scholarly journals Depicting developing trend and core knowledge of hip fracture research using bibliometric and visualized analysis

2020 ◽  
Author(s):  
Guanrong Peng ◽  
Zhenhua Guan ◽  
Yunfei Hou ◽  
Jiaxiang Gao ◽  
Wenqun Rao ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Disease Burden ◽  
Perioperative Management ◽  
Osteoporotic Fractures ◽  
Clinical Aspects ◽  
High Morbidity ◽  
Core Knowledge ◽  
H Index ◽  
Developing Trend ◽  
The Usa

Abstract Background Among all osteoporotic fractures, hip fracture is common and carries high morbidity and mortality. We aim to analyze the present status and worldwide trends of hip fracture research in various clinical aspects.Methods Publications from 2010 to 2019 were retrieved from Web of Science database and analyzed through bibliometric methodology. The software VOS viewer was utilized for visualized analysis.Results Totally, 6139 publications were included, and publications increased annually, from 152 (2000) to 592 (2019). The USA has made huge contributions with the most publications, the highest H-index, and citations. Osteoporosis International has published the most papers. Leading researchers, contributing institutions, their cooperation relationships and scientific masterpieces have been identified. Research could be divided into five clusters: "mortality", "surgical management", “rehabilitation”, “osteoporosis” and "epidemiology". A clear developing trend was described, which initiated from fracture epidemiology and prevention, transitioned to perioperative management, orthogeriatric care and patient safety, and then to functional recovery, disease burden along with national audit and initiatives in recent time.Conclusions Hip fractures resulted in conditions that extend far beyond orthopaedics, concerning epidemiology & preventive medicine, internal medicine & endocrinology, as well as critical care and gerontology. And a growing volume of publications in the future could be expected.

scholarly journals Depicting Developing Trend and Core Knowledge of Hip Fracture Research: A Bibliometric and Visualized Analysis

2020 ◽  
Author(s):  
Guan Rong Peng ◽  
Zhen Hua Guan ◽  
Qing Xi Zhang ◽  
Jia Xiang Gao ◽  
Wen Qun Rao ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Disease Burden ◽  
Perioperative Management ◽  
Osteoporotic Fractures ◽  
Clinical Aspects ◽  
High Morbidity ◽  
Core Knowledge ◽  
H Index ◽  
Developing Trend ◽  
The Usa

Abstract Background: Among all osteoporotic fractures, hip fracture is common, carries high morbidity and mortality, thus has been becoming a vital concern We aim to analyze the present status and worldwide trends of hip fracture research in various clinical aspects. Methods: Publications from 2000 to 2019 were retrieved from Web of Science database and analyzed through bibliometric methodology. The software VOS viewer was utilized for visualized analysis. Results: Totally, 6139 publications were included, and publications increased annually, from 152 (2000) to 592 (2019). The USA has made huge contributions with the most publications, the highest H-index, and citations. Osteoporosis International has published the most papers. Leading researchers, contributing institutions, their cooperation relationships and scientific masterpieces have been identified. Research could be divided into five clusters: "mortality", "surgical management", “rehabilitation”, “osteoporosis” and "epidemiology". A clear developing trend was described, which initiated from fracture epidemiology and prevention, transitioned to perioperative management, orthogeriatric care and patient safety, and then to functional recovery, disease burden along with national audit and initiatives in recent time. Conclusions: Hip fractures resulted in conditions that extend far beyond orthopaedics, concerning epidemiology & preventive medicine, internal medicine & endocrinology , as well as critical care and gerontology. And a growing volume of publications in the future could be expected.

scholarly journals Depicting developing trend and core knowledge of hip fracture research: a bibliometric and visualised analysis

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Guanrong Peng ◽  
Zhenhua Guan ◽  
Yunfei Hou ◽  
Jiaxiang Gao ◽  
Wenqun Rao ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Disease Burden ◽  
Perioperative Management ◽  
Web Of Science ◽  
High Morbidity ◽  
Core Knowledge ◽  
H Index ◽  
Cooperative Relationships ◽  
Developing Trend ◽  
Number Of Citations

