scholarly journals Higher Dependency on Visual Inputs During Posture Control: Another Long-Term Effect of mTBIs

2021 ◽  
Author(s):  
Alessander Danna-dos-Santos ◽  
Adriana Menezes Degani
Keyword(s):  
Center Of Pressure ◽  
Vertical Posture ◽  
Military Operations ◽  
Long Term Effects ◽  
Experimental Conditions ◽  
Fast Reactions ◽  
Visual Inputs ◽  
Long Term Effect ◽  
Behavioral Markers

Abstract This study investigated the hypothesis that individuals living with long-term effects of mild traumatic brain injury (mTBI) develop increased dependency on their visual inputs to control their vertical posture. To test this hypothesis we quantified visuo-postural dependency indices (VPDIs) calculated independently for multiple postural behavioral markers extracted from the body’s center of pressure coordinates signals recorded during the execution of a quiet bipedal stance. One hundred and twenty-nine volunteers participated in this study. An mTBI (n = 50) and a neurotypical Control group were formed (n = 79). VPDIs were calculated as the normalized pair-wise subtraction of recordings obtained under Vision and No-Vision experimental conditions. Consistent with our hypothesis the results of this study show that balance behavior of mTBI participants deteriorate more abruptly in the absence of visual inputs when compared to neurotypical controls. These impairments may increase the likelihood of recurrent traumas when fast reactions are needed in daily activities, sports practice, or military operations. Additionally, the methodology used in this study showed to be potentially useful to aid future investigations of neural circuitry impaired by mTBI and provide indices of recovery in future clinical trials testing mTBI-related clinical interventions.

scholarly journals Long-Term Effect of Interferon on Keratinocytes That Maintain Human Papillomavirus Type 31

2002 ◽  
Vol 76 (17) ◽  
pp. 8864-8874 ◽  
Author(s):  
Yijan E. Chang ◽  
Loren Pena ◽  
Ganes C. Sen ◽  
Jung K. Park ◽  
Laimonis A. Laimins
Keyword(s):  
Human Papillomavirus ◽  
Morphological Characteristics ◽  
Human Keratinocytes ◽  
Inducible Promoter ◽  
Interferon Treatment ◽  
Long Term Effects ◽  
Long Term Effect ◽  
High Doses ◽  
Rates Of Growth

ABSTRACT The long-term effects of interferon treatment on cell lines that maintain human papillomavirus type 31 (HPV-31) episomes have been examined. High doses and prolonged interferon treatment resulted in growth arrest of HPV-positive cells, with a high percentage of cells undergoing apoptosis. These effects were not seen with interferon treatment of either normal human keratinocytes or cells derived from HPV-negative squamous carcinomas, which exhibited only slight decreases in their rates of growth. Within 2 weeks of the initiation of treatment, a population of HPV-31-positive cells that were resistant to interferon appeared consistently and reproducibly. The resistant cells had growth and morphological characteristics similar to those of untreated cells. Long-term interferon treatment of HPV-positive cells also resulted in a reduction in HPV episome levels but did not significantly decrease the number of integrated copies of HPV. Cells that maintained HPV genomes lacking E5 were sensitive to interferon, while cells expressing only the E6/E7 genes were resistant. In contrast, cells that expressed E2 from a tetracycline-inducible promoter were found to be significantly more sensitive to interferon treatment than parental cells. This suggests that at least a portion of the sensitivity to interferon could be mediated through the E2 protein. These studies indicate that cells maintaining HPV episomes are highly sensitive to interferon treatment but that resistant populations arise quickly.

scholarly journals Nutritional deficiencies and later behavioural development

2000 ◽  
Vol 59 (1) ◽  
pp. 47-54 ◽  
Author(s):  
S. M. Grantham-McGregor ◽  
S. P. Walker ◽  
S. Chang
Keyword(s):  
Cultural Context ◽  
School Achievement ◽  
Protein Energy Malnutrition ◽  
Term Effect ◽  
Nutritional Deficiencies ◽  
Long Term Effects ◽  
Protein Energy ◽  
Long Term Effect ◽  
Long Term Follow Up

The literature on the long-term effects of nutritional deficiencies in early life is reviewed. The severity and duration of the deficiency, the stage of the children’s development, the biological condition of the children and the socio-cultural context may all modify the effect. There is substantial evidence that reduced breast-feeding, small-for-gestational-age birth weight, Fe and I deficiency, and protein-energy malnutrition (PEM) are associated with long-term deficits in cognition and school achievement. However, all these conditions are associated with poverty and poor health, which may account for the association. It is difficult to establish that the long-term relationship is causal, as it requires a randomized treatment trial with long-term follow-up. Such studies are only available for I deficiency in utero and early childhood PEM. Results from these studies indicate that I deficiency has a long-term effect and PEM probably has a long-term effect.

