scholarly journals Can prolong life with nine turn method (Yan Nian Jiu Zhuan) Qigong alleviates Fatigue, Sleep quality, Depression and anxiety on Patients with Chronic Fatigue Syndrome: a Randomized, Controlled, Clinical Study ?

2021 ◽  
Author(s):  
Fangfang Xie ◽  
Jiatuo Xu ◽  
Chong Guan ◽  
Ziji Cheng ◽  
Yuanjia Gu ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Sleep Quality ◽  
Chronic Fatigue ◽  
Anxiety And Depression ◽  
Unknown Etiology ◽  
Control Group ◽  
Depression And Anxiety ◽  
Treatment Groups ◽  
Fatigue Syndrome ◽  
Wide Range

Abstract Background Chronic fatigue syndrome (CFS) is a complex disease with unknown etiology and mechanism. Prolong life with nine turn method (PLWNT) Qigong is a system of mind-body exercise with restorative benefits that have shown a wide range of benefits in the treatment of CFS. The purpose of this study is to investigate the effect of PLWNT Qigong exercise on CFS with a focus on fatigue, sleep quality, depression and anxiety. Methods A total of 135 participants were randomly divided into treatment groups and control group in the same proportion. The treatment groups received PLWNT Qigong exercise (PLWNT Group) or cognitive behavioral therapy treatment (CBT Group). The healthy control group (HC Group) does not receive any treatment and maintains daily life. Participants from treatment groups were taught by related highly qualified professor at the Shanghai University of Traditional Chinese Medicine once a week and were supervised online during the remaining 6 days at home, over 12 consecutive weeks. The primary outcome was fatigue (MFI-20) and secondary outcomes were sleep quality (PSQI), anxiety and depression (HADS). All groups were measured at baseline (T0) and post-intervention (T1). Results 134 patient completed the study (45 in the PLWNT Group, 44 in the CBT Group and 45 in HC Group). The within group comparison of PLWNT and CBT groups were all showed significant improvement in MFI-20, PSQI and HADS after the intervention (p༜0.05). No significant difference was found between the PLWNT group and CBT group(p༞0.05),but the total effective rate of the PLWNT group was 62.22%, which was higher than the CBT group was 50.00%. The changes in the PLWNT group and CBT group were all higher than those in the HC group except for habitual sleep efficiency and sleep medicine using(p༜0.05). In additional, fatigue degree changes in the PLWBT group were positively correlated with sleep degree (r=0.315) and anxiety degree(r=0.333), but only anxiety degree(r=0.332) was found to be positively correlated with fatigue in the CBT group. Conclusion PLWNT Qigong exercise has the potential as a rehabilitation method on CFS with a focus on fatigue, sleep quality, anxiety and depression. Yet, the results need to be interpreted carefully and needs to be repeated in a larger sample. Future studies will expand the sample size for further in-depth research to determine the frequency and intensity of PLWNT Qigong intervention that is particularly beneficial to CFS. The study registered in the American Clinical Trial Registry on 4 November 2018, the registration number is NCT03496961.

scholarly journals Patient education to encourage graded exercise in chronic fatigue syndrome

2004 ◽  
Vol 184 (2) ◽  
pp. 142-146 ◽  
Author(s):  
Pauline Powell ◽  
Richard P. Bentall ◽  
Fred J. Nye ◽  
Richard H. T. Edwards
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Intensive Therapy ◽  
Chronic Fatigue ◽  
The Self ◽  
Response To Treatment ◽  
Control Group ◽  
Treatment Groups ◽  
Fatigue Syndrome ◽  
Graded Exercise ◽  
Graded Activity

BackgroundAn earlier trial demonstrated good outcomes after 1 year for patients with chronic fatigue syndrome (CFS) who received an educational intervention designed to encourage graded activity.AimsTo determine 2-year outcomes for the same treated patients and the response to treatment of patients formerly in the control condition.MethodPatients in the treatment groups (n=114) were followed up at 2 years; 32 patients from the control group were offered the intervention after 1 year and were assessed 1 year later. Assessments were the self-rated measures used in the original trial.ResultsAt 2 years 63 of the treated patients (55%) no longer fulfilled trial criteria for CFS compared with 64 patients (56%) at 1 year. Fourteen of 30 crossover patients (47%) achieved a good outcome at 1 year and seven (23%) no longer fulfilled criteria for CFS.ConclusionsBenefits of the intervention were maintained at 2 years. Delaying treatment is associated with reduced efficacy and required more intensive therapy.

