scholarly journals Association of Whole Blood Copper and Preeclampsia: A Cohort Study in China

2020 ◽  
Author(s):  
Huan Ying Xu ◽  
Ying Chen ◽  
Su Zhen Wu ◽  
Qiao Ling Zhu ◽  
Yu Chen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Whole Blood ◽  
Medical Records ◽  
Lower Risk ◽  
Copper Concentration ◽  
Tertiary Hospital ◽  
Flame Atomic Absorption ◽  
Flame Atomic Absorption Spectrometer ◽  
Medical Records System ◽  
Risk Of Preeclampsia

Abstract Background Preeclampsia is a leading cause of maternal and fetal morbidity and mortality. The associations between whole blood copper and pre-eclampsia were controversial. Our study was aimed to investigate the association between whole blood copper concentration and preeclampsia in pregnant woman in China.Methods This retrospective cohort study was conducted between August 1, 2019 to December 31, 2019 in a comprehensive tertiary hospital in Foshan city Guangdong Province, China. We measured copper concentration in maternal whole blood in 12-27 (+6) week of pregnancy, using flame atomic absorption spectrometer. We ascertained preeclampsia diagnosis from electronic medical records system. Covariates included demographic, offspring characteristics, serum biomarkers. Logistic regression was applied to explore the association between the concentration of trace element and preeclampsia.Results A total of 2134 participants were included, 57 (2.67%) women developed preeclampsia. In the multivariate regression models, per1 SD increment in copper was associated with 28% lower risk of preeclampsia (OR=0.72, 95% CI: 0.54-0.95). After Propensity-Score Matching with similar age at delivery and prepregnancy BMI,per1 SD increment in copper was associated with 28% lower risk of preeclampsia (OR=0.70,95% CI:0.51-0.97). We observed some extent evidence of a dose–response trend for Cu (P for trend=0.0321) quintiles. And the result was sustained in mild and severe preeclampsia. Conclusions women with higher blood concentration of copper may associated with lower preeclampsia. More well designed studies are needed for the interpretation of these findings.

scholarly journals Association of whole blood copper and preeclampsia: A Cohort study in China

2020 ◽  
Author(s):  
Huan Ying Xu ◽  
Ying Chen ◽  
Su Zhen Wu ◽  
Qiao Ling Zhu ◽  
Yu Chen ◽  
...  
Keyword(s):  
Cohort Study ◽  
Whole Blood ◽  
Medical Records ◽  
Lower Risk ◽  
Copper Concentration ◽  
Tertiary Hospital ◽  
Flame Atomic Absorption ◽  
Flame Atomic Absorption Spectrometer ◽  
Medical Records System ◽  
Risk Of Preeclampsia

Abstract Background Preeclampsia is a leading cause of maternal and fetal morbidity and mortality. The associations between whole blood copper and pre-eclampsia were controversial. Our study was aimed to investigate the association between whole blood copper concentration and preeclampsia in pregnant woman in China. Methods This retrospective cohort study was conducted between August 1, 2019 to December 31, 2019 in a comprehensive tertiary hospital in Foshan city Guangdong Province, China. We measured copper concentration in maternal whole blood in 12–27 (+ 6) week of pregnancy, using flame atomic absorption spectrometer. We ascertained preeclampsia diagnosis from electronic medical records system. Covariates included demographic, offspring characteristics, serum biomarkers. Logistic regression was applied to explore the association between the concentration of trace element and preeclampsia. Results A total of 2134 participants were included, 57 (2.67%) women developed preeclampsia. In the multivariate regression models, per1 SD increment in copper was associated with 28% lower risk of preeclampsia (OR = 0.72, 95% CI: 0.54–0.95). After Propensity-Score Matching with similar age at delivery and prepregnancy BMI,per1 SD increment in copper was associated with 28% lower risk of preeclampsia (OR = 0.70,95% CI:0.51–0.97). We observed some extent evidence of a dose–response trend for Cu (P for trend = 0.0321) quintiles. And the result was sustained in mild and severe preeclampsia. Conclusions women with higher blood concentration of copper may associated with lower preeclampsia. More well designed studies are needed for the interpretation of these findings.

