scholarly journals Association of Anxiety With Sperm Quality: a Multicentre Cross-sectional Study in China During the COVID-19 Outbreak

2021 ◽  
Author(s):  
Yongfeng Wang ◽  
Liting He ◽  
Yunyi Yang ◽  
Lihui Tu ◽  
Jigao Yang ◽  
...  
Keyword(s):  
Linear Regression ◽  
Semen Quality ◽  
Sperm Quality ◽  
Sperm Count ◽  
Sperm Concentration ◽  
Cross Sectional Study ◽  
Anxiety Symptoms ◽  
Quality Analysis ◽  
Cross Sectional ◽  
Progressive Motility

Abstract Objectives: There is no report about association of anxiety on sperm quality during the COVID-19 epidemic. Purpose of this study was to investigate the relationship between anxiety and sperm quality during the COVID-19 outbreak in China.Methods: 896 sperm donors from 7 sperm banks in China were investigated, and passed the screening for sperm donation between 23 January 2020 and 8 June 2020. Semen quality analysis follows the standards of the WHO Fifth Edition Human Semen Examination and Processing Manual. Anxiety symptoms were assessed by the Generalized Anxiety Disorder Scal-7(GAD-7). Logistic regression and linear regression were used to identify the association between anxiety level and sperm quality.Results: Participants with anxiety status (N = 155; 17.3%) had lower sperm concentration (56.81 ± 32.70 vs. 47.21 ± 30.76 [106/mL]), sperm volume (3.58 ± 1.65 vs. 3.04 ± 1.69 [mL], P < 0.001), total sperm count (7.29 ± 1.23 vs. 6.56 ± 1.63 [106], P < 0.001), and progressive motility (50.86 ± 12.45 vs. 38.50 ± 17.00 [%], P < 0.001) than those without anxiety. Linear regression showed that anxiety symptoms was significantly associated with 8.13 (95% confidence interval [CI]: 2.51, 13.75), 0.49 (0.20, 0.79) ,51.05 (23.43, 78.68) and 12.15 (95% CI: 23.43, 78.68), reduction in sperm concentration, semen volume, and total sperm count and progressive motility respectively.Conclusions: This study revealed that anxiety symptoms were negatively associated with semen quality, and interaction was discovered between debt stress and anxiety.

scholarly journals Semen quality pattern and age threshold: a retrospective cross-sectional study of 71,623 infertile men in China, between 2011 and 2017

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
W. N. Li ◽  
M. M. Jia ◽  
Y. Q. Peng ◽  
R. Ding ◽  
L. Q. Fan ◽  
...  
Keyword(s):  
Semen Quality ◽  
Sperm Count ◽  
Sperm Concentration ◽  
Cross Sectional Study ◽  
Semen Parameters ◽  
Sectional Study ◽  
Joinpoint Regression ◽  
Cross Sectional ◽  
Progressive Motility ◽  
Infertile Men

Abstract Background The aim of this study was to provide information on the semen quality pattern of infertile men and age thresholds for semen parameters in China. Methods This was a retrospective cross-sectional study investigating 71,623 infertile men from the Reproductive and Genetic Hospital of CITIC Xiangya in Hunan, China, from 2011 to 2017. The Kruskal-Wallis test, Mann-Kendall test, linear regression model and joinpoint regression were used. Results Although erratic changes were observed in the median semen parameters (sperm concentration 40.1–52.1 × 106/ml, total sperm count 117.8–153.1 × 106, sperm progressive motility 33.4–38.1%) during the 7 years of observation, no significant decrease in semen quality was found, and 47.88% of infertile men showed normal semen parameters according to the World Health Organization (WHO) criteria. According to the joinpoint regression analysis, sperm progressive motility appeared to decrease earlier than the sperm concentration and total sperm count (at 28, 58, and 42 years of age, respectively). Conclusions There is no evidence of a deterioration in semen quality among infertile men in Hunan, China. Semen parameters decreased with increasing age, with turning points noted at different ages. Semen parameters are not absolute evidence for the assessment of male fertility potential. Therefore, we believe that, among semen parameters, the sperm concentration is the best predictor of fertility for ART, followed by motility. Decreased sperm motility may affect natural pregnancy, but it is not necessary for successful IVF.

scholarly journals Association of the Dietary Approaches to Stop Hypertension, Physical Activity, and Their Combination with Semen Quality: A Cross-Sectional Study

