scholarly journals Burdens of Post-acute Sequelae of COVID-19 by Age, Race, Sex, and Health Status

Author(s):  
Ziyad Al-Aly ◽  
Yan Xie ◽  
Benjamin Bowe

Abstract The Post-Acute Sequelae of SARS-CoV-2 infection (PASC) have been characterized; however, the burden of PASC remains unknown. And whether the burden of individual sequela varies in different population groups is also not clear. Here we estimate that PASC — defined as the presence of at least one sequela in excess of non-infected controls — was 73.43 (72.10, 74.72) per 1000 persons at 6 months. The burden of PASC was 44.51 (43.09, 45.85), 217.08 (212.43, 222.23), and 360.16 (350.53, 369.38) among non-hospitalized, hospitalized, and those who required intensive care during the first 30-days of infection. Burdens of some sequelae were more pronounced in younger individuals, and some were more pronounced in older adults; the same picture was evident in analyses across race, and sex groups. The burden of individual sequela was consistently higher in people with poorer baseline health and increased in a graded fashion according to care setting of the acute infection. In sum, the burden of PASC is substantial; however, PASC is non-monolithic with sequelae that are differentially expressed in various population groups. Collectively, our results may be useful in informing health systems capacity planning and care strategies of people with PASC.

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yan Xie ◽  
Benjamin Bowe ◽  
Ziyad Al-Aly

AbstractThe Post-Acute Sequelae of SARS-CoV-2 infection (PASC) have been characterized; however, the burden of PASC remains unknown. Here we used the healthcare databases of the US Department of Veterans Affairs to build a cohort of 181,384 people with COVID-19 and 4,397,509 non-infected controls and estimated that burden of PASC—defined as the presence of at least one sequela in excess of non-infected controls—was 73.43 (72.10, 74.72) per 1000 persons at 6 months. Burdens of individual sequelae varied by demographic groups (age, race, and sex) but were consistently higher in people with poorer baseline health and in those with more severe acute infection. In sum, the burden of PASC is substantial; PASC is non-monolithic with sequelae that are differentially expressed in various population groups. Collectively, our results may be useful in informing health systems capacity planning and care strategies of people with PASC.


2005 ◽  
Vol 53 (9) ◽  
pp. 1469-1475 ◽  
Author(s):  
Capri Gabrielle Foy ◽  
Brenda W. H. Penninx ◽  
Sally A. Shumaker ◽  
Stephen P. Messier ◽  
Marco Pahor

1992 ◽  
Vol 3 (1) ◽  
pp. 120-126 ◽  
Author(s):  
Mickey Stanley

Elderly patients who enter the critical care setting have special nursing care needs based on the physiologic changes of aging. An overview of the changes of aging associated with the immunologic, cardiovascular, integumentary, musculoskeletal, and renal systems provides the basis for care planning to meet the needs of older adults in the intensive care unit


Author(s):  
Lucinda Barrett ◽  
Bridget Atkins

Neurosurgical infections include those of devices such as external ventricular drains and permanent shunts (e.g. ventriculo-peritoneal and ventriculo-atrial). Organisms can form biofilm on the surface of such devices, sometimes sufficient to cause blockage. Patients may present with signs of meningitis or of shunt blockage. In the intensive care setting patients may have fever and/or deterioration in their neurological status. These infections are complex to manage as they usually require removal/revision of the device and delivery of high levels of antibiotics to the central nervous system. Each of these has risks and needs to be expertly managed. This case describes an acute infection in an external ventricular drain.


2010 ◽  
Vol 15 (1) ◽  
pp. 4-11 ◽  
Author(s):  
Sridhar Krishnamurti

Alzheimer's disease is neurodegenerative disorder which affects a growing number of older adults every year. With an understanding of auditory dysfunction in Alzheimer's disease, the speech-language pathologist working in the health care setting can provide better service to these individuals. The pathophysiology of the disease process in Alzheimer's disease increases the likelihood of specific types of auditory deficits as opposed to others. This article will discuss the auditory deficits in Alzheimer's disease, their implications, and the value of clinical protocols for individuals with this disease.


Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 1398-P
Author(s):  
MARY R. ROONEY ◽  
OLIVE TANG ◽  
B. GWEN WINDHAM ◽  
JUSTIN B. ECHOUFFO TCHEUGUI ◽  
PAMELA LUTSEY ◽  
...  

Author(s):  
Ivan Cabrilo ◽  
Claudia L. Craven ◽  
Hazem Abuhusain ◽  
Laura Pradini-Santos ◽  
Hasan Asif ◽  
...  

CJC Open ◽  
2021 ◽  
Author(s):  
Kim Volle ◽  
Clément Delmas ◽  
Jean Ferrières ◽  
Olivier Toulza ◽  
Stephanie Blanco ◽  
...  

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