scholarly journals hTERT Represents an Innovative Bio-marker in Cholangiocarcinoma Detection

2020 ◽  
Author(s):  
Ning Wang ◽  
Yanni Li ◽  
Yanfang Zheng ◽  
Huoming Chen ◽  
Xiaolong Wen ◽  
...  
Keyword(s):  
Diagnostic Value ◽  
Healthy Controls ◽  
Operating Characteristics ◽  
Chi Square ◽  
Specificity And Sensitivity ◽  
Chi Square Test ◽  
Auc Value ◽  
Student’S T ◽  
Human Telomerase ◽  
Student’S T Test

Abstract Background: The study was aimed to examine the diagnostic value of serum human telomerase reverse transcriptiptase (hTERT) in patients with cholangiocarcinoma (CCA).Methods: Serum hTERT in CCA patients and healthy controls was detected by quantitative real-time PCR (qRT-PCR) and compared by student’s t-test. Relationships of serum hTERT and clinical parameters were explained by Chi-square test. The receiver operating characteristics (ROC) analysis was conducted to identify the diagnostic value of serum hTERT in CCA.Results: Serum hTERT was up-regulated in CCA patients compared with healthy controls (P<0.05). Furthermore, serum hTERT was closely related with differentiation (P=0.005), distant metastasis (P=0.015) and TNM stage (P=0.009). The AUC value of ROC curve was 0.901, demonstrating that serum hTERT could discriminate between CCA and healthy individuals, with the cutoff point of 1.88. Besides, the diagnostic specificity and sensitivity of serum hTERT in CCA were 89.7% and 76.0%, respectively.Conclusions: hTERT may be a promising biomarker for diagnosis of CCA.

scholarly journals LIM and SH3 Protein 1 Stands for a Bio-Marker for Cholangiocarcinoma Detection

2020 ◽  
Author(s):  
Ning Wang ◽  
Yanni Li ◽  
Yanfang Zheng ◽  
Huoming Chen ◽  
Xiaolong Wen ◽  
...  
Keyword(s):  
Serum Level ◽  
Roc Curve ◽  
Serum Levels ◽  
Diagnostic Value ◽  
Tissue Level ◽  
Healthy Controls ◽  
Roc Curve Analysis ◽  
Chi Square ◽  
Chi Square Test ◽  
Auc Value

Abstract Background: LIM and SH3 protein 1 (LASP-1) has been demonstrated to be overexpression in several types of cancers. The aim of this study was to verify the serum level of LASP-1 and investigate its diagnostic value in cholangiocarcinoma (CCA) patients.Methods: Quantitative real-time polymerase chain reaction (qRT-PCR) was performed to detect the expression level of LASP-1 in CCA patients and healthy controls. The correlation of LASP-1 expression with clinicopathological characteristic of CCA patients was analyzed via Chi-square test. Receiver operating characteristic (ROC) curve was built to evaluate the diagnostic value of serum LASP-1 in CCA.Results: Serum levels of LASP-1 were upregulated in CCA compared with healthy controls (P<0.01). And the serum level and tissue level of LASP-1 mRNA exhibited significant correlation (R=0.454, P=0.000). Serum expression of LASP-1 was closely associated with lymph node metastasis (P=0.018) and TNM stage (P=0.021). ROC curve analysis revealed that serum LASP-1 was of great value in differentiating CCA patients from healthy individuals. The area under the ROC curve (AUC) value was 0.879 corresponding with a sensitivity of 81.9% and a specificity of 79.6%.Conclusions: Serum LASP-1 might be an useful diagnostic biomarker for CCA.

scholarly journals Effect of ondansetron on spinal induced hypotension in caesarean deliveries

2020 ◽  
Vol 8 (4) ◽  
pp. 193-199
Author(s):  
Pujan Balla ◽  
Anil Shrestha ◽  
Ninadini Shrestha ◽  
Navindra Bista ◽  
Moda Nath Marhatta
Keyword(s):  
Spinal Anesthesia ◽  
Elective Caesarean Section ◽  
P Value ◽  
Chi Square ◽  
Induced Hypotension ◽  
Intergroup Comparison ◽  
Chi Square Test ◽  
The Mean ◽  
Student’S T ◽  
Student’S T Test