Use of antimalarial drugs is associated with a lower risk of preeclampsia in lupus pregnancy: A prospective cohort study

2020 ◽  
Vol 23 (5) ◽  
pp. 633-640 ◽  
Author(s):  
Miguel Ángel Saavedra ◽  
Dafhne Miranda‐Hernández ◽  
Alejandra Lara‐Mejía ◽  
Antonio Sánchez ◽  
Sara Morales ◽  
...  
Keyword(s):  
Cohort Study ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Lower Risk ◽  
Antimalarial Drugs ◽  
Risk Of Preeclampsia

scholarly journals General versus regional anaesthesia for caesarean section indicated for acute foetal distress: a retrospective cohort study

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Junette Arlette Mbengono Metogo ◽  
Theophile Njamen Nana ◽  
Brian Ajong Ngongheh ◽  
Emelinda Berinyuy Nyuydzefon ◽  
Christoph Akazong Adjahoung ◽  
...  
Keyword(s):  
Cohort Study ◽  
Pregnant Women ◽  
Retrospective Cohort Study ◽  
Medical Records ◽  
Regional Anaesthesia ◽  
Retrospective Cohort ◽  
Statistical Significance ◽  
Neonatal Resuscitation ◽  
Maternal Outcomes ◽  
Foetal Distress

Abstract Background Acute foetal distress (AFD) is a life-threatening foetal condition complicating 2% of all pregnancies and accounting for 8.9% of caesarean sections (CS) especially in developing nations. Despite the severity of the problem, no evidence exists as to the safest anaesthetic technique for the mother and foetus couple undergoing CS for AFD. We aimed to compare general anaesthesia (GA) versus regional (spinal and epidural) anaesthesia in terms of their perioperative maternal and foetal outcomes. Methods We carried out a retrospective cohort study by reviewing the medical records of all women who underwent CS indicated for AFD between 2015 to 2018 at the Douala General Hospital, Cameroon. Medical records of neonates were also reviewed. We sought to investigate the association between GA, and regional anaesthesia administered during CS for AFD and foetal and maternal outcomes. The threshold of statistical significance was set at 0.05. Results We enrolled the medical records of 117 pregnant women who underwent CS indicated for AFD. Their mean age and mean gestational age were 30.5 ± 4.8 years and 40 weeks respectively. Eighty-three (70.9%), 29 (24.8%) and 05 (4.3%) pregnant women underwent CS under SA, GA and EA respectively. Neonates delivered by CS under GA were more likely to have a significantly low APGAR score at both the 1st (RR = 1.93, p = 0.014) and third-minute (RR = 2.52, p = 0.012) and to be resuscitated at birth (RR = 2.15, p = 0.015). Past CS, FHR pattern on CTG didn’t affect these results in multivariate analysis. Adverse maternal outcomes are shown to be higher following SA when compared to GA. Conclusion The study infers an association between CS performed for AFD under GA and foetal morbidity. This, however, failed to translate into a difference in perinatal mortality when comparing GA vs RA. This finding does not discount the role of GA, but we emphasize the need for specific precautions like adequate anticipation for neonatal resuscitation to reduce neonatal complications associated with CS performed for AFD under GA.

scholarly journals Risk Factors for Fall-Related Serious Injury among Korean Adults: A Cross-Sectional Retrospective Analysis

2021 ◽  
Vol 18 (3) ◽  
pp. 1239
Author(s):  
Moon-Sook Kim ◽  
Hyun-Myung Jung ◽  
Hyo-Yeon Lee ◽  
Jinhyun Kim
Keyword(s):  
Risk Factors ◽  
Fall Prevention ◽  
Medical Records ◽  
Brain Injuries ◽  
Tertiary Hospital ◽  
Antiplatelet Drugs ◽  
Cross Sectional ◽  
Complete Survey ◽  
Serious Injury ◽  
Serious Injuries

The purpose of this study was to identify the risk factors of serious fall-related injuries by analyzing the differences between two fall groups: one with serious fall-related injuries and one without such injuries. Applying a retrospective, descriptive investigation study design, we analyzed the degree of fall-related injury and the risk factors related to serious falls by conducting a complete survey of the medical records of fall patients reported throughout one full year, 2017, at a tertiary hospital in Seoul, Korea. Among the patients with reported falls, 188 sustained no injury (63.1%), 72 sustained minor injury (24.2%), and 38 patients sustained serious injury (12.8%). The serious fall-related injuries included eight lacerations requiring suture (2.7%), 23 fractures (7.7%), five brain injuries (1.7%), and two deaths (0.7%). Analysis results indicated that taking anticoagulants/antiplatelet drugs (p = 0.016) and having a fall history (p = 0.038) were statistically significant in the differences between the group with serious injury related to falls and the group without serious injury. Logistic regression revealed that taking anticoagulant/antiplatelet drugs was the factor most significantly correlated with serious injuries related to falls (OR = 2.299, p = 0.022). Results show that it is necessary to develop a patient-tailored fall prevention activity program.