scholarly journals Cytokine profiling of extracellular vesicles isolated from plasma in myalgic encephalomyelitis/chronic fatigue syndrome: a pilot study

2020 ◽  
Vol 18 (1) ◽  
Author(s):  
Ludovic Giloteaux ◽  
Adam O’Neal ◽  
Jesús Castro-Marrero ◽  
Susan M. Levine ◽  
Maureen R. Hanson
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Extracellular Vesicles ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Unknown Etiology ◽  
Cytokine Signaling ◽  
Control Group ◽  
Homogeneous Population ◽  
Fatigue Syndrome ◽  
Immune System Dysfunction

Abstract Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease of unknown etiology lasting for a minimum of 6 months but usually for many years, with features including fatigue, cognitive impairment, myalgias, post-exertional malaise, and immune system dysfunction. Dysregulation of cytokine signaling could give rise to many of these symptoms. Cytokines are present in both plasma and extracellular vesicles, but little investigation of EVs in ME/CFS has been reported. Therefore, we aimed to characterize the content of extracellular vesicles (EVs) isolated from plasma (including circulating cytokine/chemokine profiling) from individuals with ME/CFS and healthy controls. Methods We included 35 ME/CFS patients and 35 controls matched for age, sex and BMI. EVs were enriched from plasma by using a polymer-based precipitation method and characterized by Nanoparticle Tracking Analysis (NTA), Transmission Electron Microscopy (TEM) and immunoblotting. A 45-plex immunoassay was used to determine cytokine levels in both plasma and isolated EVs from a subset of 19 patients and controls. Linear regression, principal component analysis and inter-cytokine correlations were analyzed. Results ME/CFS individuals had significantly higher levels of EVs that ranged from 30 to 130 nm in size as compared to controls, but the mean size for total extracellular vesicles did not differ between groups. The enrichment of typical EV markers CD63, CD81, TSG101 and HSP70 was confirmed by Western blot analysis and the morphology assessed by TEM showed a homogeneous population of vesicles in both groups. Comparison of cytokine concentrations in plasma and isolated EVs of cases and controls yielded no significant differences. Cytokine-cytokine correlations in plasma revealed a significant higher number of interactions in ME/CFS cases along with 13 inverse correlations that were mainly driven by the Interferon gamma-induced protein 10 (IP-10), whereas in the plasma of controls, no inverse relationships were found across any of the cytokines. Network analysis in EVs from controls showed 2.5 times more significant inter-cytokine interactions than in the ME/CFS group, and both groups presented a unique negative association. Conclusions Elevated levels of 30-130 nm EVs were found in plasma from ME/CFS patients and inter-cytokine correlations revealed unusual regulatory relationships among cytokines in the ME/CFS group that were different from the control group in both plasma and EVs. These disturbances in cytokine networks are further evidence of immune dysregulation in ME/CFS.

scholarly journals Qigong Exercise Alleviates Fatigue, Anxiety, and Depressive Symptoms, Improves Sleep Quality, and Shortens Sleep Latency in Persons with Chronic Fatigue Syndrome-Like Illness

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Jessie S. M. Chan ◽  
Rainbow T. H. Ho ◽  
Ka-fai Chung ◽  
Chong-wen Wang ◽  
Tzy-jyun Yao ◽  
...  
Keyword(s):  
Depressive Symptoms ◽  
Chronic Fatigue Syndrome ◽  
Sleep Quality ◽  
Sleep Latency ◽  
Chronic Fatigue ◽  
Anxiety And Depression ◽  
Subjective Sleep Quality ◽  
Subjective Sleep ◽  
Fatigue Syndrome ◽  
Time Interaction

