scholarly journals Clinical Significance of Changes in the Subendocortical Volume of Wilson Disease

2021 ◽  
Author(s):  
Xia Xiao ◽  
Xiangxue Zhou ◽  
Zihuan Huang ◽  
Jian Liao ◽  
Jianping Chu
Keyword(s):  
Nerve Cell ◽  
Wilson Disease ◽  
Cell Injury ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Control Group ◽  
Cell Necrosis ◽  
Nerve Cell Injury ◽  
Different Parts ◽  
Subcortical Volume

Abstract Wilson disease (WD) is a rare neurogenetic disease with a variety of clinical manifestations. The disorder of copper metabolism can lead to cell necrosis, while nerve cell necrosis can reduce the volume of the corresponding parts. This study quantifies the degree of nerve cell injury by studying the subcortical volume changes in WD patients, and discusses the correlation between nerve cell injury in different parts and clinical manifestations. The results showed that compared with the healthy control group, the subcortical volume of WD decreased significantly, and the decrease in different parts was related to clinical symptoms. This study shows that we can quantify the degree of nerve cell injury by measuring the change of subcortical volume. Predict possible clinical symptoms.

Bepridil Exacerbates Glutamate-Induced Deterioration of Calcium Homeostasis and Cultured Nerve Cell Injury

1996 ◽  
Vol 88 (3-4) ◽  
pp. 199-214 ◽  
Author(s):  
Tatyana P. Storozhevykh ◽  
Elena G. Sorokina ◽  
Natalya P. Vinskaya ◽  
Vsevolod G. Pinelis ◽  
Olga V. Vergun ◽  
...  
Keyword(s):  
Nerve Cell ◽  
Calcium Homeostasis ◽  
Cell Injury ◽  
Nerve Cell Injury

scholarly journals Investigation on the Correlation between Serum Immune Factor Levels and Allergic Constitution in Children with Infectious Mononucleosis

2021 ◽  
Vol 2021 ◽  
pp. 1-7
Author(s):  
Hong Sun ◽  
Weiqun Wang ◽  
Chenglei Lin ◽  
Min Chen
Keyword(s):  
Infectious Mononucleosis ◽  
Clinical Symptoms ◽  
Venous Blood ◽  
Clinical Manifestations ◽  
Allergic Diseases ◽  
Early Morning ◽  
Control Group ◽  
Serum Ige ◽  
Immune Factor ◽  
Reference Index

Objective. To investigate the correlation between serum immune factor levels and allergic constitution in children with infectious mononucleosis. Methods. A total of 120 children who visited our hospital from March, 2019, to December, 2020, were selected as the research objects, and 40 children who came to our hospital for physical examination were included in the control group (CG). 40 children with IM were classified into the IM group (IG), and 40 IM children with allergic rhinitis, allergic dermatitis, asthma, and other allergic diseases were classified into the IM allergy group (AG). On the second day of admission, 5 ml of fasting venous blood was collected from all children in the early morning to observe the serum IgE level, the level of lymphocyte subsets, and the level of immunoglobulin of the patient. Results. The serum CD3, CD4, and CD8 levels of children in AG were significantly higher than those in IG and CG ( P < 0.05 ). The serum IgE, IgA, IgM, and IgG levels of children in AG were significantly higher than those of IG and CG ( P < 0.05 ). The serum IgE levels of children in AG were positively correlated with the serum CD3, CD4, and CD8 levels ( P < 0.05 ). There was a positive correlation between the serum IgE level and serum IgA, IgM, and IgG levels in children with AG ( P < 0.05 ). Conclusion. The results of this study showed that there may be a certain relationship between allergic constitution and the incidence, clinical manifestations, and prognosis of infectious mononucleosis. IgE level can be used as a reference index for the early severity of IM clinical symptoms.

