scholarly journals METTL3-Mediated m6A Modification is Involved in Neural Tube Defects via Modulating Wnt/β-Catenin Signaling Pathway

2021 ◽  
Author(s):  
Li Zhang ◽  
Rui Cao ◽  
Dandan Li ◽  
Yuqing Sun ◽  
Juan Zhang ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Theoretical Basis ◽  
Clinical Work ◽  
Folic Acid Deficiency ◽  
Acid Deficiency ◽  
Life Threatening ◽  
Neural Tube Development

Abstract Neural tube defects (NTDs) remain one of the most life-threatening birth defects affecting infants. Most patients with a NTDs eventually develop lifelong disability, which cause significant morbidity and mortality and seriously reduce the quality of life. Therefore, identifiable of novel pathogenic strategies for NTDs patients is urgently required. Increasing evidence indicates that METTL3-mediated m6A modification is present in many physiopathological processes of cell apoptosis and survival. Our results demonstrate that SAM play not only a compensatory role, SAM can also lead to m6A modification changes in neural tube development and regulation. This research provides a good theoretical basis for further research on folic acid deficiency leading to NTDs, reveals the important role of SAM in the development of NTDs, and provides new clue for clinical researchers and clinical work.

scholarly journals Ethionine-mediated reduction of S-adenosylmethionine is responsible for the neural tube defects in the developing mouse embryo-mediated m6A modification and is involved in neural tube defects via modulating Wnt/β-catenin signaling pathway

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Li Zhang ◽  
Rui Cao ◽  
Dandan Li ◽  
Yuqing Sun ◽  
Juan Zhang ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Signaling Pathway ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Epigenetic Mechanism ◽  
Proliferation And Apoptosis ◽  
Life Threatening ◽  
Neural Tube Development

AbstractNeural tube defects (NTDs) remain one of the most life-threatening birth defects affecting infants. Most patients with NTDs eventually develop lifelong disability, which cause significant morbidity and mortality and seriously reduce the quality of life. Our previous study has found that ethionine inhibits cell viability by disrupting the balance between proliferation and apoptosis, and preventing neural stem cells from differentiating into neurons and astrocytes. However, how ethionine participates in the pathogenesis of neural tube development through N6-methyladenosine (m6A) modification remains unknown. This study aims to investigate METTL3- and ALKBH5-mediated m6A modification function and mechanism in NTDs. Herein, our results demonstrate that SAM play not only a compensatory role, it also leads to changes of m6A modification in neural tube development and regulation. Additionally, these data implicate that METTL3 is enriched in HT-22 cells, and METTL3 knockdown reduces cell proliferation and increases apoptosis through suppressing Wnt/β-catenin signaling pathway. Significantly, overexpression of ALKBH5 can only inhibit cell proliferation, but cannot promote cell apoptosis. This research reveals an important role of SAM in development of NTDs, providing a good theoretical basis for further research on NTDs. This finding represents a novel epigenetic mechanism underlying that the m6A modification has profound and lasting implications for neural tube development.

Neural Tube Defects: A Two-Pronged Approach to Primary Prevention

PEDIATRICS ◽  
1982 ◽  
Vol 70 (4) ◽  
pp. 648-650
Author(s):  
K. M. Laurence
Keyword(s):  
Folic Acid ◽  
Primary Prevention ◽  
Environmental Factors ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Genetic Background ◽  
Genetic Factors ◽  
Maternal Nutrition ◽  
Folic Acid Deficiency ◽  
Acid Deficiency

It is generally agreed that neural tube defects (NTD) have a multifactorial etiology when genetic factors render the developing fetus susceptible to intrauterine environmental factors acting during the fourth week of gestation to interfere with the orderly closure of the neural tube.1 As there is little likelihood that anything can be done about the genetic background, primary prevention would therefore be dependent on eliminating these factors from the environment or avoiding them. My intention here is to enlarge on some aspects of primary prevention of NTD as outlined by Smithells in an earlier issue (Pediatrics 69:498, 1982).2 One environmental factor, poor maternal nutrition and, more particularly, folic acid deficiency seems now to have been identified, but there are almost certainly a number of others.

scholarly journals The effect of folic acid deficiency on FGF pathway via Brachyury regulation in neural tube defects

2018 ◽  
Vol 33 (4) ◽  
pp. 4688-4702 ◽  
Author(s):  
Shaoyan Chang ◽  
Xiaolin Lu ◽  
Shan Wang ◽  
Zhigang Wang ◽  
Junsheng Huo ◽  
...  
Keyword(s):  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Folic Acid Deficiency ◽  
Acid Deficiency

