scholarly journals Traditional Chinese Medicine Reduces Hospitalization Risk of Osteoarthritis Patients: A 13- Year Population-based Cohort Study

2021 ◽  
Author(s):  
Yanping Zhao ◽  
Shuya Wang ◽  
James Cheng-Chung Wei ◽  
Yu Hsun Wang ◽  
Zhiyi Zhang
Keyword(s):  
Logistic Regression ◽  
Cohort Study ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Population Based ◽  
Hospitalization Rate ◽  
Study Patient ◽  
Research Database ◽  
Medical Expense

Abstract Introduction：Osteoarthritis (OA) is a chronic musculoskeletal disorder of the movable joints. TCM has been widely used as complementary therapy for OA in Chinese. Traditional Chinese medicine (TCM) including Duhuojishi decoction, Shujing Huoxue decoction, Angelica Niantong decoction, Guilu Erxian glue et al are widely used in the clinical of osteoarthritis treatment. However there are very few large-scale studies about long-term effect of TCM on OA treatment. This study determined the long-term effects of TCM on reducing OA patients hospitalization risk.Material and methods: This study was a population-based retrospective cohort study. Patient data were collected from the claim-based Taiwan National Health Insurance Research Database from 2000 to 2012. We enrolled 67737 TCM treated cohort and 67737 non-TCM comparison of newly diagnosed OA patients. Propensity score matching was done on age, sex and possible confounders to ensure baseline comparability. Outcomes were medical utility, including hospitalization rate, emergency visits and direct medical expense. Logistic regression was conducted to compare the differences o between TCM and non-TCM groups. Subgroup analyses were also performed by age, gender, income and urbanization.Results: TCM group had an overall higher medical expense than non-TCM group. Although Logistic regression analysis results showed that there was no difference of emergency rate in TCM group and non-TCM group, TCM treatment reduced hospitalization rate of OA significantly.Conclusions: The usage of TCM was associated with a reduced risk of hospitalization of OA patients. TCM might play a complementary role in OA treatment.

Traditional Chinese medicine use may reduce medical utility in patients with asthma: a nationwide population-based retrospective cohort study

QJM ◽  
2020 ◽  
Author(s):  
P F Liao ◽  
Y T Wang ◽  
Y H Wang ◽  
J Y Chiou ◽  
J C C Wei
Keyword(s):  
Cohort Study ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Population Based ◽  
Research Database ◽  
Continuous Variables ◽  
Emergency Visits ◽  
Asthma Patients

Summary Background Many patients with atopic diseases, including asthma, have sought complementary and alternative medicine and traditional Chinese medicine (TCM) treatments. But, limited clinical studies have yet examined TCM effects on medical utility in asthma patients. Aim To assess the medical utility of TCM in patients with asthma. Design Population-based retrospective cohort study. Methods We performed a 13-year population-based retrospective cohort study. A total of 5235 asthma patients who were TCM users and 5235 propensity-score matched asthma patients who never used TCM were sampled from the Taiwan National Health Insurance Research Database from 2000 to 2012. We compared these two groups of patients to calculate their medical utility, including numbers of emergency visits and hospitalizations until 2013. Univariate analyses were performed using Chi-square tests for dichotomous variables and t-tests for continuous variables. Cox proportional hazard models were conducted to investigate the medical utility of asthma after TCM use. Results Compared with non-TCM patients, TCM patients had a significantly decreased medical utility of asthma admission [adjusted odds ratio (OR) = 0.63; 95% confidence interval (CI): 0.46–0.85; P < 0.05], especially in patients who used TCM for >60 days. Asthma medical utility in asthma emergencies was significantly higher for male than for female patients (adjusted OR = 1.45; 95% CI: 1.08–1.96). The most frequently used TCMs for asthma control or cough treatment were antitussive agents. Conclusion This population-based retrospective cohort study showed a significantly decreased medical utility of emergency visits and admissions in TCM patients, especially using TCM for >60 days.

scholarly journals Thiazide diuretics and the risk of hip fracture after stroke: a population-based propensity-matched cohort study using Taiwan’s National Health Insurance Research Database

BMJ Open ◽  
2017 ◽  
Vol 7 (9) ◽  
pp. e016992 ◽  
Author(s):  
Shu-Man Lin ◽  
Shih-Hsien Yang ◽  
Hung-Yu Cheng ◽  
Chung-Chao Liang ◽  
Huei-Kai Huang
Keyword(s):  
Cohort Study ◽  
Health Insurance ◽  
Hip Fracture ◽  
National Health Insurance ◽  
National Health ◽  
Population Based ◽  
Research Database ◽  
Matched Cohort ◽  
Matched Cohort Study

