Influence of Dietary Metformin on the Growth Performance and Plasma Concentrations of Amino Acids and Advanced Glycation End Products in Two Types of Chickens

Vitamin B6 is a fascinating molecule involved in the vast majority of changes in the human body because it is a coenzyme involved in over 150 biochemical reactions. It is active in the metabolism of carbohydrates, lipids, amino acids, and nucleic acids, and participates in cellular signaling. It is an antioxidant and a compound with the ability to lower the advanced glycation end products (AGE) level. In this review, we briefly summarize its involvement in biochemical pathways and consider whether its deficiency may be associated with various diseases such as diabetes, heart disease, cancer, or the prognosis of COVID-19.

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Carnosine supplementation does not affect serum concentrations of advanced glycation and precursors of lipoxidation end products in autism: a randomized controlled clinical trial

Annals of Clinical Biochemistry International Journal of Laboratory Medicine ◽

10.1177/0004563218796860 ◽

2018 ◽

Vol 56 (1) ◽

pp. 148-154 ◽

Cited By ~ 3

Author(s):

Ramin Ghodsi ◽

Sorayya Kheirouri ◽

Rahmat Nosrati

Keyword(s):

Oxidative Stress ◽

Clinical Trial ◽

Advanced Glycation End Products ◽

Plasma Concentrations ◽

Assay Method ◽

Controlled Clinical Trial ◽

Autistic Children ◽

Advanced Glycation ◽

Glycation End Products ◽

End Products

Background Abundant evidence indicate the increased levels of oxidative stress in patients with autism. Advanced glycation end products and advanced lipoxidation end products and their precursors play a major role in increased oxidative stress in numerous metabolic and neurologic diseases. Carnosine is a natural dipeptide with antiglycation effects. The aim of this trial was to examine the effects of carnosine supplementation on the advanced glycation end products and the precursors of advanced lipoxidation end products in patients with autism. Method This randomized double-blind, placebo-controlled clinical trial was conducted on 36 autistic children, 18 in the carnosine group and 18 in the placebo group. The groups received a daily supplement of 500 mg carnosine or placebo for two months, respectively. Plasma concentrations of glycation and precursors of lipoxidation markers were evaluated by enzyme-linked immunosorbent assay method. Results In all, 63.9% of the autistic children had normal nutritional status. Carnosine supplementation did not significantly alter plasma concentrations of advanced glycation end products and precursors of advanced lipoxidation end products in autistic children. Conclusion The findings indicate that supplementation of carnosine could not change advanced glycation end products and precursor of advanced lipoxidation end products in autistic children.

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THE EXTRACT SOYBEAN OF LOCAL VARIETIES AS REDUCE ADVANCED GLYCATION END PRODUCTS AND HEMOGLOBIN A1C IN TYPE 2 DIABETES MICE

Asian Journal of Pharmaceutical and Clinical Research ◽

10.22159/ajpcr.2018.v11i11.26513 ◽

2018 ◽

Vol 11 (11) ◽

pp. 333 ◽

Cited By ~ 1

Author(s):

Juliana Christyaningsih ◽

Taufiqurrahman Taufiqurrahman ◽

Sujono Sujono

Keyword(s):