Nutrients ◽  
2019 ◽  
Vol 12 (1) ◽  
pp. 39
Author(s):  
Anna Danielewicz ◽  
Jakub Morze ◽  
Mariusz Przybyłowicz ◽  
Katarzyna Eufemia Przybyłowicz
Keyword(s):  
Physical Activity ◽  
Semen Quality ◽  
Sperm Count ◽  
Sperm Concentration ◽  
Cross Sectional Study ◽  
Semen Parameters ◽  
Sectional Study ◽  
Cross Sectional ◽  
Dash Diet ◽  
Progressive Motility

The influence of individual lifestyle factors is widely described in studies on semen quality. However, their synergistic effect is often neglected. The aim of the study was to examine the association between semen quality and dietary approaches to stop hypertension (DASH) diet, physical activity (PA), and the two separately and in combination. A cross-sectional study was carried out among 207 men aged 20–55. Dietary data were collected by a food frequency questionnaire (FFQ) and analysed according to the DASH scoring index. Physical activity was evaluated by the International Physical Activity Questionnaire. Semen parameters were assessed via the computer-aided semen analysis (CASA). Adherence to the DASH diet was associated with higher sperm count (ΔT3-T1 = 82.1 mln/ej) and concentration (ΔT3-T1 = 24.6 mln/mL). Higher PA was related to higher sperm count (ΔT3-T1 = 69.4 mln/ej), total (ΔT3-T1 = 11.9%), and progressive motility (ΔT3-T1 = 8.5%) and morphology (ΔT3-T1 = 2.8%) in the crude model and remained significant after adjustment. The combination of the DASH diet and PA, was significantly positively associated with sperm count (ΔT3-T1 = 98.1 mln/ej), sperm concentration (ΔT3-T1 = 17.5 mln/mL), total (ΔT3-T1 = 11.8%), and progressive motility (ΔT3-T1 = 10.0%) and morphology (ΔT3-T1 = 3.3%) in both models. Adherence to the DASH diet was related to higher sperm count and concentration, whereas after its combination with physical activity it was also positively correlated with sperm motility and morphology.

scholarly journals Association of Depression with Sperm Quality: a Multicentre Cross-Sectional Study in China During the COVID-19 Pandemic

2021 ◽  
Author(s):  
Yongfeng Wang ◽  
Yuan Zhang ◽  
Yunyi Yang ◽  
Lihui Tu ◽  
Jigao Yang ◽  
...  
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Linear Regression ◽  
Logistic Regression Analysis ◽  
Semen Quality ◽  
Sperm Count ◽  
World Health ◽  
Cross Sectional ◽  
Progressive Motility ◽  
Semen Volume

Abstract Background: Depression is a potential factor affecting semen quality. However, the relationship between depression and semen quality remains to be fully elucidated. We investigated the association between depression and semen quality in men during the COVID-19 pandemic.Methods: Cross‐sectional, participants completed a questionnaire assessing lifestyle factors the Patient Health Questionnaire-9 (PHQ-9) was used to evaluate the psychological depression status of subjects. Semen quality assessment implements the requirements of the fifth edition of the World Health Organization (WHO )manual ,multivariable logistic regression analysis and linear regression analysis were conducted to assess the associations between depression and semen quality.Results: Of the 896 participants, 173 were depressed (19.30%). A Linear regression model was fitted to assess the strength and significant level of the association between depressive symptoms and semen quality. After adjusting for potential confounders, depression was significantly associated with 9.27 (95% confidence interval [CI] 3.39, 15.15), 0.57(95% CI 0.27, 0.87), 62.20 (95% CI 32.93, 91.48), and 12.96 (95% CI 10.55, 15.37) reduction in sperm concentration, sperm volume, total sperm count, and progressive motility, respectively. Which are consistent with the logistic regression analysis results. The semen concentration and total sperm count were linearly correlated with depression scores, whereas the semen volume and progressive motility of sperm were nonlinearly correlated with depression scores.Conclusions: Depression were associated with lower levels of semen concentration, semen volume, total sperm count, and progressive motility, which could affect male reproductive health.

scholarly journals Dietary Patterns and Poor Semen Quality Risk in Men: A Cross-Sectional Study

Nutrients ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 1162 ◽  
Author(s):  
Anna Danielewicz ◽  
Katarzyna Przybyłowicz ◽  
Mariusz Przybyłowicz
Keyword(s):  
Dietary Patterns ◽  
Semen Quality ◽  
Sperm Quality ◽  
Cross Sectional Study ◽  
Quality Parameters ◽  
Semen Parameters ◽  
Sectional Study ◽  
Cross Sectional ◽  
Progressive Motility ◽  
Increased Risk

