scholarly journals Interrelationships Among Vitamin D Status and Body Composition in Mother-Infant Dyads

2021 ◽  
Author(s):  
Maryam Razaghi ◽  
Nathalie Gharibeh ◽  
Catherine A. Vanstone ◽  
Olusola F. Sotunde ◽  
Shu Qin Wei ◽  
...  
Keyword(s):  
Vitamin D ◽  
Body Composition ◽  
Fat Mass ◽  
Weight Status ◽  
Whole Body ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Neonatal Adiposity ◽  
Maternal Vitamin D Status ◽  
Maternal Adiposity

Abstract Background: Vitamin D status of pregnant women is associated with body composition of the offspring. The objective of this study was to assess whether the association between maternal vitamin D status and neonatal adiposity is modified by maternal adiposity preconception.Methods: Healthy mothers and their term appropriate weight for gestational age (AGA) infants (n=142; 59% male, Greater Montreal, March 2016-2019) were studied at birth and 1 month postpartum (2-6 weeks). Newborn (24-36 hour) serum was collected to measure total 25-hydroxyvitamin D [25(OH)D] (immunoassay); maternal pre-pregnancy BMI was obtained from the medical record. Anthropometry, body composition (dual-energy X-ray absorptiometry) and serum 25(OH)D were measured at 2-6 weeks postpartum in mothers and infants. Mothers were grouped into 4 categories based on their vitamin D status (sufficient 25(OH)D ≥50 nmol/L vs. at risk of being insufficient <50 nmol/L) and pre-pregnancy BMI (<25 vs. ≥25 kg/m2): insufficient-recommended weight (I-RW, n=24); insufficient-overweight/obese (I-OW/O, n=21); sufficient-recommended weight (S-RW, n=69); and sufficient-overweight/obese (S-OW/O, n=28). Partial correlation and mixed model ANOVA were used while adjusting for covariates.Results: At birth, infant serum 25(OH)D mean concentrations were below the cut-point for sufficiency of 50 nmol/L for both maternal pre-pregnancy BMI categories; 47.8 [95%CI: 43.8, 51.9] nmol/L if BMI <25 kg/m2 and 38.1 [95%CI: 33.5, 42.7] nmol/L if BMI ≥25 kg/m2. Infant serum 25(OH)D concentrations at birth (r=0.77; p<0.0001) and 1 month (r=0.59, p<0.0001) were positively correlated with maternal postpartum serum 25(OH)D concentrations. Maternal serum 25(OH)D concentration was inversely associated with maternal percent whole body fat mass (r=-0.26, p=0.002). Infants of mothers in I-OW/O had higher fat mass versus those of mothers in S-OW/O (914.0 [95%CI: 766.4, 1061.6] vs. 780.7 [95%CI: 659.3, 902.0] g; effect size [Hedges' g: 0.42]; p=0.04) with magnitude of difference of 220.4 g or ~28% difference (adjusting for covariates). Conclusions: Maternal vitamin D status is positively correlated with neonatal vitamin D. In this study, maternal adiposity and serum 25(OH)D <50 nmol/L are dual exposures for neonatal adiposity. These findings reinforce the importance of vitamin D supplementation early in infancy irrespective of vitamin D stores acquired in utero and maternal weight status.

scholarly journals Correction of Low Neonatal Vitamin D Status Using 1000 IU/d of Vitamin D Improved Body Composition (Lean Mass and Fat Mass) Compared to Using the Standard of Care by 6 Months of Age (P11-094-19)

2019 ◽  
Vol 3 (Supplement_1) ◽  
Author(s):  
Maryam Razaghi ◽  
Catherine Vanstone ◽  
Olusola Sotunde ◽  
Nathalie Gharibeh ◽  
Sarah Kimmins ◽  
...  
Keyword(s):  
Vitamin D ◽  
Body Composition ◽  
Fat Mass ◽  
Lean Mass ◽  
Gestational Age ◽  
Skin Color ◽  
Reference Group ◽  
Combined Treatment ◽  
Whole Body ◽  
Vitamin D Status

