scholarly journals The Prevalence of Human Immunodeficiency Virus Infection among Voluntary Blood Donors in Mainland China: A Systematic Review and Meta-Analysis

2021 ◽  
Author(s):  
Zhan Gao ◽  
Yuhui Li ◽  
Liu Zhiyang ◽  
Yang Huang ◽  
Miao He
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hiv Infection ◽  
Blood Donors ◽  
Meta Analysis ◽  
Mainland China ◽  
Hiv Prevalence ◽  
Residual Risk ◽  
Hiv Screening ◽  
Immunodeficiency Virus ◽  
Epidemiological Characteristics

Abstract BACKGROUND: The epidemic of Human Immunodeficiency Virus (HIV) in China has been increasing. Despite the implementation of screening strategies, there was still the residual risk of transfusion-transmitted HIV. This study investigated the HIV prevalence among voluntary blood donors during the past 24 years in order to characterize the epidemiology of HIV.METHODS: The literature concerning the HIV screening reactive rate and prevalence in Chinese voluntary blood donors were collected through the systematic searching of four electronic databases. After integrating data, following the Preferred Reporting of Items for Systematic Reviews and Meta-Analyses guidelines, data manipulation and statistical analyses were conducted by Stata 12.0. We investigated the trend of HIV prevalence (and 95% CIs) and related epidemiological characteristics among blood donors in mainland China.RESULTS: The results indicated that HIV prevalence was 0.0165% (95% CI, 0.0155%-0.0176%) with a remarkable rise, which varied from 2000 (0.0034%) to 2017 (0.0247%). Importantly, the heterogeneity was found in occupations and Donation frequency. Additionally, the HIV prevalence were significantly higher among male donors than among female donors.CONCLUSIONS: Our results indicated obvious difference between HIV screening reactive rate and HIV prevalence in Chinese blood donors and HIV screening reactive rate cannot reflect reality of HIV infection. In this study, continuous increased trend of HIV prevalence demonstrates extended residual risk of blood transfusion, and the whole society is supposed to pay close attention to HIV infection.

scholarly journals Human Immunodeficiency Virus Infected Patients are Not at Higher Risk for Hepatitis E Virus Infection: A Systematic Review and Meta-Analysis

2019 ◽  
Vol 7 (12) ◽  
pp. 618
Author(s):  
Pedro Lopez-Lopez ◽  
Mario Frias ◽  
Angela Camacho ◽  
Antonio Rivero ◽  
Antonio Rivero-Juarez
Keyword(s):  
Systematic Review ◽  
Human Immunodeficiency Virus ◽  
Hiv Infection ◽  
Fixed Effects ◽  
Hepatitis E Virus ◽  
Meta Analysis ◽  
Geographical Area ◽  
Hepatitis E ◽  
Immunodeficiency Virus ◽  
Hiv Negative

Hepatitis E virus (HEV) infection is the most common cause of acute hepatitis in the world. It is not well established whether people infected with the human immunodeficiency virus (HIV) are more susceptible to infection with HEV than people not infected with HIV. Many studies have evaluated this relationship, although none are conclusive. The aim of this systematic review and meta-analysis was to assess whether patients with HIV infection constitute a risk group for HEV infection. A systematic review and meta-analysis was performed in line with Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), to find publications comparing HEV seroprevalences among HIV infected and uninfected populations. The analysis was matched by sex, age and geographical area, and compared patients who live with HIV and HIV-negative individuals. The odds ratio (OR) for patients with HIV was 0.87 (95% CI: 0.74–1.03) in the fixed effects meta-analysis and 0.88 (95% CI: 0.70–1.11) in random effects, with I2 = 47%. This study did not show that HIV infection was a risk factor for HEV infection when compared with those who are HIV-negative.

Global Burden of Hepatitis B Infection in People Living With Human Immunodeficiency Virus: A Systematic Review and Meta-analysis

2019 ◽  
Vol 71 (11) ◽  
pp. 2799-2806 ◽  
Author(s):  
Steve Leumi ◽  
Jean Joel Bigna ◽  
Marie A Amougou ◽  
Anderson Ngouo ◽  
Ulrich Flore Nyaga ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hepatitis B ◽  
Meta Analysis ◽  
Hiv Prevalence ◽  
Hbv Infection ◽  
Sub Saharan Africa ◽  
Global Burden ◽  
Pool Data ◽  
The Pacific ◽  
Immunodeficiency Virus

