scholarly journals A comparative analysis of lung function and spirometry parameters in genotype-controlled natives living at low and high altitude

Author(s):  
Esteban Ortiz-Prado ◽  
Sebastián Encalada ◽  
Johanna Mosquera ◽  
Katherine Simbaña-Rivera ◽  
Lenin Gomez-Barreno ◽  
...  

Abstract BackgroundThe reference values for lung function are associated to anatomical and lung morphology parameters, but anthropometry it is not the only influencing factor: altitude and genetics are two important agents affecting respiratory physiology. Altitude and its influence on respiratory function has been studied independently of genetics, considering early and long-term acclimatization.ObjectiveThe objective of this study is to evaluate lung function through a spirometry study in autochthonous Kichwas permanently living at low and high-altitude.MethodologyA cross-sectional study of spirometry differences between genetically matched lowland Kichwas from Limoncocha (230 m) at Amazonian basin and high-altitude Kichwas from Oyacachi (3,180 m) in Andean highlands. Chi-square method was used to analyze association or independence of categorical variables, while Student’s t test was applied to comparison of means within quantitative variables. ANOVA, or in the case that the variables didn’t meet the criteria of normality, Kruskal Wallis test were used to compare more than two groups.ResultsPeople from Oyacachi (high altitude) showed a higher predicted values than those from Limonocha (low altitude). The FVC and the FEV1 were significantly greater among highlanders than lowlanders (p value < 0.001). The FEV1/FVC was significantly higher among lowlanders than highlanders for men and women. A restrictive pattern was found in 12.9% of the participants.ConclusionResidents of Oyacachi had greater lung capacity than their peers from Limoncocha, a finding physiologically plausible according to published literature. When analyzing the spirometric patterns obtained in these populations, it was evident that no person had an obstructive pattern, while on the other hand, the restrictive pattern appeared in Limoncocha and Oyacachi populations in 12.9% although it is clear that there is a predominance of this in the individuals belonging to Limoncocha.

2017 ◽  
Vol 16 (2) ◽  
pp. 47-54
Author(s):  
Raj Kumar Thapa ◽  
Kanchan KC ◽  
Rishi Khatri ◽  
Rajeeb Deo ◽  
Arun Sharma ◽  
...  

Introduction: Paracetamol (PCM) is one of the most common drug in clinical practice and it is generally safe for use at recommended doses. However, its overdose can cause mild hepatotoxicity to severe hepatic necrosis and even hepatic failure. N-acetylcysteine (NAC) is the standard recommended antidote for PCM poisoning which is available in both intravenous (IV) and oral formulations. This study aimed to measure outcome in PCM poisoning after treatment with oral or IV NAC.Methods: A descriptive cross-sectional study was conducted in randomly selected 50 consecutive patients presented within 72 hours of PCM poisoning. Comparative outcomes measured in correlation of dynamics of liver enzymes alanine aminotransferase, aspartate aminotransferase and prothrombin time along with development of adverse drug reactions and clinical cure rate. Comparison of categorical variables by Chi-square test and Fisher's test and the comparison of mean between groups by Student's t-test with p-value <0.05 as statistically significant.Results: Among 50 cases 20 (40%) were treated with oral NAC and 30 (60%) with IV NAC. PCM poisoning was more common in young adults (15-30 years) with mean age of 19 (n=43; 86%) and most of them had taken with an intent of suicide (n=47; 94%). Majority of patients were asymptomatic at presentation with female preponderance (M:F=1:4; 80%). There was no statistical difference in both the treatment groups and as an outcome measure there were no severe liver enzymes derangement, no serious adverse drug reactions and 100% clinical cure rate.Conclusion: NAC in both IV and oral forms are equally effective as an antidote in PCM poisoning.


2021 ◽  
Vol 20 (2) ◽  
pp. 120-127
Author(s):  
Dicky Zulhanda ◽  
Mona Lestari ◽  
Desheila Andarini ◽  
Novrikasari Novrikasari ◽  
Yuanita Windusari ◽  
...  