NERVE CELL INJURY IN CASES OF HUMAN ELECTROCUTION

JAMA ◽  
1930 ◽  
Vol 95 (2) ◽  
pp. 107 ◽  
Author(s):  
ORTHELLO R. LANGWORTHY
Keyword(s):  
Nerve Cell ◽  
Cell Injury ◽  
Nerve Cell Injury

scholarly journals Vitamin D Receptor Gene BsmI Polymorphism in Polish Patients with Systemic Lupus Erythematosus

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Beata Kaleta ◽  
Jarosław Bogaczewicz ◽  
Ewa Robak ◽  
Anna Sysa-Jędrzejowska ◽  
Małgorzata Wrzosek ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Vitamin D ◽  
Lupus Erythematosus ◽  
Clinical Symptoms ◽  
Receptor Gene ◽  
Active Form ◽  
Clinical Manifestations ◽  
Control Group ◽  
Systemic Lupus ◽  
Bsmi Polymorphism

The hormonally active form of vitamin D3, 1,25(OH)2D3 (calcitriol), exerts actions through VDR receptor, which acts as a transcriptional factor. Calcitriol is an immunomodulator that affects various immune cells, and several studies link it to many autoimmune diseases. BsmI polymorphism affects the level of VDR gene transcription, transcript stability, and posttranscriptional modifications. It seems to be related to the systemic lupus erythematosus (SLE). Our study examined the characteristics of VDR gene BsmI polymorphism in Polish SLE patients and their relationship with clinical manifestations of the disease. We genotyped 62 patients with SLE and 100 healthy controls using the real-time PCR. There were no differences observed in the frequency of BsmI genotypes in SLE patients and in the control group. There was no significant correlation between BsmI genotypes and clinical symptoms of SLE, but the AA genotype correlates with higher levels of antinuclear antibodies (ANA) in this group (r=0.438; P=0.002). A larger study examining BsmI and other VDR gene polymorphisms is needed. It may allow explaining differences in the clinical picture of the disease and choosing a personalized therapy.

scholarly journals Enterosorbent for endotoxicosis as a factor influencing the development of young cattle

2019 ◽  
Vol 190 (11) ◽  
pp. 66-70
Author(s):  
А. КРАСНОПЕРОВ ◽  
A. KRASNOPEROV ◽  
С. Малков ◽  
S. Malkov ◽  
Наталья Верещак ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Recovery Period ◽  
Clinical Manifestations ◽  
The Body ◽  
Control Group ◽  
Phagocytic Cells ◽  
Immunological Parameters ◽  
Endogenous Intoxication ◽  
Newborn Calves ◽  
Young Cattle

Abstract. Purpose – study the effect of enterosorbent on the immunological parameters of blood and the productivity of young cattle. Methods. The object of the study was newborn calves from 2 to 6 days of age (n = 54). Studies on the enterosorbent based on colloidal silicon dioxide (CSD) for calves with alimentary dyspepsia have been carried out. During the experiment, the clinical condition of the animals, the increase in live body weight were evaluated, blood samples were taken for immunohematological studies. Results. In calves at 2–6 days of age, alimentary dyspepsia is accompanied by the development of endogenous intoxication of the body. Animals show leukocytosis – 16.60 ± 5.11×109/l; leukocyte shift to the left with an increase in the number of adolescent and stab neutrophils – 1.41 ± 0.23×109/l; monocytes up to 1.21 ± 0.13x×109/l; circulating immune complexes (CIC) level in blood serum up to 202.4 ± 8.5 cu Under conditions of endogenous intoxication, the immunological protection of the organism was characterized by an increase in the number of phagocytic cells to 71 % of the total number of granulocytes. Clinical symptoms of endogenous intoxication in 86 % of cases disappeared by the 5th day of the use of enterosorbent CSD in the treatment regimen of calves with alimentary dyspepsia. This is associated with blocking and weakening the inflammatory response in the gastrointestinal tract. The effect of enterosorbent CSD on the immunological parameters was expressed in a balanced stabilization of the processes of phagocytosis and immunogenesis. The trend towards normalization of immunological parameters was registered: the level of the CIC was significantly reduced to 97.5 ± 5.48 cu; the phagocytic activity (PA) of the neutrophilic cells was 50.1 ± 2.4 %. Treatment of animals according to the basic scheme approved by the farm turned out to be less effective. In calves that did not receive enterosorbent CSD, in 11 % of cases, clinical manifestations of endogenous intoxication were recorded up to and including 14 days. In these animals, the level of the CIC remained high – 143.6 ± 8.57 cu, the voltage of phagocytic function was noted – 64.3 ± 7.6 % and the imbalance in the ratio of T/B-lymphocytes – 1.13 (normal 1.5–2.0). The effect of the CSD enterosorbent on the calves productivity was reflected in the fact that the rate of weight gain during the experiment was higher in the experimental group. At 4 months, their weight was 149.17 ± 13.57 kg, while in the control group and the comparison group – 135.00 ± 5.00 and 130.00 ± 22.73 kg, respectively. Scientific novelty. Alimentary dyspepsia causes the development of endogenous intoxication in the body of newborn calves. The lack of therapeutic measures leads to a long recovery period and a decrease in productivity.

