scholarly journals Joint Modeling of Incidence of Tuberculosis and Change in Viral Load Over Time Among Adult HIV/AIDS Patients on Anti-Retroviral Therapy at Zewditu Memorial Hospital in Addis Ababa, Ethiopia

2021 ◽  
Vol Volume 13 ◽  
pp. 239-249
Author(s):  
Galana Mamo Ayana ◽  
Temesgen Yihunie Akalu ◽  
Tadesse Awoke Ayele
Keyword(s):  
Viral Load ◽  
Addis Ababa ◽  
Joint Modeling ◽  
Memorial Hospital ◽  
Aids Patients ◽  
Over Time ◽  
Hiv Aids

scholarly journals Adult HIV/AIDS Patients’ Level of Satisfaction on Pharmaceutical Service: Institutional Prospective Cross Sectional Study

2019 ◽  
Author(s):  
Adey Girmay ◽  
Zelalem Tilahun ◽  
Muluemebet Zinabu Akele ◽  
solomon Assefa Huluka
Keyword(s):  
Addis Ababa ◽  
Cross Sectional Study ◽  
Memorial Hospital ◽  
Sources Of Information ◽  
Sectional Study ◽  
Aids Patients ◽  
Cross Sectional ◽  
Pharmaceutical Service ◽  
Level Of Satisfaction ◽  
Hiv Aids

Abstract Objective : Patients are essential sources of information to assess the accessibility and effectiveness of pharmaceutical care. Patients’ perception and satisfaction on the care they received has direct influence on treatment adherence. This study was thus aimed to assess HIV/AIDS patients’ level of satisfaction on the pharmaceutical services provided in Zewditu Memorial Hospital, Addis Ababa, Ethiopia. An institution based cross sectional study was conducted from April 16, 2018 to May 16, 2018 in Zewditu Memorial Hospital. Result: Among the total 285 participants enrolled in the study, 172(60.4%) of them were females and the mean age of the participants was 42.5±9.8. The participants of this study received ART service for a mean duration of 7.3±3.5 years. In this study, 26.7%, 13.7%, 38.6%, 13% and 8.1% of the study participants rated the overall satisfaction to the ART pharmaceutical service as excellent, very good, good, fair, and poor, respectively. Participants who were provided information about drug-drug and drug-food interaction were 2.72 times more likely to be satisfied than those who weren’t provided (AOR=2.72, 95%CI : 1.13-6.54).

scholarly journals Adult HIV/AIDS Patients’ Level of Satisfaction on Pharmaceutical Service: Institutional Prospective Cross Sectional Study

2019 ◽  
Author(s):  
Adey Girmay ◽  
Zelalem Tilahun ◽  
Muluemebet Zinabu Akele ◽  
Solomon Assefa Huluka
Keyword(s):  
Addis Ababa ◽  
Cross Sectional Study ◽  
Memorial Hospital ◽  
Sources Of Information ◽  
Sectional Study ◽  
Aids Patients ◽  
Cross Sectional ◽  
Pharmaceutical Service ◽  
Level Of Satisfaction ◽  
Hiv Aids

Abstract Objective : Patients are essential sources of information to assess the accessibility and effectiveness of pharmaceutical care. Patients’ perception and satisfaction on the care they received has direct influence on treatment adherence. This study was thus aimed to assess HIV/AIDS patients’ level of satisfaction on the pharmaceutical services provided in Zewditu Memorial Hospital, Addis Ababa, Ethiopia. An institution based cross sectional study was conducted from April 16, 2018 to May 16, 2018 in Zewditu Memorial Hospital. Result: Among the total 285 participants enrolled in the study, 172(60.4%) of them were females and the mean age of the participants was 42.5±9.8. The participants of this study received ART service for a mean duration of 7.3±3.5 years. In this study, 26.7%, 13.7%, 38.6%, 13% and 8.1% of the study participants rated the overall satisfaction to the ART pharmaceutical service as excellent, very good, good, fair, and poor, respectively. Participants who were provided information about drug-drug and drug-food interaction were 2.72 times more likely to be satisfied than those who weren’t provided (AOR=2.72, 95%CI : 1.13-6.54).

scholarly journals Magnitude of Anemia and Associated Factors among Pediatric HIV/AIDS Patients Attending Zewditu Memorial Hospital ART Clinic, Addis Ababa, Ethiopia

