utilized in pediatric patients. In larger children with PARDS, where it may be more difficult to perform a manual prone position, use of a rotational bed can be considered a safe alternative.

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Prostatic abscess: clinical features, management, and outcomes of a “Stealth” infection: retrospective case series and review of the literature

Diagnostic Microbiology and Infectious Disease ◽

10.1016/j.diagmicrobio.2020.115285 ◽

2021 ◽

Vol 99 (4) ◽

pp. 115285

Author(s):

Margaux E. Wooster ◽

Glen Huang ◽

John W. Sanders ◽

James E. Peacock

Keyword(s):

Clinical Features ◽

Case Series ◽

Review Of The Literature ◽

Retrospective Case ◽

Prostatic Abscess ◽

Retrospective Case Series

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Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study

BMJ ◽

10.1136/bmj.i3182 ◽

2016 ◽

pp. i3182 ◽

Cited By ~ 4

Keyword(s):

Clinical Features ◽

Zika Virus ◽

Case Series ◽

Congenital Infection ◽

Mri Findings ◽

Retrospective Case ◽

Retrospective Case Series ◽

Case Series Study ◽

Series Study ◽

Ct And Mri

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Surfactant Therapy In Neonates With Respiratory Deterioration Due to Pulmonary Hemorrhage

PEDIATRICS ◽

10.1542/peds.95.1.32 ◽

1995 ◽

Vol 95 (1) ◽

pp. 32-36

Author(s):

Paresh B. Pandit ◽

Michael S. Dunn ◽

Enza A. Colucci

Keyword(s):

Repeated Measures ◽

Neonatal Intensive Care ◽

Controlled Trial ◽

Case Series ◽

Pulmonary Hemorrhage ◽

Oxygenation Index ◽

Surfactant Therapy ◽

Exogenous Surfactant ◽

Retrospective Case ◽

Clinically Significant

Objective. To study the effect of exogenous bovine surfactant on oxygen and ventilatory requirements in neonates with respiratory deterioration due to pulmonary hemorrhage. Design. Retrospective case series. Setting. Three regional neonatal intensive care units. Methods. Infants who received surfactant following a clinically significant pulmonary hemorrhage during the time period July 1991 to December 1993 were identified from a database. Infants were excluded if any other cause was found to explain their deterioration. The primary outcome was change in respiratory status following surfactant therapy, as reflected by oxygenation index (OI) and arterial/Alveolar oxygen ratio. Data points were taken as averages of 3 through 6 hours and 0 through 3 hours for the 6 hours before and after surfactant. Differences were analyzed using analysis of variance for repeated measures, with treatment and time as co-variates. Results. Fifteen patients fulfilled inclusion criteria. Median values (range): birth weight, 960 g (595 to 4045); age at pulmonary hemorrhage, 24.4 hours (0.3 to 62); and interval between pulmonary hemorrhage and surfactant therapy, 10 hours (3.7 to 46.5). Mean OI improved from 24.6, at 0 to 3 hours presurfactant, to 8.6 at 3 to 6 hours postsurfactant (P .001). No patient deteriorated following surfactant therapy. The primary respiratory diagnosis was respiratory distress syndrome (RDS) in 8, meconium aspiration syndrome in 3, and isolated pulmonary hemorrhage in 4. All those with RDS had also received surfactant before their pulmonary hemorrhage. Conclusions. Exogenous surfactant appears to be useful adjunctive therapy in neonates with a clinically significant pulmonary hemorrhage. Its use for this indication should be further investigated by a randomized controlled trial.

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Clinical features of rheumatic patients infected with COVID-19 in Wuhan, China

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2020-217627 ◽

2020 ◽

Vol 79 (8) ◽

pp. 1007-1013 ◽

Cited By ~ 31

Author(s):

Cong Ye ◽

Shaozhe Cai ◽

Guifen Shen ◽

Hanxiong Guan ◽

Liling Zhou ◽

...

