The relationship between maternal vitamin D status during third trimester of pregnancy and maternal and neonatal outcomes: A longitudinal study

AbstractSeafood intake in pregnancy has been positively associated with childhood cognitive outcomes which could potentially relate to the high vitamin D content of oily fish. However, whether higher maternal vitamin D status (serum 25-hydroxyvitamin D (25(OH)D)) in pregnancy is associated with a reduced risk of offspring suboptimal neurodevelopmental outcomes is unclear. A total of 7065 mother–child pairs were studied from the Avon Longitudinal Study of Parents and Children cohort who had data for both serum total 25(OH)D concentration in pregnancy and at least one measure of offspring neurodevelopment (pre-school development at 6–42 months; ‘Strengths and Difficulties Questionnaire’ scores at 7 years; intelligence quotient (IQ) at 8 years; reading ability at 9 years). After adjustment for confounders, children of vitamin D-deficient mothers (<50·0 nmol/l) were more likely to have scores in the lowest quartile for gross-motor development at 30 months (OR 1·20; 95 % CI 1·03, 1·40), fine-motor development at 30 months (OR 1·23; 95 % CI 1·05, 1·44) and social development at 42 months (OR 1·20; 95 % CI 1·01, 1·41) than vitamin D-sufficient mothers (≥50·0 nmol/l). No associations were found with neurodevelopmental outcomes, including IQ, measured at older ages. However, our results suggest that deficient maternal vitamin D status in pregnancy may have adverse effects on some measures of motor and social development in children under 4 years. Prevention of vitamin D deficiency may be important for preventing suboptimal development in the first 4 years of life.

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Maternal Vitamin D Status and the Relationship with Neonatal Anthropometric and Childhood Neurodevelopmental Outcomes: Results from the Seychelles Child Development Nutrition Study

Nutrients ◽

10.3390/nu9111235 ◽

2017 ◽

Vol 9 (11) ◽

pp. 1235 ◽

Cited By ~ 14

Author(s):

Eamon Laird ◽

Sally Thurston ◽

Edwin van Wijngaarden ◽

Conrad Shamlaye ◽

Gary Myers ◽

...

Keyword(s):

Vitamin D ◽

Child Development ◽

Vitamin D Status ◽

Neurodevelopmental Outcomes ◽

Maternal Vitamin ◽

Nutrition Study ◽

The Relationship ◽

Maternal Vitamin D Status

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Randomized open‐label trial of two weekly oral vitamin D3 supplementation regimens during the third trimester of pregnancy in Bangladeshi women: effects on maternal vitamin D status and safety

The FASEB Journal ◽

10.1096/fasebj.25.1_supplement.236.6 ◽

2011 ◽

Vol 25 (S1) ◽

Author(s):

Daniel E. Roth ◽

Abdullah Al‐Mahmud ◽

Shams El Arifeen ◽

Rubhana Raqib ◽

Robert E Black ◽

...

Keyword(s):

Vitamin D ◽

Vitamin D Status ◽

Third Trimester ◽

Oral Vitamin ◽

Open Label ◽

Maternal Vitamin ◽

The Third ◽

Vitamin D3 Supplementation ◽

Open Label Trial ◽

Maternal Vitamin D Status

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Maternal Vitamin D Status and Neonatal Outcomes

The Indian Journal of Pediatrics ◽

10.1007/s12098-017-2508-9 ◽

2017 ◽

Vol 85 (5) ◽

pp. 403-404 ◽

Cited By ~ 1

Author(s):

R. Hemalatha ◽

Vijayendra Chary Anchoju ◽

Vasundhara Donugama ◽

Himaja Nallagatla ◽

Devaraj Parasannanavar ◽

...

Keyword(s):

Vitamin D ◽

Neonatal Outcomes ◽

Vitamin D Status ◽

Maternal Vitamin ◽

Maternal Vitamin D Status

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Vitamin D Deficiency in Mexican Pregnant Women: Is Supplementation with ≤400 IU/day Enough?

Nutrients ◽

10.3390/nu12092517 ◽

2020 ◽

Vol 12 (9) ◽

pp. 2517

Author(s):

Otilia Perichart-Perera ◽

Carla Patricia González-Leyva ◽

Isabel González-Ludlow ◽

Maricruz Tolentino-Dolores ◽

Mario Solis-Paredes ◽

...

Keyword(s):

Vitamin D ◽

Pregnant Women ◽

Vitamin D Deficiency ◽

Vitamin D3 ◽

Mexican Women ◽

Vitamin D Status ◽

Third Trimester ◽

Maternal Vitamin ◽

The Third ◽

Maternal Vitamin D Status

Controversy remains surrounding vitamin D routine supplementation in healthy pregnancy, and the doses are unclear. The aim of this study was to describe maternal vitamin D status throughout pregnancy in a group of Mexican women and evaluate the effect of frequently prescribed doses of vitamin D3 on longitudinal 25-OH-D concentrations, adjusting for obesity, season, and other factors. We conducted a cohort study (Instituto Nacional de Perinatología-INPer) (2017–2020)) of healthy pregnant women without complications. Pregestational overweight/obesity (body mass index ≥ 25), vitamin D3 supplementation (prescribed by physician; 0–250, 250–400, and >400 IU/day), and serum 25-OH-D concentrations (ELISA) were evaluated in each trimester of pregnancy. Vitamin D deficiency or insufficiency was computed (<20 and <30 ng/mL, respectively). We studied 141 adult women; 58.5% had pregestational obesity or overweight. In the first trimester, 45.8% of the women were supplemented with vitamin D3; 51.4% had vitamin D insufficiency and 37.3%, deficiency. In the third trimester, 75.4% of the women were supplemented, and 20% of them still had deficiency. The final general mixed linear model showed that 25-OH-D significantly increased throughout pregnancy (p < 0.001); the highest increase was observed in the third trimester in women with doses >400 IU/day of vitamin D3 (+4 ng/mL, 95% CI: 1.72–8.11 ng/mL). In winter/autumn, 25-OH-D concentrations were also lower (p ≤ 0.05). In this group of pregnant Mexican women, the prevalence of vitamin D deficiency and insufficiency was high. A higher increase in 25-OH-D concentrations during pregnancy was observed when the women were supplemented with >400 IU/day. Common supplementation doses of 250–400 IU/day were insufficient for achieving an adequate maternal vitamin D status.

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