Type 2 Diabetes ◽

Amino Acids ◽

Advanced Glycation End Products ◽

Hemoglobin A1c ◽

Control Group ◽

Advanced Glycation ◽

Local Varieties ◽

Glycation End Products ◽

End Products

Objectives: Glucose and amino acids or fat in diabetic patients if were oxidized to form a compound amadori product (hemoglobin A1c [HbA1c]) and intermediate dicarbonyl that uses reactive carbonyl groups to bind with the amino acids to form advanced glycation end products (AGEs). Soybean is classified as a low index glycemic and content of polyphenol compounds are reported to have various biological activities, which are beneficial to health. Project objectives: The aim of this study was to determine the effect of extract soybean of local varieties obtained on AGEs and HbA1c.Methods: This study was a randomized pretest-posttest control group design. The amount of 28 Mus musculus Balb/C was divided into seven groups. The control group was divided four, while the test group was given extracts of three varieties of soybean, that is, Gema, Wilis, and Argomulyo at a dose equivalent to 1 g of soy/kg BW/day for 25 days. Type 2 diabetes (T2D) mice made with the administration of STZ at a dose of 55 mg/kg in mice.Results: There is a sign of differences in HbA1c levels in the group of mice, and there are different levels of AGEs, though not statistically significant in the group of mice.Conclusions: The extract soybean was a positive effect on the levels of AGEs and HbA1c in T2D mice.

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Profile of urinary amino acids and their post-translational modifications (PTM) including advanced glycation end-products (AGEs) of lysine, arginine and cysteine in lean and obese ZSF1 rats

Amino Acids ◽

10.1007/s00726-021-03042-3 ◽

2021 ◽

Author(s):

Svetlana Baskal ◽

Petra Büttner ◽

Sarah Werner ◽

Christian Besler ◽

Philipp Lurz ◽

...

Keyword(s):

Amino Acids ◽

Advanced Glycation End Products ◽

Serum Glucose ◽

Advanced Glycation ◽

Post Translational Modifications ◽

Urinary Creatinine ◽

Glycation End Products ◽

End Products ◽

Urinary Amino Acids ◽

Urinary Amino

AbstractHeart failure with preserved ejection fraction (HFpEF) is associated with high mortality and has an increasing prevalence associated with the demographic change and limited therapeutic options. Underlying mechanisms are largely elusive and need to be explored to identify specific biomarkers and new targets, which mirror disease progression and intervention success. Obese ZSF1 (O-ZSF1) rats are a useful animal model, as they spontaneously develop hypertension, hyperlipidemia and glucose intolerance and finally HFpEF. The urinary profile of amino acids and their metabolites of post-translational modifications (PTM), including the advanced glycation end-products (AGEs) of lysine, arginine and cysteine, are poorly investigated in HFpEF and ZSF1 rats. The aim of the present study was to characterize the status of free amino acids and their metabolites of PTM and glycation in lean ZSF1 (L-ZSF1) and O-ZSF1 rats in urine aiming to find possible effects of glucose on the excretion of native and modified amino acids. In the urine of twelve L-ZSF1 and twelve O-ZFS1 rats collected at the age of 20 weeks, we measured the concentration of native and modified amino acids by reliable previously validated stable-isotope dilution gas chromatography-mass spectrometry (GC–MS) approaches. Serum glucose was 1.39-fold higher in the O-ZSF1 rats, while urinary creatinine concentration was 2.5-fold lower in the O-ZSF1 rats. We observed many differences in urinary amino acids excretion between L-ZSF1 and O-ZSF1 rats. The creatinine-corrected homoarginine excretion was twofold lower in the O-ZSF1 rats. We also observed distinct associations between the concentrations of serum glucose and urinary amino acids including their PTM and AGE metabolites in the L-ZSF1 and O-ZSF1 rats. Our study shows that PTM metabolites and AGEs are consistently lower in the L-ZSF1 than in the O-ZSF1 rats. Serum malondialdehyde (MDA) concentration was higher in the O-ZSF1 rats. These results suggest that hyperglycemia, hyperlipidemia and elevated oxidative stress in the O-ZSF1 rats favor PTM methylation of arginine and lysine and the glycation of lysine and cysteine. The area under the receiver operation characteristic (ROC) curve values were 0.996 for serum glucose, 0.951 for urinary creatinine, 0.939 for serum MDA, 0.885 for Nε-carboxyethyl-lysine, 0.830 for carboxyethyl-cysteine, and 0.792 for monomethyl-lysine. Non-invasive measurement of methylation and glycation products of arginine, lysine and cysteine residues in proteins in urine of L-ZSF1 and O-ZSF1 rats may be useful in studying pathophysiology and pharmacology of HFpEF.