Background: Spinal anesthesia is the preferred technique of anesthesia employed for caesarean sections. However, it is very often complicated by hypotension. Different drugs and techniques have been used to prevent the hypotension induced by spinal anesthesia. In this study, the effect of ondansetron on the prevention of hypotension after spinal anesthesia was evaluated. Objectives: To determine the effect of prophylactic ondansetron on prevention of spinal induced hypotension in elective caesarean section. Methodology: Eighty-six parturients planned for elective caesarean deliveries were randomized into two groups of 43 each. Group O received Ondansetron 4 mg (4 ml) and Group S received Normal Saline (4 ml) intravenously 10 minutes prior to spinal anesthesia. Blood pressure, heart rate, phenylephrine requirements, occurrence of nausea and vomiting and APGAR scores of neonates were compared between the groups. Hemodynamic data was analyzed using Student’s t-test for intergroup comparison and ANOVA was used for intragroup comparison. Categorical data was analyzed using Pearson Chi-Square test. For all determinants, p-value <0.05 was considered significant. Results: Occurrence of hypotension in Group O (20.9 %) was significantly lower than in Group S (72.1%) (p < 0.05). The mean arterial pressure was significantly higher in Group O at 2, 6, 8, 12 and 14 minutes (p < 0.05). The use of phenylephrine (37.21 mcg vs. 146.51 mcg, p < 0.05) and occurrence of nausea (11.6%, vs. 41.9% p < 0.002) was significantly lower in ondansetron group. Conclusion: Ondansetron is effective in preventing spinal induced hypotension in elective caesarean sections.

scholarly journals Fishery regulamentation or ethnoknowledge? The dilemma of the management of the mapará fisheries on the lower Tocantins river in northern Brazil

2021 ◽  
Vol 10 (11) ◽  
pp. e131101118963
Author(s):  
Esther Mirian Cardoso ◽  
Paulo Allison Costa da Mata ◽  
Matheus dos Santos Souza ◽  
Maria Clara Pinheiro de Souza ◽  
Victoria Isaac
Keyword(s):  
Socioeconomic Development ◽  
Economic Importance ◽  
Chi Square ◽  
Great Economic Importance ◽  
Chi Square Test ◽  
Northern Brazil ◽  
The Mean ◽  
Tocantins River ◽  
Student’S T ◽  
Student’S T Test

The fishery of mapará (Hypophthalmus marginatus) is of great economic importance in the Amazon region. Despite this, it is observed that the current norms of management disagree with the ethnoknowledge of fishermen of the Tocantins river. Therefore, there are many seizures and fines in the Tocantins Low region. This work appeared as a demand of the fishermen of the region and had as purpose to test the pertinence of the fishing legislation on the capture of the species and to provide subsidies for the adaptation of the norms to the local reality. For this, a mapará fishery was taken on the Pindobal Grande river, in the municipality of Igarapé-Miri, in the state of Pará. A sample of the captured individuals was collected, and identification, sexing and biometry were done. Fishing was described, and the sex ratio tested with the Chi-Square test and the mean length differences between the sexes with the Student's t-test. The results were compared with current legislation and literature data. The captured mapará individuals were mostly above 30 cm, as determined by legislation. It is concluded that, despite using a network that is prohibited, the capture of the species in the region acts selectively, due to the ethno-cognition and the fisherman's action ("taleiro"). Therefore, it is necessary that the legislation be revised, seeking the reconciliation between the conservation of ecosystems, the traditional knowledge and the socioeconomic development of the region.

scholarly journals Sports potential modeling of young basketball players: a preliminary analysis

2019 ◽  
Vol 21 ◽  
Author(s):  
Dilson Borges Ribeiro Junior ◽  
Jeferson Macedo Vianna ◽  
André de Assis Lauria ◽  
Emerson Filipino Coelho ◽  
Francisco Zacaron Werneck
Keyword(s):  
Adult Height ◽  
High Potential ◽  
Basketball Players ◽  
Chi Square ◽  
Chi Square Test ◽  
Student’S T ◽  
The Relationship ◽  
Student’S T Test ◽  
Adult Stature

