scholarly journals GDF-15 as a biomarker of aging

2020 ◽  
Author(s):  
Huan Liu ◽  
Yun Huang ◽  
Yongnan Lyu ◽  
Wen Dai ◽  
Yongqing Tong ◽  
...  
Keyword(s):  
Telomere Length ◽  
Hematological Parameters ◽  
Negative Relationship ◽  
Multivariate Regression Analysis ◽  
Telomerase Activity ◽  
Cross Sectional Study ◽  
Htert Mrna ◽  
Human Telomerase Reverse Transcriptase ◽  
Cross Sectional ◽  
Biomarkers Of Aging

Abstract Background: The aging process is accompanied by the gradual development of chronic systemic inflammation (inflamm-aging). Growth differentiation factor-15 (GDF-15) is associated with inflammation and known to be a stress-induced factor. The present study aimed to explore the association of GDF-15 with aging.Methods: In this cross-sectional study, serum GDF-15, hematological parameters, and biomedical parameters were determined in 120 healthy individuals (23-83 years old, males). Three telomere related parameters, including telomere length, telomerase activity, and the expression of human telomerase reverse transcriptase (hTERT) mRNA were also quantified.Results: The older group has a higher levels of GDF-15 and lower expression of hTERT mRNA, and PBMC telomerase activity (p<0.001). In individuals with high GDF-15 levels, they were older, and presented with the lower level of hTERT mRNA and T/S ratio (p<0.01). Spearman correlation analysis shows that GDF-15 positively correlated with age (r=0.664, p<0.001), and negatively correlated with telomere length (r=-0.434, p<0.001), telomerase activity (r=-0.231, p=0.012), and hTERT mRNA (r=-0.206, p=0.024). Furthermore, in multivariate regression analysis, GDF-15 levels showed a statistically significant linear and negative relationship with PBMC telomerase activity (β-coefficient=-0.583, 95% CI -1.044 to -0.122, p=0.014), telomere length (β-coefficient=-0.200, 95% CI -0.305 to -0.094, p<0.001), and hTERT mRNA (β-coefficient=-0.207, 95% CI -0.312 to -0.102, p<0.001) after adjusting for confounders.Conclusions: In conclusion, our results show that circulating GDF-15 is the potential biomarkers of aging that may influence the risk and progression of multiple aging conditions.

scholarly journals Oxidative stress, telomere length, and frailty in an old age population

2018 ◽  
Author(s):  
José Darío Martínez-Ezquerro ◽  
Aleida Rodriguez-Castañeda ◽  
Mauricio Ortiz-Ramirez ◽  
Sergio Sanchez-Garcia ◽  
Haydee Rosas-Vargas ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Older Adults ◽  
Telomere Length ◽  
Old Age ◽  
Cross Sectional Study ◽  
Frailty Phenotype ◽  
Cross Sectional ◽  
Adverse Health Outcomes ◽  
Biomarkers Of Aging ◽  
Dichlorofluorescin Diacetate

AbstractBackgroundA global aging population requires focusing on the risk factors for unhealthy aging, preventive medicine, and chronic disease management. The identification of adverse health outcomes in older adults has been addressed by the characterization of frailty as a biological syndrome. On the other hand, oxidative stress and telomere length have been suggested as biomarkers of aging.ObjectiveTo study the association of oxidative stress, telomere length, and frailty in an old age population.MethodsThis was a cross-sectional study based on 2015 data from 202 members from a cohort of older adults (n=202; gender F/M ratio: 133/69; mean age: 69.89 ± 7.39 years). Reactive oxygen species (ROS) were measured by dichlorofluorescin diacetate, and lipid peroxidation by malondialdehyde. Telomere length was determined using qPCR with SYBR Green Master Mix.ResultsStatistical analysis showed an association between telomere length and frailty but no association between oxidative stress on telomere length or frailty.ConclusionsTelomere length could eventually be used as a marker to discriminate between healthy and unhealthy aging as expressed by frailty phenotype. However, oxidative stress seems as just a biological process of aging.

