scholarly journals Iron metabolismin conditions of infection. Review

2020 ◽  
pp. 90-99
Author(s):  
Yuriy P. Orlov ◽  
N. V Govorova ◽  
V. N Lukach ◽  
G. A Baitugaeva ◽  
A. V Klementyev ◽  
...  
Keyword(s):  
Fungal Pathogens ◽  
Medical Literature ◽  
Bacterial Flora ◽  
Medical Community ◽  
Therapeutic Approaches ◽  
Iron Supply ◽  
Review Analysis ◽  
The Relationship ◽  
Iron Exchange

The purpose of writing the review. Analysis of publications on the role of iron metabolism in the manifestation of the septic process and the dependence of bacterial flora activity on the conditions of their access to iron. Methods. More than 200 publications in pubmed, Medline, EMBASE medical literature databases were analyzed between 2000 and 2018 using the search words: iron and infection, iron and sepsis, iron exchange, iron and bacteria - including and available works in domestic (e-library) literature. Results. The review uses materials from 61 publications that meet the challenges of the search and reflect both the relationship between iron exchange and the development of the septic process and the importance for the medical community of understanding the identified relationships in the search for future therapeutic approaches. Conclusion. The review provides evidence of direct iron involvement in the manifestation of the septic process caused by various bacterial (q/-) and fungal flora. Introduction of iron-hesing agents and ciderophon - conjugate drugs to infected patients today seems to be a biologically acceptable approach as an auxiliary therapy in the treatment of septic process caused by pathogens dependent on iron supply (many bacterial and fungal pathogens), but the problem that is being raised certainly requires further experimental and clinical research.

Some Current Issues in Psychotherapy

1965 ◽  
Vol 17 (2) ◽  
pp. 651-658
Author(s):  
Daniel G. Brown
Keyword(s):  
Therapeutic Approaches ◽  
The Past ◽  
Session Types ◽  
The Relationship

Some of the basic issues in psychotherapy today include: the nature of neurotic symptoms, the role of insight, emphasis on reconstructing the past versus readjusting to the present, the relationship between therapist and patient, activeness-passiveness of the therapist, distinctive techniques used, length of psychotherapy, total number of sessions and duration of a session, types of patients in relation to therapeutic approaches, permanence of improvement, and principal goal or purpose of psychotherapy.

Depression in Institutionalized Adolescents: The Role of Memories of Warmth and Safeness, Shame and Self-criticism

2021 ◽  
Vol 24 ◽  
Author(s):  
Sara Santos ◽  
Maria do Céu Salvador
Keyword(s):  
Current Problem ◽  
The Self ◽  
Therapeutic Approaches ◽  
External Shame ◽  
Psychological Maladjustment ◽  
The Individual ◽  
Institutionalized Adolescents ◽  
The Relationship ◽  
A Current

Abstract Institutionalization is a current problem, related to several indicators of psychological maladjustment. In the same way, there are several studies that point to the role of shame and self-criticism in the development of psychopathology. Therefore, our study explored, in institutionalized adolescents, whether early memories of warmth and safeness (EMWS) were associated to depression through external shame and self-criticism. The sample included 171 institutionalized adolescents (60.2% girls; Mage = 15.56; SD = 1.49). Depression, EMWS, external shame and self-criticism were assessed. The EMWS didn’t show a direct effect on depression, exerting its effect indirectly through external shame and self-criticism. The relationship between EMWS and self-criticism was fully mediated by external shame, and the relationship between external shame and depression was fully mediated by self-criticism. In conclusion, the way the individual sees and relates to the self seems to impact on psychological adjustment and in the development of psychopathology. The fact that external shame and self-criticism fully mediated the relationship between EMWS and depression emphasizes the relevance of preventive and therapeutic approaches that aim to promote a healthier way of relating to the self.

scholarly journals Role of Sex in the Therapeutic Targeting of p53 Circuitry

2021 ◽  
Vol 11 ◽  
Author(s):  
Francesca Mancini ◽  
Ludovica Giorgini ◽  
Emanuela Teveroni ◽  
Alfredo Pontecorvi ◽  
Fabiola Moretti
Keyword(s):  
Age Of Onset ◽  
Preclinical Studies ◽  
Therapeutic Approaches ◽  
Related Factors ◽  
Therapeutic Targeting ◽  
Estrogenic Hormones ◽  
Preclinical And Clinical Studies ◽  
P53 Network ◽  
The Relationship

Sex profoundly affects cancer incidence and susceptibility to therapy, with sex hormones highly contributing to this disparity. Various studies and omics data suggest a relationship between sex and the oncosuppressor p53 circuitry, including its regulators MDM2 and MDM4. Association of this network with genetic variation underlies sex-related altered cancer risk, age of onset, and cancer sensitivity to therapy. Moreover, sex-related factors, mainly estrogenic hormones, can affect the levels and/or function of the p53 network both in hormone-dependent and independent cancer. Despite this evidence, preclinical and clinical studies aimed to evaluate p53 targeted therapy rarely consider sex and related factors. This review summarizes the studies reporting the relationship between sex and the p53 circuitry, including its associated regulators, MDM2 and MDM4, with particular emphasis on estrogenic hormones. Moreover, we reviewed the evaluation of sex/hormone in preclinical studies and clinical trials employing p53-target therapies, and discuss how patients’ sex and hormonal status could impact these therapeutic approaches.