Abstract Background Hip fracture is common and carries high morbidity and mortality; thus, it has become a vital concern. We aim to analyse the present status, worldwide trends in hip fracture and state of clinical research. Methods Publications from 2000 to 2019 were retrieved from the Web of Science database and analysed using a bibliometric methodology. VOSviewer software was utilised for analysis. Results In total, 6139 publications were included, and publications increased annually from 152 in 2000 to 592 in 2019. U.S. researchers have produced the most publications, the highest H-index and the greatest number of citations. Osteoporosis International has published the most papers on the topic. Leading researchers, contributing institutions, their cooperative relationships and scientific masterpieces have been identified. The publications can be divided into five clusters: ‘mortality’, ‘surgical management’, ‘rehabilitation’, ‘osteoporosis’ and ‘epidemiology’. A clear developing trend was described, which began with fracture epidemiology and prevention, transitioned to perioperative management, orthogeriatric care and patient safety and then to functional recovery, disease burden and national audits in recent times. Conclusions Hip fractures result in conditions that extend far beyond orthopaedics concerning epidemiology and preventive medicine, internal medicine and endocrinology, as well as critical care and gerontology. Interest, research and publications are on the rise.

scholarly journals Depicting developing trend and core knowledge of hip fracture research: a bibliometric and visualized analysis

2021 ◽  
Author(s):  
Guan Rong Peng ◽  
Zhen Hua Guan ◽  
Yun Fei Hou ◽  
Jia Xiang Gao ◽  
Wen Qun Rao ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Disease Burden ◽  
Perioperative Management ◽  
Web Of Science ◽  
High Morbidity ◽  
Core Knowledge ◽  
H Index ◽  
Cooperative Relationships ◽  
Developing Trend ◽  
Number Of Citations

Abstract Background: Hip fracture is common and carries high morbidity and mortality; thus, it has become a vital concern. We aim to analyse the present status, worldwide trends in hip fracture, and state of clinical research.Methods: Publications from 2000 to 2019 were retrieved from the Web of Science database and analysed using a bibliometric methodology. VOSviewer software was utilised for analysis.Results: In total, 6,139 publications were included, and publications increased annually from 152 in 2000 to 592 in 2019. U.S. researchers have produced the most publications, the highest H-index, and the greatest number of citations. Osteoporosis International has published the most papers on the topic. Leading researchers, contributing institutions, their cooperative relationships, and scientific masterpieces have been identified. The publications can be divided into five clusters: "mortality", "surgical management", “rehabilitation”, “osteoporosis” and "epidemiology". A clear developing trend was described, which began with fracture epidemiology and prevention, transitioned to perioperative management, orthogeriatric care and patient safety, and then to functional recovery, disease burden, and national audits in recent times.Conclusions: Hip fractures result in conditions that extend far beyond orthopaedics concerning epidemiology and preventive medicine, internal medicine and endocrinology, as well as critical care and gerontology. Interest, research, and publications are on the rise.

Bibliometric Analysis of Current Drug Metabolism: The Twentieth Anniversary from 2000-2019

2020 ◽  
Vol 21 (9) ◽  
pp. 685-703
Author(s):  
Waseem Hassan ◽  
Jean Paul Kamdem ◽  
Mohammad Amjad Kamal ◽  
Joao Batista Teixeira da Rocha
Keyword(s):  
United States ◽  
Drug Metabolism ◽  
Bibliometric Analysis ◽  
Continuous Growth ◽  
H Index ◽  
Current Drug ◽  
The Usa ◽  
Twentieth Anniversary ◽  
Number Of Publications ◽  
Number Of Citations

Background: Scopus is regularly covering Current Drug Metabolism from 2000 onwards. Objective: The major objective is to perform the 1st bibliometric analysis of Current Drug Metabolism (CDM). Methods: The data was retrieved from Scopus in April-May 2020 for detail analysis. Results: The total number of publications was found to be 1551, with 955 reviews (61.57%) and 466 articles (30.05%). From 2000 onwards, we calculated the relative growth rate and doubling time. Based on the number of publications, total 4418 authors, 3235 institutions and 83 countries were directly involved in all publications. M.A. Kamal is the highly productive scientist with fifty-three (53 or 3.73%) publications, King Abdulaziz University is the top university with the highest number of publications (58 or 4.13%) and the USA is the top-ranked country with 365 publications (25.96%). We also provided the h-index, total citations (TC), h-index without self-citations (WSC) and total WSC of the top ten authors, universities and countries. In citations analysis, Prof. Zhou S.F. was the top scientist with the highest (1594) number of citations. In institutional category Department of Drug Metabolism, Merck Research Laboratories, Rahway, United States, is the top ranked institutes with 654 total citations. While, United States is the top-ranked country with 18409 total citations. In co-words analysis, 3387, 30564 and 17333 terms in titles of the manuscripts, abstracts and keywords were recorded, respectively. This indicated that CDM principally focused on understanding drug development ranging from its efficacy to delivery, metabolism, distribution, safety and mechanism of actions. Similarly, various specific drugs were thoroughly discussed in publications. Various enzymatic, genetics, proteins and cancer-related aspects were also described. For data presentations, we used VOSviewer graphical maps. Conclusion: The data confirm that CDM showed continuous growth in the number of publications and citations. However significant measures are needed to make overall progress and improve the rankings in relevant categories.