ObjectivesThis study aimed to investigate the association between thiazide use and the risk of hip fracture after stroke.SettingA population-based, propensity-matched cohort study was conducted on the basis of Taiwan’s National Health Insurance Research Database.ParticipantsPatients with newly diagnosed ischaemic stroke between 2000 and 2011 were included. After propensity score matching, 7470 patients were included, of whom 3735 received thiazides and 3735 did not.Outcome measuresHRs for developing hip fractures within 2 years after stroke were calculated using Cox proportional hazards regression model with adjustments for sociodemographic and coexisting medical conditions.ResultsOverall, patients using thiazides after stroke had a lower risk of hip fracture than those not using thiazides (8.5 vs 13.9 per 1000 person-years, adjusted HR=0.64, 95% CI 0.46 to 0.89, p=0.007). Further sensitivity analysis based on the duration of thiazide use revealed that the risk of hip fracture tended to decrease as the duration of exposure of thiazides increased. However, the effect was significant only in patients with long-term use of thiazides (using thiazides for >365 days within 2 years after stroke), with a 59% reduction in the risk of hip fracture when compared with patients not using thiazide (adjusted HR=0.41, 95% CI 0.22 to 0.79, p=0.008).ConclusionsThe long-term use of thiazides is associated with a decreased risk of hip fracture after stroke.

scholarly journals Reduced risk of skin cancer and internal malignancies in vitiligo patients: a retrospective population-based cohort study in Taiwan

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Yu-Ching Weng ◽  
Hsiu J. Ho ◽  
Yi-Ling Chang ◽  
Yun-Ting Chang ◽  
Chun-Ying Wu ◽  
...  
Keyword(s):  
Cohort Study ◽  
Cell Carcinoma ◽  
Systemic Disease ◽  
Population Based ◽  
Incidence Rates ◽  
Research Database ◽  
Hazard Ratios ◽  
History Of ◽  
Rate Ratios

AbstractThe relationship between cancer and vitiligo has been explored but with inconsistent results. To examine the long-term cancer risk in vitiligo patients, we conducted a retrospective nationwide cohort study. From the National Health Insurance Research Database of Taiwan, a total of 13,824 vitiligo patients were identified and matched with 55,296 reference subjects without vitiligo by age, gender, and propensity score estimated by major comorbidities from 1997 to 2013. Demographic characteristics and comorbidities were compared between these two groups. Incidence rate ratios and hazard ratios (HRs) were calculated to examine cancer risks. The 16-year incidence rates of overall cancers were 621.06 (566.56–675.55) and 726.99 (697.24–756.74) per 100,000 person-years in the vitiligo and reference groups. Patients with vitiligo showed a significantly decreased risk of overall cancers [adjusted HR, 0.85; 95% confidence interval (CI), 0.77 to 0.93, p < 0.001] compared with reference subjects without vitiligo after adjusting for age, sex, comorbidities, and treatments. The risks of basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) were significantly reduced (adjusted HR 0.21, 95% CI 0.11–0.38, p < 0.001), as well as internal malignancies (adjusted HR 0.89, 95% CI 0.81–0.99, p = 0.026). The results were consistent across different subgroups of patients, including male gender, ages more than 40 years, and those receiving long-term systemic disease-modifying antirheumatic drugs and phototherapies. Information related to phenotype, disease duration, vitiligo lesion sites, family history of vitiligo or cancer, occupation, and personal lifestyle was not included in the database. Vitiligo is associated with reduced risks of BCC and SCC, as well as internal malignancies.

scholarly journals Migraine and subsequent chronic kidney disease risk: a nationwide population-based cohort study

BMJ Open ◽  
2017 ◽  
Vol 7 (12) ◽  
pp. e018483 ◽  
Author(s):  
Shuo-Chun Weng ◽  
Chia-Lin Wu ◽  
Chew-Teng Kor ◽  
Ping-Fang Chiu ◽  
Ming-Ju Wu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Cohort Study ◽  
Kidney Disease ◽  
Disease Risk ◽  
Population Based ◽  
Interactive Effects ◽  
Control Group ◽  
Research Database ◽  
Control Subjects

ObjectiveWe compared the incidence and risk of chronic kidney disease (CKD) between subjects with new-onset migraine and matched controls without migraine in this large-scale retrospective cohort study.DesignPopulation-based cohort study.Setting8880 subjects with migraine and 503 070 subjects without migraine were enrolled between January 1, 2000 and December 31, 2013, all diagnosed to be without kidney disease. All the participants were registered in the National Health Insurance Research Database.ParticipantsFinally, data from 7156 subjects with migraine and 7156 propensity-score-matched control subjects were analysed.Primary outcome measureWe used Cox proportional hazards regression to estimate adjusted HRs for incident CKD; subgroup analyses were performed to assess the interactive effects of migraine with demographics, comorbidities and long-term medications.ResultsThe incidence of CKD was higher in the migraine group than in the control group. The risk of developing CKD was significantly higher in subjects with migraine than without migraine (P=0.031). Subjects with migraine aged <65 years (age 40–64 (adjusted HR (aHR) 1.35; 95% CI 1.05 to 1.73); age <40 (aHR 1.55; 95% CI 1.02 to 2.36)), with ≥1 comorbid diseases (1–2 diseases (aHR 1.30; 95% CI 1.01 to 1.68); ≥3 diseases (aHR 1.45; 95% CI 1.01 to 2.07)), and not receiving anti-migraine agents (aHR 1.26; 95% CI 1.04 to 1.54) were at a higher risk of developing CKD compared with the control subjects. The interaction between migraine and comorbidities was not significant; age, male gender and long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) were independent risk factors for CKD in subjects with migraine.ConclusionMigraine may be an independent risk factor for CKD. Young subjects with migraine, and those with comorbid conditions or without medical control, are likely to be at higher risk for CKD. Ageing, male sex and NSAIDs tend to have an association with CKD in subjects with migraine.

