scholarly journals Association of the Tight Junction Protein Claudin-4 with Lung Function and Exacerbations in Chronic Obstructive Pulmonary Disease

2021 ◽  
Vol Volume 16 ◽  
pp. 2735-2740
Author(s):  
Shinhee Park ◽  
Pureun-Haneul Lee ◽  
Ae Rin Baek ◽  
Jong Sook Park ◽  
Junehyuk Lee ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Lung Function ◽  
Tight Junction ◽  
Pulmonary Disease ◽  
Tight Junction Protein ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease ◽  
Junction Protein

Screening of High-risk Patients for Chronic Obstructive Pulmonary Disease in Primary Care: A Narrative Review (Preprint)

2020 ◽  
Author(s):  
Ponrathi Athilingam ◽  
Andrew Bugajski ◽  
Usha Menon
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Lung Function ◽  
Pulmonary Disease ◽  
Current Knowledge ◽  
Screening Tools ◽  
Chronic Obstructive ◽  
Early Screening ◽  
Obstructive Pulmonary Disease ◽  
Impaired Lung Function ◽  
Risk Patients

UNSTRUCTURED Chronic obstructive pulmonary disease (COPD) predominantly affects older adults, and claimed 3 million lives in 2016, making it the third leading cause of death worldwide. Over 35 million Americans aged 40 or older have lung function consistent with diagnosable COPD. COPD and cardiovascular disease (CVD) have a bidirectional relationship, in that one is a risk factor for developing the other. National and international consortiums recommend early screening of adults at risk of COPD, such as those with CVD. Recommended screening strategies include screening tools to assess symptoms, medical history, and handheld spirometry. Handheld spirometry has high diagnostic accuracy and if impaired lung function is indicated, these patients are referred for pulmonary function testing (PFT), the diagnostic gold standard for COPD. However, there is no clinical consensus for pulmonary screening in people with CVD. Current knowledge relating to the prevalence and incidence of CVD in people with COPD and the mechanisms that underlie their coexistence is key in combating the global burden of COPD.

scholarly journals Effect of Occupational Exposures on Decline of Lung Function in Early Chronic Obstructive Pulmonary Disease

2007 ◽  
Vol 176 (10) ◽  
pp. 994-1000 ◽  
Author(s):  
Philip Harber ◽  
Donald P. Tashkin ◽  
Michael Simmons ◽  
Lori Crawford ◽  
Eva Hnizdo ◽  
...  
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Lung Function ◽  
Pulmonary Disease ◽  
Occupational Exposures ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals Mechanisms of gas exchange response to lung volume reduction surgery in severe emphysema

2011 ◽  
Vol 110 (4) ◽  
pp. 1036-1045 ◽  
Author(s):  
George Cremona ◽  
Joan A. Barbara ◽  
Teresa Melgosa ◽  
Lorenzo Appendini ◽  
Josep Roca ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Chronic Obstructive Pulmonary Disease ◽  
Lung Function ◽  
Gas Exchange ◽  
Pulmonary Disease ◽  
Lung Volume ◽  
Chronic Obstructive ◽  
Lung Volume Reduction Surgery ◽  
Lung Volume Reduction ◽  
Obstructive Pulmonary Disease

Lung volume reduction surgery (LVRS) improves lung function, respiratory symptoms, and exercise tolerance in selected patients with chronic obstructive pulmonary disease, who have heterogeneous emphysema. However, the reported effects of LVRS on gas exchange are variable, even when lung function is improved. To clarify how LVRS affects gas exchange in chronic obstructive pulmonary disease, 23 patients were studied before LVRS, 14 of whom were again studied afterwards. We performed measurements of lung mechanics, pulmonary hemodynamics, and ventilation-perfusion (V̇a/Q̇) inequality using the multiple inert-gas elimination technique. LVRS improved arterial Po2 (PaO2) by a mean of 6 Torr ( P = 0.04), with no significant effect on arterial Pco2 (PaCO2), but with great variability in both. Lung mechanical properties improved considerably more than did gas exchange. Post-LVRS PaO2 depended mostly on its pre-LVRS value, whereas improvement in PaO2 was explained mostly by improved V̇a/Q̇ inequality, with lesser contributions from both increased ventilation and higher mixed venous Po2. However, no index of lung mechanical properties correlated with PaO2. Conversely, post-LVRS PaCO2 bore no relationship to its pre-LVRS value, whereas changes in PaCO2 were tightly related ( r2 = 0.96) to variables, reflecting decrease in static lung hyperinflation (intrinsic positive end-expiratory pressure and residual volume/total lung capacity) and increase in airflow potential (tidal volume and maximal inspiratory pressure), but not to V̇a/Q̇ distribution changes. Individual gas exchange responses to LVRS vary greatly, but can be explained by changes in combinations of determining variables that are different for oxygen and carbon dioxide.

Serum heavy metals and lung function in a chronic obstructive pulmonary disease cohort

2017 ◽  
Vol 9 (1) ◽  
pp. 30-35 ◽  
Author(s):  
Jeongwon Heo ◽  
Hyun Sun Park ◽  
Yoonki Hong ◽  
Jinkyeong Park ◽  
Seok-Ho Hong ◽  
...  
Keyword(s):  
Heavy Metals ◽  
Chronic Obstructive Pulmonary Disease ◽  
Lung Function ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

Study of Body Composition, Lung Function, and Quality of Life Following Use of Anabolic Steroids in Patients With Chronic Obstructive Pulmonary Disease

2014 ◽  
Vol 29 (2) ◽  
pp. 238-245 ◽  
Author(s):  
Mradul Kumar Daga ◽  
Naushad Ahmad Khan ◽  
Varun Malhotra ◽  
Suman Kumar ◽  
Govind Mawari ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Chronic Obstructive Pulmonary Disease ◽  
Body Composition ◽  
Lung Function ◽  
Pulmonary Disease ◽  
Anabolic Steroids ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease

scholarly journals Effect of temperature on lung function and symptoms in chronic obstructive pulmonary disease

1999 ◽  
Vol 13 (4) ◽  
pp. 844 ◽  
Author(s):  
G.C. Donaldson ◽  
T. Seemungal ◽  
D.j Jeffries ◽  
J.a Wedzicha
Keyword(s):  
Chronic Obstructive Pulmonary Disease ◽  
Lung Function ◽  
Pulmonary Disease ◽  
Effect Of Temperature ◽  
Chronic Obstructive ◽  
Obstructive Pulmonary Disease
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