Association of whole blood copper, magnesium and zinc levels with metabolic syndrome components in 6–12-year-old rural Chinese children: 2010–2012 China National Nutrition and Health Survey

Abstract Background: Copper (Cu), magnesium (Mg) and zinc (Zn) are essential elements that participate in a series of oxidative stress and inflammation pathways related to metabolic reactions. Many studies have analyzed the relationship between Cu, Mg and Zn and metabolic syndrome (MetS) in adolescents and adults, but there have been few studies of children. We aimed to investigate the association of whole blood Cu, Mg and Zn with MetS components in 6–12-year-old rural Chinese children. Methods: A total of 911 children (51.2% male, 48.7% female) aged 6–12 years were enrolled from the 2010–2012 China National Nutrition and Health Survey. Basic characteristics, metals and MetS component parameters were collected. Multivariate logistic regression analysis was performed to examine the independent relationship between metals and the incidence of MetS components.Results: Copper was positively associated with elevated waist circumference when analyzed alone (OR=2.00, 1.18–3.28). Combined with Zn, this association approached zero. For elevated triglyceride levels, the combination of low Cu and high Zn showed the opposite association with triglyceride relative to Cu alone (OR=2.21, 1.18–4.13 versus OR=0.33, 0.16–0.65, respectively), but was similar to the analysis of Zn alone (OR=2.12, 1.10–4.10). There was no association between whole blood Mg and waist circumference. However, the presence of both high Cu and high Mg levels significantly increased the risk of waist circumference exceeding the standard value (OR=2.03, 1.26–3.27). In addition, separate analysis of the distribution of Mg and Zn found no association with the risk of reduced high density lipoprotein-cholesterol (HDL-C); but high Zn combined with low Mg negatively associated with the risk of reduced HDL-C levels (OR=0.47, 0.28–0.77). Conclusions: Both the single and combined effects of Cu, Mg and Zn were associated with components of MetS. These results indicate the importance of combined analysis of multiple elements, and also provide new avenues for the early screening of MetS. The current results need to be further investigated in future work and other populations.

Download Full-text

Association of whole blood copper, magnesium and zinc levels with metabolic syndrome components in 6–12-year-old rural Chinese children: 2010–2012 China National Nutrition and Health Survey

Nutrition & Metabolism ◽

10.1186/s12986-021-00593-w ◽

2021 ◽

Vol 18 (1) ◽

Author(s):

Huidi Zhang ◽

Qingqing Man ◽

Pengkun Song ◽

Siran Li ◽

Xiaobing Liu ◽

...

Keyword(s):

Metabolic Syndrome ◽

Health Survey ◽

Whole Blood ◽

Multivariate Logistic Regression Analysis ◽

Chinese Children ◽

Single Element ◽

Combined Effects ◽

Nutrition And Health ◽

Element Analysis ◽

Metabolic Syndrome Components

Abstract Background Metabolic syndrome (MetS) is significantly associated with the risk of cardiovascular disease and its prevalence is showing a trend of getting younger. Previous studies on the relationship between elements and MetS were mostly reported in adults with single element analysis, while reports in children with combined effects of multiple elements were very limited. The aim of this study is to investigate the association between whole blood Cu, Mg and Zn in both single and combined effects and MetS components in rural Chinese children aged 6–12 years based on the data from 2010–2012 China National Nutrition and Health Survey. Methods A total of 911 children (51.2% male, 48.7% female) aged 6–12 years were included. Basic characteristics and MetS component parameters were collected and determined by trained stuffs. Elements were detected by Inductively Coupled Plasma Mass Spectrometry (ICP-MS). Multivariate logistic regression analysis was performed to examine the independent relationship between elements and MetS components. Results In single metal analysis, copper was positively associated with elevated waist (OR = 2.00, 1.18–3.28) and all of the metals were associated with elevated TG. And the comprehensive analysis of multiple elements were mostly consistent with the results of single element analysis (low Cu + high Zn with elevated TG (OR = 2.21, 1.18–4.13), high Cu + low Mg with elevated TG (OR = 0.40, 0.16–0.95), high Cu + high Mg with elevated waist (OR = 2.03, 1.26–3.27)), except the combination of Zn and Mg (high Zn + low Mg with reduced HDL-C (OR = 0.47, 0.28–0.77)). Conclusions Our study suggested Cu, Zn and Mg in children are indeed associated with metabolic syndrome components, whether in single element or multi-element combined analysis. The results will be confirmed through additional cohort research.