scholarly journals ERβ in Triple-Negative Breast Cancer: Emerging Concepts and Therapeutic Possibilities

Endocrines ◽  
2021 ◽  
Vol 2 (3) ◽  
pp. 356-365
Author(s):  
Alessandra Monaco ◽  
Fabrizio Licitra ◽  
Martina Di Gisi ◽  
Giovanni Galasso ◽  
Marzia Di Donato ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Estrogen Receptor Alpha ◽  
Triple Negative ◽  
Therapeutic Approaches ◽  
Therapeutic Implications ◽  
Mediated Effects ◽  
The Relationship ◽  
Tnbc Subtype

Despite the improvements in diagnostic and therapeutic approaches, breast cancer still remains one of the world’s leading causes of death among women. Particularly, triple negative breast cancer (TNBC) is characterized by aggressiveness, metastatic spreading, drug resistance and a very high percentage of death in patients. Nowadays, identification of new targets in TNBC appears very compelling. TNBC are considered negative for the estrogen receptor alpha (ERα) expression. Nevertheless, they often express ERβ and its variants. As such, this TNBC subtype still responds to estrogens. While the ERβ1 variant seems to act as a tumor-suppressor, the two variants ERβ2 and 5 exhibit pro-oncogenic activities in TNBC. Thus, ERβ1 activation might be used to limit the growth and spreading as well as to increase the drug sensitivity of TNBC. In contrast, the pro-oncogenic properties of ERβ2 and ERβ5 suggest the possible development and clinical use of specific antagonists in TNBC treatment. Furthermore, the role of ERβ might be regarded in the context of the androgen receptor (AR) expression, which represents another key marker in TNBC. The relationship between AR and ERβ as well as the ability to modulate the receptor-mediated effects through agonists/antagonists represent a challenge to develop more appropriate therapies in clinical management of TNBC patients. In this review, we will discuss the most recent data in the field. Therapeutic implications of these findings are also presented in the light of the discovery of specific ERβ modulators.

Interactive effects of consideration leadership on the association of injury with training among home health aides

2014 ◽  
Vol 27 (1) ◽  
pp. 41-50 ◽  
Author(s):  
Doohee Lee ◽  
Won Jun Kwak
Keyword(s):  
National Level ◽  
Training Transfer ◽  
Home Health ◽  
Interactive Effects ◽  
Medical Community ◽  
Content Type ◽  
Home Health Aides ◽  
The Relationship ◽  
And Training

Purpose – Performance of home health aides remains imperative in the medical community, but understanding the potential role of consideration leadership (CL) in improving performance of home health aides in the literature has gone undetected. This paper seeks to address these issues. Design/methodology/approach – The present study, using the 2007 National Home Health Aides Survey (n=3,308), aims to investigate the moderating role of consideration leadership (CL) in the relationship between injury and training among home health aides at the national level. Descriptive statistics and a hierarchical logistic regression analysis were performed. Findings – Not all consideration practices play a positive role in the relationship between training and injury. The authors found only employee-focused consideration leadership practices, when introduced together with training, may benefit home health aides in reducing injury. Research limitations/implications – To maximize training effectiveness, leaders may need to understand the importance of their own role in training transfer processes and attempt to demonstrate adequate influence behaviors such as consideration. Originality/value – This research is the first of its kind to explore the role of consideration leadership in the relationship with injury and training among home health aides.

scholarly journals THE PROBLEM OF THE CORRELATION BETWEEN SPIRIT AND REALITY IN T. MANN’S NOVEL “TRISTAN”

2021 ◽  
pp. 25-30
Author(s):  
T. KONIEVA
Keyword(s):  
Short Stories ◽  
Short Story ◽  
The Novel ◽  
Personal Attitude ◽  
Scientific Investigations ◽  
Review Analysis ◽  
Literary Process ◽  
The Relationship ◽  
Cutting Problem

Short stories are an integral part of T. Mann’s creative heritage, which are distinguished by ideological, thematic and artistic richness, they give an idea of the evolution of the creative method and style of the writer. And although nowadays there is already a number of scientific investigations devoted to the review analysis of T. Mann’s creative path, there is a need to study the problem of culture “end of time” (in T. Mann’s terminology) in the novelistic work of the writer who went to political and social activities through art. The purpose of the article is to reveal the nuances of the relationship between spirit and reality in T. Mann’s short story “Tristan”.The article proves that within the cross-cutting problem of the relationship between art and life, which never ceased to bother the German writer, also the novel “Tristan” clearly distinguishes the related ones: art and beauty, art and morality, aesthetics and life, beauty and death, decadence and a disease of the spirit, the artist and reality, which allowed to clarify both the ideological concepts of creative individuality and the essence of its art. At the same time, the divergence between the views of the hero of the novel and T. Mann’s personal attitude to reality and art is shown. Enough attention is paid to identifying the role of the comic and the means of its formation in the novel. “Tristan” is interpreted in the context of the development of T. Mann’s work and the European literary process at the turn of the XIX - early XX centuries.The article identifies the place of the short story “Tristan” in the work of the German master of the word and outlines the ways of its further analysis.