Abstract Background This meta-analysis was conducted to estimate the global burden of hepatitis B virus (HBV) infection in people living with human immunodeficiency virus (PLWH). Methods We searched multiple databases for studies published between January 1990 and December 2017. HBV infection (hepatitis B surface antigen) was diagnosed with serological assays. A random-effects meta-analysis served to pool data. Results We included 358 studies (834 544 PLWH from 87 countries). The pooled prevalence of HBV infection was 8.4% (95% confidence interval [CI], 7.9%–8.8%), among which 26.8% (95% CI, 22.0%–31.9%) was positive to hepatitis B e antigen. HBV prevalence (with 95% CIs) differed according to region: West and Central Africa, 12.4% (11.0%–13.8%); Middle East and North Africa, 9.9% (6.0%–14.6%); Asia and the Pacific, 9.8% (8.7%–11.0%); Eastern and Southern Africa, 7.4% (6.4%–8.4%); Western and Central Europe and North America, 6.0% (5.5%–6.7%); and Latin America and the Caribbean, 5.1% (4.2%–6.2%) (P < .0001). The prevalence decreased from 10.4% in low-developed to 6.6% in highly developed countries (P < .0001) and increased from 7.3% in countries with HIV prevalence ≤1% to 9.7% in countries with HIV prevalence >1% (P < .0001). Globally, we estimated that there were 3 136 500 (95% CI, 2 952 000–3 284 100) cases of HBV in PLWH, with 73.8% of estimated regional cases from sub-Saharan Africa and 17.1% from Asia and the Pacific. Conclusions This study suggests a high burden of HBV infection in PLWH, with disparities according to region, level of development, and country HIV prevalence.

scholarly journals Seroprevalence of HIV in blood donors at tertiary care center, M.Y.H. Indore, India

2018 ◽  
Vol 7 (1) ◽  
pp. 183
Author(s):  
Priyanka Solanki ◽  
Ashok Yadav ◽  
Khushboo Likhar
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hiv Infection ◽  
Blood Donors ◽  
Care Center ◽  
Tertiary Care ◽  
Blood Bank ◽  
Hiv Positive ◽  
Screening Programs ◽  
Immunodeficiency Virus ◽  
Voluntary Donor

Background: Transfusion of blood has become an important mode of transmission of infections such as human immunodeficiency virus and hepatitis B to the recipients. Blood transfusion is a boon in medical era if properly screened. The aim of study was to determine the seroprevalence of HIV donors in blood bank at M.Y.H. Indore.Methods: The study was conducted in the blood bank, M.Y.H. Hospital, Indore. Total 115775 donors attending blood bank were included in the study. All the donor samples were screened for detection of antibodies for human immunodeficiency virus by microwell Enzyme Linked Immunosorption Assay (ELISA) method. The seroprevalence of HIV infection among the donors was determined over a period of five years since January 2013 to December 2017.Results: Total 115775 blood donors were recorded. Out of total 115775 blood donors included in the study, replacement donor were 10766 (9.29%) while voluntary donor were 105009 (90.70%). In the duration of five-year study period, total 80 cases (0.06%) were reactive to HIV. Out of total 115775 blood donors included in the study, maximum cases i.e. 22 (0.08%) cases were found to be positive for HIV infection in year 2017. Out of 10766 replacement donors included in the study, 64 cases (0.59%) were reactive to HIV infection. While out of 105009 voluntary donors, 16 cases (0.01%) were found to be reactive to HIV infection. Voluntary donors are more as compared to the replacement donors. Number of HIV positive patients were found to more in replacement donor as compared to the voluntary donors.Conclusions: The seroprevalence of HIV is low in this study and hence it is concluded that the more the number of voluntary donors, the less the number of HIV positive cases. Voluntary donors can be motivated by proper health education and high quality screening programs.

scholarly journals Seropositivity of Human Immunodeficiency Virus among Intending Blood Donors in Rivers State, Nigeria

2020 ◽  
pp. 22-29
Author(s):  
B. A. Abeni ◽  
N. Frank- Peterside ◽  
O. E. Agbagwa ◽  
S. A. Adewuyi ◽  
T. I. Cookey ◽  
...  
Keyword(s):  
Public Health ◽  
Human Immunodeficiency Virus ◽  
Blood Donors ◽  
Hiv Prevalence ◽  
Sub Saharan Africa ◽  
Enzyme Linked Immunosorbent Assay ◽  
Strict Adherence ◽  
Immunodeficiency Virus ◽  
Safe Blood ◽  
Rivers State