scholarly journals Sex-Specific Association of Serum Anti-Oxidative Capacity and Leukocyte Telomere Length

Antioxidants ◽  
2021 ◽  
Vol 10 (12) ◽  
pp. 1908
Author(s):  
Eva Hassler ◽  
Gunter Almer ◽  
Gernot Reishofer ◽  
Gunther Marsche ◽  
Harald Mangge ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Telomere Length ◽  
Oxidative Capacity ◽  
Telomerase Activity ◽  
Cross Sectional Study ◽  
Total Serum ◽  
Sectional Study ◽  
Cross Sectional ◽  
Lipid Panel ◽  
Total Antioxidant

Telomeres are a crucial factor in the preservation of genomic integrity, and an elevated risk for diseases such as cancer and cardiovascular events is related to shortened telomeres. However, telomere deterioration could be caused by factors such as chronic oxidative stress and inflammation, which are promoted by an imbalance among reactive oxygen species (ROS) and antioxidants. In this cross-sectional study, we investigated the relationship between telomeres and oxidative stress. The serum leucocyte telomer length (LTL), serum total antioxidant capacity (TAC) and the total serum lipid panel of 180 healthy athletic volunteers (90 males, 90 females) were measured Additionally, a questionnaire about sports behaviour and the type of training was completed. We observed a positive significant relation between serum LTL and TAC in the male group (cc = 3.4/p = 0.001) but not in females. There was no statistically significant correlation between age and physical activity and LTL in both groups. This is the first cross sectional study demonstrating an association between total serum TAC and LTL in healthy males, but interestingly, not in the females. Nevertheless, these results should be interpreted as preliminary, and further studies in independent cohorts are needed to investigate the sex-specific effects of oxidative stress on telomere length and telomerase activity.

scholarly journals Financial Resources and Biomarkers of Aging in the National Health and Aging Trends Study

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 589-589
Author(s):  
Laura Samuel ◽  
Laken Roberts ◽  
Danielle Boyce ◽  
Melissa Hladek ◽  
Sarah LaFave ◽  
...  
Keyword(s):  
Hemoglobin A1c ◽  
Income Group ◽  
Cross Sectional Study ◽  
Financial Strain ◽  
Diabetes Diagnosis ◽  
Lower Income ◽  
Sampling Weights ◽  
Cross Sectional ◽  
Lower Income Group ◽  
Biomarkers Of Aging

Abstract Lower income and financial strain (i.e. difficulty making ends meet) are associated with worse aging biomarkers, but evidence among nationally representative samples is limited. This cross-sectional study tested whether income to poverty ratio (analyzed separately for those &lt;500% vs. ≥500% poverty threshold) and financial strain are associated with biomarkers of aging among NHATS participants aged ≥65 years (n=4,648), adjusting for age, race/ethnicity, gender, smoking, BMI, and diabetes diagnosis for hemoglobin A1c. Sampling weights were applied. Among those with incomes &lt;500% poverty, higher income was associated with lower hemoglobin A1c (b= -0.0196, p=0.007), CMV (b= -0.0689, p&lt;0.001) and CRP (b= -0.0428, p=0.012). Among those with incomes ≥500%, higher income was associated with lower IL-6 (b= -0.0001, p=0.023) and lower CMV (b= -0.0001, p&lt;0.001). Financial strain was not associated with biomarkers. Income is more strongly associated with biomarkers among the lower income group, calling for special attention to this vulnerable population.

scholarly journals Influenza Vaccination in Psoriatic Patients—Epidemiology and Patient Perceptions: A German Multicenter Study (Vac-Pso)

Vaccines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 843
Author(s):  
Christian Kromer ◽  
Phoebe Wellmann ◽  
Ralf Siemer ◽  
Selina Klein ◽  
Johannes Mohr ◽  
...  
Keyword(s):  
Influenza Vaccination ◽  
Inflammatory Diseases ◽  
Influenza Virus Infection ◽  
Multivariate Regression Analysis ◽  
Cross Sectional Study ◽  
Patient Perceptions ◽  
Cross Sectional ◽  
Vaccination Rates ◽  
Disease Characteristics ◽  
History Of