Choosing a Markov blanket

2020 ◽  
Vol 43 ◽  
Author(s):  
Thomas Parr
Keyword(s):  
Markov Blanket ◽  
Target Article ◽  
The Relationship

Abstract This commentary focuses upon the relationship between two themes in the target article: the ways in which a Markov blanket may be defined and the role of precision and salience in mediating the interactions between what is internal and external to a system. These each rest upon the different perspectives we might take while “choosing” a Markov blanket.

Staring Down Death

Crisis ◽  
2016 ◽  
Vol 37 (3) ◽  
pp. 212-217 ◽  
Author(s):  
Thomas E. Joiner ◽  
Melanie A. Hom ◽  
Megan L. Rogers ◽  
Carol Chu ◽  
Ian H. Stanley ◽  
...  
Keyword(s):  
Suicide Risk ◽  
Clinical Utility ◽  
Blink Rate ◽  
Specific Task ◽  
Careful Planning ◽  
Eye Blink ◽  
Eye Blinks ◽  
Potential Clinical Utility ◽  
The Relationship

Abstract. Background: Lowered eye blink rate may be a clinically useful indicator of acute, imminent, and severe suicide risk. Diminished eye blink rates are often seen among individuals engaged in heightened concentration on a specific task that requires careful planning and attention. Indeed, overcoming one’s biological instinct for survival through suicide necessitates premeditation and concentration; thus, a diminished eye blink rate may signal imminent suicidality. Aims: This article aims to spur research and clinical inquiry into the role of eye blinks as an indicator of acute suicide risk. Method: Literature relevant to the potential connection between eye blink rate and suicidality was reviewed and synthesized. Results: Anecdotal, cognitive, neurological, and conceptual support for the relationship between decreased blink rate and suicide risk is outlined. Conclusion: Given that eye blinks are a highly observable behavior, the potential clinical utility of using eye blink rate as a marker of suicide risk is immense. Research is warranted to explore the association between eye blink rate and acute suicide risk.

Parenting Behaviors and Anxiety in Young Adults

2015 ◽  
Vol 36 (3) ◽  
pp. 170-176 ◽  
Author(s):  
Erin N. Stevens ◽  
Joseph R. Bardeen ◽  
Kyle W. Murdock
Keyword(s):  
Effortful Control ◽  
Parenting Behaviors ◽  
Protective Role ◽  
Anxiety Symptoms ◽  
Interactive Effects ◽  
Parental Overprotection ◽  
High Control ◽  
Development Of Anxiety ◽  
The Relationship

Parenting behaviors – specifically behaviors characterized by high control, intrusiveness, rejection, and overprotection – and effortful control have each been implicated in the development of anxiety pathology. However, little research has examined the protective role of effortful control in the relation between parenting and anxiety symptoms, specifically among adults. Thus, we sought to explore the unique and interactive effects of parenting and effortful control on anxiety among adults (N = 162). Results suggest that effortful control uniquely contributes to anxiety symptoms above and beyond that of any parenting behavior. Furthermore, effortful control acted as a moderator of the relationship between parental overprotection and anxiety, such that overprotection is associated with anxiety only in individuals with lower levels of effortful control. Implications for potential prevention and intervention efforts which specifically target effortful control are discussed. These findings underscore the importance of considering individual differences in self-regulatory abilities when examining associations between putative early-life risk factors, such as parenting, and anxiety symptoms.

Social Support, Emotional Intelligence, and Posttraumatic Stress Disorder Symptoms

2016 ◽  
Vol 37 (1) ◽  
pp. 31-39 ◽  
Author(s):  
Nicole L. Hofman ◽  
Austin M. Hahn ◽  
Christine K. Tirabassi ◽  
Raluca M. Gaher
Keyword(s):  
Social Support ◽  
Posttraumatic Stress Disorder ◽  
Emotional Intelligence ◽  
Protective Factors ◽  
Posttraumatic Stress ◽  
Stress Disorder ◽  
Traumatic Events ◽  
Ptsd Symptoms ◽  
The Relationship

Abstract. Exposure to traumatic events and the associated risk of developing Posttraumatic stress disorder (PTSD) symptoms is a significant and overlooked concern in the college population. It is important for current research to identify potential protective factors associated with the development and maintenance of PTSD symptoms unique to this population. Emotional intelligence and perceived social support are two identified protective factors that influence the association between exposure to traumatic events and PTSD symptomology. The current study examined the mediating role of social support in the relationship between emotional intelligence and PTSD symptoms. Participants included 443 trauma-exposed university students who completed online questionnaires. The results of this study indicated that social support mediates the relationship between emotional intelligence and reported PTSD symptoms. Thus, emotional intelligence is significantly associated with PTSD symptoms and social support may play an integral role in the relationship between emotional intelligence and PTSD. The current study is the first to investigate the role of social support in the relationship between emotional intelligence and PTSD symptoms. These findings have important treatment and prevention implications with regard to PTSD.

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