scholarly journals Hip geometry in hip fracture patients in Greenland occurring over a 7.7-year period

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Inuuteq Fleischer ◽  
Mogens Laursen ◽  
Stig Andersen
Keyword(s):  
Hip Fracture ◽  
Femoral Neck ◽  
Fracture Risk ◽  
Cortical Thickness ◽  
Geometric Analysis ◽  
Osteoporotic Fractures ◽  
Premature Death ◽  
Neck Length ◽  
Hip Geometry ◽  
Lesser Trochanter

Abstract Background Hip geometry influences hip fracture risk. Hip fractures are common, and they are associated with pain, disability, premature death and marked costs on society. Osteoporotic fractures are frequent in Arctic populations and increase with advancing age in this society with a steep rise in life expectancy. Greenland Inuit is a distinct ethnic group, and data on hip geometry is missing. We thus aimed to describe hip geometry in 7.7 years of consecutive hip fracture patients in Greenland. Methods We evaluated collodiaphysial angle, femoral neck length, the outer and inner diameter of the femur at 2 and 5 centimetres below the centre of the lesser trochanter and the cortical thickness from pelvic and hip radiographs in all patients operated in Greenland over 7.7 years. We included all 84 patients with one non-fractured hip visible for geometric analysis. Analyses were conducted in duplicate. Results We found a collodiaphysial angle of 134.8/132.6o in men/women (p = 0.06) and a femoral neck length of 38.0/33.9 mm in men/women (p = 0.001). Cortical thickness was affected by sex in the adjusted analysis (p < 0.001). Cortical thickness index at 5 cm below the centre of the lesser trochanter decreased with age (p = 0.026) and may be influenced by height (2 cm below the centre of the lesser trochanter, p = 0.053). Conclusion Our findings differed from European data and suggest a delicate balance in hip geometry in Arctic populations. Ethnic peculiarities influence the structure of the hip and may influence fracture risk. A focus on hip geometry and risk factors for osteoporotic fractures in Arctic populations is warranted.

scholarly journals Fragility Fractures and Imminent Fracture Risk in the Spanish Population: A Retrospective Observational Cohort Study

2021 ◽  
Vol 10 (5) ◽  
pp. 1082
Author(s):  
Maria-José Montoya-García ◽  
Mercè Giner ◽  
Rodrigo Marcos ◽  
David García-Romero ◽  
Francisco-Jesús Olmo-Montes ◽  
...  
Keyword(s):  
Cohort Study ◽  
Incidence Rate ◽  
Public Health Problem ◽  
Osteoporotic Fractures ◽  
Fragility Fractures ◽  
Population Based ◽  
High Morbidity ◽  
Major Public Health Problem ◽  
Skeletal Site ◽  
Mortality Incidence

Fragility fractures constitute a major public health problem worldwide, causing important high morbidity and mortality rates. The aim was to present the epidemiology of fragility fractures and to assess the imminent risk of a subsequent fracture and mortality. This is a retrospective population-based cohort study (n = 1369) with a fragility fracture. We estimated the incidence rate of index fragility fractures and obtained information on the subsequent fractures and death during a follow-up of up to three years. We assessed the effect of age, sex, and skeletal site of index fracture as independent risk factors of further fractures and mortality. Incidence rate of index fragility fractures was 86.9/10,000 person-years, with highest rates for hip fractures in women aged ≥80 years. The risk of fracture was higher in subjects with a recent fracture (Relative Risk(RR), 1.80; p < 0.01). Higher age was an independent risk factor for further fracture events. Significant excess mortality was found in subjects aged ≥80 years and with a previous hip fracture (hazard ratio, 3.43 and 2.48, respectively). It is the first study in Spain to evaluate the incidence of major osteoporotic fractures, not only of the hip, and the rate of imminent fracture. Our results provide further evidence highlighting the need for early treatment.