The risk of developing severe complications from an influenza virus infection is increased in patients with chronic inflammatory diseases such as psoriasis (PsO) and atopic dermatitis (AD). However, low influenza vaccination rates have been reported. The aim of this study was to determine vaccination rates in PsO compared to AD patients and explore patient perceptions of vaccination. A multicenter cross-sectional study was performed in 327 and 98 adult patients with PsO and AD, respectively. Data on vaccination, patient and disease characteristics, comorbidity, and patient perceptions was collected with a questionnaire. Medical records and vaccination certificates were reviewed. A total of 49.8% of PsO and 32.7% of AD patients were vaccinated at some point, while in season 2018/2019, 30.9% and 13.3% received an influenza vaccination, respectively. There were 96.6% and 77.6% of PsO and AD patients who had an indication for influenza vaccination due to age, immunosuppressive therapy, comorbidity, occupation, and/or pregnancy. Multivariate regression analysis revealed higher age (p < 0.001) and a history of bronchitis (p = 0.023) as significant predictors of influenza vaccination in PsO patients. Considering that most patients had an indication for influenza vaccination, the rate of vaccinated patients was inadequately low.

Sonographic Assessment of Renal Volume in Normotensive Pregnant Women and Women With Pregnancy-Induced Hypertension in Enugu Metropolis

2021 ◽  
pp. 875647932110210
Author(s):  
Idigo Felicitas Ugochinyere ◽  
Nwankwo Sylvia Chiamaka ◽  
Abonyi Everistus Obinna ◽  
Anakwue Angel-Mary Chukwunyelu ◽  
Agbo Julius Amechi
Keyword(s):  
Reference Range ◽  
Interobserver Variability ◽  
Correct Diagnosis ◽  
Negative Relationship ◽  
Tertiary Hospital ◽  
Cross Sectional Study ◽  
Renal Volume ◽  
Cross Sectional ◽  
Significant Difference ◽  
Induced Hypertension

Objective: Renal volume (RV) assessment during obstetric sonography is rarely considered in our locality. Understanding the changes in RV in both normotensive pregnant (NP) and pregnancy-induced hypertensive (PIH) women is important in making correct diagnosis regarding pregnancy outcome. This study is aimed at determining the RV in NP and PIH women and correlating RV with fetal gestational age (FGA), body mass index (BMI), and parity in NP women. Materials and Methods: This cross-sectional study involved 450 patients recruited at a Tertiary Hospital. A pilot study was done to determine the interobserver variability in RV measurement. RV was calculated using the following formula: L × W × AP × 0.523. Parity, BMI, and blood pressure were documented, while FGA was calculated as an average of FGAs obtained from the measurements of fetal biometric parameters. Results: Mean RV of PIH women was significantly higher than that of NP women ( P < .05). RV shows a positive significant relationship with BMI and FGA, while it shows a negative relationship with parity in NP ( P < .05). Conclusion: Reference range values of RV were generated for clinical use in our locality, while there is statistically significant difference between RV in NP and PIH women.

scholarly journals Poor Sleep during the First Peak of the SARS-CoV-2 Pandemic: A Cross-Sectional Study

2021 ◽  
Vol 18 (1) ◽  
pp. 306
Author(s):  
Stefania Costi ◽  
Sara Paltrinieri ◽  
Barbara Bressi ◽  
Stefania Fugazzaro ◽  
Paolo Giorgi Rossi ◽  
...  
Keyword(s):  
Physical Activity ◽  
Multivariate Regression Analysis ◽  
Cross Sectional Study ◽  
Poor Sleep ◽  
Italian Population ◽  
Sectional Study ◽  
Financial Problems ◽  
Cross Sectional ◽  
Convenience Sample ◽  
Novel Coronavirus