Abstract The aims of this study were: 1) to evaluate the sports potential of young basketball players; 2) to identify variables that discriminate sports potential assessed by coaches; 3) to verifythe relationship between classification of the multidimensional profile of athletes and classification of the sports potential by coaches. Sixty-two young basketball players aged 15.6±1.1 years from U-15 (n = 24) and U-17 (n = 38) categories participated in the study. A test battery was applied to evaluate sports potential indicators: 1) anthropometric; 2) physicomotor; 3) psychological;4) skills;5) socio-environmental;6) maturational and 7) sports potential.Clusteranalysis was performed in three groups: high, medium and low potential. Student’s t-test was used for the comparison between athletes evaluated by the coach as excellent and the others and the Chi-Square test to verify the relationship between sports potential classifications. It was observed that in the high-potential group, athletes were chronologically older, with higher % predicted adult height (PMS), competitive and determined sports orientation, higher body size, lower skinfold summation, and greater physicomotor performance. In comparison with other athletes, high-potential basketball players presented higher stature, wider wingspan,longer limb length, greater predicted adult stature and higher Z score of the % PMS. It could be concluded that the multidimensional approach was useful for the evaluation of the sports potential of young basketball players, requiring the use of multidimensional variables, in addition to coaches’ opinion regarding the potential of their athletes.

scholarly journals MiR-210 has the capacity to serve as a diagnostic biomarker for laryngeal carcinoma patient

2020 ◽  
Author(s):  
Lili Wang ◽  
Hongguang Song ◽  
Shiming Yang
Keyword(s):  
Laryngeal Carcinoma ◽  
Clinical Characteristics ◽  
Roc Analysis ◽  
Diagnostic Value ◽  
Diagnostic Biomarker ◽  
Chi Square ◽  
Qrt Pcr ◽  
Elevated Expression ◽  
Chi Square Test ◽  
Auc Value

Abstract Background Early diagnosis represents a great challenge for laryngeal carcinoma patients. MiR-210 is involved in various human cancers. In this study, we aimed to investigate the diagnostic performance of serum miR-210 in laryngeal carcinoma. Methods In our study, qRT-PCR was performed to determine the serum miR-210 level in 137 laryngeal carcinoma patients and 79 healthy volunteers. The association of serum miR-210 level with clinical characteristics of the patients was estimated by chi-square test. ROC analysis was applied to evaluate the diagnostic value of miR-210 in laryngeal carcinoma. Results Serum miR-210 level was higher in laryngeal carcinoma patients than that in healthy group (P < 0.001). Moreover, its elevated expression was positively associated with TNM stage (P = 0.000) and distant metastasis (P = 0.001). The AUC value of the ROC curve was 0.893, suggesting the possibility of serum miR-210 as a diagnostic biomarker for the disease. The cut-off value was 4.685, with the sensitivity of 83.2% and the specificity of 84.8%. Conclusion MiR-210 serves as an oncogene in progression of laryngeal carcinoma. Serum miR-210 may be a potential diagnostic biomarker for laryngeal carcinoma.

scholarly journals ACUTE APPENDICITIS

2015 ◽  
Vol 22 (09) ◽  
pp. 1212-1216
Author(s):  
Abdul Salam Memon ◽  
Shahida Khatoon ◽  
Riaz Ahmed Memon ◽  
Afzal Junejo
Keyword(s):  
Acute Appendicitis ◽  
Mean Platelet Volume ◽  
P Value ◽  
Platelet Volume ◽  
Chi Square ◽  
Chi Square Test ◽  
The Difference ◽  
Student’S T ◽  
Control Study ◽  
Student’S T Test

Objectives: To study mean platelet volume (MPV) in acute appendicitis andits correlation with leukocyte count. Study Design: Case control study Place and Duration:Department of Surgery, Liaquat University of Medical and Health Sciences Jamshoro/Hyderabadfrom January 2013 to February 2014. Subjects and Methods: Subjects with clinical suspicionof acute appendicitis were selected according inclusion and exclusion criteria. A sample of 49acute appendicitis patients and 37 controls were studied. The Blood samples were collected insodium citrate vacutainers and processed on Sysmex KX 21 analyzers. The main analysis wasthe comparison of the difference of MPV between acute appendicitis and controls. Data wasanalyzed on SPSS version 21.0 by student’s t-test, Chi-square test and Pearson’s correlation (r)was used to evaluate association of MPV with platelet counts and leukocytes. A p-value of ≤0.05was taken significant. Results: The mean platelet volume and leukocytes were significantlyelevated in patients with acute appendicitis. MPV and leukocytosis in controls and cases werenoted as 7.93±2.1 vs. 9.10±2.9fl (p=0.0001) and 6980±120 vs. 13980±340 μL-1 respectively.MPV was positively correlated with leukocytosis (r=0.419) (p=0.0001), while Platelets showeda negative correlation. Conclusion: Elevated MPV and leukocytosis are observed in acuteappendicitis. MPV may be exploited for clinical diagnosis of acute appendicitis but in a properclinical context along with leukocytosis.