Anemia ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-6 ◽  
Author(s):  
Hylemariam Mihiretie ◽  
Bineyam Taye ◽  
Aster Tsegaye
Keyword(s):  
T Cell ◽  
Associated Factors ◽  
Addis Ababa ◽  
Pediatric Hiv ◽  
Cd4 T Cell ◽  
Memorial Hospital ◽  
Aids Patients ◽  
Cell Counts ◽  
Prevalence Of Anemia ◽  
Hiv Aids

Background. Anemia is one of the most commonly observed hematological abnormalities and an independent prognostic marker of HIV disease. The aim of this study was to determine the magnitude of anemia and associated factors among pediatric HIV/AIDS patients attending Zewditu Memorial Hospital (ZMH) ART Clinic in Addis Ababa, Ethiopia.Methods. A cross-sectional study was conducted among pediatric HIV/AIDS patients of Zewditu Memorial Hospital (ZMH) between August 05, 2013, and November 25, 2013. A total of 180 children were selected consecutively. Stool specimen was collected and processed. A structured questionnaire was used to collect data on sociodemographic characteristics and associated risk factors. Data were entered into EpiData 3.1.1. and were analyzed using SPSS version 16 software. Logistic regressions were applied to assess any association between explanatory factors and outcome variables.Results. The total prevalence of anemia was 22.2% where 21 (52.5%), 17 (42.5%), and 2 (5.0%) patients had mild, moderate, and severe anemia. There was a significant increase in severity and prevalence of anemia in those with CD4+ T cell counts below 350 cells/μL (P<0.05). Having intestinal parasitic infections (AOR = 2.7, 95% CI, 1.1–7.2), having lower CD4+ T cell count (AOR = 3.8, 95% CI, 1.6–9.4), and being HAART naïve (AOR = 2.3, 95% CI, 1.6–9.4) were identified as significant predictors of anemia.Conclusion. Anemia was more prevalent and severe in patients with low CD4+ T cell counts, patients infected with intestinal parasites/helminthes, and HAART naïve patients. Therefore, public health measures and regular follow-up are necessary to prevent anemia.

scholarly journals Factors associated with prognostic or treatment outcomes in HIV/AIDS patients with and without hypertension in Eswatini

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sabelo Bonginkosi Dlamini ◽  
Hans-Uwe Dahms ◽  
Ming-Tsang Wu
Keyword(s):  
Viral Load ◽  
P Value ◽  
Aids Patients ◽  
Large Hospital ◽  
Hypertensive Patients ◽  
Factors Associated ◽  
Cell Counts ◽  
Cd4 Cell Counts ◽  
Cd4 Cell ◽  
Hiv Aids

AbstractNon-communicable diseases are increasing faster in HIV/AIDS patients than in the general population. We studied the association between hypertension and other possible confounding factors on viral load and CD4-cell counts in hypertensive and non-hypertensive HIV/AIDS patients receiving antiretroviral therapy (ART) at a large hospital in Eswatini over a 4-year period. We performed a retrospective longitudinal review of the medical records of 560 ART patients divided into non-hypertension and hypertension groups (n = 325 and n = 235) from July 27 to September 8, 2018. Generalized Estimated Equation was used to analyze the longitudinal data. Hypertensive patients were more likely to have improved CD4-cell counts than non-hypertensive patients (OR = 1.83, [1.37–2.44]). ART patients with hypertension were more likely to have detectable viral loads, though not significant (OR = 1.37 [0.77–2.43]). In non-hypertensive patients, second line ART was significantly associated with viral load (OR = 8.61 [2.93–25.34]) and adverse side effects (OR = 3.50 [1.06–11.54]), while isoniazid preventive therapy was significantly associated with CD4-cell counts (OR = 1.68 [1.16–2.45]). In hypertensive patients, factors associated with viral load were WHO HIV stage (OR = 2.84 [1.03–7.85]) and adherence (OR = 8.08 [1.33–49.04]). In both groups, CD4-cell counts significantly and steadily increased over time (p-value < 0.001). Results show a significant association between hypertension and CD4 cell counts but not viral load. In ART patients with and without hypertension, the factors associated with prognostic markers were different. More attention may need to be paid to ART patients with well controlled HIV status to monitoring and controlling of hypertension status.

scholarly journals Impact of default rate of antiretroviral use on viral load among HIV/AIDS patients in Tamale and Sunyani