Latar belakang: Pabrik tahu merupakan salah satu tempat kerja yang berpotensi menimbulkan iklim kerja panas. Hal ini tidak terlepas dari penggunaan api sebagai media produksi yang dapat menyebabkan seseorang mengalami heat strain. Untuk itu, penelitian ini bertujuan untuk mengetahui proporsi gejala heat strain pada pekerja pembuat tahu dan faktor apa yang paling mempengaruhi gejala heat strain tersebut.Metode: Penelitian ini menggunakan desain cross sectional study dan penetapan sampel menggunakan teknik total sampling. Sampel dalam penelitian ini berjumlah 54 orang yang berasal dari enam pabrik tahu. Analisis data penelitian menggunakan uji chi square untuk analisis bivariat dan uji regresi logistik berganda untuk analisis multivariat.Hasil: Hasil penelitian menunjukkan proporsi gejala heat strain pada pekerja sebesar 64,8% dan diketahui bahwa adanya hubungan antara iklim kerja panas (p-value = 0,008), usia (p-value = 0,014), dan konsumsi air minum (p-value = 0,002) dengan gejala heat strain, dan tidak adanya hubungan antara lama kerja (p-value = 0,077) dengan gejala heat strain. Hasil analisis multivariat menunjukkan bahwa terdapat hubungan antara iklim kerja panas dengan gejala heat strain (p-value = 0,004) setelah dikontrol oleh variabel perancu.Simpulan: Hasil penelitian diketahui bahwa iklim kerja panas merupakan faktor yang paling mempengaruhi gejala heat strain pada pekerja pembuat tahu di Kawasan Kamboja Kota Palembang. Pemilik pabrik tahu dapat melakukan perbaikan ventilasi dan memasang plafon di pabrik, serta menyediakan fasilitas air minum untuk memenuhi kebutuhan air 2,8 liter/hari bagi pekerja. Title: Heat Strain Symptoms in Tofu Production Workers in Kamboja Area of Palembang CityBackground: Tofu industry is one of workplaces which has potential in creating hot working climate. This industry cannot be separated from the use of fire as one of production element where exposure to fire may cause workers to experience heat strain. This study aimed to determine the proportion of heat strain symptoms in tofu workers and what factors most influence the symptoms of heat strain.Method: This study used cross sectional study design and samples were determined by using total sampling technique.  Samples in this study amounted to 54 workers from six tofu making businesses. Analysis for study data was using chi-square test for bivariate analysis and multiple logistic regression test for multivariate analysis.Result: The study showed that the proportion for workers with heat strain symptoms was 64.8%. It was found that there was a correlation between hot work climate (p-value = 0.008), age (p-value = 0.014), and water consumption (p-value = 0.002) with heat strain symptoms. Meanwhile, there is no correlation between work length (p-value = 0.077) with heat strain symptoms. The result of multivariate analysis showed that there was a correlation between hot working climate and heat strain symptoms (p-value = 0.004) after control applied from confounding variables.Conclusion: The result showed that the hot working climate was the most influencing factor for the symptoms of heat strain on tofu workers. Tofu factory owners can repair ventilation and install ceilings in the factory. Besides, provide drinking water facilities to meet 2.8 liters/day for workers’ water needs.


2021 ◽  
Vol 14 (2) ◽  
pp. 111-117
Author(s):  
Deepa Kunwar ◽  
Snigdha Subham ◽  
Manisha Nepal ◽  
Jwolan Khadka