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Three-year variability in plasma concentrations of the soluble receptor for advanced glycation end products (sRAGE)

Clinical Biochemistry ◽

10.1016/j.clinbiochem.2013.11.005 ◽

2014 ◽

Vol 47 (1-2) ◽

pp. 132-134 ◽

Cited By ~ 10

Author(s):

Julie K. Bower ◽

James S. Pankow ◽

Mariana Lazo ◽

Eric Christenson ◽

Ron C. Hoogeveen ◽

...

Keyword(s):

Advanced Glycation End Products ◽

Plasma Concentrations ◽

Soluble Receptor ◽

Advanced Glycation ◽

Glycation End Products ◽

End Products

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Amino acids injure mesangial cells by advanced glycation end products, oxidative stress, and protein kinase C

Kidney International ◽

10.1111/j.1523-1755.2005.00159.x ◽

2005 ◽

Vol 67 (3) ◽

pp. 953-968 ◽

Cited By ~ 28

Author(s):

Katherine R. Tuttle ◽

Emily C. Johnson ◽

Sheryl K. Cooney ◽

Robert J. Anderberg ◽

Edward K. Johnson ◽

...

Keyword(s):

Oxidative Stress ◽

Amino Acids ◽

Protein Kinase C ◽

Protein Kinase ◽

Advanced Glycation End Products ◽

Mesangial Cells ◽

Advanced Glycation ◽

Kinase C ◽

Glycation End Products ◽

End Products

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Revisiting amino acids and peptides as anti-glycation agents

MedChemComm ◽

10.1039/c7md00514h ◽

2018 ◽

Vol 9 (4) ◽

pp. 614-624 ◽

Cited By ~ 5

Author(s):

H. Chilukuri ◽

M. J. Kulkarni ◽

M. Fernandes

Keyword(s):

Amino Acids ◽

Advanced Glycation End Products ◽

Advanced Glycation ◽

Glycation End Products ◽

End Products

The importance of amino acids and peptides in countering glycation and the formation of advanced glycation end-products (AGEs) is reviewed.

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Differential Effects of Dietary Patterns on Advanced Glycation end Products: A Randomized Crossover Study

Nutrients ◽

10.3390/nu12061767 ◽

2020 ◽

Vol 12 (6) ◽

pp. 1767 ◽

Cited By ~ 2

Author(s):

Yoona Kim ◽

Jennifer B. Keogh ◽

Permal Deo ◽

Peter M. Clifton

Keyword(s):

Type 2 Diabetes ◽

Advanced Glycation End Products ◽

Plasma Concentrations ◽

Processed Meat ◽

Advanced Glycation ◽

Dietary Interventions ◽

Glycation End Products ◽

End Products ◽

Liquid Chromatography Tandem Mass

Dietary advanced glycation end products (AGEs) are believed to contribute to pathogenesis of diabetes and cardiovascular disease. The objective of this study was to determine if a diet high in red and processed meat and refined grains (HMD) would elevate plasma concentrations of protein-bound AGEs compared with an energy-matched diet high in whole grain, dairy, nuts and legumes (HWD). We conducted a randomized crossover trial with two 4-week weight-stable dietary interventions in 51 participants without type 2 diabetes (15 men and 36 women aged 35.1 ± 15.6 y; body mass index (BMI), 27.7 ± 6.9 kg/m2). Plasma concentrations of protein-bound Nε-(carboxymethyl) lysine (CML), Nε-(1-carboxyethyl) lysine (CEL) and Nδ-(5-hydro-5-methyl-4-imidazolon-2-yl)-ornithine (MG-H1) were measured by liquid chromatography–tandem mass spectrometry (LC-MS/MS). The HMD significantly increased plasma concentrations (nmol/mL) of CEL (1.367, 0.78 vs. 1.096, 0.65; p < 0.01; n = 48) compared with the HWD. No differences in CML and MG-H1 between HMD and HWD were observed. HMD increased plasma CEL concentrations compared with HWD in individuals without type 2 diabetes.

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