Download Full-text

Association of whole blood copper, zinc and magnesium levels with risk of metabolic syndrome components in Chinese rural 6-12 years old children: the 2010-2012 China National Nutrition and Health Survey

10.21203/rs.3.rs-31447/v1 ◽

2020 ◽

Author(s):

Huidi Zhang ◽

Qingqing Man ◽

Pengkun Song ◽

Siran Li ◽

Xiaobing Liu ◽

...

Keyword(s):

Metabolic Syndrome ◽

Health Survey ◽

Whole Blood ◽

Multivariate Logistic Regression Analysis ◽

Essential Elements ◽

Future Research ◽

Nutrition And Health ◽

Copper Zinc ◽

Basic Characteristics ◽

Metabolic Syndrome Components

Abstract Background Copper, zinc and magnesium are essential elements and participate in a series of oxidative stress and inflammation related to metabolic reactions. There are many studies analyzed the relationship between Cu, Zn, Mg and metabolic syndrome(MetS), which involved in adults and adolescents, but there are still few in children. Objective We aim to estimate the association of whole blood copper, zinc and magnesium with metabolic syndrome components in Chinese rural 6–12 years old children. Method: A total of 911 children aged 6–12 were enrolled from the 2010–2012 China National Nutrition and Health Survey in this study. The basic characteristics, metals and MetS components parameters were collected. Multivariate logistic regression analysis was performed to confirm the independent relationship between metals and the incident of MetS components. Results Elevated waist was positively associated with higher whole blood Cu concentration(OR = 2.00) and higher ratio of Cu/Zn(OR = 2.08), whereas elevated TG was negatively associated with higher Cu (OR = 0.33) and higher Cu/Zn(OR = 0.35) level. And higher level of Zn (OR = 2.12) and Mg (OR = 2.34) were both positively associated with elevated TG. In the combination of low Cu and high Zn level, it increased the risk of elevated TG(OR = 2.21), which consistent with the single analysis of these two metals. Mg has no significant effect on elevated waist when analysis alone. However, when there was high Mg and Cu at the same time, the risk of elevated waist increased significantly (OR = 2.03). In addition, different from single analysis of Zn and Mg, when high Zn and low Mg combined, it can significantly decreased the risk of reduced HDL-C (OR = 0.47). Conclusion The level of whole blood Cu, Zn, Cu/Zn and Mg within the normal range in children is associated with the risk of MetS components, especially in elevated TG and elevated waist. And the combination of each two metals has also shown to be correlated to MetS components. The future research will conduct a cohort to further confirm these findings. And the results will also need to be verified in other populations.

Download Full-text

Association of Whole Blood Copper, Magnesium and Zinc Levels with Metabolic Syndrome Components in 6–12-Year-Old Rural Chinese Children: 2010–2012 China National Nutrition and Health Survey

10.21203/rs.3.rs-99026/v1 ◽

2020 ◽

Author(s):

Huidi Zhang ◽

Qingqing Man ◽

Pengkun Song ◽

Siran Li ◽

Xiaobing Liu ◽

...