Background: Coronavirus disease, 2019 (COVID-19) is an infectious disease caused by the severe acute respiratorysyndrome coronavirus 2 (SARS-CoV-2).COVID-19 is a global pandemic affecting all aspects of life in all countries. Endodontist are at inherent risk because of aerosol generating procedures. The objective of the study was to assess the knowledge, attitude and practice (KAP) among Endodontists of Nepal to combat the COVID 19 pandemic. Method:A web-based cross-sectional study was conducted among Endodontist of Nepal from March to June 2021.Convenient sampling method was adopted. The data were analysed using SPSS version 20.Descriptive statistics was performed, percentage and frequency distribution were assessed. Chi-square tests wereused to see the association between the categorical variables. A p-value of <0.05 was considered statistically significant. Results:  Out of the total 81 Endodontists who responded to our study, 55.6% of them were females and 44.4% males. Around 65%were from Bagmati province.Majority (87.7%) of responders reported that they categorize the cases on the basis risk assessment, 56.8% do not perform routine procedures during the pandemic. Maximum (97.5%) of the responders discuss about COVID-19 with the patients.About 55% of the responders use rubber dam during the endodontic procedures, while 17.3% of the responders do not use them at all. Conclusion:Endodontists of Nepal werefound to have good knowledge, attitude and practice score, which is important to overcome the present pandemic scenario of COVID19.Certain pitfalls in attitude and practice level can be decreased by efficient training programs, precise guidelines, and treatment protocols.


Author(s):  
Ubong Akpan Okon ◽  
Adebola Olayinka ◽  
Pamela Mwansa ◽  
Hope Mwansa ◽  
Rabi Usman

Background: Coronavirus disease 2019 is a highly infectious viral disease reported across more than 210 countries of the world. Isolation is a very critical component of COVID-19 public health responses were infected or exposed persons are separated from the unexposed individual for the purposing of protecting and preventing or containing disease spread. Our study assessed and compared community willingness to isolate during COVID-19 pandemic among urban and rural dwellers.Methods: A multi-stage comparative cross-sectional study was used to assess respondents’ willingness to isolate between January and April 2021. Response was scored and each composite scores were converted to a percentage. The assessment was done using three questions with a maximum score of 15. A score of ≥80% of the maximum score was categorized as more willing to quarantine or isolate, score from 51% to 79% was categorized as slightly willing to quarantine or isolate while ≤50% was categorized as less willing to quarantine or isolate. Data was analysed using STATA SE 64 software and level of significance set at 5%. Categorical variables were summarised as frequency and percentages and presented in tables urban and rural comparisons were done with Chi square test and the corresponding p-values presented.Results: One thousand three hundred and thirty-one respondents recruited into the study had a mean age of 33.7±12.83. Urban respondents aged 25-34 years were 36.64% (358) while rural respondents 31.94% (145) were aged 25-34 years (p=0.013). Most the respondents in both urban and rural communities were females 58.15% (574) and 55.73% (253) respectively. 549 (56.19%) of urban respondents were willing to be quarantined after contact with a suspected COVID-19 patient when compared with the rural respondent 292 (64.32%). Only 524 (53.63%) of urban respondents were willing to isolate after having had contact with a confirmed patient compared with the rural respondents 277 (61.01%). More than half of the respondents in urban and rural 629 (64.38%) and 303 (66.74%) respectively showed their willingness to isolate if confirmed to have COVID-19. Overall, 758 (77.58%) of the respondents were willing to go into isolation during COVID-19 pandemic when compared with rural communities 377 (83.04%) of respondents (p value =0.06).Conclusions: Willingness to isolate during COVID-19 pandemic is higher among rural dwellers than the urban dwellers.


2017 ◽  
Vol 6 (2) ◽  
pp. 129
Author(s):  
Entia Nopa ◽  
Ranissa Dwi Imansari ◽  
Irwandi Rachman

