Tissue Engineering and its future perspective in therapeutic medicine- A Brief Review

2016 ◽  
Vol 4 (4) ◽  
pp. 159-164 ◽  
Author(s):  
Savreen Kaur ◽  
Sukhleen Sandhu ◽  
Sehaj K. Dhillon ◽  
Simran K. Makhni
Keyword(s):  
Tissue Engineering ◽  
Future Perspective

scholarly journals Biomimicry in Bio-Manufacturing: Developments in Melt Electrospinning Writing Technology Towards Hybrid Biomanufacturing

2019 ◽  
Vol 9 (17) ◽  
pp. 3540 ◽  
Author(s):  
Ferdows Afghah ◽  
Caner Dikyol ◽  
Mine Altunbek ◽  
Bahattin Koc
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Cell Attachment ◽  
Three Dimensional ◽  
Future Perspective ◽  
Melt Electrospinning ◽  
Wide Range ◽  
Challenges And Opportunities ◽  
Potential Applications ◽  
Homogeneous Cell

Melt electrospinning writing has been emerged as a promising technique in the field of tissue engineering, with the capability of fabricating controllable and highly ordered complex three-dimensional geometries from a wide range of polymers. This three-dimensional (3D) printing method can be used to fabricate scaffolds biomimicking extracellular matrix of replaced tissue with the required mechanical properties. However, controlled and homogeneous cell attachment on melt electrospun fibers is a challenge. The combination of melt electrospinning writing with other tissue engineering approaches, called hybrid biomanufacturing, has introduced new perspectives and increased its potential applications in tissue engineering. In this review, principles and key parameters, challenges, and opportunities of melt electrospinning writing, and particularly, recent approaches and materials in this field are introduced. Subsequently, hybrid biomanufacturing strategies are presented for improved biological and mechanical properties of the manufactured porous structures. An overview of the possible hybrid setups and applications, future perspective of hybrid processes, guidelines, and opportunities in different areas of tissue/organ engineering are also highlighted.

scholarly journals The Application Status of Nanoscale Cellulose-Based Hydrogels in Tissue Engineering and Regenerative Biomedicine

2021 ◽  
Vol 9 ◽  
Author(s):  
Chenyang Wang ◽  
Jin Bai ◽  
Pei Tian ◽  
Rui Xie ◽  
Zifan Duan ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Biomedical Applications ◽  
Cellulose Nanofibers ◽  
Three Dimensional ◽  
Drug Carriers ◽  
Wound Dressings ◽  
Skeletal Structure ◽  
Future Perspective ◽  
Dimensional Structure ◽  
Mechanical And Thermal Properties

As a renewable, biodegradable, and non-toxic material with moderate mechanical and thermal properties, nanocellulose-based hydrogels are receiving immense consideration for various biomedical applications. With the unique properties of excellent skeletal structure (hydrophilic functional groups) and micro-nano size (small size effect), nanocellulose can maintain the three-dimensional structure of the hydrogel to a large extent, providing mechanical strength while ensuring the moisture content. Owing to its unique features, nanocellulose-based hydrogels have made excellent progress in research and development on tissue engineering, drug carriers, wound dressings, development of synthetic organs, 3D printing, and biosensing. This review provides an overview of the synthesis of different types of nanocellulose, including cellulose nanocrystals, cellulose nanofibers, and bacterial nanocellulose, and describes their unique features. It further provides an updated knowledge of the development of nanocellulose-based functional biomaterials for various biomedical applications. Finally, it discusses the future perspective of nanocellulose-based research for its advanced biomedical applications.

scholarly journals Nanotopography in directing osteogenic differentiation of mesenchymal stem cells: potency and future perspective

2021 ◽  
Author(s):  
Anggraini Barlian ◽  
Katherine Vanya
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Growth Factors ◽  
Osteogenic Differentiation ◽  
Future Perspective ◽  
Osteogenic Markers

Severe bone injuries can result in disabilities and thus affect a person's quality of life. Mesenchymal stem cells (MSCs) can be an alternative for bone healing by growing them on nanopatterned substrates that provide mechanical signals for differentiation. This review aims to highlight the role of nanopatterns in directing or inducing MSC osteogenic differentiation, especially in bone tissue engineering. Nanopatterns can upregulate the expression of osteogenic markers, which indicates a faster differentiation process. Combined with growth factors, nanopatterns can further upregulate osteogenic markers, but with fewer growth factors needed, thereby reducing the risks and costs involved. Nanopatterns can be applied in scaffolds for tissue engineering for their lasting effects, even in vivo, thus having great potential for future bone treatment.

Decellularized scaffolds for tissue engineering: Current status and future perspective

2020 ◽  
Vol 44 (10) ◽  
pp. 1031-1043 ◽  
Author(s):  
Taufiek Konrad Rajab ◽  
Thomas J. O’Malley ◽  
Vakhtang Tchantchaleishvili
Keyword(s):  
Tissue Engineering ◽  
Current Status ◽  
Future Perspective ◽  
Decellularized Scaffolds

scholarly journals Recent advanced development of calcium phosphate in spherical form: syntheses and applications

2018 ◽  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Biomedical Applications ◽  
Spherical Particles ◽  
Future Perspective ◽  
Spherical Form ◽  
Spherical Core ◽  
Advanced Development ◽  
Hydrothermal Methods

The advantages of calcium phosphate in biomedical applications such as drug delivery, bone regeneration and tissue engineering have been recognized. An overview of calcium phosphate in spherical form including spherical particles, spherical core and spherical shell was carried out in this work. Advanced spheres manufacturing as well as characterisation methodologies by biomimic remineralisation, seawater and hydrothermal methods was investigated. Their use in dental and vaccine applications was focused and presented in this review. Finally, a brief conclusion of the existing challenges and future perspective are presented.

Decellularized bone extracellular matrix in skeletal tissue engineering

2020 ◽  
Vol 48 (3) ◽  
pp. 755-764
Author(s):  
Benjamin B. Rothrauff ◽  
Rocky S. Tuan
Keyword(s):  
Tissue Engineering ◽  
Bone Regeneration ◽  
Tissue Regeneration ◽  
Animal Studies ◽  
Tumor Resection ◽  
Regenerative Capacity ◽  
Skeletal Tissue ◽  
Large Bone

Bone possesses an intrinsic regenerative capacity, which can be compromised by aging, disease, trauma, and iatrogenesis (e.g. tumor resection, pharmacological). At present, autografts and allografts are the principal biological treatments available to replace large bone segments, but both entail several limitations that reduce wider use and consistent success. The use of decellularized extracellular matrices (ECM), often derived from xenogeneic sources, has been shown to favorably influence the immune response to injury and promote site-appropriate tissue regeneration. Decellularized bone ECM (dbECM), utilized in several forms — whole organ, particles, hydrogels — has shown promise in both in vitro and in vivo animal studies to promote osteogenic differentiation of stem/progenitor cells and enhance bone regeneration. However, dbECM has yet to be investigated in clinical studies, which are needed to determine the relative efficacy of this emerging biomaterial as compared with established treatments. This mini-review highlights the recent exploration of dbECM as a biomaterial for skeletal tissue engineering and considers modifications on its future use to more consistently promote bone regeneration.

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