Effects of Learning on Smooth Pursuit During Transient Disappearance of a Visual Target

2003 ◽  
Vol 90 (2) ◽  
pp. 972-982 ◽  
Author(s):  
Laurent Madelain ◽  
Richard J. Krauzlis
Keyword(s):  
Smooth Pursuit ◽  
Visual Target ◽  
Visual Signals ◽  
Control Group ◽  
Long Term Effects ◽  
Velocity Gain ◽  
Visual Inputs ◽  
Before And After ◽  
Pursuit Velocity

Previous research has demonstrated learning in the pursuit system, but it is unclear whether these effects are the result of changes in visual or motor processing. The ability to maintain smooth pursuit during the transient disappearance of a visual target provides a way to assess pursuit properties in the absence of visual inputs. To study the long-term effects of learning on nonvisual signals for pursuit, we used an operant conditioning procedure. By providing a reinforcing auditory stimulus during periods of accurate tracking, we increased the pursuit velocity gain during target blanking from 0.59 in the baseline session to 0.89 after 8 to 10 daily sessions of training. Learning also reduced the occurrence of saccades. The learned effects generalized to untrained target velocities and persisted in the presence of a textured visual background. In a yoked-control group, the reinforcer was independent of the subjects' responses, and the velocity gain remained unchanged (from 0.6 to 0.63, respectively, before and after training). In a control group that received no reinforcer, gain increased slightly after repetition of the task (from 0.63 to 0.71, respectively, before and after training). Using a model of pursuit, we show that these effects of learning can be simulated by modifying the gain of an extra-retinal signal. Our results demonstrate that learned contingencies can increase eye velocity in the absence of visual signals and support the view that pursuit is regulated by extra-retinal signals that can undergo long-term plasticity.

Brassinosteroid-induced de-etiolation of Arabidopsis thaliana seedlings resembles the long-term effects of cytokinins

1998 ◽  
Vol 25 (6) ◽  
pp. 719 ◽  
Author(s):  
Jie Luo ◽  
Ji-Chu Chen ◽  
Yu-Ju Zhao
Keyword(s):  
Arabidopsis Thaliana ◽  
Term Effect ◽  
Hypocotyl Elongation ◽  
Long Term Effects ◽  
Short Term ◽  
Expression Of Genes ◽  
Long Term Effect ◽  
In The Wild ◽  
Positive Regulators

Cytokinins can cause de-etiolation of Arabidopsis thaliana (L.) Heynh. seedlings growing in the dark. Brassinosteroids (BRs) have been considered to regulate negatively the de-etiolation in dark-grown Arabidopsis seedlings. We show here that epi-brassinolide (epi-BL) can partially produce the phenotype of de-etiolation as caused by treatment with cytokinins in the dark, including the development of leaves and epicotyls in the wild-type and the BR-deficient mutant det2. But BRs cannot inhibit hypocotyl elongation, nor restore all the inhibition caused by cytokinins and light. We have found that there are distinct short term and long term phases of induction of de-etiolation by cytokinins. The short-term effect is probably coupled to ethylene in the inhibition of the hypocotyl elongation; the long-term effect causes morphogenesis of leaves and epicotyls. BRs can only regulate de-etiolation in the long term. We propose that the inhibition of hypocotyl elongation of det2 in darkness is caused by the absence of BR-dependent elongation rather than the inhibition caused by the expression of genes for photomorphogenesis. We propose that BRs resemble cytokinins in regulating de-etiolation as positive regulators, and that the inhibition of hypocotyl elongation and the development of leaves and epicotyls in de-etiolation are independent processes.