Keyword(s):

Metabolic Syndrome ◽

Health Survey ◽

Whole Blood ◽

Multivariate Logistic Regression Analysis ◽

Chinese Children ◽

Single Element ◽

Major Public Health Problem ◽

Combined Effects ◽

Nutrition And Health ◽

Element Analysis

Abstract Background: Metabolic syndrome (MetS) is a major public health problem in the world and some studies indicated that it is significantly associated with the future risk of cardiovascular disease. There is also a certain prevalence of Mets in childhood and shows a trend of younger age. Previous studies on the relationship between elements and MetS were mostly seen in adults with single element analysis, and reports on children and the combined effects of multiple elements were very limited. With the data form 2010–2012 China National Nutrition and Health Survey, we aim to investigate the association between whole blood Cu, Mg and Zn in both single and combined effects and MetS components in 6–12-year-old rural Chinese children.Methods: A total of 911 children (51.2% male, 48.7% female) aged 6–12 years were enrolled. Basic characteristics, metals and MetS component parameters were collected. Multivariate logistic regression analysis was performed to examine the independent relationship between metals and MetS components.Results: Copper was positively associated with elevated waist (OR=2.00, 1.18–3.28) and negatively associated with elevated TG (OR=0.33, 0.16-0.65). When high Cu combined with Zn, the association with elevated waist and elevated TG both disappeared. In the combination of Cu and Mg, high Cu with high Mg had a positive association with elevated waist (OR=2.03, 1.26-3.27) and high Cu with low Mg had a negative asscoiation with elevated TG (OR=0.40, 0.16-0.95). Conclusions: Our study suggested that both the single and combined effects of Cu, Mg and Zn were associated with MetS components, especially in elevated waist and TG. And the comprehensive analysis of multiple elements was different from the results of single element analysis, which provide new avenues for the early screening of MetS. Additional research is needed to confirm these findings in other populations.

Download Full-text

Association of Iron Storage Markers with Metabolic Syndrome and Its Components in Chinese Rural 6–12 Years Old Children: The 2010–2012 China National Nutrition and Health Survey

Nutrients ◽

10.3390/nu12051486 ◽

2020 ◽

Vol 12 (5) ◽

pp. 1486 ◽

Cited By ~ 1

Author(s):

Huidi Zhang ◽

Lijuan Wang ◽

Siran Li ◽

Xiaobing Liu ◽

Yuqian Li ◽

...

Keyword(s):

Metabolic Syndrome ◽

Health Survey ◽

Whole Blood ◽

Multivariate Logistic Regression Analysis ◽

Density Lipoprotein ◽

Nutrition And Health ◽

Iron Storage ◽

Body Iron ◽

Total Body ◽

The Relationship

Background: Elevated ferritin, which is often used to represent iron storage, is known to increase the risk of metabolic syndrome (MetS) or its components, but its increase is affected by many factors. Therefore, it is necessary to analyze the relationship between other indicators of iron storage, and MetS and its components in order to fully understand the role of iron in the occurrence and development of these diseases. Although there are many studies to analyze the relationship involved in adults and adolescents, in children there is limited research. In this study, we aim to estimate the association of whole blood iron, ferritin, and total body iron with metabolic syndrome, and especially its components in Chinese rural children aged 6–12 years old. Method: A total of 1333 children aged 6–12 years old were enrolled from the 2010–2012 China National Nutrition and Health Survey in this study. Markers of iron storage (whole blood iron, ferritin, and total body iron (TBI)) and MetS component parameters (waist, blood pressure, high-density lipoprotein cholesterol (HDL-C), triglyceride (TG), and fast glycose) were collected. A multivariate logistic regression analysis was performed to confirm the independent relationship between iron storage markers, and the incident of metabolic syndrome and its components. Results: After adjusting for age, gender, C-reactive protein (CRP), and body mass index (BMI), a negative association was found between whole blood iron, ferritin, and TBI and incidence of reduced HDL-C (odds ratio (OR) = 0.63, 0.49, and 0.57, respectively). The highest tertile of whole blood iron increased the risk of the incidence of hyperglycemia (OR = 1.74), while TBI decreased the risk by 61%. No significant association was found between ferritin tertiles and the incidence of hyperglycemia. Conclusion: An iron storage level within the normal range in children is associated with a risk of MetS components, especially in hyperglycemia and reduced HDL-C. The relationship between the three iron indexes and metabolic syndrome and its components is not completely consistent, which suggests that the underlying mechanism is complex and needs to be further explored.