The etiology of diminished sperm quality in about 30% of male infertility cases generally remains unexplained. Some studies have suggested that specific nutritional factors can affect semen quality. The aim of this study was to evaluate an association between dietary patterns (DPs) and the risk of abnormal semen quality parameters in men. This cross-sectional study was carried out in 114 men aged 20–55 years from Poland. Semen parameters were assessed via computer-aided semen. Diet was assessed by a food frequency questionnaire (FFQ). DPs were derived using Principal Component Analysis (PCA). Two DPs were derived: Pro-healthy and Western. After adjusting for potential confounders, the risk of abnormal progressive motility was significantly higher in the middle (OR: 2.89, 95% CI: 1.03–8.09) and upper (OR: 7.78, 95% CI: 1.52–15.06) tertiles of the Western DP. A trend for increased risk of the abnormal total count, progressive motility, and morphology (P-trend < 0.050) was found in Western DP. To conclude, the Western DP may increase the risk of abnormal semen parameters, whereas no association was found in the case of Pro-healthy DP. These findings stand in contrast to an increasing number of research findings indicating a positive relation between intake of healthy foods or diet and semen quality parameters. The results highlight the need to study whether modifications in diet and lifestyle factors improve semen quality.

Built Environment and Semen Quality in Korean Men with a History of Infertility: A Cross-Sectional Study

2020 ◽  
Author(s):  
Seung-Ah Choe ◽  
Seulgi Kim ◽  
Changmin Im ◽  
Sun-Young Kim ◽  
Gregory Wellenius ◽  
...  
Keyword(s):  
Built Environment ◽  
Semen Quality ◽  
Sperm Count ◽  
Positive Association ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Progressive Motility ◽  
History Of ◽  
Total Motile Sperm Count

Abstract Background: There is growing interest in the potential impact of the physical environment on human fertility. This study aimed to explore the association between built environment and semen parameters among men who sought fertility evaluation . Methods: This is a cross-sectional study involving 5,886 men living in the Seoul Capital Area whose semen was tested at a single fertility center during 2016–2018. Environmental exposures evaluated were distance to fresh water (river and lake), the coast, major roadways, and neighborhood greenness measured by Normalized Difference Vegetation Index (NDVI). Outcome indicators were semen volume, sperm concentration, percentage of progressive motility, vitality, normal morphology, and total motile sperm count. We used linear regression to model standardized values of six semen quality indicators.Results: Majority of the study population (mean age 39 years) were white-collar workers, clerks, and service workers. None of the mean values of semen quality indicators showed linear trends across quartiles of built environment components. Linear associations between built environment features and semen quality indicators were not evident except for NDVI within 500 m and sperm vitality (β = 0.05 per 0.1-increase; 95% confidence interval (CI): 0.01, 0.09). The 2nd quartile of distance to fresh water was associated with lower progressive motility compared to the 1st quartile (β = −0.10; 95% CI: −0.17, −0.03). Proportion of vitality was higher among men in the 2nd quartile of distance to roadways than those in the 1st quartile (0.08; 95% CI: 0.01, 0.15). Men in the 2nd quartile of NDVI showed higher total motile sperm count than those in the 1st quartile (0.09; 95% CI: 0.01, 0.17). In multi-exposure model, the positive association between NDVI and vitality remained (0.03, 95% CI: 0.00, 0.06). Conclusions: This study contributes potential evidence regarding the impact of built environment on male fertility ; specifically, a positive association between residential greenness and percentage of sperm vitality among Korean men with a history of infertility .

scholarly journals Effect of macrophages in semen on sperm quality

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Gangxin Chen ◽  
Beihong Zheng
Keyword(s):  
Cell Membrane ◽  
Sperm Motility ◽  
Semen Quality ◽  
Sperm Quality ◽  
Sperm Concentration ◽  
Membrane Integrity ◽  
Cross Sectional Study ◽  
High Group ◽  
Cross Sectional ◽  
Cell Membrane Integrity