The restrictions enacted during lockdown to limit the spread of the novel coronavirus (SARS-CoV-2) have led to changes in people’s lifestyle habits. In Italy, these restrictions have dramatically changed the way people work and spend their leisure time, also with repercussions on diet and physical activity. An anonymous survey was disseminated via websites and social media to a convenience sample of the Italian population during and immediately after the first lockdown (10 March–18 May 2020). Data collected on 1826 individuals show that lockdown might have worsened the quality of sleep of almost half of the participants in this cross-sectional study. This worsening was associated with a deterioration in crucial determinants of health, such as physical activity and diet (OR 1.68; 95% CI 1.18–2.40 and OR 4.19; 95% CI 2.51–6.96, respectively), with symptoms of psychological distress, such as tension (OR 3.88; 95% CI 2.74–5.52) and loneliness (OR 3.27; 95% CI 2.23–4.79), and with the presence of financial problems (some OR 1.86; 95% CI 1.27–2.72; many OR 7.27; 95% CI 3.59–14.73). The multivariate regression analysis models confirmed these associations. This impact on sleep quality was seen especially among females, those with low education level, and those who experienced financial problems.

scholarly journals Prevalence of Microalbuminuria and Overt Proteinuria in Hypertension and Their Relations with Renal Function in a Rural Population of Bangladesh

2014 ◽  
Vol 24 (2) ◽  
pp. 59-64 ◽  
Author(s):  
ANME Karim ◽  
D Das ◽  
M Salahuddin ◽  
GA Marjan ◽  
MN Islam ◽  
...  
Keyword(s):  
Adult Population ◽  
Negative Relationship ◽  
Cross Sectional Study ◽  
Dipstick Test ◽  
Significant Deterioration ◽  
Cross Sectional ◽  
Spot Urine ◽  
Urine Dipstick Test ◽  
Overt Proteinuria ◽  
Stage Renal Disease

Hypertension is the third leading cause of chronic kidney disease (CKD) in Bangladesh. Microalbuminuria and overt proteinuria are the markers of the CKD. So detection of microalbuminuria and overt proteinuria in hypertensive subjects will help to identify the patient at risk of developing progressive renal impairment. This cross sectional study was carried out in a rural area of Bangladesh.1134 adult population (age between 18 and 65 years) were screened. A total of 217 (19.1%) were detected hypertensive; spot urine dipstick test was done among them. Those who where dipstick negative further studied for presence of microalbumin [ mg/L ]. Blood glucose level, serum creatinine, and estimated glomerular filtration rate (eGFR) were evaluated. A group of normotensive people (n=245) taken as comparison group. Microalbuminuria and overt proteinuria were present in 26.4% and 9.7% of the hypertensive subjects, respectively. Correlation between microalbuminuria and eGFR showed that two variables exhibited a tendency for negative relationship, although correlation was not statistically significant (P=0.186, r=-0.064). Overt proteinuric subjects showed no statistically significant deterioration of eGFR (81.6±21.1). Microalbuminuria and overt proteinuria are prevalent among the hypertensive rural Bangladeshi people. So early detection of microalbuminuria and overt proteinuria will help to prevent or delay the development of end stage renal disease. DOI: http://dx.doi.org/10.3329/bjmed.v24i2.18700 Bangladesh J Medicine 2013; 24 : 59-64

scholarly journals Leukocyte Telomere Length in Relation to 17 Biomarkers of Cardiovascular Disease Risk: A Cross-Sectional Study of US Adults

PLoS Medicine ◽  
2016 ◽  
Vol 13 (11) ◽  
pp. e1002188 ◽  
Author(s):  
David H. Rehkopf ◽  
Belinda L. Needham ◽  
Jue Lin ◽  
Elizabeth H. Blackburn ◽  
Ami R. Zota ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Telomere Length ◽  
Disease Risk ◽  
Cardiovascular Disease Risk ◽  
Cross Sectional Study ◽  
Leukocyte Telomere Length ◽  
Sectional Study ◽  
Cross Sectional
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