2021 ◽  
Vol 8 (3) ◽  
pp. 87-91
Author(s):  
James Abugri
Keyword(s):  
Viral Load ◽  
Antiretroviral Therapy ◽  
Highly Active Antiretroviral Therapy ◽  
Hematological Parameters ◽  
Research Centre ◽  
Full Blood Count ◽  
P Value ◽  
Aids Patients ◽  
Persons Living With Hiv ◽  
Hiv Aids

Background: Highly Active Antiretroviral Therapy (HAART) for persons living with HIV/AIDS (PLWHA) is the gold standard for the management of HIV patients. Purportedly, patients who are not on HAART or defaulted from its use have adverse effects compared to those who adhere to the intake of HAART. Compliant individuals have improved quality of life and show healthy hematological parameters and HIV load as compared to HAART naïve individuals and defaulters. Supplementary and supportive treatment is crucial in HIV/AIDS patients on patients on antiretroviral therapy? Objective: This study was conducted to assess the consistency and default of HAART intake and other supportive treatments and its relationship with viral load on hematological parameters in two different geographical sites. Methods: Ethical clearance was obtained from Navrongo Health Research Centre. Questionnaires were administered to participants for their consent, demographic data, consistency of taking antiretrovirals, and types of antiretrovirals used. Full blood count and HIV load tests were carried out using Urit 5250 and Cobas Taqman / Cobas ampliprep fully automated analysers respectively. Results: Defaulters had a significant (p value=0.003) rise in their viral load (845334.38±409285.62) copies/mL in comparison to adherents in HAART intake 49571.69±30548.89) copies/mL. The hemoglobin level (10.51±0.60 g/dL) of defaulters was significantly (p-value = 0.007) lower than that of adherent (12.04±0.17 g/dL). The default rates in the two study sites were close (9.8% in Sunyani and 9.4% in Tamale). Conclusion: Antiretroviral default does not only lead to an increase in HIV load but also causes a reduction in hemoglobin levels. Hematinics supplementation therapy may help normalize hematological parameters in HIV infection

scholarly journals A Comparative Study of Different Joint Modeling Approaches for HIV/AIDS Patients in Southern Iran

2020 ◽  
Author(s):  
Narges ROUSTAEI ◽  
Jamshid JAMALI ◽  
Seyyed Mohammad TAGHI AYATOLLAHI ◽  
Najaf ZARE
Keyword(s):  
Latent Class ◽  
Joint Modeling ◽  
Latent Class Models ◽  
Repeated Measurements ◽  
Survival Outcomes ◽  
Fars Province ◽  
Aids Patients ◽  
Southern Iran ◽  
Hiv Aids

Background: The prevalence of HIV/AIDS has been increasing in Iran, especially amongst the young population, recently. The joint model (JM) is a statistical method that represents an effective strategy to incorporate all information of repeated measurements and survival outcomes simultaneously. In many theoretical studies, the population under the study were heterogeneous. This study aimed at comparing three approaches by considering heterogeneity in the patients. Methods: This study was conducted on 750 archived files of patients infected with HIV in Fars Province, southern Iran, from 1994 to 2017. Proposed Approach (PA), Joint Latent Class Models (JLCM), and Separated Approach (SA) were compared to evaluate the influence covariates on the longitudinal and time-to-event outcomes in the heterogeneous HIV/AIDS patients. Results: Gender (P<0.001) and HCV (P<0.01) were two significant covariates in the classification of HIV/AIDS patients. Time had a significant effect on CD4 (P<0.001) in both classes in the three approaches. In PA and SA, females had higher CD4 than males (P<0.001) in the first class. In JLCM, females had higher CD4 than males (P<0.01) in both classes. The patients with higher Hgb had also higher CD4 (P<0.001) in both classes in the three approaches. HCV reduced the CD4 significantly in both classes in PA (P<0.05) and SA (P<0.001). Within the survival sub-model, HCV reduced survival rate significantly in the second class in PA (P<0.05), JLCM (P<0.01) and SA (P<0.001). Conclusion: PA was an appropriate approach for joint modeling longitudinal and survival outcomes for this heterogeneous population.

scholarly journals The Association of CD4, CD8, and CD4/CD8 Ratio with Thyroid Dysfunction in HIV/AIDS

2021 ◽  
Vol 27 (3) ◽  
pp. 326
Author(s):  
Sri Mulyani ◽  
MI. Diah Pramudianti ◽  
Dian Ariningrum
Keyword(s):  
Viral Load ◽  
Thyroid Dysfunction ◽  
Opportunistic Infections ◽  
Prevalence Ratio ◽  
Aids Patients ◽  
Cross Sectional ◽  
Cd4 Counts ◽  
Hiv Rna ◽  
Cross Sectional Design ◽  
Hiv Aids