Abstract Background This was a cross-sectional study in China which analyzed the levels of macrophages (Mφ) in semen and evaluated the influence of Mφ levels in semen on sperm quality. Methods The subjects involves 78 males, 25- to 35-year old. The samples were divided into a low group (Mφ < 6 × 105/ml) and a high group (Mφ > 6 × 105/ml). Evaluation included consideration of the influencing factors of male semen quality, macrophage concentration, sperm motility, morphology, membrane integrity DNA fragmentation index (DFI), anti-sperm antibodies (AsAb), IL-10, and IL-12 in semen. Results There was no difference in the physical or chemical indices of the semen, sperm concentration, AsAb, IL-10, or IL-12 between the two groups (P > 0.05). The percentage of sperm forward motility (PR%), the rate of normal sperm shape, and the integrity of cell membranes in the low group were higher than those in the high group (P < 0.05), while the percentage of sperm inactivity (IM%), the rate of sperm head deformity, the rate of deformity in the neck and middle segment, the sperm deformity index (SDI), the teratozoospermia index (TZI), and the sperm DFI in the low group were lower than those in the high group (P < 0.05). The concentration of Mφ in the semen was linearly correlated with sperm concentration, sperm PR%, IM%, sperm normal shape rate, head deformity rate, neck and middle deformity rate, SDI, TZI, sperm DFI, and sperm cell membrane integrity (P < 0.05), but there was no linear correlation with IL-10 or IL-12 (P > 0.05). Conclusions The Mφ concentration in semen is not significantly correlated with semen volume or sperm concentration, but negatively correlated with sperm motility, morphology, cell membrane integrity, and DNA damage rate. There is no significant correlation between the macrophages and the concentration of IL-10 or IL-12.

scholarly journals The Association Between Race, Obesity, and Sperm Quality Among Men Attending a University Physician Practice in Washington, DC

2020 ◽  
Vol 14 (3) ◽  
pp. 155798832092598
Author(s):  
Nathan L. McCray ◽  
Heather A. Young ◽  
Michael S. Irwig ◽  
David Frankfurter ◽  
Arnold M. Schwartz ◽  
...  
Keyword(s):  
Semen Quality ◽  
Sperm Quality ◽  
Sperm Count ◽  
Sperm Concentration ◽  
World Health ◽  
Washington Dc ◽  
Physician Practice ◽  
Research Attention ◽  
Men Of Color ◽  
Hispanic Men

A decades-long decline in sperm counts in Western countries has coincided with an increase in obesity rates, prompting study into their association. Few of these studies have incorporated men of color, the sperm health of whom is relatively unknown. The present exploratory study evaluated the association between body mass index (BMI), race, ethnicity, and sperm parameters among a diverse sample of U.S. men attending a Washington, DC physician practice. Semen samples were collected and processed at a single laboratory and sperm concentration, motility, morphology, and count were evaluated according to World Health Organization (WHO) 5th edition criteria. Multivariate models accounted for covariates related to sperm health. The study population ( n = 128) was largely obese (45.3%) or overweight (34.4%), and 36.0% were black or Hispanic. Black men had lower adjusted sperm concentration compared to white men (75.0 million/mL to 107.4 million/mL, p = .01) and were more likely to have oligozoospermia ( p = .01), asthenozoospermia ( p = .004), and low sperm count ( p < .0001). Hispanic men had higher adjusted sperm concentration compared to non-Hispanic men (124.5 million/mL to 62.1 million/mL, p = .007) and were less likely to have teratozoospermia ( p = .001). Obesity and BMI were associated with lower sperm motility and count in crude models only. Given the study’s sample size its findings should be interpreted with caution but align with the limited epidemiological literature to date that has evaluated racial and ethnic differences in semen quality. Heightened clinical research attention is needed to ensure men of color are included in representative numbers in studies of urologic and andrologic health.

scholarly journals The Association Between Abstinence Period and Semen Parameters: Results in Normal Samples and Different Sperm Pathology

2021 ◽  
Author(s):  
Min Xie ◽  
Silvan Hämmerli ◽  
Kerstin Blickenstorfer ◽  
Brigitte Leeners
Keyword(s):  
Semen Quality ◽  
Sperm Quality ◽  
Sperm Count ◽  
Sperm Concentration ◽  
Semen Parameters ◽  
Sexual Abstinence ◽  
Normal Morphology ◽  
Few Data ◽  
Total Motile Sperm Count ◽  
Abstinence Period

Abstract Purpose: The length of sexual abstinence seems to influence sperm quality. However, few data on the relevance of abstinence time in pathological sperm samples are available. With our study, we look for associations of abstinence length and semen quality. Methods: We studied semen samples from 4423 men undergoing fertility evaluation. Sperm concentration, percentage of progressively motile spermatozoa, total motile sperm count, percentage of spermatozoa with normal morphology, were compared after each day and 0-2, 3-7 and >7 days of abstinence. Results: We found that a longer abstinence time was related to higher sperm concentration in normal semen samples (P<0.001) and in semen samples with any sperm pathology (P<0.001, P=0.004) with the exception of oligozoospermia (P=0.125). Longer abstinence time was also associated with significantly reduced progressive motility in normal samples (P<0.001) and in cases of teratozoospermia (P<0.001). In normal samples a higher percentage of sperm were morphologically normal after a shorter abstinence period (P=0.03); in oligoasthenoteratozoospermia (OAT) samples, this was the case after a longer abstinence period (P=0.013). Conclusion: A longer abstinence time is associated with higher sperm concentration, whereas sperm motility is optimal after shorter abstinence times; results on morphology are controversial. The recommendation on abstinence time needs to be adjusted in relation to the parameter that needs to be improved.