Long-term regulation of hexose uptake by isoproterenol in cultured 3T3 adipocytes

1985 ◽  
Vol 248 (6) ◽  
pp. E706-E711 ◽  
Author(s):  
J. P. van Putten ◽  
H. M. Krans
Keyword(s):  
Protein Synthesis ◽  
Prolonged Exposure ◽  
Term Effect ◽  
Long Term Effects ◽  
Fat Cell ◽  
Short Term ◽  
Long Term Effect ◽  
Short Term Exposure ◽  
Hexose Uptake

Catecholamines are known to have short-term regulatory effects on fat cell hexose uptake. We examined the long-term effects of catecholamines on the insulin-sensitive 2-deoxyglucose (dGlc) uptake in cultured 3T3-L1 adipocytes. Prolonged exposure (48 h) to isoproterenol (beta-adrenergic agonist) stimulated the basal dGlc uptake up to 90%. The effect was specific, time, concentration, and protein synthesis dependent and reversible. The effect of insulin was unaltered and superimposed on the increase in basal dGlc uptake. The long-term effect of isoproterenol was mimicked by epinephrine, dibutyryl cAMP (DBcAMP), and 1-methyl-3-isobutylxanthine (IBMX). By contrast, short-term exposure to isoproterenol (and epinephrine) induced a protein synthesis-independent increase in basal dGlc uptake (30%) not accompanied by an increase in insulin responsiveness. Moreover, on short-term basis, DBcAMP and IBMX suppressed both the basal and insulin-stimulated uptake up to 50%. Determination of the intracellular nonphosphorylated dGlc during the uptake and of the hexokinase activity revealed that the long-term effect of isoproterenol was most likely due to alterations low in dGlc transport. In conclusion, long-term regulators of hexose uptake are in cultured 3T3-L1 adipocytes, isoproterenol, and other cAMP stimulators. The long-term effect is independent from the short-term regulatory effect of the agents and from the effect of insulin.

scholarly journals Long-Term Effect of Erythritol on Dental Caries Development during Childhood: A Posttreatment Survival Analysis

2016 ◽  
Vol 50 (6) ◽  
pp. 579-588 ◽  
Author(s):  
Gwen Falony ◽  
Sisko Honkala ◽  
Riina Runnel ◽  
Jana Olak ◽  
Rita Nõmmela ◽  
...  
Keyword(s):  
Mixed Dentition ◽  
Primary School Children ◽  
Tooth Surface ◽  
Second Grade ◽  
Control Group ◽  
Long Term Effects ◽  
Daily Consumption ◽  
Dentin Caries ◽  
Long Term Effect

Objective: To assess the effect of daily consumption of erythritol, xylitol, and sorbitol candies on caries development in mixed dentition during a 3-year intervention and 3 years after the intervention. Methods: 485 Estonian first- and second-grade primary school children participated. Children were randomly allocated to an erythritol, xylitol, or sorbitol (control) group. Polyol-containing candies were administered on school days with a daily polyol consumption of 3 × 2.5 g. Yearly, caries development was assessed by calibrated dentists using the ICDAS criteria. Six years after initiation of the study and 3 years after cessation of daily polyol consumption, 420 participants were re-examined to identify potential long-term effects of polyol consumption. Survival curves were generated at the end of the intervention period and 3 years after intervention. The model included age of the subjects, schools, tooth surface ages and years of surface exposure to intervention. ICDAS scoring system-based events included enamel/dentin caries development, dentin caries development, increase in caries score, and dentist intervention. Results: At the end of the intervention, time to enamel/dentin caries development, dentin caries development, increase in caries score, and dentist intervention were significantly longer in the erythritol group as compared to the sorbitol group. Except for increase in caries score, all effects persisted 3 years after cessation of daily polyol consumption. Conclusions: A caries-preventive effect of 3-year erythritol consumption as compared to sorbitol was established in children with mixed dentition. The effect persisted up to 3 years after the end of the intervention.

The Long-Term Effects of Price Promotions on Category Incidence, Brand Choice, and Purchase Quantity

2002 ◽  
Vol 39 (4) ◽  
pp. 421-439 ◽  
Author(s):  
Koen Pauwels ◽  
Dominique M. Hanssens ◽  
S. Siddarth
Keyword(s):  
Brand Choice ◽  
Term Effect ◽  
Dynamic Effects ◽  
Long Term Effects ◽  
Price Promotions ◽  
Perishable Product ◽  
Long Term Effect ◽  
Purchase Quantity ◽  
Scanner Panel

To what extent do price promotions have a long-term effect on the components of brand sales, namely, category incidence, brand choice, and purchase quantity? The authors answer this question by using persistence modeling on weekly sales data of a perishable and a storable product derived from a scanner panel. Their analysis reveals, first, that permanent promotion effects are virtually absent for each sales component. Next, the authors develop and apply an impulse response approach to estimate the promotional adjustment period and the total dynamic effects of a price promotion. Specifically, they calculate the long-term equivalent of Gupta's (1988) 14/84/2 breakdown of promotional effects. Because of positive adjustment effects for incidence but negative adjustment effects for choice, the authors find a reversal of the importance of category incidence and brand choice: 66/11/23 for the storable product and 58/39/3 for the perishable product. The authors discuss the implications of the findings and suggest some areas for further research.