Faktor Risiko Kejadian Penyakit Kulit Pada Pekerja Pengangkut Sampah Di Kota Jambi 1Entianopa, 2Ranissa Dwi Imansari, 3Irwandi Rachman       123Program Studi Kesehatan Masyarakat STIKES Harapan Ibu, Jambi   Abstrak Latar Belakang: Kulit merupakan organ terbesar pada tubuh manusia yang membungkus otot-otot dan organ-organ dalam serta merupakan jalinan jaringan pembuluh darah, saraf, dan kelenjar yang tidak berujung, semuanya memiliki potensi untuk terserang penyakit yang salah satunya adalah penyakit kulit. Penyakit kulit merupakan salah satu gangguan kesehatan yang sering dialami oleh pekerja pengangkut sampah. Berdasarkan komposisi sampah yang diangkut serta waktu paparan kerja. Tujuan penelitian ini untuk mengetahui hubungan antara masa kerja, pemakaian Alat Pelindung Diri (APD), dan personal hygiene dengan kejadian penyakit kulit pada pekerja pengangkut sampah di Kota Jambi. Metode: Penelitian ini merupakan penelitian kuantitatif dengan desain penelitian cross sectional study. Sampel penelitian yaitu sebanyak 62 pekerja pengangkut sampah yang berada di Kantor Pekerjaan Umum dan Penata Ruang, yang mana seluruh populasi dijadikan sampel. Data dikumpulkan berdasarkan pemeriksaan kesehatan oleh dokter dan dengan kuesioner, kemudian dianalisa menggunakan uji statistik chi-square. Hasil: Hasil menunjukan bahwa pekerja yang mengalami penyakit kulit sebanyak 35 pekerja (56,5%). Berdasarkan hasil analisis chi-square didapatkan bahwa ada hubungan yang bermakna antara masa kerja dengan kejadian penyakit kulit pada pekerja pengangkut sampah dimana nilai (p-value= 0,006), Pemakaian Alat Pelindung Diri (APD) nilai (p-value= 0,008), personal hygiene nilai (p-value= 0,008). Kesimpulan: Untuk meminimalisir risiko terjadinya penyakit kulit pada pekerja pengangkut sampah disarankan perlunya disusun standar operasional prosedur yang aman, penyediaan sarana sanitasi agar dapat mengurangi resiko terkena penyakit kulit. Pentingnya pemakaian APD dan perilaku hidup bersih dan sehat selama bekerja, serta diharapkan pekerja menggunakan APD pada saat bekerja dan lebih memperhatikan personal hygiene.   Kata kunci      : Masa Kerja, APD, Personal Hygiene


2019 ◽  
Author(s):  
Stephen Banda

BACKGROUND Occupational conditions are deadly health hazards especially where dust exposure is inevitable causing chronic disabilities, impaired respiratory function and ultimately leading to death if no intensive measures are put in place. Unhealthy practices and negative attitudes rise in the number of cases of pneumoconiosis due to poor health education and awareness strategies. Pneumoconiosis is not only a health problem but also a social and economic burden on the livelihood of people living in mining areas around the globe. OBJECTIVE to assess knowledge, attitude and practices of miners and post-occupational miners towards pneumoconiosis in Wusakile Township, Kitwe, Zambia. METHODS A cross-sectional study was employed to conduct a research in Wusakile Township and a questionnaire was customized in order to syphon data relevant to the study as well to be brief. The study was conducted among 73 participants who were randomly selected among miners and post-occupational miners and all satisfied the inclusion criteria. Both quantitative and qualitative methods were used to collect data. The data was entered and analysed using IBM SPSS software version 23. RESULTS Among 73 participants interviewed, 33.99% of participants had poor knowledge on the complications of pneumoconiosis. However, despite this poor knowledge, all participants had an idea about pneumoconiosis particularly silicosis. 13.70% of the respondents had bad practices towards pneumoconiosis while 86.30% had some good practices towards pneumoconiosis. Of the total participants, 19.18% of the participants had a negative attitude towards pneumoconiosis. Correlation between the level of education and practices of participants using Pearson Chi-Square, a p value of 0.021 (significant) was found ruling out the null hypothesis. CONCLUSIONS Information about pneumoconiosis and awareness programs towards pneumoconiosis are not widely disseminated among miners and post-occupational miners. There is still a significant number of participants who need to be educated more about pneumoconiosis and its complications so that attitude and practices are improved and also promote full community participation by involving competent health professionals to help in implementing preventive measures.