scholarly journals Impairment in activities of daily living and readmission in older patients with heart failure: a cohort study

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e044416
Author(s):  
Tan Van Nguyen ◽  
Huyen Thanh Dang ◽  
Mason Jenner Burns ◽  
Hiep HH Dao ◽  
Tu Ngoc Nguyen
Keyword(s):  
Heart Failure ◽  
Cohort Study ◽  
Activities Of Daily Living ◽  
Daily Living ◽  
Older Patients ◽  
Tertiary Hospital ◽  
Logistic Regression Models ◽  
Hospitalised Patients ◽  
Patients With Heart Failure ◽  
The Impact

ObjectivesThis study aims to investigate the prevalence of impairment of activities of daily living (ADLs) in older patients with heart failure (HF), and to examine the impact of ADL impairment on readmission after discharge.Design and settingsA prospective cohort study was conducted in patients aged ≥65 years with HF admitted to a tertiary hospital in Vietnam from August 2016 to June 2017. Difficulties with six ADLs were assessed by a questionnaire. Participants were classified into two categories (with and without ADL impairment). The associations of ADL impairment with 3-month readmission were examined using logistic regression models.ResultsThere were 180 participants (mean age 80.6±8.2, 50% female) and 26.1% were classified as having ADL impairment. The most common impaired activity was bathing (21.1%), followed by transferring (20.0%), toileting (12.2%), dressing (8.9%), eating (3.3%), and continence (2.8%). During 3-month follow-up, 32.8% of the participants were readmitted to hospitals (55.3% in participants with ADL impairment, 24.8% in those without ADL impairment, p<0.001). ADL impairment significantly increased the risk of 3-month readmission (adjusted OR 2.75, 95% CI 1.25 to 6.05, p=0.01).ConclusionsIn summary, ADL impairment was common in older hospitalised patients with HF and was associated with increased readmission. These findings suggest further studies on ADL assessment and intervention during transition care for older patients with HF after discharge to prevent readmission.

scholarly journals Higher anticoagulation targets and risk of thrombotic events in severe COVID-19 patients: bi-center cohort study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Julie Helms ◽  
◽  
François Severac ◽  
Hamid Merdji ◽  
Maleka Schenck ◽  
...  
Keyword(s):  
Cohort Study ◽  
Mortality Rate ◽  
Bleeding Risk ◽  
Tertiary Hospital ◽  
Biological Data ◽  
Bleeding Complications ◽  
Therapeutic Group ◽  
Vein Thrombosis ◽  
Icu Stay ◽  
Thrombotic Complications

Abstract Background Thromboprophylaxis of COVID-19 patients is a highly debated issue. We aimed to compare the occurrence of thrombotic/ischemic events in COVID-19 patients with acute respiratory distress syndrome (ARDS) treated with either prophylactic or therapeutic dosage of heparin. All patients referred for COVID-19 ARDS in two intensive care units (ICUs) from two centers of a French tertiary hospital were included in our cohort study. Patients were compared according to their anticoagulant treatment to evaluate the risk/benefit of prophylactic anticoagulation versus therapeutic anticoagulation. Medical history, symptoms, biological data and imaging were prospectively collected. Results One hundred and seventy-nine patients (73% men) were analyzed: 108 in prophylactic group and 71 in therapeutic group. Median age and SAPS II were 62 [IQR 51; 70] years and 47 [IQR 37; 63] points. ICU mortality rate was 17.3%. Fifty-seven patients developed clinically relevant thrombotic complications during their ICU stay, less frequently in therapeutic group (adjusted OR 0.38 [0.14–0.94], p = 0.04). The occurrences of pulmonary embolism (PE), deep vein thrombosis (DVT) and ischemic stroke were significantly lower in the therapeutic group (respective adjusted OR for PE: 0.19 [0.03–0.81]; DVT: 0.13 [0.01–0.89], stroke: 0.06 [0–0.68], all p < 0.05). The occurrence of bleeding complications was not significantly different between groups, neither were ICU length of stay or mortality rate. D-dimer levels were significantly lower during ICU stay, and aPTT ratio was more prolonged in the therapeutic group (p < 0.05). Conclusion Increasing the anticoagulation of severe COVID-19 patients to a therapeutic level might decrease thrombotic complications without increasing their bleeding risk.

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