Abstract Objectives Vitamin D status is positively associated with lean mass phenotype in healthy infants born with sufficient vitamin D stores. The objective is to test whether rapid correction of low neonatal vitamin D status improves body composition (lean mass and fat mass) at 6 mo of age. Methods In a double-blinded randomized parallel group controlled trial (NCT02563015), healthy term neonates of appropriate weight for gestational age were recruited from Montreal. Capillary blood samples were collected 24–36 h post natally for measurement of serum 25-hydroxyvitamin D [25(OH)D] (Liaison, Diasorin Inc.). Infants with serum 25(OH)D < 50 nmol/L (n = 87) were randomized to receive 400 or 1000 IU/d until 6 mo of age. Those with 25(OH)D ≥ 50 nmol/L (n = 31) were recruited as a reference group, and received 400 IU/d. Anthropometry, lean mass and fat mass (dual-energy x-ray absorptiometry) were measured at baseline, 3 and 6 mo. Skin color was measured using a spectrophotometer. Differences between treatments and reference groups were tested using mixed model and repeated measures ANOVA accounting for the effects of sex, season of birth, skin color and gestational age (GA). Results Neonates (67 males, 51 females) were 39.6 ± 1wk GA and 3387 ± 371 g at birth. There were no differences between groups in lean mass or fat mass at baseline; nor in weight or length at any time-point. Combined treatment groups, had lower serum 25(OH)D concentrations at birth compared to the reference group (33 ± 11 vs. 69 ± 13 nmol/L, P < 0.0001). However, at 6 mo of age, serum 25(OH)D concentration was higher in the group receiving 1000 IU/d (n = 34), in comparison to the group receiving 400 IU/d (n = 29), and the reference (n = 19) group (125.0 ± 34.0, 82.2 ± 21.5 vs. reference 85.4 ± 32.1 nmol/L, P < 0.0001). Whole body lean mass was significantly different among groups (5071.3 ± 750.0, 4944.1 ± 616.3 and 5166.0 ± 645.4 g, respectively, P = 0.03), with infants in the treatment group provided a 400 IU/d supplement having a lower lean mass by 6 mo of age compared to the 1000 IU/d group. Fat mass was not different among groups following post-hoc testing (2967.0 ± 929.0 and 2962.0 ± 952.0, 2742.0 ± 754.0 g, P = 0.16). Conclusions Higher dosage supplementation of vitamin D rapidly improved vitamin D status and supported a leaner body phenotype in infancy. Funding Sources Canadian Institutes of Health Research.

scholarly journals Interrelationships Among Vitamin D Status and Body Composition in Mother-Infant Dyads

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1061-1061
Author(s):  
Maryam Razaghi ◽  
Catherine Vanstone ◽  
Olusola Sotunde ◽  
Nathalie Gharibeh ◽  
Shu Qin Wei ◽  
...  
Keyword(s):  
Vitamin D ◽  
Body Composition ◽  
Lean Body Mass ◽  
Body Mass ◽  
Maternal Serum ◽  
Whole Body ◽  
Vitamin D Status ◽  
Group 2 ◽  
Maternal Vitamin D Status ◽  
Group 1