scholarly journals Changes choroidal area following trabeculectomy: long-term effect of intraocular pressure reduction

2018 ◽  
Author(s):  
Kazuhiro Kojima ◽  
Kazuyuki Hirooka ◽  
Shozo Sonoda ◽  
Taiji Sakamoto ◽  
Yoshiaki Kiuchi
Keyword(s):  
Intraocular Pressure ◽  
Enhanced Depth Imaging ◽  
Long Term Effects ◽  
Prospective Longitudinal Study ◽  
Binary Images ◽  
Long Term Effect ◽  
Before And After ◽  
Method Factors ◽  
Prospective Longitudinal

Purpose: To investigate the long-term effects of intraocular pressure (IOP) changes after trabeculectomy on the macular and peripapillary choroidal areas. Methods: This prospective longitudinal study examined 30 eyes of 30 patients with glaucoma that was uncontrolled by medical therapy. At 1 day before and at 1 year after the trabeculectomy surgery, macular and peripapillary choroidal images were recorded by enhanced depth imaging optical coherence tomography (EDI-OCT). Luminal and interstitial areas were converted to binary images using the Niblack method. Factors influencing the macular choroidal and peripapillary area were examined by multivariate analysis. Results: After trabeculectomy, the mean IOP was 10.8±3.2 mmHg compared to 17.8±7.2 mmHg at baseline (P < 0.001). The total macular choroidal area after the surgery increased from 317,735±77,380 to 338,120±90,700 μm2, while the interstitial area increased from 108,598±24,502 to 119,172±31,495 μm2 (all P < 0.05). The total peripapillary choroidal area after the surgery also increased from 1,557,487±431,798 to 1,650,253±466,672 μm2, while the interstitial area increased from 689,891±149,476 to 751,816±162,457 μm2 (all P < 0.05). However, there were no significant differences observed in the luminal area before and after the surgery. A decrease in the IOP was among the factors associated with the changes in the peripapillary choroidal area. Conclusions: IOP reductions after trabeculectomy led to increases in the macular and peripapillary choroidal areas for at least 1 year postoperative. Increases in the interstitial areas were the primary reason for observed changes in the choroidal area after trabeculectomy.

scholarly journals A brief overview of COVID-19 long-term effect on cardiovascular system

2021 ◽  
Vol 2 (5) ◽  
Author(s):  
Usman Sawar ◽  
◽  
Ali Hussain ◽  
Nikky Bardia ◽  
Hassan Tahir ◽  
...  
Keyword(s):  
Cardiovascular System ◽  
Current Literature ◽  
Acute Effect ◽  
Term Effect ◽  
Long Term Effects ◽  
Active Infection ◽  
Multiple Organs ◽  
Long Term Effect

COVID-19 infection affects multiple organs including cardiovascular system. Besides acute effect in active infection, COVID-19 also has a long-term effect on the cardiovascular system and reporting of these effects are increasing along with increased number of survivors recovering from COVID-19 infection. In this article, we reviewed the current literature available for long-term effects of COVID-19 on the heart.

Long-term effects of warren ripping for rabbit control in semi-arid South Australia.

1991 ◽  
Vol 13 (2) ◽  
pp. 96 ◽  
Author(s):  
GJ Mutze
Keyword(s):  
South Australia ◽  
Cost Effective ◽  
Long Term Effects ◽  
Short Term ◽  
Long Term Effect ◽  
Perennial Shrubs ◽  
Control Work ◽  
Semi Arid

Warren ripping and poisoning were used to control rabbits on the flood-out plain of a major creek system on Manunda Station, a sheep-grazing property near Yunta in semi-arid South Australia. Rabbit numbers were initially reduced by >99 per cent, as indicated by the number of active entrances remaining in rabbit warrens. After nearly 10 years without follow-up control work, ripped warrens had only two per cent of the pre-control number of active entrances. Poisoning effectively reduced rabbit numbers in the short-term, but had no long-term effect on the number of active entrances, either in ripped or unripped warrens. Perennial shrubs regenerated on and around ripped warrens. Warren ripping on this part of Manunda is a cost-effective management option.

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