2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Bingsi Gao ◽  
Yu-Ligh Liou ◽  
Yang Yu ◽  
Lingxiao Zou ◽  
Waixing Li ◽  
...  

AbstractThis cross-sectional study investigated the characteristics of cervical HPV infection in Changsha area and explored the influence of Candida vaginitis on this infection. From 11 August 2017 to 11 September 2018, 12,628 outpatient participants ranged from 19 to 84 years old were enrolled and analyzed. HPV DNA was amplified and tested by HPV GenoArray Test Kit. The vaginal ecology was detected by microscopic and biochemistry examinations. The diagnosis of Candida vaginitis was based on microscopic examination (spores, and/or hypha) and biochemical testing (galactosidase) for vaginal discharge by experts. Statistical analyses were performed using SAS 9.4. Continuous and categorical variables were analyzed by t-tests and by Chi-square tests, respectively. HPV infection risk factors were analyzed using multivariate logistic regression. Of the total number of participants, 1753 were infected with HPV (13.88%). Females aged ≥ 40 to < 50 years constituted the largest population of HPV-infected females (31.26%). The top 5 HPV subtypes affecting this population of 1753 infected females were the following: HPV-52 (28.01%), HPV-58 (14.83%), CP8304 (11.47%), HPV-53 (10.84%), and HPV-39 (9.64%). Age (OR 1.01; 95% CI 1–1.01; P < 0.05) and alcohol consumption (OR 1.30; 95% CI 1.09–1.56; P < 0.01) were found to be risk factors for HPV infection. However, the presence of Candida in the vaginal flora was found to be a protective factor against HPV infection (OR 0.62; 95% CI 0.48–0.8; P < 0.001). Comparing with our previous study of 2016, we conclude that the subtype distribution of HPV infection is relatively constant in Changsha. Our data suggest a negative correlation between vaginal Candida and HPV, however, more radical HPV management is required in this area for perimenopausal women and those who regularly consume alcohol.


Author(s):  
Fitra Yulia Ningshi ◽  
Suhadi Suhadi ◽  
Jumakil Jumakil

 Stres kerja merupakan gangguan fisik serta emosional pekerja yang diakibatkan oleh banyaknya jumlah beban kerja yang harus diselesaikan oleh para pekerja dan menghasilkan tingkat kelelahan karena mengejartargetproduksi yang akan di pasarkan, sehingga memicu terjadinya stres kerja. Serta ketidakpastian pekerjaan yang dimiliki dapat menyebabkan stres kerja karena sebagian besar dari pekerja merupakan pekerja harian yang tidak terikat oleh kontrak kerja sehingga berpeluang untuk kehilangan pekerjaannya. Tujuan penelitian ini yaitu untuk mengetahui hubungan faktor pekerjaan dengan stres kerja pada pekerja di PT. Sultratuna Samudra Kendari tahun 2020. Jenis penelitian ini adalah deskriptif analitik dengan rancangan cross sectional study. Sampel pada penelitian ini sebanyak 72 orang dengan tehnik menggunakan probability sampling. Analisis data meliputi analisis univariat dan analisis bivariat dengan menggunakan uji chi square. Hasil penelitian menunjukan bahwa ada hubungan yang signifikan antara ketidakpastian pekerjaan dengan stres kerja di PT. Sultratuna Samudra Kendari (p value = 0.003) dan tidak ada hubungan yang signifikan antara jumlah beban kerja dengan stres kerja di PT. Sultratuna Samudra Kendari (p value = 0,893). Adapun kesimpulan dari penelitian ini adalah terdapat hubungan ketidakpastian pekerjaan dengan stres kerja pada pekerja di PT. Sultratuna Samudra Kendari dantidak terdapat hubungan antara jumlah beban kerja dengan stres kerja pada pekerja di PT. Sultratuna Samudra kendari


2021 ◽  
Vol 11 (1) ◽  
pp. 4-8
Author(s):  
Amna Khan ◽  
Anila Farhat ◽  
Hamayun Anwar ◽  
Sajid Shamim ◽  
Mujeeb Ur Rehman ◽  
...  