scholarly journals Role of Dietary Antioxidants and Vitamins Intake in Semen Quality Parameters: A Cross-sectional Study

2020 ◽  
Author(s):  
Reza Ghiasvand ◽  
Laleh Dehghan Marvast ◽  
Mehran Nouri ◽  
Aida Jahanbakhsh ◽  
farahnaz haeri
Keyword(s):  
Dietary Intake ◽  
Semen Quality ◽  
Sperm Count ◽  
Cross Sectional Study ◽  
Quality Parameters ◽  
Dietary Antioxidants ◽  
Cross Sectional ◽  
Infertile Men ◽  
Semen Volume

Abstract Objective Infertility had an increasing trend between couples in Iran. Several factors such as lifestyle, physical activity, unhealthy dietary habits and stress are associated with production of ROS in seminal fluid. The aim of this study was to identify the role of dietary antioxidants and vitamins intake on semen quality parameters, among Iranian infertile men. Methods This cross-sectional study was performed on 400 newly diagnosed infertile men in Yazd Reproductive sciences Institute from July 2019 to December 2019. The presence of infertility was confirmed by an expert andrologist, based on WHO criteria. Dietary antioxidants and vitamins intake were assessed using a 168 items semi-quantitative food frequency questionnaire (FFQ). Results We found an association between semen volume and Alpha Carotene dietary intake, total motility and Beta Cryptoxanthin dietary intake, and sperm count with riboflavin intake (P = 0.03). Conclusions We concluded that dietary intake of Alpha Carotene, Beta Cryptoxanthin, and Riboflavin are related to sperm count, semen volume and total motility in Iranian infertile men, respectively. Our data suggest that that adhering to a diet that is rich in sources of antioxidant and vitamin can have a positive effect on men’s sexual health. However, more research is needed to confirm these relations and provide the evidence needed to exert these findings into clinical practice.

scholarly journals Processed meat intake in relation to semen quality indicators among men attending a fertility clinic

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Anna Danielewicz ◽  
Katarzyna Przybyłowicz ◽  
Jakub Morze
Keyword(s):  
Quality Indicators ◽  
Semen Quality ◽  
Negative Impact ◽  
Sperm Count ◽  
Semen Analysis ◽  
Sperm Concentration ◽  
World Health ◽  
Processed Meat ◽  
Cross Sectional ◽  
Meat Intake

AbstractIt is estimated that in Central and Eastern Europe 8–12% of men are infertile, and in the case of 20% of infertile couples in the region, indicates a 56% part of the malefactor in the occurrence of infertility. Numerous studies have shown that a healthy diet with a high intake of fish and seafood, poultry, vegetables, fruits, legumes, through the high content of antioxidants are associated with better parameters of semen quality and reduced risk of asthenozoospermia. Men's diets may affect spermatogenesis as reflected in semen quality indicators, but the literature on the relation between meat intake and semen quality is limited. Our objective was to prospectively examine the relation between meats including red, poultry, proceesed and fish and indicators of semen quality. Men in subfertile couples presenting for evaluation at the Olsztyn Hospital Fertility Center were invited to participate in an ongoing study of environmental factors and fertility. This cross-sectional study was carried out in 208 men aged 18–55 years from Northern-Eastern Poland. Semen samples were collected at the clinic and analyses were performed by an experienced technician. Semen microscopic measurements were determined with the use of computer-aided semen analysis (CASA) and evaluated according to the World Health Organization (WHO) guidelines. A total of men completed a validated food-frequency questionnaire and subsequently provided semen samples. We used linear mixed regression models to examine the relation between meat intake and semen quality indicators (total sperm count, sperm concentration, progressive motility, morphology, and semen volume) while adjusting for potential confounders. After adjustment for age, BMI, physical activity, residence place and education, one serving increase in intake of processed meat was associated with a 56% higher risk of abnormal progressive sperm motility (OR = 1.56 95%CI:1.09–2.21). Consuming processed meat may have a negative impact on sperm counts and morphology. Potentially, these products may be a significant source of saturated and trans fatty acids, xenobiotics, mainly xenoestrogen, and steroids. Is need to clarify the potential effect of meat products, especially processed meat, on male reproductive potential in RCTs or longitudinal studies. Future findings may be useful to establish a more precise recommendation connected with red and processed meat intake in the context of reproductive health.

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