Incidence of thyroid dysfunction increases in HIV/AIDS patients. It can be a hypothyroid or hyperthyroid, with subclinical hypothyroid predomination. Thyroid dysfunction is associated with the progression of HIV and low CD4 counts. There has been controversy over how HIV affects thyroid function. Opportunistic infections and HBV/HCV co-infections might increase the probability of thyroid dysfunction. Medication of HIV is also an important factor of thyroid dysfunction. Research shows that the use of ART increases the probability of thyroid dysfunction. This study aimed to analyze the association between CD4 counts, CD8, CD4/CD8 ratio, and HIV RNA viral load with thyroid dysfunction in HIV/AIDS patients. An observational study with a cross-sectional design was conducted from August to September 2020 in Dr. Moewardi Hospital, Surakarta on 60 HIV/AIDS patients. All subjects were 18-60 years old. The research data were analyzed with a 2x2 test table to determine the Prevalence Ratio (PR) of each variable, then multivariate analysis with logistic regression was continued. The study showed 6.7% thyroid dysfunction in HIV/AIDS patients, 5% subclinical hyperthyroidism, and 1.7% subclinical hypothyroidism. The CD4 counts [PR 13.36 (95% CI: 1.53-116,65; p=0.017) and CD8 counts [PR 0.91 (95% CI: 3 0.02-0.51; p=0.032)] significantly associated with thyroid dysfunction in HIV/AIDS patients. CD4 counts < 200 cells/mm and 3 CD8 counts ≥500 cells/mm were associated with the incidence of thyroid dysfunction in HIV/AIDS patients, while CD4/CD8 ratio and HIV RNA viral load were not associated. CD4 count was not an independent predictor of thyroid dysfunction in HIV/AIDS patients.

scholarly journals Detection of HIV-1 viral load in tears of HIV/AIDS patients

Infection ◽  
2020 ◽  
Vol 48 (6) ◽  
pp. 929-933
Author(s):  
Yujing Qian ◽  
Zunyou Wu ◽  
Chao Chen ◽  
Kuifang Du ◽  
Wenbin Wei
Keyword(s):  
Viral Load ◽  
T Cell ◽  
Cell Count ◽  
Highly Active Antiretroviral Therapy ◽  
Plasma Viral Load ◽  
Aids Patients ◽  
Cross Sectional ◽  
Laboratory Test Results ◽  
Hiv 1 ◽  
Hiv Aids

Abstract Objectives The tear, as an important bodily secretion, plays a crucial role in preventing infection and maintaining homeostasis of ocular surfaces. Although accumulating studies have reported on the HIV-1 viral load profile among varying bodily fluids and secretions, little was known concerning HIV-1 dynamics in tears. Therefore, the objectives of this study were to investigate the HIV-1 viral load in tears of HIV/AIDS patients and study factors influencing their tear viral load. Methods A cross-sectional study was conducted. 67 patients with a confirmed HIV-1 infection or AIDS were recruited from the Beijing You’an Hospital, China between April 2018 and September 2018. Socio-demographic information and laboratory test results were collected. At the same time, ophthalmic examinations were carried out and tear samples were tested. Results Of 30 highly active antiretroviral therapy (HAART)-naïve patients, 53.3% had detectable HIV-1 RNA in tears. Of 37 patients on HAART, HIV-1 RNA was undetectable in their tears, regardless of treatment duration and blood viral load. Tear viral load ranged from TND (target not detected) to 13,096 copies/mL. Viral load was lower in tears than in blood plasma (p < 0.001), and was significantly correlated with plasma viral load (Rho = 0.566, p < 0.001) and AIDS stage (Rho = 0.312, p = 0.01), but negatively correlated with CD4 + T cell count, CD4 +/CD8 + T cell count, and duration of HIV infection (Rho = -0.450, Rho = − 0.464, Rho = − 0.565; p < 0.001). Conclusions HIV-1 RNA is present in tears of more than half of the HAART-naïve patients, whereas absent in tears of patients on HAART. Tear viral load is positively associated with plasma viral load while it is negatively correlated with CD4 cell count. This study provides novel insights into the area with limited understanding–HIV-1 viral load in tears.

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