The Top 100 Most Highly Cited Original Articles on Immune and Gut Microbiota
Abstract BackgroundCrosstalk between the gut microbiota and the host immune system is related to multiple diseases, and in recent years, this crosstalk has gradually become a research hotspot. Because the research involves many diseases, the mechanisms are extremely complicated, so both the screening out of the high-quality articles from the massive amount of literature and the in-depth interpretation of their data are helpful in guiding the direction of research.MethodsIn this study, the top 100 most highly cited original articles were obtained from a total of 43,858 papers. According to the number of citations in the Web of Science database, the results are sorted in descending order. One may download the data obtained by Web of Science into tab-delimited (Win) format and import it into VOSviewer (Leiden University, Leiden, Netherlands) for subsequent bibliometric analysis. We summarized the country, institution, journal, author and other indicators for all publications. Through the online bibliometric platform, we analyzed the publication volume and growth trends for different countries/regions. VOSviewer was used to classify keywords into different clusters based on co-occurrence analysis and color them according to the time course. ResultsThe number of citations for each article ranged from 914 to 5,460, and the most cited manuscript was written by PJ Turnbaugh and RE Ley. Washington University, the University of Colorado and Harvard University performed well in terms of the quality and quantity of publications. Manuscripts in NATURE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA and SCIENCE were the most influential. In addition, we identified six clusters of hotspots in the field of gut microbiota and immunity research.ConclusionsObesity and diabetes are the diseases most related to the gut microbiota, and their pathogenesis may be associated with a change in intestinal wall permeability and an imbalance of Bacteroides and Firmicutes. The balance of energy metabolism plays a key role in the crosstalk between host immunity and intestinal microbiota.