Keyword(s):

Respiratory Failure ◽

Rheumatic Disease ◽

Hospital Stay ◽

Clinical Features ◽

Early Stage ◽

Case Series ◽

Medication History ◽

Retrospective Case ◽

Case Series Study ◽

Rheumatic Patients

ObjectiveThe clinical features of rheumatic patients with coronavirus disease 2019 (COVID-19) have not been reported. This study aimed to describe the clinical features of COVID-19 in rheumatic patients and provide information for handling this situation in clinical practice.MethodsThis is a retrospective case series study. Deidentified data, including gender, age, laboratory and radiological results, symptoms, signs, and medication history, were collected from 2326 patients diagnosed with COVID-19, including 21 cases in combination with rheumatic disease, in Tongji Hospital between 13 January and 15 March 2020.ResultsLength of hospital stay and mortality rate were similar between rheumatic and non-rheumatic groups, while the presence of respiratory failure was more common in rheumatic cases (38% vs 10%, p<0.001). Symptoms of fever, fatigue and diarrhoea were seen in 76%, 43% and 23% of patients, respectively. There were four rheumatic patients who experienced a flare of rheumatic disease during hospital stay, with symptoms of muscle aches, back pain, joint pain or rash. While lymphocytopaenia was seen in 57% of rheumatic patients, only one patient (5%) presented with leucopenia in rheumatic cases. Rheumatic patients presented with similar radiological features of ground-glass opacity and consolidation. Patients with pre-existing interstitial lung disease showed massive fibrous stripes and crazy-paving signs at an early stage. Five rheumatic cases used hydroxychloroquine before the diagnosis of COVID-19 and none progressed to critically ill stage.ConclusionsRespiratory failure was more common in rheumatic patients infected with COVID-19. Differential diagnosis between COVID-19 and a flare of rheumatic disease should be considered.Trial registration numberChiCTR2000030795.

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Clinical Features of Patients with Probable 2019 Novel Coronavirus Infected Pneumonia in Rasht, Iran: A Retrospective Case Series

Open Access Macedonian Journal of Medical Sciences ◽

10.3889/oamjms.2020.4755 ◽

2020 ◽

Vol 8 (T1) ◽

pp. 16-22

Author(s):

Samad Karkhah ◽

Mohammad Javad Ghazanfari ◽

Amir Shamshirian ◽

Latif Panahi ◽

Meysam Molai ◽

...

Keyword(s):

Clinical Features ◽

Clinical Laboratory ◽

Clinical Symptoms ◽

Case Series ◽

Symptomatic Treatment ◽

Retrospective Case ◽

Laboratory Findings ◽

Retrospective Case Series ◽

Case Series Study ◽

Novel Coronavirus

BACKGROUND: Coronavirus disease-19 (COVID-19) is the first pandemic infectious disease caused by a novel coronavirus. Viral pneumonia is a severe complication of COVID-19. AIM: Due to the high prevalence of this disease globally, especially in Iran, the aim of this study was to determine the clinical features of seven patients with probable COVID-19 infected pneumonia in Rasht, North Iran. MATERIALS AND METHODS: In this retrospective case series study, we described the clinical, laboratory, and radiological features of seven patients with probable COVID-19 infected pneumonia at Razi Hospital, Rasht, north of Iran, from February 27 to March 16, 2020. RESULTS: In this study, the most common clinical symptoms during hospitalization in patients with COVID-19 were poor appetite (seven cases), dehydration (seven cases), cough (six cases), dyspnea (six cases), fatigue (six cases), fever above 38°C (five cases), myalgia (five cases), Chills (five cases), feeling fever (five cases), sore throat (five cases), and nausea (five cases), respectively. The average body temperature in these patients was 39.32°C. In laboratory findings, erythrocyte sedimentation rate was elevated in three patients. Contrary to most of the evidence, C-reactive protein was not elevated in five patients. All patients received antibiotic and antiviral medications and received symptomatic treatment. Finally, four patients responded to the treatments and were discharged from the hospital; two patients were still hospitalized and only one patient died. CONCLUSION: Patients with COVID-19 associated pneumonia can be treated by evaluating and implementing appropriate therapeutic management. However, at the moment the disease progression for patients with COVID-19 cannot be accurately predicted.

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