The Association Between Sarcopenia and Postoperative Outcomes Among Older Adults With Hip Fracture: A Systematic Review

2021 ◽  
pp. 073346482110065
Author(s):  
Ming-Hsiu Chiang ◽  
Yi-Jie Kuo ◽  
Yu-Pin Chen
Keyword(s):  
Systematic Review ◽  
Older Adults ◽  
Hip Fracture ◽  
Postoperative Mortality ◽  
Clinical Event ◽  
High Morbidity ◽  
Adverse Health Outcomes ◽  
Age Related ◽  
Study Selection ◽  
And Function

Hip fracture is a serious clinical event with high morbidity and mortality. Sarcopenia is characterized by age-related loss of muscle mass and function, leading to several adverse health outcomes. In this systematic review, no limitation criteria were used for study selection and 327 studies were identified in the initial search. Of these, 11 studies comprising a total of 2,314 patients were selected. The overall proportion of older adults with hip fracture having sarcopenia was 44%, with a disparity of approximately 10% between men and women. Most studies have indicated that older adults with sarcopenia had poorer postoperative functional recovery than those without sarcopenia; the association between sarcopenia and high postoperative mortality or long hospital stay was heterogeneous. Well-organized studies with longer follow-up periods are warranted.

scholarly journals A Bibliometric Evaluation of the Top 100 Cited Dimethyl Fumarate Articles

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 1085
Author(s):  
Francisco Javier García-Fernández ◽  
Alba Estela García-Fernández ◽  
Ichiro Ikuta ◽  
Eduardo Nava ◽  
Julian Solis García del Pozo ◽  
...  
Keyword(s):  
Dimethyl Fumarate ◽  
Original Research ◽  
H Index ◽  
Early Access ◽  
Research Areas ◽  
Electronic Search ◽  
Time Period ◽  
The Usa ◽  
Immunomodulatory Drug ◽  
Number Of Citations

Dimethyl fumarate is a cytoprotective and immunomodulatory drug used in the treatment of multiple sclerosis. We performed a bibliometric study examining the characteristics and trends of the top 100 cited articles that include dimethyl fumarate in the title. On 21 September 2020 we carried out an electronic search in the Web of Science (WOS), seeking articles that include the following terms within the title: dimethyl fumarate, BG-12, or Tecfidera. To focus our investigation on original research, we refined the search to include only articles, early access, others, case report, and clinical trials. We obtained a total of 1115 items, which were cited 7169 times, had a citation density of 6.43 citations/item, and an h-index of 40. Around 2010, there was a jump in the number of published articles per year, rising from 5 articles/year up to 12 articles/year. We sorted all the items by the number of citations and selected the top 100 most cited (T100). The T100 had 4164 citations, with a density of 37 citations/year and contained 16 classic research articles. They were published between 1961 and 2018; the years 2010–2018 amassed nearly 80% of the T100. We noted 17 research areas with articles in the T100. Of these, the number one ranking went to neurosciences/neurology with 39 articles, and chemistry ranked second on the T100 list with 14 items. We noticed that the percentage of articles belonging to different journals changed depending on the time period. Chemistry held the highest number of papers during 1961–2000, while pharmacology andneurosciences/neurology led the 2001–2018 interval. A total of 478 authors from 145 institutions and 25 countries were included in the T100 ranking. The paper by Gold R et al. was the most successful with 14 articles, 1.823 citations and a density of 140.23 citations/year. The biotechnological company Biogen led the T100 list with 20 articles. With 59 published articles, the USA was the leading country in publications. We concluded that this study analyzed the use of and research on dimethyl fumarate from a different perspective, which will allow the readership (expert or not) to understand the relevance of classic and recent literature on this topic.

scholarly journals SAT0476 COMPLIANCE AND PERSISTENCE OF ANTI-OSTEOPOROTIC TREATMENTS IN PATIENTS WITH HIP FRACTURE

2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 1194.2-1195
Author(s):  
S. Paredes ◽  
M. Guinovart ◽  
A. Basco ◽  
C. Llop
Keyword(s):  
Hip Fracture ◽  
Health Service ◽  
Hospital Discharge ◽  
Treatment Time ◽  
Osteoporotic Fractures ◽  
Main Diagnosis ◽  
Pharmacological Treatments ◽  
Cross Sectional ◽  
Good Compliance ◽  
Number Of Patients