scholarly journals Effect of Use of Ambulance as Emergency Medical Service in Patients of ST-Elevation Myocardial Infarction

2021 ◽  
Vol 2 (3) ◽  
pp. 4
Author(s):  
Majid Bashir ◽  
Kubra Maryam ◽  
Nazeer Ahmed ◽  
Tariq Mehmood ◽  
Adnan Aslam
Keyword(s):  
Myocardial Infarction ◽  
St Elevation Myocardial Infarction ◽  
Base Line ◽  
Chi Square ◽  
Level Of Satisfaction ◽  
Significant Difference ◽  
Chi Square Test ◽  
St Elevation ◽  
Student’S T ◽  
Student’S T Test

Objective: To study the frequency of ambulance utilization by the St-elevation Myocardial Infarction patients toreach hospital, perception of ambulance users about the facilities available in the ambulance, and evaluate theclinical outcomes of STEMI between ambulance users and non-users.Study Design: Cross-section survey-based study.Place and Duration of Study: The study was carried out in the Department of Cardiology at Chaudry Pervaizth th Elahi Institute of Cardiology (CPEIC) Multan from 14 April 2020 to 14 September 2020.Materials and Methods: Patients with the diagnosis of STEMI were included in the study and were classifiedinto two groups' ambulance and non-ambulance users, to reach the facility. Patients' demographics, initialpresenting symptoms, availability of ambulance, and time to reach the hospital were recorded. Moreover, theywere followed for complication during their stay and base line laboratory indicators. Ambulance users werealso evaluated for their perception about availability of medical services in the ambulance. The data collectedfrom both of the groups were compared through student's t-test and chi-square test. Statistical value less than0.05 was considered as significant.Results: Out of 300 patients, 32.6% were ambulance users while 67.4% were non-ambulance user. Nosignificant difference was found in age, gender, underlying comorbidity, and initial presenting symptomsbetween two groups. Majority of ambulance users (74%) arrived in less than 45minutes. Differentcomplications were recorded but no significant difference was found between two groups. Majority ofambulance users 31.5% were neutral about the level of satisfaction for ambulance facilities.Conclusion: Frequency of ambulance utilization by STEMI patients is not only low in Pakistan, but ambulancesystem is also not successful in producing significant change in clinical outcomes. Therefore an awarenesscampaign along with ambulance improvement campaigns should be launched to bring a meaningful change.

The significance of pigment epithelial detachment in central serous chorioretinopathy

2020 ◽  
pp. 112067212090467
Author(s):  
Argyrios Chronopoulos ◽  
Vinodh Kakkassery ◽  
Marc Andre Strobel ◽  
Luise Fornoff ◽  
Lars-Olof Hattenbach
Keyword(s):  
Central Serous Chorioretinopathy ◽  
Pigment Epithelial Detachment ◽  
Chi Square ◽  
Pigment Epithelial ◽  
Single Center Study ◽  
Chi Square Test ◽  
Acute Central Serous Chorioretinopathy ◽  
Student’S T ◽  
Clear Statement ◽  
Student’S T Test

Purpose: To investigate the significance of the presence and form of pigment epithelial detachment in the course of central serous chorioretinopathy as well as corticosteroid use as a risk in our patient cohort. Material and methods: Retrospective, single center study of central serous chorioretinopathy patients between January 2013 and January 2019 recording corticosteroid use prior to onset and presence and type of pigment epithelial detachment (flat-irregular, dome-shaped, none) in relationship to disease course. Results: We analyzed 53 eyes of 53 consecutive central serous chorioretinopathy patients treated in our department. Mean patient age was 53 ± 13 years. A flat-irregular pigment epithelial detachment was associated with either chronic or recurrent central serous chorioretinopathy, whereas the absence of a pigment epithelial detachment correlated positively with acute central serous chorioretinopathy (chi-square test, p < 0.05). Of the 53 patients, 10 reported corticosteroid use, 40 denied steroid use, and 3 patients failed to make a clear statement. Corticosteroid use was not correlated with the onset of central serous chorioretinopathy (Student’s t-test, p = 0.0001, chi-square test, p < 0.005). Conclusion: A small, flat-irregular pigment epithelial detachment could be a marker for chronic or recurrent central serous chorioretinopathy, whereas the absence of pigment epithelial detachment could favor acute central serous chorioretinopathy. Advanced imaging studies may provide more information on the exact characteristics and nature of pigment epithelial detachments. Corticosteroid use as possible disease trigger was not confirmed in this study.