Abstract Objectives To explore the associations between postpartum maternal vitamin D status and body composition to neonatal serum 25-hydroxyvitamin D (25(OH)D) and body composition. Methods Healthy mothers and term-born infants of appropriate size for gestational age were recruited from Greater Montreal (March 2016 through March 2019). The present analysis includes data from mothers and infants (n = 144). Maternal characteristics and lifestyle factors were surveyed and newborn capillary blood samples were taken within 36 h of delivery to assess vitamin D status using total serum 25(OH)D (Liaison, Diasorin). Maternal and infant anthropometry and body composition (Dual-energy X-ray absorptiometry) and maternal serum 25(OH)D were measured within 1 mo postpartum. Mothers were classified into 2 groups (group 1: ≥50 nmol/L; group 2: &lt;50 nmol/L). Data were analyzed descriptively (mean ± SD or n (%)) and using a mixed model with Tukey post hoc tests accounting for neonatal sex, gestational age, season, family income, maternal age, education, and race. Correlation tests were used to identify linear relationships between continuous variables. Results Neonates (85 males, 59 females) were 39.7 ± 1.0 wk GA and 3393 ± 363 g at birth. Mothers (32.1 ± 4.5 years) in group 1 had considerably higher serum 25(OH)D concentrations compared to mothers in group 2 (80.3 ± 22.0 n = 96 vs. 38.7 ± 9.0 n = 48, nmol/L, P &lt; 0.0001). Moreover, maternal serum 25(OH)D concentrations were positively associated with their % whole body lean mass (r = 0.28, P = 0.0009) and inversely associated with their % whole body fat mass (r = −0.25, P = 0.003). At birth, infants of mothers in group 1 had higher serum 25(OH)D concentrations compared to infants in group 2 (51.0 ± 18.1 vs. 27.0 ± 12.0 nmol/L, P &lt; 0.0001), and were correlated with maternal 25(OH)D (r = 0.74, P &lt; 0.0001). Maternal lean body mass and lean mass index (LMI) (kg/m2) explained some positive variations in infant lean body mass and LMI (Estimate = 0.01, P = 0.004; Estimate = 27.7, P = 0.04). Conclusions Higher maternal vitamin D status is associated with higher neonatal vitamin D with possible implications to neonatal lean body mass. This study reinforces the importance of ensuring adequate maternal-fetal transfer of vitamin D. Funding Sources Canadian Institutes of Health Research.

Maternal Vitamin D Status and Development of Asthma and Allergy in Early Childhood

2015 ◽  
Vol 15 (11) ◽  
pp. 900-912 ◽  
Author(s):  
Anna Papadopoulou ◽  
Evangelia Bountouvi ◽  
Vasiliki Papaevaggelou ◽  
Kostas Priftis
Keyword(s):  
Vitamin D ◽  
Early Childhood ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Asthma And Allergy ◽  
Maternal Vitamin D Status

scholarly journals Low maternal vitamin D status and fetal bone development: Cohort study

2009 ◽  
Vol 25 (1) ◽  
pp. 14-19 ◽  
Author(s):  
Pamela Mahon ◽  
Nicholas Harvey ◽  
Sarah Crozier ◽  
Hazel Inskip ◽  
Sian Robinson ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Bone Development ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Fetal Bone ◽  
Maternal Vitamin D Status

scholarly journals Maternal Vitamin D Status and Risk of Gestational Diabetes: a Meta-Analysis

2018 ◽  
Vol 45 (1) ◽  
pp. 291-300 ◽  
Author(s):  
Lingmin Hu ◽  
Yue Zhang ◽  
Xing Wang ◽  
Lianghui You ◽  
Pengfei Xu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Gestational Diabetes ◽  
Observational Studies ◽  
Meta Analysis ◽  
Vitamin D Insufficiency ◽  
Significant Heterogeneity ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Increased Risk ◽  
Maternal Vitamin D Status

Background/Aims: Whether maternal vitamin D deficiency is associated with gestational diabetes remains controversial. This meta-analysis aimed to systematically evaluate published evidence on the association between maternal vitamin D status and the risk of gestational diabetes. Methods: We retrieved relevant articles from the PubMed, Medline and Embase databases up to May 2017 for observational studies investigating the association between vitamin D status and the risk of gestational diabetes. Odds ratios (OR) or risk ratios (RR) from individual studies were pooled using the fixed and random effect models. Results: The meta-analysis of 29 observational studies included 28,982 participants, of which 4,634 were diagnosed with gestational diabetes, and showed that maternal vitamin D insufficiency was associated with a significantly increased risk of gestational diabetes by 39% (pooled OR = 1.39, 95%CI = 1.20-1.60) with moderate heterogeneity (I2 = 50.2%; P = 0.001). Moreover, the 25(OH)D level was significantly lower in gestational diabetes cases than in controls with a pooled effect of -4.79 nmol/L (95% CI = -6.43, -3.15). Significant heterogeneity was also detected (I2 = 65.0%, P < 0.001). Further subgroup analysis indicated that this association was also evident in most subpopulations. Conclusion: This meta-analysis indicated a significant association between vitamin D insufficiency and increased risk of gestational diabetes. Further well-designed large-scale clinical trials are essential to verify this association.

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