scholarly journals Study of the FUT2 gene association with infection and clinical manifestations of Helicobacter pylori infection

2021 ◽  
pp. 27-32
Author(s):  
A. S. Klimova ◽  
E. V. Shrayner ◽  
A. I. Khavkin ◽  
N. V. Kokh ◽  
G. I. Lifshits ◽  
...  
Keyword(s):  
Clinical Symptoms ◽  
Polymorphic Locus ◽  
Clinical Manifestations ◽  
Main Group ◽  
Control Group ◽  
Significant Difference ◽  
Taqman Pcr ◽  
Pcr Method ◽  
H Pylori ◽  
Fut2 Gene

The aim of the pilot study of a group of adolescents with H. pylori infection was to study the preliminary data obtained on the rs602662 locus of the FUT2 gene and to establish its role in the realization of clinical manifestations of chronic gastritis, gastric ulcer and duodenal ulcer associated with H. pylori.Methods: The study included 91 patients. The study for the presence of the polymorphic locus rs602662 of the FUT2 gene was carried out by the standard TaqMan PCR method on a Real-Time CFX96 Touch amplifier. The duration of the study was 6 months.Results: The main group included 25 adolescents aged 16 to 17 years 11 months, the control group included 20 patients. Patients infected with H. pylori more often noticed symptoms of dyspepsia - in 36%, compared with the control group - 9.7%. The presence of a family history in the main group for associated diseases had a significant difference, χ2 = 4.97, p <0.05.To assess the contribution of the genotype of the rs602662 locus of the FUT2 gene to the risk of clinical manifestations in H. pylori infection, the main group was divided into subgroups. In the distribution of alleles in these groups, statistically significant differences were revealed.Allele “A” has a protective effect against the onset of clinical symptoms of dyspepsia. The odds ratio (OR) with the carriage of allele “A” (genotypes A / A and G / A versus G / G) to have clinical symptoms with a positive H. pylori status was 0.175 (CI = [0.049-0.625] chi2 = 7.79 p = 0.0053).Conclusion. As a result of the study, we were unable to identify a significant association of alleles and genotypes of the rs602662 locus of the FUT2 gene with clinical manifestations of H. pylori infection. At the same time, carriers of the A allele have a pronounced association with the absence of clinical symptoms in patients with a positive H. pylori infection status of 0.175 (C.I. = [0.049-0.625] chi2 = 7.79 p = 0.0053).

scholarly journals The clinical manifestations of keratoconus in the patients presenting with Down syndrome

2016 ◽  
Vol 11 (3) ◽  
pp. 118-120
Author(s):  
M. M Bikbov ◽  
V. K Surkova ◽  
E. L Usubov ◽  
Karine Khachaturovna Oganisyan
Keyword(s):  
Down Syndrome ◽  
General Population ◽  
Clinical Symptoms ◽  
Corneal Thickness ◽  
Clinical Manifestations ◽  
Control Group ◽  
Study Group ◽  
Healthy Children ◽  
Ophthalmological Examination ◽  
Biometric Parameters