scholarly journals Persistence of Neonatal Brachial Plexus Palsy among Nulliparous Versus Parous Women

2019 ◽  
Vol 09 (01) ◽  
pp. e1-e5
Author(s):  
Rodney McLaren ◽  
Kate Chang ◽  
Nana-Ama Ankumah ◽  
Lynda Yang ◽  
Suneet Chauhan
Keyword(s):  
Brachial Plexus ◽  
University Of Michigan ◽  
Brachial Plexus Palsy ◽  
Chi Square ◽  
Neonatal Brachial Plexus Palsy ◽  
Multiparous Women ◽  
Chi Square Test ◽  
Student’S T ◽  
The University ◽  
Student’S T Test

Objective Our objective was to compare persistence of neonatal brachial plexus palsy (NBPP) at 1 and 2 years in children of nulliparous versus parous women. Study Design We conducted a retrospective cohort study of children diagnosed with NBPP followed at the University of Michigan, Interdisciplinary Brachial Plexus Program (UM-BPP). Self-reported demographics, delivery history, including birth weight (BW) < versus ≥ 9 lbs, and presence of shoulder dystocia (SD) were recorded. Student's t-test and Chi-square test with odds ratio (OR) with 95% confidence intervals (CI) were calculated for comparisons of maternal, neonatal, and peripartum characteristics. Results Of 337 children with NBPP, 43% (146) were of nulliparas and 57% (191) of multiparas. At 1 year, children with persistent NBPP were similar in both groups (87% vs. 88%, aOR 1.357, 95% CI: 0.297–6.208). Persistent NBPP was not significantly different among nulliparous and multiparous women at 2 years (97% vs. 92% respectively, aOR 0.079, 95% CI: 0.006–1.050). Conclusion In one of the largest cohorts of NBPP, maternal parity did not influence the likelihood of NBPP persistence at 1 and 2 years.

scholarly journals A New Premixed Self-Etch Adhesive for Bonding Orthodontic Brackets

2008 ◽  
Vol 78 (6) ◽  
pp. 1101-1104 ◽  
Author(s):  
Samir E. Bishara ◽  
Adam W. Otsby ◽  
Raed Ajlouni ◽  
John Laffoon ◽  
John J. Warren
Keyword(s):  
Testing Machine ◽  
Orthodontic Brackets ◽  
Chi Square ◽  
Adhesive Remnant Index ◽  
Chi Square Test ◽  
Group 2 ◽  
Student’S T ◽  
Self Etch ◽  
Bracket Failure ◽  
Student’S T Test

Abstract Objective: To determine if a new premixed self-etch adhesive can be used to successfully bond orthodontic brackets to enamel. Materials and Methods: Forty human molars were cleaned, mounted, and randomly divided into two groups. In group 1, 20 teeth were conditioned using the self-etching primer Transbond Plus (3M Unitek, Monrovia, Calif). In group 2, 20 teeth were conditioned using a new premixed self-etching adhesive, AdheSE One (Ivoclar Vivadent Inc, Amherst, NY). Both groups were bonded using brackets precoated with a composite adhesive. The teeth were debonded within half an hour following initial bonding using a universal testing machine. After debonding, the enamel surface was examined under 10× magnifications to determine the amount of residual adhesive remaining on the tooth. A Student's t-test was used to compare the shear bond strength (SBS) of the two groups, and the Chi-square test was used to compare the adhesive remnant index (ARI) scores for the two adhesive systems. Results: The mean SBS of the brackets bonded to the teeth using AdhesSE One was 3.6 ± 1.3 MPa and was significantly lower (t = 2.80, P = .01) than the SBS of the brackets bonded using Transbond Plus (x̄ = 5.9 ± 3.2 MPa). The comparisons of the ARI scores between the two groups (χ2 = 19.26) indicated that bracket failure mode was also significantly different (P &lt; .001), with more adhesive remaining on the teeth bonded using Transbond Plus. Conclusions: The SBS of the new premixed self-etching adhesive needs to be increased for it to be successfully used for bonding orthodontic brackets.

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