Download Full-text

Metabolic syndrome and socioeconomic status in France: The French Nutrition and Health Survey (ENNS, 2006–2007)

International Journal of Public Health ◽

10.1007/s00038-013-0501-2 ◽

2013 ◽

Vol 58 (6) ◽

pp. 855-864 ◽

Cited By ~ 40

Author(s):

M. Vernay ◽

B. Salanave ◽

C. de Peretti ◽

C. Druet ◽

A. Malon ◽

...

Keyword(s):

Metabolic Syndrome ◽

Socioeconomic Status ◽

Health Survey ◽

Nutrition And Health

Download Full-text

Adherence to Daily Food Guides Is Associated with Lower Risk of Metabolic Syndrome: The Nutrition and Health Survey in Taiwan

Nutrients ◽

10.3390/nu12102955 ◽

2020 ◽

Vol 12 (10) ◽

pp. 2955

Author(s):

Ming-Chieh Li ◽

Hsin-Yu Fang

Keyword(s):

Metabolic Syndrome ◽

Health Survey ◽

Lower Risk ◽

Health Knowledge ◽

Family Income ◽

Final Analysis ◽

Food Groups ◽

Nutrition And Health ◽

Cross Sectional ◽

Daily Food

Although nutritional health knowledge serves as the basis for the daily food guides, limited epidemiologic studies were conducted to verify whether adherence to the daily food guides reduced the prevalence of diseases. This study aims to examine whether adherence to the daily food guides relates to the lower risk of having metabolic syndrome, as well as to assess the association between levels of adherence to daily food guides and demographic characteristics. A cross-sectional study was conducted using data from the Nutrition and Health Survey in Taiwan (NAHSIT) 2013–2016. Face-to-face dietary assessments were conducted using a validated food-frequency questionnaire. Six food groups were defined according to the daily food guides in Taiwan. We constructed a daily food guide index to measure the levels of adherence to the daily food guides. Logistic regression was performed to assess the association between the levels of adherence to the daily food guides and the risk of having metabolic syndrome. A total of 2534 participants (51% of females) were included in the final analysis. After adjusting for age, sex, body mass index, education level, marital status, and family income, we found a negative correlation between the levels of adherence to daily food guides and the prevalence of metabolic syndrome. The odds ratios (ORs) for the highest versus lowest quartile of the adherence level was 0.65 (95% confidence interval (CI) = 0.48–0.88). In addition, males, younger age, lower education, divorced, separated, and widowed, and lower family income were associated with lower adherence to daily food guides. In conclusion, participants reporting better adherence to the daily food guides during the past month had a lower risk of having metabolic syndrome.

Download Full-text

Physical activity and sedentary behavior among Chinese children aged 6–17 years: a cross-sectional analysis of 2010–2012 China National Nutrition and health survey

BMC Public Health ◽

10.1186/s12889-019-7259-2 ◽

2019 ◽

Vol 19 (1) ◽

Cited By ~ 5

Author(s):

Chao Song ◽

Weiyan Gong ◽

Caicui Ding ◽

Fan Yuan ◽

Yan Zhang ◽

...

Keyword(s):

Physical Activity ◽

Sedentary Behavior ◽

Health Survey ◽

Chinese Children ◽

Nutrition And Health ◽

Cross Sectional ◽

Cross Sectional Analysis ◽

Sectional Analysis

Download Full-text

The Association of Hypertension with Obesity and Metabolic Abnormalities among Chinese Children

International Journal of Hypertension ◽

10.4061/2011/987159 ◽

2011 ◽

Vol 2011 ◽

pp. 1-5 ◽

Cited By ~ 2

Author(s):

Haiquan Xu ◽

Xiaoqi Hu ◽

Qian Zhang ◽

Songming Du ◽

Hongyun Fang ◽

...