Down syndrome is one the most widespread forms of genomic pathology accompanied by mental retardation and impairment of cognitive functions. One of the commonest eye diseases in the patients with Down syndrome is corneal ectasia that occurs 10 times more frequently in the children with Down syndrome than in the general population. Objective. Of the present study was the comparative analysis of the biometric parameters of the cornea and the clinical manifestations of keratoconus in the patients presenting with Down syndrome. Materials and methods. We undertook the comprehensive analysis of the biometric parameters of the cornea in 54 patients (108 eyes) with Down syndrome who made up the main study group. The control group was comprised of 62 practically healthy children (124 eyes). Results. The patients presenting with Down syndrome were found to have a higher refractive power of the cornea, a more pronounced elevation of the posterior corneal surface and its irregular patterns, a smaller corneal thickness, and lower degree of corneal hysteresis in comparison with the control children. The verified diagnosis of keratoconus was established in 11 patients of the main group. Conclusion. The present study has revealed keratoconus in 11 (20.4%) children presenting with Down syndrome which suggests a higher prevalence of this pathology in our study group in comparison with its mean prevalence reported thus far for the general population. The early subclinical forms of ceratoconus are known to more frequently occur in the children aged from 12 to 18 years, with the incidence of its later stages being especially high in the group of the patients between 19 and 38 years of age. This discrepancy is supposed to be attributable to the progression of the clinical symptoms of the eye disease with age and its late diagnostics. The deviation of corneal biometric characteristics from the respective normal values documented in 79.6% of the patients included in the present study should be regarded as reflecting the objective situation. It is concluded that the patients presenting with Down syndrome should be referred to the group at enhanced risk of development of keratoconus and undergo the regular ophthalmological examination.

Experience of low-intensity LED radiation (LILEDR) in combination treatment of radiation-induced rectal injuries.

2021 ◽  
Vol 39 (15_suppl) ◽  
pp. e17514-e17514
Author(s):  
Olga G. Rodionova ◽  
Vitaliy I. Voshedskiy ◽  
Pavel G. Sakun ◽  
Elena A. Sheiko ◽  
Marina A. Gusareva ◽  
...  
Keyword(s):  
Exposure Time ◽  
Combination Treatment ◽  
Conservative Therapy ◽  
Radiation Treatment ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Main Group ◽  
Control Group ◽  
Rehabilitation Period ◽  
Radiation Induced

e17514 Background: Malignant pelvic tumors account for more than 25% of cancer incidence in Russia. Radiation therapy is the most common treatment for such patients; however, 10-15% of patients develop radiation-induced complications of the pelvic organs, and more effective treatments are required to manage these complications. Methods: The study included 30 patients with cervical cancer T3NхM0 after combination treatment. 7-10 months after combined radiation treatment (total radiation dose to the primary focus 80 Gy), patients developed erosive ulcerative radiation rectitis (RTOG grade 1 and 2). Patients were divided into 2 groups: main group (n = 15) – conservative treatment combined with LILEDR. Each course included 10 LILEDR sessions, the red spectrum λ = 640 nm on the cubital vein projection (exposure time 5 minutes, dose 6.86 J/cm2) and locally on the ulcerated zones (exposure time 3 minutes, dose 3.96 J/cm2). Patients received 2 LILEDR courses with a 1-month interval. The control group received only conservative therapy. Results: Main clinical manifestations of rectitis (tenesmus, bloody mucous discharge) disappeared in the main group already on the 3-4th day of the first course, epithelialization of ulcerative defects occurred in a shorter period of 7-10 days. Soft superficial scars not causing rectal stenosis formed at the site of the ulcer by the end of LILEDR courses. The control group showed long periods of the ulcer epithelialization up to 30 days, late remission and a lingering recurrent character of the disease. Conclusions: LILEDR in combination with the main conservative therapy allows rapid managing with the clinical symptoms of radiation rectitis and regression of disorders developed after the complex treatment, which improves the quality of life of patients and shortens the rehabilitation period.

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