Objectives. To evaluate the effectiveness of Baduanjin Qigong exercise on sleep, fatigue, anxiety, and depressive symptoms in chronic fatigue syndrome- (CFS-) like illness and to determine the dose-response relationship.Methods. One hundred fifty participants with CFS-like illness (mean age= 39.0,SD = 7.9) were randomly assigned to Qigong and waitlist. Sixteen 1.5-hour Qigong lessons were arranged over 9 consecutive weeks. Pittsburgh Sleep Quality Index (PSQI), Chalder Fatigue Scale (ChFS), and Hospital Anxiety and Depression Scale (HADS) were assessed at baseline, immediate posttreatment, and 3-month posttreatment. The amount of Qigong self-practice was assessed by self-report.Results. Repeated measures analyses of covariance showed a marginally nonsignificant (P= 0.064) group by time interaction in the PSQI total score, but it was significant for the “subjective sleep quality” and “sleep latency” items, favoring Qigong exercise. Improvement in “subjective sleep quality” was maintained at 3-month posttreatment. Significant group by time interaction was also detected for the ChFS and HADS anxiety and depression scores. The number of Qigong lessons attended and the amount of Qigong self-practice were significantly associated with sleep, fatigue, anxiety, and depressive symptom improvement.Conclusion. Baduanjin Qigong was an efficacious and acceptable treatment for sleep disturbance in CFS-like illness. This trial is registered with Hong Kong Clinical Trial Register:HKCTR-1380.

scholarly journals Exploratory study into the relationship between the symptoms of chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) and fibromyalgia (FM) using a quasiexperimental design

BMJ Open ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. e041947
Author(s):  
Pamela G Mckay ◽  
Helen Walker ◽  
Colin R Martin ◽  
Mick Fleming
Keyword(s):  
Quality Of Life ◽  
Chronic Fatigue Syndrome ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Anxiety And Depression ◽  
Symptom Experience ◽  
Fatigue Syndrome ◽  
The Impact ◽  
The Relationship

ObjectiveTo explore the relationship between symptoms of chronic fatigue syndrome (CFS)/myalgic encephalomyelitis (ME) and fibromyalgia (FM). The hypothesis predicated that there would be no significant differences between the group’s symptom experience.DesignA quasiexperimental design. Structural equation modelling (SEM) and invariance testing.ParticipantsMales (M) and females (F) >16 with a confirmed diagnosis of CFS/ME or FM by a general practitioner or specialist. CFS/ME (n=101, F: n=86, M: n=15, mean (M) age M=45.5 years). FM (n=107, F: n=95, M: n=12, M=47.2 years).Outcome measuresDiagnostic criteria: the American Centers for Disease Control and Prevention (CDC) for CFS/ME and the American College of Rheumatology (ACR) criteria for FM. Additional symptom questionnaires measuring: pain, sleep quality, fatigue, quality of life, anxiety and depression, locus of control and self-esteem.ResultsInvariance was confirmed with the exception of the American CDC Symptom Inventory, Fibromyalgia Impact Questionnaire and Hospital Anxiety and Depression Scale (p<0.05) based on five questions. Consequently, it was erroneous to conclude differences. Therefore, the Syndrome Model was created. SEM could not have tested the ACR previously, as it comprised a single data point. Thus, it was combined with these three questionnaires, increasing the data points, to create this new measurable model. Results confirmed no significant differences between groups (p=0.07 (p<0.05)).ConclusionParticipants responded in a similar manner to the questionnaire, confirming the same symptom experience. It is important to consider this in context with differing criteria and management guidelines, as this may influence diagnosis and the trajectory of patient’s management. With the biomedical cause currently unclear, it is the symptom experience and the impact on quality of life that is important. These findings are meaningful for patients, clinicians and policy development and support the requirement for future research.

scholarly journals Sleep Quality in Adolescents With Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME)

2017 ◽  
Vol 13 (09) ◽  
pp. 1057-1066 ◽  
Author(s):  
Elisha K. Josev ◽  
Melinda L. Jackson ◽  
Bei Bei ◽  
John Trinder ◽  
Adrienne Harvey ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Sleep Quality ◽  
Chronic Fatigue ◽  
Myalgic Encephalomyelitis ◽  
Fatigue Syndrome

scholarly journals Life events, difficulties and dilemmas in the onset of chronic fatigue syndrome: a case–control study