Objective: To determine the frequency of hypocalcemia in neonates with unconjugated hyperbilirubinemia receivingphototherapy.Study design and setting: Cross sectional study conducted at neonatal intensive care unit, King Abdullah Teaching Hospital,Mansehra for one year from December 2017 to November 2018.Methodology: Total 213 full term stable neonates of either gender with jaundice were studied in this study. Out of which,143 with unconjugated hyperbilirubinemia were exposed to phototherapy while 70 neonates with exaggerated physiologicalhyperbilirubinemia taken as control were not exposed to phototherapy. Serum calcium level was determined through bloodtest before and after 24 hours of phototherapy. SPSS version 22 was used to analyze the data. Frequency and percentageswere used to describe categorical variables like gender and hypocalcemia. Hypocalcemia was stratified by age and genderto see effect modifiers. Post stratified chi-square test was applied in which p value = 0.05 was considered as significancevalue.Results: In study group, 143 neonates who received phototherapy had mean age of 7 days ± 2.62 SD. Total 65% neonateswere male and 35% neonates were female. Mean serum calcium level of neonates before and after provision of phototherapywas 9.28 mg/dl ± 0.23 and 8.54 mg/dl ± 0.68 respectively, which is statistically significant. The frequency of hypocalcemiawas 40% in neonates with unconjugated hyperbilirubinemia after 24 hours of phototherapy.Conclusion: Hypocalcemia is an important complication in neonates with unconjugated hyperbilirubinemia after continuousphototherapy. Hypocalcemia has clinical impact and adds to morbidity, and if left untreated, can lead to mortality.


2021 ◽  
Vol 2 (01) ◽  
pp. 41-50
Author(s):  
Nurasisa Lestari ◽  
Eva Novawaty ◽  
Muh. Fajrin Wijaya ◽  
St. Fadhillah Oemar Mattalitti ◽  
Lilies Anggarwati Astuti ◽  
...  

Pendahuluan : Pencabutan gigi merupakan suatu tindakan pembedahan yang melibatkan jaringan tulang dan jaringan lunak dari rongga mulut, tindakan tersebut dibatasi oleh bibir, pipi dan terdapat faktor yang dapat mempersulit dengan gerakan lidah dan rahang bawah. Berbagai macam cara dilakukan untuk mencegah terjadinya infeksi silang antara lain dengan pemakaian proteksi diri yaitu masker, kacamata pelindung, sarung tangan, baju praktek, maupun penutup rambut dan kebersihan lingkungan tempat kerja yang meliputi cara pembersihan alat dan lingkungan. Tujuan Penelitian : Untuk mengetahui hubungan pengetahuan mahasiswa kepaniteraan terhadap tindakan kontrol infeksi pada pasien pencabutan gigi. Bahan dan Metode: Penelitian ini menggunakan jenis penelitian bersifat observasional analitik dengan menggunakan pendekatan cross sectional study. Sampel penelitian ini adalah mahasiswa kepaniteraan Fakultas Kedokteran Gigi UMI di RSIGM YW-UMI Makassar. Hasil: Sebagai mahasiswa kepaniteraan diketahui terdapat 5,71% dengan pengetahuan yang cukup, dan diketetahui terdapat 94,29% dengan pengetahuan baik. Sedangkan untuk tindakan kontrol infeksi mahasiswa kepaniteraan diketahui terdapat 65,71% dengan tindakan yang cukup dan diketahui terdapat 34,29% dengan tindakan yang baik. Berdasarkan hasil pengujian hipotesis dengan uji statistic chi-square diperoleh p-value sebesar 0,044. Karena p-value < alpha (0,05). Kesimpulan : Terdapat hubungan yang signifikan antara pengetahuan mahasiswa kepaniteraan tentang kontrol infeksi dengan tindakan kontrol infeksi pada pasien pencabutan gigi


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