Background:Osteoporotic fractures have a high health and economic impact. The best strategy to minimize the incidence of fractures is, certainly, the prevention of these that includes pharmacological treatments. However, long-term discontinuation treatment and sub-optimal compliance of the treatment are common.Objectives:The aim of the study is to quantify the therapeutic compliance and permanence of the osteoporosis pharmacological treatments for patients who were discharged from hospitals in Catalonia with hip fracture during 2017.Methods:From the Hospital Discharge Database of the Catalan Health Service, all patients who had been discharged during 2017 were selected with the main diagnosis of femur fracture, according to the coding CIM-9. The consumption of drugs to assess compliance and permanence was obtained from the Catalan Health Service pharmacy Database. The study period was 18 months from the date of hospital discharge. Patients who died, moved to other areas or switched their treatment were excluded from the study. Good compliance was considered when sufficient drug was obtained to cover 80% of the time since treatment was prescribed until the end of the study period. In the case of denosumab, good post-fracture compliance was considered when the treatment time was remained at least 12 months. Permanence was considered positive if a drug had been obtained during the last three months of the study period. To compare the differences in compliance and permanence between the patients treated with different drugs, the chi-square statistic was used, considering statistically significant differences if p<0.05.Results:8,354 patients were discharged with the main diagnosis of hip fracture. Of these, 1,712 patients (20.49%) were treated after been discharged. After applying the exclusion criteria, the final sample was made up of 1,327 patients. 81,54% were women, and the median age was 84,79 years.The most commonly used treatments were bisphosphonates (69%), denosumab (23%) and teriparatide (7%)The results of good compliance and permanence of treatment were those described in the table.nCompliancePermanenceAlendronate86363,27%64,77%Alendronate+colecalciferol2774,07%81,48%Ibandronate366,67%100%Risedronate2339,13%60,87%Raloxifene1100%100%Bazedoxifene10%0%Teriparatide9976,77% (*)73,74%Denosumab31076,77% (*)74,52% (*)(*) p<0.05 for total bisphosphonates and for alendronateConclusion:The results obtained suggest that a small number of patients were treated after a hip fracture (20.49%) in addition the instituted treatments are followed in a suboptimal way. It is necessary to investigate which factors may lead to the detection of potential non-compliant patients. It seems appropriate to consider drugs that facilitate compliance and permanence of treatment.Our results suggest that denosumab and teriparatide improve compliance compared with oral bisphosphonates.The introduction of specific plans and cross-sectional health structures between levels of care should lead to improve detection, treatment and compliance in patients with osteoporosis.Disclosure of Interests:SILVIA PAREDES Consultant of: Amgen, Lilly, Ferrer, Roche, Novartis; BMS, Maria Guinovart: None declared, Aida Basco: None declared, Carles Llop: None declared

scholarly journals Morbidity and mortality after fragility hip fracture in a Saudi Arabian population: Report from a single center

2017 ◽  
Vol 45 (3) ◽  
pp. 1175-1180 ◽  
Author(s):  
Mir Sadat-Ali ◽  
Moaad Alfaraidy ◽  
Abdulaziz AlHawas ◽  
Ahmed Abdallah Al-Othman ◽  
Dakheel A Al-Dakheel ◽  
...  
Keyword(s):  
Hip Fracture ◽  
Mortality Rate ◽  
Demographic Data ◽  
Femoral Fractures ◽  
Morbidity And Mortality ◽  
High Morbidity ◽  
Fragility Hip Fracture ◽  
Asa Score ◽  
Telephone Interviews ◽  
American Society

Objective To determine the functional morbidity and mortality after fragility hip fracture and compare the mortality with three other common diseases. Methods Data were collected from patients admitted to King Fahd Hospital of the University, AlKhobar from January 2010 to December 2014. Demographic data included the preoperative American Society of Anesthesiologists (ASA) score as assessed by the anesthetist and the type of surgery. Personal and telephone interviews were performed, and data were entered into a database and analyzed. Results We identified 203 patients with fragility proximal femoral fractures, and the data of 189 patients (109 male, 80 female; average age, 66.90 ± 13.43 years) were available for analysis. The overall mortality rate was 26.98% (51 patients). The mortality rate was significantly higher among patients with an ASA score of 4 (36.36%) than 1 (20.45%). With respect to morbidity, only 48.23% of patients were able to return to their pre-fracture status; 32.35% of those who required assisted walking and 83.4% of those who required a wheelchair became bedridden. Conclusions Our data demonstrate that patients with fragility hip fractures have high morbidity and a mortality rate approaching 30%. Age and the ASA score significantly influence this high mortality rate.

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