2003 ◽  
Vol 33 (7) ◽  
pp. 1185-1192 ◽  
Author(s):  
SIMON HATCHER ◽  
ALLAN HOUSE
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Life Events ◽  
Stressful Life Events ◽  
Chronic Fatigue ◽  
Case Control ◽  
Stressful Events ◽  
Control Group ◽  
Liaison Psychiatry ◽  
Fatigue Syndrome

Background. The role of stress in the onset of chronic fatigue syndrome is unclear. Our objectives in this study were first, to determine the relation between the onset of chronic fatigue syndrome and stressful life events and difficulties. Secondly, we examined the role of a particular type of problem, dilemmas, in the onset of chronic fatigue syndrome.Method. We used a case–control design with 64 consecutive referrals from an Infectious Diseases/Liaison Psychiatry Fatigue clinic and 64 age- and sex-matched controls from a general practice population control group in Leeds. We had two main outcome measures; the odds ratios of the risk of developing chronic fatigue syndrome after experiencing a severe life event, severe difficulties or both in the year and 3 months preceding onset; and the proportion of subjects in each group who experienced a dilemma prior to onset.Results. Patients with chronic fatigue syndrome were more likely to experience severe events and difficulties in the 3 months (OR=9, 95% CI 3·2 to 25·1) and year (OR=4·3, 95% CI 1·8 to 10·2) prior to onset of their illness than population controls. In the 3 months prior to onset 19 of the 64 patients (30%) experienced a dilemma compared to none of the controls.Conclusions. Chronic fatigue syndrome is associated with stressful events and difficulties prior to onset. Those events and difficulties characterized as being dilemmas seem to be particularly important.

scholarly journals Chronic fatigue syndrome: a clinical and laboratory study with a well matched control group

1995 ◽  
Vol 237 (5) ◽  
pp. 499-506 ◽  
Author(s):  
CAROLINE M. A. SWANINK ◽  
JAN H. M. M. VERCOULEN ◽  
GIJS BLEIJENBERG ◽  
JAN F. M. FENNIS ◽  
JOEP M. D. GALAMA ◽  
...  
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Laboratory Study ◽  
Matched Control ◽  
Chronic Fatigue ◽  
Control Group ◽  
Matched Control Group ◽  
Fatigue Syndrome

scholarly journals RESPONSE TO ADAMSON ET AL. (2020): “COGNITIVE BEHAVIOURAL THERAPY FOR CHRONIC FATIGUE AND CHRONIC FATIGUE SYNDROME: OUTCOMES FROM A SPECIALIST CLINIC IN THE UK”

2021 ◽  
Author(s):  
Brian Hughes ◽  
David Tuller
Keyword(s):  
Chronic Fatigue Syndrome ◽  
Cognitive Behavioural Therapy ◽  
Chronic Fatigue ◽  
Scientific Publication ◽  
Behavioural Therapy ◽  
Control Group ◽  
Fatigue Syndrome ◽  
Sample Attrition ◽  
Cognitive Behavioural ◽  
The Uk

In this review, we consider the paper by Adamson et al., published in the October 2020 issue of the Journal of the Royal Society of Medicine. The authors interpret their data as revealing significant improvements following cognitive behavioural therapy in a large sample of patients with chronic fatigue syndrome and chronic fatigue. Overall, the research is hampered by several fundamental methodological limitations that are not acknowledged sufficiently, or at all, by the authors. These include: (a) sampling ambiguity; (b) weak measurement; (c) survivor bias; (d) missing data; and (e) lack of a control group. In particular, the study is critically hampered by sample attrition, rendering the presentation of statements in the Abstract misleading with regard to points of fact, and, in our view, urgently requiring a formal published correction. In light of the fact that the paper was approved by multiple peer-reviewers and editors, we reflect on what its publication can teach us about the nature of contemporary scientific publication practices.

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