The effect of folic acid deficiency on Mest/Peg1 in neural tube defects

2020 ◽  
pp. 1-10
Author(s):  
Shaoyan Chang ◽  
Jia Jing ◽  
Shaofang Shangguan ◽  
Baiyi Li ◽  
Xiuying Yao ◽  
...  
Keyword(s):  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Folic Acid Deficiency ◽  
Acid Deficiency

Neural tube defects, their implications and solutions in Muslim society

2020 ◽  
pp. 1-8
Author(s):  
Muhammad Fayyaz ◽  
Arshad Khushdil ◽  
Shehla Baqai
Keyword(s):  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Time Frame ◽  
Value Systems ◽  
Complex Issue ◽  
Empathic Understanding ◽  
The Given

Abstract Neural Tube Defects (NTDs) are serious congenital abnormalities and most of them are incompatible with life. The extremely debilitating quality of life, if one survives, calls for actions to prevent such sufferings.  Experts agree on the role of Folic Acid in primary prevention of NTDs, yet, despite best efforts, the use of Folic Acid has reduced NTDs by only 50%. These cases too can be prevented by employing secondary preventive measures. These involve timely interruption of pregnancy -- a decision which, in addition to a medical judgment, is based on ethics, social, cultural and Muslim religious value systems in Pakistan. Indeed, it is a complex issue but empathic understanding and strong co-ordination, once established between different disciplines, can help parents to decide and opt for necessary secondary prevention by interruption of malformed foetus within the given time frame mandated by medical and religious authorities. Continuous....

scholarly journals Awareness of Folic Acid Intake among Women of Childbearing Age in Ha’il region, Kingdom of Saudi Arabia

2021 ◽  
pp. 42-54
Author(s):  
Farida Habib Khan Khan ◽  
Shog K. Alahmed ◽  
Wijdan S. Alsaad ◽  
Ashwaq H. Alshammari
Keyword(s):  
Socioeconomic Status ◽  
Saudi Arabia ◽  
Folic Acid ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Folic Acid Deficiency ◽  
Women Of Childbearing Age ◽  
Childbearing Age ◽  
Kingdom Of Saudi Arabia ◽  
Acid Deficiency

Background: Folic acid deficiency is one of the most common vitamin deficiencies among women of childbearing-age. Folic acid is a water-soluble B-complex vitamin. Although the deficiency is easily corrected by administration of folic acid, but still the prevalence of folic acid deficiency is high. It can lead to neural tube defects (NTDs) in fetus, which are a major cause of severe disability and mortality among infant population, occurring in over one quarter of a million new-borns per year, worldwide. NTDs occur in the very early phase of pregnancy when the mother herself does not know that she is pregnant. This study has assessed awareness of women of childbearing age on folic acid i.e., timing of folic acid supplementation, different sources, symptoms of its deficiency, toxicity and its effect on fetus. Study was conducted in Ha’il region and its suburbs, Kingdom of Saudi Arabia in the period between October 2020 and February 2021. Methodology: An analytical cross-sectional community-based study was carried out among 842 women aged between18 and 45 years using a close-ended questionnaire. Results: In total, Folic Acid was taken by just 23.87% of participants. Only 33% knew that Folic Acid deficiency causes neural tube defects in fetus. Further it was revealed that postgraduates had a significantly better knowledge on Folic Acid  0.000) than others. Similarly, those who belonged to household where total monthly income was 5000 Saudi Riyals or more had better awareness on Folic Acid than participants who belonged to low socioeconomic status (  0.05). Conclusion: It’s concluded that in Ha’il and its suburb area, women of childbearing age do not possess adequate knowledge on Folic Acid. Neural tube defects in fetus due to folic acid deficiency were not known by a large majority of respondents. However, awareness has a strong association with educational level and socioeconomic status. Hence it is recommended that female literacy and female employment should be promoted, encouraged and supported in Kingdom in order to improve our health indicators.

scholarly journals Reducing inequities in preventable neural tube defects: the critical and underutilized role of neurosurgical advocacy for folate fortification

2018 ◽  
Vol 45 (4) ◽  
pp. E20 ◽  
Author(s):  
Dagoberto Estevez-Ordonez ◽  
Matthew C. Davis ◽  
Betsy Hopson ◽  
Anastasia Arynchyna ◽  
Brandon G. Rocque ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Implementation Strategies ◽  
Indirect Costs ◽  
Childhood Mortality ◽  
High Morbidity ◽  
Disability Adjusted Life ◽  
Life Years