scholarly journals Traditional Chinese Medicine Use among Patients with Psoriasis in Taiwan: A Nationwide Population-Based Study

2016 ◽  
Vol 2016 ◽  
pp. 1-13 ◽  
Author(s):  
Shu-Wen Weng ◽  
Bor-Chyuan Chen ◽  
Yu-Chiao Wang ◽  
Chun-Kai Liu ◽  
Mao-Feng Sun ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Population Based ◽  
Research Database ◽  
Newly Diagnosed ◽  
Population Based Study ◽  
Chinese Herbal Formula ◽  
Chinese Herbal ◽  
White Collar Workers ◽  
Median Interval

Traditional Chinese medicine (TCM) has long been used for patients with psoriasis. This study aimed to investigate TCM usage in patients with psoriasis. We analyzed a cohort of one million individuals representing the 23 million enrollees randomly selected from the National Health Insurance Research Database in Taiwan. We identified 28,510 patients newly diagnosed with psoriasis between 2000 and 2010. Among them, 20,084 (70.4%) patients were TCM users. Patients who were female, younger, white-collar workers and lived in urbanized area tended to be TCM users. The median interval between the initial diagnosis of psoriasis to the first TCM consultation was 12 months. More than half (N=11,609; 57.8%) of the TCM users received only Chinese herbal medicine. Win-qing-yin and Bai-xian-pi were the most commonly prescribed Chinese herbal formula and single herb, respectively. The core prescription pattern comprised Mu-dan-pi, Wen-qing-yin, Zi-cao, Bai-xian-pi, and Di-fu-zi. Patients preferred TCM than Western medicine consultations when they had metabolic syndrome, hepatitis, rheumatoid arthritis, alopecia areata, Crohn’s disease, cancer, depression, fatty liver, chronic airway obstruction, sleep disorder, and allergic rhinitis. In conclusion, TCM use is popular among patients with psoriasis in Taiwan. Future clinical trials to investigate its efficacy are warranted.

scholarly journals Decreased risk of dementia in migraine patients with traditional Chinese medicine use: a population-based cohort study

Oncotarget ◽  
2017 ◽  
Vol 8 (45) ◽  
pp. 79680-79692 ◽  
Author(s):  
Chun-Ting Liu ◽  
Bei-Yu Wu ◽  
Yu-Chiang Hung ◽  
Lin-Yi Wang ◽  
Yan-Yuh Lee ◽  
...  
Keyword(s):  
Cohort Study ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Population Based ◽  
Medicine Use

scholarly journals Association Between Aspirin Use and Decreased Risk of Pneumonia in Patients With Cardio-Cerebra-Vascular Ischemic Disease: A Population-Based Cohort Study

2021 ◽  
Vol 9 ◽  
Author(s):  
Ying-Cheng Chen ◽  
Yin-Yang Chen ◽  
Han Wei Yeh ◽  
Tung-Ying Yeh ◽  
Jing-Yang Huang ◽  
...  
Keyword(s):  
Cohort Study ◽  
Low Dose ◽  
Population Based ◽  
Hazard Ratio ◽  
Cumulative Probability ◽  
Research Database ◽  
Cox Regression Analysis ◽  
Dose Aspirin ◽  
Low Dose Aspirin

This study evaluated the association between long-term low-dose aspirin use and decreased risk of pneumonia in patients with cardio-cerebra-vascular ischemic diseases (CCVDs). This retrospective cohort study used records from Taiwan's National Health Insurance Research Database of claims made between 1997 and 2013. After propensity score matching (PSM), patients who took a low dose of aspirin for more than 90 days within 1 year of diagnosis with CCVDs were identified as the exposure group (n = 15,784). A matched total of 15,784 individuals without aspirin use were selected for the non-aspirin group. The main outcome was the development of pneumonia after the index date. Multivariable Cox regression analysis and Kaplan–Meier survival analysis were performed to estimate the adjusted hazard ratio (aHR) and cumulative probability of pneumonia. The result after PSM indicated a lower hazard ratio for pneumonia in aspirin users (aHR = 0.890, 95% confidence interval = 0.837–0.945). Therefore, patients with CCVDs who took aspirin had a lower risk of developing pneumonia than those who did not. In conclusion, this population-based cohort study demonstrated that long-term low-dose aspirin use is associated with a slightly decreased risk of pneumonia in patients with CCVDs.

Sign in / Sign up

Export Citation Format

Share Document