Aims: Provision of constant and safe blood has been a public health challenge in Sub-Saharan Africa with a high prevalence of transfusion-transmissible infections (TTIs). This study aimed at determining the seroprevalence of the Human Immunodeficiency Virus (HIV) among prospective blood donors at two Hospitals (government and private-owned) in Rivers State, and also to relate some demographic studies to the screening results. Study Design:  Cross-sectional study. Place and Duration of Study: Two Hospitals (a government-owned and private-owned) in Rivers State, Nigeria, between January 2018 and April 2019. Methodology: Two hundred and eighty-two (185 males and 97 females) blood donors were recruited for this study. Sera samples were screened for antibodies to HIV-1 and -2 using enzyme-linked immunosorbent assay (ELISA) based kits following the manufacturer’s description. Results: Of the 282 screened prospective donors (males and females) in this study, the overall prevalence of HIV from both hospitals was 6.0% with a seronegativity of 94.0%. There was a significant relationship (p <0.05) between the overall seroprevalence of HIV concerning gender (p-0.006) all other demographics had no significant association with HIV. Age group 21-30 had the highest prevalence of HIV (53.80%). Donors with tertiary education had the highest prevalence rate (52.90%) of HIV. About marital status, the unmarried donors had higher HIV prevalence (64.70%) when compared with the married donors (35.30%). However, family donors had the highest prevalence of HIV (52.90%). Finally, concerning occupation, students had a higher HIV prevalence (47.10%). Conclusion: The seroprevalence of HIV in Port Harcourt, Rivers State, Nigeria was high. This shows that HIV remains a threat to safe blood transfusion and public health in Nigeria. Strict adherence to selection criteria and algorithm of donor screening is hereby advocated.

scholarly journals Socioeconomic Inequalities in Human Immunodeficiency Virus (HIV) Sero-Prevalence among Women in Namibia: Further Analysis of Population-Based Data

2021 ◽  
Vol 18 (17) ◽  
pp. 9397
Author(s):  
Michael Ekholuenetale ◽  
Herbert Onuoha ◽  
Charity Ehimwenma Ekholuenetale ◽  
Amadou Barrow ◽  
Chimezie Igwegbe Nzoputam
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hiv Infection ◽  
Formal Education ◽  
Household Survey ◽  
Population Based ◽  
Socioeconomic Inequalities ◽  
Hiv Prevalence ◽  
High Concentration ◽  
Hiv Prevention Strategies ◽  
Immunodeficiency Virus

Socioeconomic inequality is a major factor to consider in the prevention of human immunodeficiency virus (HIV) transmission. The aim of this study was to investigate socioeconomic inequalities in HIV prevalence among Namibian women. Data from a population-based household survey with multistage-stratified sample of 6501 women were used to examine the link between socioeconomic inequalities and HIV prevalence. The weighted HIV prevalence was 13.2% (95% CI: 12.1–14.3%). The HIV prevalence among the poorest, poorer, middle, richer, and richest households was 21.4%, 19.7%, 16.3%, 11.0%, and 3.7%, respectively. Similarly, 21.2%, 21.7%, 11.8%, and 2.1% HIV prevalence was estimated among women with no formal education and primary, secondary, and higher education, respectively. Women from poor households (Conc. Index = −0.258; SE = 0.017) and those with no formal education (Conc. Index = −0.199; SE = 0.015) had high concentration of HIV infection, respectively. In light of these findings, HIV prevention strategies must be tailored to the specific drivers of transmission in low socioeconomic groups, with special attention paid to the vulnerabilities faced by women and the dynamic and contextual nature of the relationship between socioeconomic status and HIV infection.

Human Immunodeficiency Virus Infection and Acute Deep Vein Thromboses

2008 ◽  
Vol 14 (3) ◽  
pp. 352-355 ◽  
Author(s):  
Susan Louw ◽  
Barry F. Jacobson ◽  
Harry Büller
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hiv Infection ◽  
South African ◽  
Hiv Infections ◽  
Hiv Prevalence ◽  
Control Group ◽  
Vein Thrombosis ◽  
Immunodeficiency Virus ◽  
Healthy Control ◽  
Deep Vein

Abnormalities that predispose to a hypercoagulable state with an increased incidence of venous thrombosis have been described in human immunodeficiency virus (HIV) infections and are associated with an increased mortality. A recent systematic review by Klein et al concluded that further studies are essential to elucidate the link between HIV infection and deep vein thrombosis (DVT). We prospectively evaluated 24 consecutive, active people presenting with an acute DVT; 13 consented to HIV testing, revealing an HIV prevalence of 84% (95% confidence interval [CI], 0.65-1.04). In a matched healthy control group, the HIV prevalence was 4% (95% CI, 0.039-0.041). The high HIV prevalence in the DVT group that consented to testing was also significantly higher compared to that in the South African population, estimated to be 10% in 2005. Although the study numbers were low, a statistically significant increased prevalence of HIV infection was found in patients with acute DVTs.

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