Neural tube defects (NTDs) are one of the greatest causes of childhood mortality and disability-adjusted life years worldwide. Global prevalence at birth is approximately 18.6 per 10,000 live births, with more than 300,000 infants with NTDs born every year. Substantial strides have been made in understanding the genetics, pathophysiology, and surgical treatment of NTDs, yet the natural history remains one of high morbidity and profound impairment of quality of life. Direct and indirect costs of care are enormous, which ensures profound inequities and disparities in the burden of disease in countries of low and moderate resources. All indices of disease burden are higher for NTDs in developing countries. The great tragedy is that the majority of NTDs can be prevented with folate fortification of commercially produced food. Unequivocal evidence of the effectiveness of folate to reduce the incidence of NTDs has existed for more than 25 years. Yet, the most comprehensive surveys of effectiveness of implementation strategies show that more than 100 countries fail to fortify, and consequently only 13% of folate-preventable spina bifida is actually prevented. Neurosurgeons harbor a disproportionate, central, and fundamental role in the management of NTDs and enjoy high standing in society. No organized group in medicine can speak as authoritatively or convincingly. As a result, neurosurgeons and organized neurosurgery harbor disproportionate potential to advocate for more comprehensive folate fortification, and thereby prevent the most common and severe birth defect to impact the human nervous system. Assertive, proactive, informed advocacy for folate fortification should be a central and integral part of the neurosurgical approach to NTDs. Only by making the prevention of dysraphism a priority can we best address the inequities often observed worldwide.

scholarly journals Altered GNAS imprinting due to folic acid deficiency contributes to poor embryo development and may lead to neural tube defects

Oncotarget ◽  
2017 ◽  
Vol 8 (67) ◽  
pp. 110797-110810 ◽  
Author(s):  
Li Wang ◽  
Shaoyan Chang ◽  
Zhen Wang ◽  
Shan Wang ◽  
Junsheng Huo ◽  
...  
Keyword(s):  
Folic Acid ◽  
Embryo Development ◽  
Neural Tube ◽  
Neural Tube Defects ◽  
Folic Acid Deficiency ◽  
Acid Deficiency

scholarly journals The role of primary cilia in the pathophysiology of neural tube defects

2012 ◽  
Vol 33 (4) ◽  
pp. E2 ◽  
Author(s):  
Timothy W. Vogel ◽  
Calvin S. Carter ◽  
Kingsley Abode-Iyamah ◽  
Qihong Zhang ◽  
Shenandoah Robinson
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Neural Development ◽  
Planar Cell Polarity ◽  
Primary Cilia ◽  
Integration Site ◽  
Genetics Research ◽  
Neural Tube Development ◽  
Insight Into

Neural tube defects (NTDs) are a set of disorders that occur from perturbation of normal neural development. They occur in open or closed forms anywhere along the craniospinal axis and often result from a complex interaction between environmental and genetic factors. One burgeoning area of genetics research is the effect of cilia signaling on the developing neural tube and how the disruption of primary cilia leads to the development of NTDs. Recent progress has implicated the hedgehog (Hh), wingless-type integration site family (Wnt), and planar cell polarity (PCP) pathways in primary cilia as involved in normal neural tube patterning. A set of disorders involving cilia function, known as ciliopathies, offers insight into abnormal neural development. In this article, the authors discuss the common ciliopathies, such as Meckel-Gruber and Joubert syndromes, that are associated with NTDs, and review cilia-related signaling cascades responsible for mammalian neural tube development. Understanding the contribution of cilia in the formation of NTDs may provide greater insight into this common set of pediatric neurological disorders.

Resveratrol: A new potential therapeutic agent for melanoma?

2019 ◽  
Vol 26 ◽  
Author(s):  
Mohamad Hossein Pourhanifeh ◽  
Kazem Abbaszadeh-Goudarzi ◽  
Mohammad Goodarzi ◽  
Sara G.M. Piccirillo ◽  
Alimohammad Shafiee ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Therapeutic Agent ◽  
Current Knowledge ◽  
Treatment Resistance ◽  
Anti Cancer ◽  
Apoptosis Inducer ◽  
Life Threatening ◽  
First Time

: Melanoma is the most life-threatening and aggressive class of skin malignancies. The incidence of melanoma has steadily increased. Metastatic melanoma is greatly resistant to standard anti-melanomatreatments such as chemotherapy, and 5-year survival rate of cases with melanoma who have metastatic form of disease is less than 10%. The contributing role of apoptosis, angiogenesis and autophagy in the pathophysiology of melanoma has been previously demonstrated. Thus, it is extremely urgent to search for complementary therapeutic approachesthat couldenhance the quality of life of subjects and reduce treatment resistance and adverse effects. Resveratrol, known as a polyphenol component present in grapes and some plants, has anti-cancer properties due to its function as an apoptosis inducer in tumor cells, and anti-angiogenic agent to prevent metastasis. However, more clinical trials should be conducted to prove resveratrol efficacy. : Herein, for first time, we summarize current knowledge of anti-cancerous activities of resveratrol in melanoma.

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