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Waist Circumference ◽

Odds Ratio ◽

Serum Lipid ◽

Education Level ◽

Chinese Children ◽

Healthy Children ◽

Metabolic Abnormalities ◽

Obese Children

A total of 8898 Chinese children (4580 boys and 4318 girls) aged 7–13 years in 6 cities of east China were recruited. Data on height, weight, waist circumference, blood pressure, serum lipid profiles, glucose, and insulin were collected. The overall prevalence of hypertension was 11.1%. Overweight and obese children had a higher risk of developing hypertension than their counterparts (29.1%, 17.4%, and 7.8%, resp.) (P=0.0001). The means levels of triglycerides, glucose, insulin, and HOMA-IR (1.0 mmol/L, 4.5 mmol/L, 8.4 mU/mL and 1.7, resp.) among hypertensive children were all significantly higher than their normotensive counterparts (0.8 mmol/L, 4.5 mmol/L, 5.9 mU/mL, and 1.2, resp.) (P=0.0001). Compared with the healthy children, the risk (odds ratio, OR) of having hypertension among children with high triglycerides, hyperglycemia, and metabolic syndrome was 1.4 (95% confidence interval (CI): 1.0–2.0,P=0.0334), 1.5 (95% CI: 0.9–2.5,P=0.0890), and 2.8 (95%CI: 1.5–5.4,P=0.0014), respectively, after controlling for age, gender, BMI, income level, parents' education level and puberty. In conclusion, overweight and obese children have higher risk of having hypertension and children with dyslipidemia, hyperglycemia, and metabolic syndrome and higher HOMA-IR have higher risk of developing hypertension.

Download Full-text

Nutrition patterns and metabolic syndrome: A need for action in young adults (French Nutrition and Health Survey — ENNS, 2006–2007)

Preventive Medicine ◽

10.1016/j.ypmed.2010.09.009 ◽

2010 ◽

Vol 51 (6) ◽

pp. 488-493 ◽

Cited By ~ 13

Author(s):

Chantal Julia ◽

Michel Vernay ◽

Benoît Salanave ◽

Valérie Deschamps ◽

Aurélie Malon ◽

...

Keyword(s):

Metabolic Syndrome ◽

Young Adults ◽

Health Survey ◽

Nutrition And Health

Download Full-text

The prevalence of metabolic syndrome in male patients of early onset androgenic alopecia compared to age matched controls

International Journal of Research in Dermatology ◽

10.18203/issn.2455-4529.intjresdermatol20214824 ◽

2021 ◽

Author(s):

Nitin D. Chaudhari ◽

Chandrakant B. Poulkar ◽

Swapna S. Khatu ◽

Gaurav H. Khandait ◽

Rajvardhan M. Bagane ◽

...

Keyword(s):

Blood Pressure ◽

Metabolic Syndrome ◽

Waist Circumference ◽

Early Onset ◽

High Density ◽

High Density Lipoproteins ◽

P Value ◽

Early Screening ◽

Androgenic Alopecia ◽

Male Patients

Background: Androgenic alopecia is most common type of non-scarring alopecia in men. It is associated with high risk of cardiovascular events. Aim was to study the prevalence of metabolic syndrome in male patients of early onset androgenic alopecia.Methods: A case-control study was conducted at the dermatology out-patient department over a period of 6 months which included 100 patients of androgenic alopecia and 100 age matched controls. All subjects were aged 20 to 35 years and underwent detailed history, clinical examination including trichoscopic examination and measurement of waist circumference and blood pressure. Fasting blood sugar, triglyceride and high-density lipoproteins were tested following overnight fasting. Diagnosis of metabolic syndrome was based on criteria of national cholesterol education program (NCEP) adult treatment panel III. Chi square test was used as a test of significance. P value <0.05 was considered statistically significant.Results: Prevalence of metabolic syndrome was more in androgenic alopecia patients than in controls (48% versus 18%, p value <0.001). Androgenic alopecia patients had higher prevalence of increased waist circumference (76% versus 28%, p value <0.0001), increased diastolic blood pressure (32% versus 12%, p value=0.007), increased serum triglycerides (46% versus 24%, p value=0.0011) and decreased serum high-density lipoproteins (36% versus 18%, p value=0.0042) compared to controls.Conclusions: Early screening for metabolic syndrome and its components is beneficial in patients with androgenic alopecia to reduce cardiovascular mortality.

Download Full-text